Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression
Conclusions: These findings highlight the mechanism by which dysregulation of Kras/YY1/ZNF322/Shh transcriptional axis enhances neo-angiogenesis and cancer progression in lung cancer. Therapeutic strategies that target Kras/YY1/ZNF322A/Shh signaling axis may provide new insight on targeted therapy for lung cancer patients. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Che-Chung Lin, I-Ying Kuo, Li-Ting Wu, Wen-Hui Kuan, Sheng-You Liao, Jayu Jen, You-En Yang, Cheng-Wei Tang, Yi-Rong Chen, Yi-Ching Wang Tags: Research Paper Source Type: research

Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer
Conclusions: Our study provides a novel rational strategy to eradicate TICs through reshaping epigenetic landscape in CRC, which might also be beneficial for optimizing current therapeutics. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Junbao Zhang, Ying Ying, Meiqi Li, Maolin Wang, Xiaoyan Huang, Min Jia, Junhui Zeng, Canjie Ma, Yixiang Zhang, Chen Li, Xiaomei Wang, Xing-sheng Shu Tags: Research Paper Source Type: research

Bacteria responsive polyoxometalates nanocluster strategy to regulate biofilm microenvironments for enhanced synergetic antibiofilm activity and wound healing
Conclusion: Therefore, in addition to providing a prospective antibacterial agent, intelligent acid/reductive dual-responsive POMs will establish a new representative paradigm for the areas of healthcare with minimal side effects. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yuetong Zhang, Yang Pi, Yusheng Hua, Jiani Xie, Chengyan Wang, Kun Guo, Zhigang Zhao, Yuan Yong Tags: Research Paper Source Type: research

Enhanced tuberculosis clearance through the combination treatment with recombinant adenovirus-mediated granulysin delivery
Conclusions: Delivery of granulysin by recombinant adenovirus to the infected lung could enhance the clearance of TB in vivo and might be a promising adjunct therapeutic vaccine for TB and MDR-TB. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Ling Hao, Jilei Ma, Chunwei Shi, Xiaosong Lin, Yandi Zhang, Banga Ndzouboukou Jo-Lewis, Qing Lei, Nadeem Ullah, Zhongjie Yao, Xionglin Fan Tags: Research Paper Source Type: research

Palladium-based nanomaterials for cancer imaging and therapy
In recent decade, palladium-based (Pd-based) nanomaterials have shown significant potential for biomedical applications because of their unique optical properties, excellent biocompatibility and high stability in physiological environment. Compared with other intensively studied noble nanomaterials, such as gold (Au) and silver (Ag) nanomaterials, research on Pd-based nanomaterials started late, but the distinctive features, such as high photothermal conversion efficiency and high photothermal stability, have made them getting great attention in the field of nanomedicine. The goal of this review is to provide a comprehensi...
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yongchun Liu, Jingchao Li, Mei Chen, Xiaolan Chen, Nanfeng Zheng Tags: Research Paper Source Type: research

Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer
Conclusions: Herein, we successfully identified a novel 14-gene signature for glycogene-type classification of UBC patients. ST3GAL6 gene, from this signature, was demonstrated as a potential biomarker for poor outcomes and cell invasion in UBCs. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Sumiya Dalangood, Zhen Zhu, Zhihui Ma, Jiaxuan Li, Qinghe Zeng, Yilin Yan, Bing Shen, Jun Yan, Ruimin Huang Tags: Research Paper Source Type: research

Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes
Conclusion: Our study provides a promising nanoplatform for integrating ultrasound-controlled drug release and NIR fluorescence imaging for RA treatment. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Haohan Wu, Yanni He, Hao Wu, Meijun Zhou, Zhili Xu, Ran Xiong, Fei Yan, Hongmei Liu Tags: Research Paper Source Type: research

Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine
Conclusions: This macrophage-biomimetic nanomedicine leverages the inflammatory tropism and inflammatory cytokine sequestration effects of macrophage membrane for targeted delivery and local inflammation suppression, the ROS-responsiveness of β-cyclodextrin-based matrix for specific payload release, and the macrophage-polarizing effect of rosiglitazone for inflammatory regulation, thereby exhibiting considerable therapeutic efficacy against UC in mice. This study offers important new insights on the design and development of biomimetic nanomaterials for inflammation regulations. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Tianlei Sun, Cheryl H. T. Kwong, Cheng Gao, Jianwen Wei, Ludan Yue, Jianxiang Zhang, Richard Dequan Ye, Ruibing Wang Tags: Research Paper Source Type: research

A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer
Conclusions: The results implicated that a reciprocal feedback loop between Myc and MTSS1-AS contributed to the extracellular acidity-promoted metastasis of PC, and indicated that MTSS1-AS was a valuable biomarker and therapeutic target for PC. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yuhang Hu, Fan Wang, Fengyu Xu, Kaifeng Fang, Zhi Fang, Xiaoming Shuai, Kailin Cai, Jinhuang Chen, Ping Hu, Ding Chen, Peng Xu, Chaojie Hu, Zhu Zeng, Jianxin Zhong, Wei Li, Jiang Tang, Mengqi Huang, Yong Zhao, Chunyou Wang, Gang Zhao Tags: Research Paper Source Type: research

The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination
Despite dramatic advances in drug discovery over the decades, effective therapeutic strategies for cancers treatment are still in urgent demands. PROteolysis TArgeting Chimera (PROTAC), a novel therapeutic modality, has been vigorously promoted in preclinical and clinical applications. Unlike small molecule PROTAC, peptide PROTAC (p-PROTAC) with advantages of high specificity and low toxicity, while avoiding the limitations of shallow binding pockets through large interacting surfaces, provides promising substitutions for E3 ubiquitin ligase complex-mediated ubiquitination of “undruggable proteins”. It is worth...
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Jinmei Jin, Ye Wu, Jinjiao Chen, Yiwen Shen, Lijun Zhang, Hong Zhang, Lili Chen, Hebao Yuan, Hongzhuan Chen, Weidong Zhang, Xin Luan Tags: Review Source Type: research

TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin
Conclusions: These results suggest that TRPM8 may be a valid therapeutic target in the potential application of NB, and show that NB is a chemosensitizer for lung cancer treatment. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Haoqiang Lai, Chang Liu, Liyuan Hou, Wenwei Lin, Tianfeng Chen, An Hong Tags: Research Paper Source Type: research

Me6TREN targets β -catenin signaling to stimulate intestinal stem cell regeneration after radiation
Conclusion: The small molecule Me6TREN induced ISC proliferation, enhanced intestinal organoid growth in vitro, and promoted intestinal tissue regeneration after radiation injury by activating β-catenin signaling. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Sihan Wang, Yi Han, Jing Zhang, Shu Yang, Zeng Fan, Feiling Song, Lijuan He, Wen Yue, Yanhua Li, Xuetao Pei Tags: Research Paper Source Type: research

Phorbol ester activates human mesenchymal stem cells to inhibit B cells and ameliorate lupus symptoms in MRL.Faslpr mice
Conclusion: Taken together, our data demonstrate that phorbol esters might be good tool compounds to activate MSCs to inhibit B cells and suggest that our chemical approach might allow for improvements in the therapeutic efficacy of hMSCs in SLE. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Hong Kyung Lee, Hyung Sook Kim, Minji Pyo, Eun Jae Park, Sundong Jang, Hye Won Jun, Tae Yong Lee, Kyung Suk Kim, Sang-Cheol Bae, Youngsoo Kim, Jin Tae Hong, Jaesuk Yun, Sang-Bae Han Tags: Research Paper Source Type: research

