Bioassay for monitoring the anti-aging effect of cord blood treatment
Conclusions: The cMES platform will empower both pre- and clinical anti-aging research by enabling minimally invasive, longitudinal treatment surveillance; these capacities will accelerate the development of anti-aging therapies, improving the quality of individual lives. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Sang-Hun Bae, Ala Jo, Jae Hyun Park, Chul-Woo Lim, Yuri Choi, Juhyun Oh, Ji-Min Park, TaeHo Kong, Ralph Weissleder, Hakho Lee, Jisook Moon Tags: Research Paper Source Type: research

In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats
Conclusions: [18F]NS12137 was synthesized in good yield and high molar activity and demonstrated the characteristics of a good radiotracer, such as good brain penetration, fast washout, and high specific binding to NET. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Francisco R. L ó pez-Pic ó n, Anna K. Kirjavainen, Sarita Forsback, Jatta S. Takkinen, Dan Peters, Merja Haaparanta-Solin, Olof Solin Tags: Research Paper Source Type: research

Self-Luminescing Theranostic Nanoreactors with Intraparticle Relayed Energy Transfer for Tumor Microenvironment Activated Imaging and Photodynamic Therapy
Conclusion: The nanosystem reported here might serve as a targeted, smart, precise, and noninvasive strategy triggered by the tumor microenvironment rather than by an outside light source for cancer NIR imaging and PDT treatment without limitations on penetration depth. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Ming Wu, Lingjie Wu, Jiong Li, Da Zhang, Shanyou Lan, Xiaolong Zhang, Xinyi Lin, Gang Liu, Xiaolong Liu, Jingfeng Liu Tags: Research Paper Source Type: research

Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca2+-NFAT1 Axis
Conclusions: Our findings have provided underlying molecular details for the aggressive behavior of BLBC. The Snail-mediated downregulation of ABAT expression in BLBC provides tumorigenic and metastatic advantages by activating GABA-mediated Ca2+-NFAT1 axis. Thus, our results have identified potential prognostic indicators and therapeutic targets for this challenging disease. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Xingyu Chen, Qianhua Cao, Ruocen Liao, Xuebiao Wu, Shining Xun, Jian Huang, Chenfang Dong Tags: Research Paper Source Type: research

CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin
Conclusion: We demonstrated increased topical drug delivery of curcumin to inflamed tissues using HA-ES targeting the highly expressed CD44 protein. This innovative strategy could be applied for the development of topical drug delivery systems targeting inflamed skin. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yongtai Zhang, Qing Xia, Yanyan Li, Zehui He, Zhe Li, Teng Guo, Zhonghua Wu, Nianping Feng Tags: Research Paper Source Type: research

Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration
Conclusion: This work offers a new approach for repairing chronic wounds completely through a multifunctional hydrogel with controlled exosomes release. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Chenggui Wang, Min Wang, Tianzhen Xu, Xingxing Zhang, Cai Lin, Weiyang Gao, Huazi Xu, Bo Lei, Cong Mao Tags: Research Paper Source Type: research

A Turn-On Optoacoustic Probe for Imaging Metformin-Induced Upregulation of Hepatic Hydrogen Sulfide and Subsequent Liver Injury
Conclusion: The probe responds quickly to H2S in tumors and the liver, and MSOT imaging with the probe offers cross-secitonal and 3D spatial information of liver injury. This study may provide an effective approach for accessing medication side effects by tracking drug-metabolism-related products. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Lihe Sun, Yinglong Wu, Junjie Chen, Jun Zhong, Fang Zeng, Shuizhu Wu Tags: Research Paper Source Type: research

Redox Dual-Responsive and O2 ‑ Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors
Conclusions: RA-S-S-Cy@PLGA NPs would be efficient theranostic nanosystems for more precise therapy against hypoxic tumors and provides a potential tool for deeper understanding of drug release mechanisms. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Huachao Chen, Fei Li, Yongrong Yao, Zhe Wang, Zhihao Zhang, Ninghua Tan Tags: Research Paper Source Type: research

Selective Autophagy Regulates Cell Cycle in Cancer Therapy
Aberrant function of cell cycle regulators results in uncontrolled cell proliferation, making them attractive therapeutic targets in cancer treatment. Indeed, survival of many cancers exclusively relies on these proteins, and several specific inhibitors are in clinical use. Although the ubiquitin-proteasome system is responsible for the periodic quality control of cell cycle proteins during cell cycle progression, increasing evidence clearly demonstrates the intimate interaction between cell cycle regulation and selective autophagy, important homeostasis maintenance machinery. However, these studies have often led to diver...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Kai Zheng, Zhendan He, Kaio Kitazato, Yifei Wang Tags: Review Source Type: research

Engineering Nanoparticles for Targeted Remodeling of the Tumor Microenvironment to Improve Cancer Immunotherapy
Owing to the fast-paced growth and cross-infiltration of oncology, immunology and molecular biology, tumor immunotherapy technology represented by immune checkpoint blockade and chimeric antigen receptor (CAR) T cell therapy has lately made remarkable advancements. In comparison with traditional chemotherapy, immunotherapy has the potential to elicit a stronger sustained antitumor immune response in those patients who have advanced malignant malignancies. In spite of the advancements made, a significant number of clinical research works have validated that an extensive proportion of cancer patients still manifest insensiti...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Shan Gao, Dongjuan Yang, Yan Fang, Xiaojie Lin, Xuechao Jin, Qi Wang, Xiyan Wang, Liyuan Ke, Kai Shi Tags: Review Source Type: research

Multimodal and Multiscale Analysis Reveals Distinct Vascular, Metabolic and Inflammatory Components of the Tissue Response to Limb Ischemia
Conclusion: Combined nuclear imaging and cell population analysis reveals distinct components of the ischemic tissue response and associated cell subsets, which could be targeted for therapeutic interventions. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Tamar Kapanadze, Jens P. Bankstahl, Alexander Wittneben, Wolfgang Koestner, Matthias Ballmaier, Jaba Gamrekelashvili, Kashyap Krishnasamy, Anne Limbourg, Tobias L. Ross, Geerd-J ü rgen Meyer, Hermann Haller, Frank M. Bengel, Florian P. Limbourg Tags: Research Paper Source Type: research

Enhancement of mitochondrial ROS accumulation and radiotherapeutic efficacy using a Gd-doped titania nanosensitizer
Conclusion: The designed nanosensitizer in combination with X-ray radiation exposure could be used for radiotherapy against cancer in living cells and in vivo. Moreover, the nanosensitizer with mitochondria targeting played a pivotal role in triggering a “domino effect” of ROS and cell apoptosis. The current strategy could provide new opportunities in designing efficient radiosensitizers for future cancer therapy. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yuanyuan Chen, Na Li, Jianbo Wang, Xia Zhang, Wei Pan, Longhai Yu, Bo Tang Tags: Research Paper Source Type: research

OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer
Conclusion: Taken together, the present study provides the first evidence that OTUB2 acts as a pivotal driver in NSCLC tumorigenesis by stabilizing U2AF2 and activating the AKT/mTOR pathway and the Warburg effect. It may serve as a new potential prognostic indicator and therapeutic target in NSCLC. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Jing Li, Dongdong Cheng, Miaoxin Zhu, Huajian Yu, Zhen Pan, Lei Liu, Qin Geng, Hongyu Pan, Mingxia Yan, Ming Yao Tags: Research Paper Source Type: research

Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease
Conclusions: These findings suggest that MM-EVs play a pivotal role in the development of severely impaired osteoblast activity, which represents a novel biomarker for the precise diagnosis of MBD and a compelling rationale for exploring MM-EVs as a therapeutic target. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Liming Zhang, Qian Lei, Hongxiang Wang, Cuiwei Xu, Teng Liu, Fancong Kong, Cui Yang, Guoxin Yan, Li Sun, Aiqi Zhao, Wenlan Chen, Yu Hu, Hui Xie, Yulin Cao, Fenfen Fu, Guolin Yuan, Zhichao Chen, An-Yuan Guo, Qiubai Li Tags: Research Paper Source Type: research

An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency
Conclusion: In summary, our study highlights the potential of IgM subtype antibodies in combatting pathogenic microbes. Moreover, C7G6-IgM is a promising candidate for the development of prophylactics or therapeutics against influenza B infection. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Chenguang Shen, Minwei Zhang, Yuanzhi Chen, Limin Zhang, Guosong Wang, Junyu Chen, Siyuan Chen, Zizhen Li, Feixue Wei, Jing Chen, Kunyu Yang, Shuxin Guo, Yujing Wang, Qingbing Zheng, Hai Yu, Wenxin Luo, Jun Zhang, Honglin Chen, Yixin Chen, Ningshao Xia Tags: Research Paper Source Type: research

Artificial intelligence-based decision-making for age-related macular degeneration
In this study, we used a dataset of labeled 35,900 optical coherence tomography (OCT) images obtained from age-related macular degeneration (AMD) patients and used them to train three types of CNNs to perform AMD diagnosis.Results: Here, we present an AI- and cloud-based telemedicine interaction tool for diagnosis and proposed treatment of AMD. Through deep learning process based on the analysis of preprocessed optical coherence tomography (OCT) imaging data, our AI-based system achieved the same image discrimination rate as that of retinal specialists in our hospital. The AI platform's detection accuracy was generally hig...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: De-Kuang Hwang, Chih-Chien Hsu, Kao-Jung Chang, Daniel Chao, Chuan-Hu Sun, Ying-Chun Jheng, Aliaksandr A. Yarmishyn, Jau-Ching Wu, Ching-Yao Tsai, Mong-Lien Wang, Chi-Hsien Peng, Ke-Hung Chien, Chung-Lan Kao, Tai-Chi Lin, Lin-Chung Woung, Shih-Jen Chen, S Tags: Research Paper Source Type: research

Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles
Conclusion: In summary, the synthesized UCNP@TTD-cRGD NPs showed great potential in NIR light-regulated photodynamic therapy of deep-seated tumors. Our study will inspire further exploration of novel theranostic nanoplatforms that combine UCNPs and various AIEgen PSs for the advancement of deep-seated tumor treatments with potential clinical translations. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Guorui Jin, Rongyan He, Qian Liu, Min Lin, Yuqing Dong, Kai Li, Ben Zhong Tang, Bin Liu, Feng Xu Tags: Research Paper Source Type: research

Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin β 3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery
Conclusion: This study provides a promising simvastatin-based nanomedicine strategy targeting cholesterol metabolism to reverse EMT and repolarize TAM to treat drug-resistant cancer. The elucidation of the molecular pathways (cholesterol/lipid raft/integrin β3/FAK and cholesterol-associated LXR/ABCA1 regulation) for anti-EMT and the new application of simvastatin should be of clinical significance. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Hongyue Jin, Yang He, Pengfei Zhao, Ying Hu, Jin Tao, Jiang Chen, Yongzhuo Huang Tags: Research Paper Source Type: research

An innovative “ unlocked mechanism ” by a double key avenue for one-pot detection of microRNA-21 and microRNA-141
Conclusion: The designed sensor based on an “unlocked mechanism” and a signal enrichment strategy resulted in a one-pot, highly specific and sensitive detection of multiplex miRNAs. The whole detection without the need for a complex purification process is based on a FCM and is expected to have a great value in cancer diagnosis and biomedical research. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Weipan Peng, Qian Zhao, Minghui Chen, Jiafang Piao, Weichen Gao, Xiaoqun Gong, Jin Chang Tags: Research Paper Source Type: research