Radiologist-like artificial intelligence for grade group prediction of radical prostatectomy for reducing upgrading and downgrading from biopsy
In this study, we retrospectively enrolled 575 patients from two medical institutions. All patients received prebiopsy magnetic resonance (MR) examinations, and pathological evaluations of NB and RP were available. A total of 12,708 slices of original male pelvic MR images (T2-weighted sequences with fat suppression, T2WI-FS) containing 5405 slices of prostate tissue, and 2,753 tumor annotations (only T2WI-FS were annotated using RP pathological sections as ground truth) were analyzed for the prediction of patient-level RP GGs. We present a prostate cancer (PCa) framework, PCa-GGNet, that mimics radiologist behavior based ...
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Lizhi Shao, Ye Yan, Zhenyu Liu, Xiongjun Ye, Haizhui Xia, Xuehua Zhu, Yuting Zhang, Zhiying Zhang, Huiying Chen, Wei He, Cheng Liu, Min Lu, Yi Huang, Lulin Ma, Kai Sun, Xuezhi Zhou, Guanyu Yang, Jian Lu, Jie Tian Tags: Research Paper Source Type: research

Preparation of high precision multilayer scaffolds based on Melt Electro-Writing to repair cartilage injury
Conclusion: A cartilage repair scaffold was established with high precision as well as promising mechanical and biological properties. This scaffold can promote the repair of cartilage injury by using, and inducing the differentiation and expression of, autologous bone marrow mesenchymal stem cells. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yu Han, Meifei Lian, Binbin Sun, Bo Jia, Qiang Wu, Zhiguang Qiao, Kerong Dai Tags: Research Paper Source Type: research

Bifunctional supramolecular nanofiber inhibits atherosclerosis by enhancing plaque stability and anti-inflammation in apoE-/- mice
Conclusions: Our study provides a novel supramolecular nanomaterial to inhibit pathological progress of atherosclerosis through regulating cholesterol efflux and inflammation, which may contribute to the development of a promising nanomedicine for the treatment of atherosclerosis in the clinic. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yuna Shang, Chuanrui Ma, Jing Zhang, Zhongyan Wang, Chunhua Ren, Xin Luo, Rong Peng, Jingfei Liu, Jingyuan Mao, Yang Shi, Guanwei Fan Tags: Research Paper Source Type: research

Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma via AMPK-FOXO1-ULK1 signaling axis-mediated autophagy
Conclusion: We demonstrated that HDIs triggers FOXO1-dependent autophagy, which ultimately promotes EMT, limiting the clinical outcome of HDI-based therapies. Our study suggests that the combination of an HDI and a FOXO1 inhibitor is an effective therapeutic strategy for the treatment of HCC. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qiang Xiao, Hao Liu, Hong-Sheng Wang, Meng-Ting Cao, Xiao-Jun Meng, Ya-Li Xiang, Ya-Qin Zhang, Feng Shu, Qiu-Gui Zhang, Hong Shan, Guan-Min Jiang Tags: Research Paper Source Type: research

An ultrasensitive hybridization chain reaction-amplified CRISPR-Cas12a aptasensor for extracellular vesicle surface protein quantification
Conclusion: The platform was simple and easy to operate, and this approach should be useful for the highly sensitive and versatile quantification of TEV proteins in clinical samples. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Shan Xing, Zedong Lu, Qi Huang, Huilan Li, Yu Wang, Yanzhen Lai, Yi He, Min Deng, Wanli Liu Tags: Research Paper Source Type: research

LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer
Conclusions: These data provide evidence for LAMA4 as a possible biomarker of disease progression and poor prognosis in pancreatic cancer. Our findings indicate that LAMA4 may contribute to pancreatic cancer metastasis via recruitment or activation of CAFs. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Biao Zheng, Jianhua Qu, Kenoki Ohuchida, Haimin Feng, Stephen Jun Fei Chong, Zilong Yan, Yicui Piao, Peng Liu, Nan Sheng, Daiki Eguchi, Takao Ohtsuka, Kazuhiro Mizumoto, Zhong Liu, Shazib Pervaiz, Peng Gong, Masafumi Nakamura Tags: Research Paper Source Type: research

Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells
Conclusion: Our studies have uncovered a potential Celastrol-interacting protein Prdx2 and a ROS-dependent mechanism of its action. The findings also highlight Prdx2 as a potential target for the treatment of gastric cancer. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Xi Chen, Ying Zhao, Wu Luo, Sian Chen, Feng Lin, Xi Zhang, Shijie Fan, Xian Shen, Yi Wang, Guang Liang Tags: Research Paper Source Type: research

Multiplexed non-invasive tumor imaging of glucose metabolism and receptor-ligand engagement using dark quencher FRET acceptor
Conclusions: Overall, our methodology enables for the first time simultaneous non-invasive monitoring of intracellular drug delivery and metabolic response in preclinical studies. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Alena Rudkouskaya, Nattawut Sinsuebphon, Marien Ochoa, Sez-Jade Chen, Joseph E. Mazurkiewicz, Xavier Intes, Margarida Barroso Tags: Research Paper Source Type: research

PML-RAR α interaction with TRIB3 impedes PPAR γ /RXR function and triggers dyslipidemia in acute promyelocytic leukemia
Conclusion: Our work reveals the critical role of the PML-RARα/PPARγ/TRIB3 axis in the development of dyslipidemia in APL patients, potentially conferring a rationale for combining ATRA/arsenic with the PPAR activator for APL treatment. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Ke Li, Feng Wang, Zhao-Na Yang, Bing Cui, Ping-Ping Li, Zhen-Yu Li, Zhuo-Wei Hu, Hong-Hu Zhu Tags: Research Paper Source Type: research

The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy: Erratum
(Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qiang Guo, Meiyu Quan, Jinglai Dong, Jing Bai, Jie Wang, Rui Han, Wei Wang, Yaxin Cai, Yu-Qing Lv, Qianjie Chen, Huijing Xu, Han-Deng Lyu, Liancheng Deng, Depu Zhou, Xueyuan Xiao, Stijn De Langhe, Daniel D. Billadeau, Zhenkun Lou, Jin-San Zhang Tags: Erratum Source Type: research

PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK
Conclusion: Collectively, our findings indicate that the PTP PRL-3 plays a crucial role in the progression of HCC and provides an example of how co-amplified genes work together in HCC. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qiming Zhou, Qianlei Zhou, Qinghua Liu, Zhanghai He, Yongcong Yan, Jianhong Lin, Zheng Chen, Chuanchao He, Kai Mao, Jie Wang, Zhenyu Zhou, Zhiyu Xiao, Jianlong Zhang Tags: Research Paper Source Type: research

Managing therapeutic resistance in breast cancer: from the lncRNAs perspective
Breast cancer (BC) is the most common female malignancy and the second leading cause of cancer-related death worldwide. In spite of significant advances in clinical management, the mortality of BC continues to increase due to the frequent occurrence of treatment resistance. Intensive studies have been conducted to elucidate the molecular mechanisms underlying BC therapeutic resistance, including increased drug efflux, altered drug targets, activated bypass signaling pathways, maintenance of cancer stemness, and deregulated immune response. Emerging evidence suggests that long noncoding RNAs (lncRNAs) are intimately involve...
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Liyuan Peng, Jingwen Jiang, Bo Tang, Edouard C. Nice, Yuan-Yuan Zhang, Na Xie Tags: Review Source Type: research

Bladder reconstruction using autologous smooth muscle cell sheets grafted on a pre-vascularized capsule
Rationale: Construction of functional vascularized three-dimensional tissues has been a longstanding objective in the field of tissue engineering. The efficacy of using a tissue expander capsule as an induced vascular bed to prefabricate functional vascularized smooth muscle tissue flaps for bladder reconstruction in a rabbit model was tested.Methods: Skin tissue expanders were inserted into the groin to induce vascularized capsule pouch formation. Smooth muscle cells and endothelial progenitor cells were harvested and cocultured to form pre-vascularized smooth muscle cell sheet. Then repeated transplantation of triple-lay...
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Hai-Lin Guo, Xu-Feng Peng, Xing-Qi Bao, Lin Wang, Zhi-Ming Jia, Yi-Chen Huang, Jun-Mei Zhou, Hua Xie, Fang Chen Tags: Research Paper Source Type: research