Direct in vivo application of induced pluripotent stem cells is feasible and can be safe
Conclusion: Teratoma can be easily and completely avoided by disseminating the cells. Direct in vivo iPSC application is feasible and can be safe. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Meng Xiang, Meng Lu, Jing Quan, Ming Xu, Dan Meng, Anfeng Cui, Ning Li, Yingying Liu, Peng Lu, Xueling Kang, Xiaokai Wang, Ning Sun, Meng Zhao, Qiujuan Liang, Lili Le, Xinhong Wang, Jianyi Zhang, Sifeng Chen Tags: Research Paper Source Type: research

Microhexagon gradient array directs spatial diversification of spinal motor neurons
Conclusions: The differentiated cells showed progressive RNA and protein signatures, consistent with that of representative brachial, thoracic and lumbar regions of the human spinal cord. The microHIVE platform can thus be utilized to develop advanced biomimetic systems for the study of diseases in vitro. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Geok Soon Lim, Jin Hui Hor, Nicholas R.Y. Ho, Chi Yan Wong, Shi Yan Ng, Boon Seng Soh, Huilin Shao Tags: Research Paper Source Type: research

β -catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer
Conclusion: ß-catenin activation, coupled with K-ras mutation and p53 loss, activates an autocrine PDGF/Src signaling in pancreatic cancer and defines a subset of patients who might be sensitive to Src inhibition. In addition, serum PDGF level could be a reliable biomarker for patient selection in clinic. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Tzu-Lei Kuo, Kuang-Hung Cheng, Yan-Shen Shan, Li-Tzong Chen, Wen-Chun Hung Tags: Research Paper Source Type: research

Low Molecular Weight Heparin-Coated and Dendrimer-Based Core-Shell Nanoplatform with Enhanced Immune Activation and Multiple Anti-Metastatic Effects for Melanoma Treatment
Conclusion: The immune activation and multiple anti-metastatic effects of LMWH/PPD/CpG establish a novel therapeutic strategy for melanoma. This anti-metastatic nanoplatform could be broadly applied for the co-delivery of other nucleic acids and chemotherapeutic drugs to treat highly aggressive tumors. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Chunyu Xia, Sheng Yin, Shanshan Xu, Guangyao Ran, Miao Deng, Ling Mei, Xian Tang, Jingdong Rao, Man Li, Zhirong Zhang, Qin He Tags: Research Paper Source Type: research

Chemotherapy priming of the Pancreatic Tumor Microenvironment Promotes Delivery and Anti-Metastasis Efficacy of Intravenous Low-Molecular-Weight Heparin-Coated Lipid-siRNA Complex
Conclusion: These results suggested our sequential delivery of PTX-Lip and LH-Lip/siBCL-2 might provide a practical approach for PDAC or other ECM-rich tumors. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Qianwen Yu, Yue Qiu, Xiaoxiao Chen, Xuhui Wang, Ling Mei, Haiyao Wu, Kai Liu, Yayuan Liu, Man Li, Zhirong Zhang, Qin He Tags: Research Paper Source Type: research

Fabrication of Red Blood Cell-Based Multimodal Theranostic Probes for Second Near-Infrared Window Fluorescence Imaging-Guided Tumor Surgery and Photodynamic Therapy
Conclusion: The proposed strategy will develop a new platform to increase surgical resection completeness and improve PDT efficiency, resulting in the successful and complete inhibition of tumor and metastasis, which could offer a promising approach for the clinical translation of malignant tumor treatment. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Peiyuan Wang, Xuandong Wang, Qiang Luo, Yang Li, Xiaoxiao Lin, Lingling Fan, Yun Zhang, Jingfeng Liu, Xiaolong Liu Tags: Research Paper Source Type: research

Highly-Soluble Cyanine J-aggregates Entrapped by Liposomes for In Vivo Optical Imaging around 930 nm
Conclusions: DCP-Cy is simple to synthesize and exhibits high aqueous solubility and red-shifted absorption from J-aggregate formation. Liposomal dye entrapment is possible, which facilitates in vivo photoacoustic and fluorescence imaging around 930 nm. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Dyego Miranda, Haoyuan Huang, Homan Kang, Ye Zhan, Depeng Wang, Yang Zhou, Jumin Geng, Hailey I. Kilian, Wesley Stiles, Aida Razi, Joaquin Ortega, Jun Xia, Hak Soo Choi, Jonathan F. Lovell Tags: Research Paper Source Type: research

A Novel Multimodal NIR-II Nanoprobe for the Detection of Metastatic Lymph Nodes and Targeting Chemo-Photothermal Therapy in Oral Squamous Cell Carcinoma
Conclusion: With a good imaging capability and anti-tumor efficacy, our NPs successfully outlined orthotopic tongue tumors and metastatic lymph nodes as well as enabled chemo-photothermal therapy combination. Our study established a solid foundation for the application of new clinical diagnosis and treatment patterns in the future. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yufeng Wang, Wansu Zhang, Pengfei Sun, Yu Cai, Wenguang Xu, Quli Fan, Qingang Hu, Wei Han Tags: Research Paper Source Type: research

Delayed Remote Ischemic Preconditioning ConfersRenoprotection against Septic Acute Kidney Injury via Exosomal miR-21
Conclusion: This study demonstrates a critical role for exosomal miR-21 in renoprotection conferred by limb rIPC against sepsis and suggests that rIPC and exosomes might serve as the possible therapeutic strategies for sepsis-induced kidney injury. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Tianyi Pan, Ping Jia, Nan Chen, Yi Fang, Yiran Liang, Man Guo, Xiaoqiang Ding Tags: Research Paper Source Type: research

Low Levels of Sox2 are required for Melanoma Tumor-Repopulating Cell Dormancy
Conclusion: These findings provide a novel insight into the role of the Sox2 gene in tumor cell stemness, tumor dormancy, and apoptosis. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Qiong Jia, Fang Yang, Wei Huang, Yao Zhang, Binghao Bao, Ke Li, Fuxiang Wei, Cunyu Zhang, Haibo Jia Tags: Research Paper Source Type: research

MSC-Delivered Soluble TRAIL and Paclitaxel as Novel Combinatory Treatment for Pancreatic Adenocarcinoma
Conclusion: In summary, this study uncovers the potential of a combinatory approach between MSC-delivered TRAIL and PTX, supporting the combination of cell-based products and conventional chemotherapeutics as a tool to improve the efficacy of the treatments, also addressing possible mechanisms of resistance. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Filippo Rossignoli, Carlotta Spano, Giulia Grisendi, Elisabetta Manuela Foppiani, Giulia Golinelli, Ilenia Mastrolia, Marco Bestagno, Olivia Candini, Tiziana Petrachi, Alessandra Recchia, Francesca Miselli, Giulia Rovesti, Giulia Orsi, Elena Veronesi, Gre Tags: Research Paper Source Type: research

MiR-454-3p-Mediated Wnt/ β -catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis
Conclusions: The findings indicate that miR-454-3p-mediated suppression of Wnt/β-catenin antagonist RPRD1A, as well as AXIN2, DKK3 and SFRP1, sustains the constitutive activation of Wnt/β-catenin signaling; thus, miR-454-3p and RPRD1A might be potential diagnostic and therapeutic targets for breast cancer metastasis. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Liangliang Ren, Han Chen, Junwei Song, Xuhong Chen, Chun Lin, Xiaolan Zhang, Ning Hou, Jinyuan Pan, Zhongqiu Zhou, Lan Wang, Danping Huang, Jianan Yang, Yingying Liang, Jun Li, Hongbiao Huang, Lili Jiang Tags: Research Paper Source Type: research

Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac Diseases
The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) was first identified in 1998 as a PGC-1 family member that regulates adaptive thermogenesis and mitochondrial function following cold exposure in brown adipose tissue. The PGC-1 family has drawn widespread attention over the past two decades as the energetic regulator. We recently summarized a review regarding PGC-1 signaling pathway and its mechanisms in cardiac metabolism. In this review, we elaborate upon the PGC-1 signaling network and highlight the recent progress of its versatile roles in cardiac diseases, includi...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Jianjun Lv, Chao Deng, Shuai Jiang, Ting Ji, Zhi Yang, Zheng Wang, Yang Yang Tags: Review Source Type: research

Argon Mitigates Impaired Wound Healing Process and Enhances Wound Healing In Vitro and In Vivo
Conclusion: Together these findings indicate that argon gas may be a promising candidate for clinical use in treatment of diabetic ulcers. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Jiaolin Ning, Hailin Zhao, Bin Chen, Emma Zheling Mi, Zhen Yang, Wenhan Qing, Kwok Wing Joyce Lam, Bin Yi, Qian Chen, Jianteng Gu, Thomas Ichim, Vladimir Bogin, Kaizhi Lu, Daqing Ma Tags: Research Paper Source Type: research

Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy
Traditional tissue biopsy is limited in understanding heterogeneity and dynamic evolution of tumors. Instead, analyzing circulating cancer markers in various body fluids, commonly referred to as “liquid biopsy”, has recently attracted remarkable interest for their great potential to be applied in non-invasive early cancer screening, tumor progression monitoring and therapy response assessment. Among the various approaches developed for liquid biopsy analysis, surface-enhanced Raman spectroscopy (SERS) has emerged as one of the most powerful techniques based on its high sensitivity, specificity, tremendous spect...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yuying Zhang, Xue Mi, Xiaoyue Tan, Rong Xiang Tags: Review Source Type: research

Stimuli-Responsive Nanotheranostics for Real-Time Monitoring Drug Release by Photoacoustic Imaging
Conclusions: We developed a multifunctional PDI based theranostic platform for noninvasive real-time ratiometric PA imaging of tumor acidic pH and monitoring of drug release in living mice simultaneously. This strategy will shed light on the development of smart activatable theranostic nanoplatforms and will significantly advance the application of PA theranostics in biology and medicine. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Zhen Yang, Jibin Song, Wei Tang, Wenpei Fan, Yunlu Dai, Zheyu Shen, Lisen Lin, Siyuan Cheng, Yijing Liu, Gang Niu, Pengfei Rong, Wei Wang, Xiaoyuan Chen Tags: Research Paper Source Type: research

Low-intensity focused ultrasound for the treatment of brain diseases: safety and feasibility
The use of focused ultrasound (FUS) as a tool for blood-brain barrier (BBB) permeabilization is opening new ways for the treatment of several pathologies, in particular brain tumors and neurodegenerative diseases. However, even if there are promising results in these fields, the efficacy and safety of this technique is unknown in long-term follow-up. The study of Blackmore et al. [Theranostics 2018; 8(22):6233-6247. doi:10.7150/thno.27941] evaluated the long-term effects of FUS on brain parenchyma in aged mice with Alzheimer's disease. This is the first study which applied a multimodal analysis to demonstrate the safety of...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Giada Toccaceli, Giuseppe Barbagallo, Simone Peschillo Tags: Editorial Source Type: research

Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistance
Conclusion: Taken together, this first comprehensive exome-wide analysis of the mutational landscape in HMCLs provides unique resources for further studies and identifies novel genes potentially associated with MM pathophysiology, some of which may be targets for future therapeutic intervention. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Veronika Vikova, Michel Jourdan, Nicolas Robert, Guilhem Requirand, St é phanie Boireau, Ang é lique Bruyer, Laure Vincent, Guillaume Cartron, Bernard Klein, Olivier Elemento, Alboukadel Kassambara, J é r ô me Moreaux Tags: Research Paper Source Type: research

Evaluation of [11C]NMS-E973 as a PET tracer for in vivo visualisation of HSP90
Conclusion: [11C]NMS-E973 is a PET tracer for in vivo visualisation of tumour HSP90 expression and can potentially be used for quantification of HSP90 occupancy. Further translational evaluation of [11C]NMS-E973 is warranted. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Koen Vermeulen, Evelyne Naus, Muneer Ahamed, Bala Attili, Maxime Siemons, Kaat Luyten, Sofie Celen, Joost Schymkowitz, Frederic Rousseau, Guy Bormans Tags: Research Paper Source Type: research

USP5 promotes epithelial-mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma
Conclusion: Our findings reveal that USP5 serve as a potential target for tumor intervention and provide a preliminary antitumor therapy for inhibit EMT by targeting USP5 or its interaction with SLUG in HCC. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Jing Meng, Xiaoyu Ai, Yueyang Lei, Weilong Zhong, Baoxin Qian, Kailiang Qiao, Xiaorui Wang, Bijiao Zhou, Hongzhi Wang, Longcong Huai, Xiaoyun Zhang, Jingxia Han, Yinyin Xue, Yuan Liang, Honggang Zhou, Shuang Chen, Tao Sun, Cheng Yang Tags: Research Paper Source Type: research

Circular RNAs in immune responses and immune diseases
Circular RNAs (circRNAs) are novel clusters of endogenous noncoding RNAs (ncRNAs) that are widely expressed in eukaryotic cells. In contrast to the generation of linear RNA transcripts, circRNAs undergo a “back-splicing” process to form a continuous, covalently closed, stable loop structure without 5ʹ or 3ʹ polarities and poly (A) tails during posttranscriptional modification. Due to the widespread availability of several technologies, especially high-throughput RNA sequencing, numerous circRNAs have been discovered not only in mammals but also in plants and insects. Notably, due to their abilities to serve a...
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Xu Chen, Tian Yang, Wei Wang, Wenjin Xi, Tianze Zhang, Qi Li, Angang Yang, Tao Wang Tags: Review Source Type: research

Upconversion-Magnetic Carbon Sphere for Near Infrared Light-Triggered Bioimaging and Photothermal Therapy
Conclusions: Hollow carbon spheres, photothermal agents loaded with upconversion nanoparticles inside and magnetic nanoparticles outside were prepared for photothermal therapy. The aggregation of FeCUPs in tumors by the local magnetic field was verified by MRI and UCL imaging, and PTT was enhanced. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Jiaxin Wang, Chenjie Yao, Bin Shen, Xiaohui Zhu, Yong Li, Liyi Shi, Yong Zhang, Jinliang Liu, Yanli Wang, Lining Sun Tags: Research Paper Source Type: research

Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression
Conclusion: Taken together, we have identified a novel target that contributes to the disease pathogenesis of endometriosis and provided a potential therapeutic regimen to treat it. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Shih-Chieh Lin, Hsiu-Chi Lee, Ching-Ting Hsu, Yi-Han Huang, Wan-Ning Li, Pei-Ling Hsu, Meng-Hsing Wu, Shaw-Jenq Tsai Tags: Research Paper Source Type: research

A Synthetic Receptor as a Specific Antidote for Paraquat Poisoning
Conclusion: CB[7] may be used as a specific oral antidote for PQ poisoning by strongly binding with PQ and inhibiting its absorption in the gastrointestinal tracts. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Xiangjun Zhang, Xiaoqiu Xu, Shengke Li, Lanlan Li, Jianxiang Zhang, Ruibing Wang Tags: Research Paper Source Type: research

Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder
Conclusion: We propose the targeting of CRTC1 as a unique strategy in the treatment of acquired pigmentary disorders. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Cheong-Yong Yun, Seung Deok Hong, Young Hee Lee, Jiyeon Lee, Da-Eun Jung, Ga Hyun Kim, Song-Hee Kim, Jae-Kyung Jung, Ki Ho Kim, Heesoon Lee, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim Tags: Research Paper Source Type: research

VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness
Conclusion: Our study revisited the admitted dogma linking VEGFC to tumor aggressiveness. We conclude that targeting VEGFC for therapy must be considered with caution. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Papa Diogop Ndiaye, Maeva Dufies, Sandy Giuliano, Laetitia Douguet, Renaud Gr é pin, J é r ô me Durivault, Philippe Lenormand, Natacha Glisse, Janita Mintcheva, Val é rie Vouret-Craviari, Baharia Mograbi, Maud Wurmser, Damien Ambrosetti, Nathalie Riou Tags: Research Paper Source Type: research

TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer
Conclusions: TBC1D8 drives OVCA tumorigenesis and metabolic reprogramming, and TBC1D8 serves as an independent prognosis factor for OVCA patients. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Min Chen, Xiu-Jie Sheng, Yuan-Yi Qin, Song Zhu, Qing-Xia Wu, Liqing Jia, Nan Meng, Yu-Tian He, Guang-Rong Yan Tags: Research Paper Source Type: research

Mitochondria-Responsive Drug Release along with Heat Shock Mediated by Multifunctional Glycolipid Micelles for Precise Cancer Chemo-Phototherapy
Conclusion: Such multifunctional IR780-CSOSA/DOX micelles with integration of mitochondria-responsive drug release and heat shock are demonstrated to be superior to the non-mitochondria-responsive therapy. This study opens up new avenues for the future cancer diagnosis and treatment. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yanan Tan, Yun Zhu, Lijuan Wen, Xiqin Yang, Xuan Liu, Tingting Meng, Suhuan Dai, Yuan Ping, Hong Yuan, Fuqiang Hu Tags: Research Paper Source Type: research

Enhanced Therapeutic Effect of RGD-Modified Polymeric Micelles Loaded With Low-Dose Methotrexate and Nimesulide on Rheumatoid Arthritis
Conclusion: Our results confirmed that the targeted delivery of the combination of a low dose of methotrexate and nimesulide mediated by RGD-modified polymeric micelles could enhance the therapeutic effect on rheumatoid arthritis. These findings provide a promising potential for the clinical therapy of rheumatoid arthritis. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yunlong Wang, Zhongbing Liu, Ting Li, Lin Chen, Jiayao Lyu, Chunhong Li, Yan Lin, Na Hao, Meiling Zhou, Zhirong Zhong Tags: Research Paper Source Type: research

Fto Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice via Alterations in Gut Microbiota
Conclusion: Together, our findings uncover the roles of Fto on depression and provide insights into microbiota-related biological mechanisms underlying the association between obesity and depression. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Lijuan Sun, Lanjing Ma, Haohao Zhang, Ying Cao, Chenchen Wang, Nannan Hou, Niu Huang, Karen M. von Deneen, Changhai Zhao, Yupeng Shi, Yan Pan, Meixia Wang, Gang Ji, Yongzhan Nie Tags: Research Paper Source Type: research

Spatial Distribution of Motor Endplates and its Adaptive Change in Skeletal Muscle
Conclusions: The MEP lamella clusters might be the basis of neuromuscular function, and the spatial distribution of MEPs could serve as a testbed for evaluating the functional status of muscle and the therapeutic targeting map related to MEPs. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Xiaofeng Yin, Tingting Yu, Bo Chen, Jianyi Xu, Wentao Chen, Yisong Qi, Peixun Zhang, Yusha Li, Yuhui Kou, Yilin Ma, Na Han, Peng Wan, Qingming Luo, Dan Zhu, Baoguo Jiang Tags: Research Paper Source Type: research