Recognition of G-quadruplex topology through hybrid binding with implications in cancer theranostics
Conclusion: Intervention of GQ mediated lethality by TGP18 has translated into anti-cancer activity in both in vitro 3D spheroid culture and in vivo xenograft models of lung and breast cancer with superior efficacy for the former. In vivo therapeutic efficacy supplemented with tumor 3D spheroid and tissue imaging potential define the role of TGP18 in GQ-targeted cancer theranostics. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yelisetty Venkata Suseela, Pardhasaradhi Satha, N. Arul Murugan, Thimmaiah Govindaraju Tags: Research Paper Source Type: research

Statins ameliorate cholesterol-induced inflammation and improve AQP2 expression by inhibiting NLRP3 activation in the kidney
Conclusion: Serum cholesterol level has a negative correlation with AQP2 protein expression in the kidney biopsy specimens of patients. Statins can ameliorate cholesterol-induced inflammation by promoting the degradation of ASC speck, and improve the expression of aquaporin in the kidneys of animals on a HFD. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yonglun Kong, Weijing Feng, Xiaoduo Zhao, Puhua Zhang, Suchun Li, Zhijian Li, Yu Lin, Boen Liang, Chunling Li, Weidong Wang, Hui Huang Tags: Research Paper Source Type: research

HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma
Conclusions: Our findings illustrate a crucial role for HRG in suppressing HCC via inclining TNFR1 to a pro-apoptotic cellular phenotype. Restoring HRG expression in HCC tissues might be a promising pharmacological approach to blocking tumor progression by shifting cellular fate from cell survival to apoptosis. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Xuejing Zou, Dongyan Zhang, Yang Song, Shanshan Liu, Qian Long, Liheng Yao, Wenwen Li, Zhijiao Duan, Dehua Wu, Li Liu Tags: Research Paper Source Type: research

Opto-acoustic synergistic irradiation for vaporization of natural melanin-cored nanodroplets at safe energy levels and efficient sono-chemo-photothermal cancer therapy
Conclusion: Melanin-cored and doxorubicin-loaded perfluoropentane nanodroplets hold great promise for translational sono-chemo-photothermal cancer therapy. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yaxin Hu, Shan Xue, Ting Long, Peizhao Lyu, Xinyu Zhang, Jingqin Chen, Siping Chen, Chengbo Liu, Xin Chen Tags: Research Paper Source Type: research

Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8+ T-cell memory in wild-type and humanized mice
Conclusion: We have provided the first evidence that DHA is advantageous over MTX in preventing psoriasis relapse by reducing memory CD8+ T-cells. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yuchao Chen, Yuhong Yan, Huazhen Liu, Feifei Qiu, Chun-Ling Liang, Qunfang Zhang, Run-Yue Huang, Ling Han, Chuanjian Lu, Zhenhua Dai Tags: Research Paper Source Type: research

Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis
Conclusion: We present a comprehensive single-cell landscape of the skin immune cells in Vsir-/- psoriatic mice. These unprecedented data uncovered the transcriptional landscape and phenotypic heterogeneity of skin macrophages in psoriasis and identified their gene expression signature suggesting specialized functions in Vsir-/- mice. Our findings will open novel opportunities to investigate the role of VISTA in driving psoriasis. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Chenxin Qie, Jingwei Jiang, Wanmei Liu, Xinlei Hu, Wenting Chen, Xiaoxue Xie, Jun Liu Tags: Research Paper Source Type: research

Combination therapy with B7H3-redirected bispecific antibody and Sorafenib elicits enhanced synergistic antitumor efficacy
Conclusions: Overall, our study indicates that combination therapy with sorafenib and B7H3×CD3 BiTE may be a new therapeutic option for the further study of preclinical treatment of OC. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Cheng Huang, Hongjian Li, Yunyu Feng, Xiaoling Li, Zongliang Zhang, Caiying Jiang, Jichao Wang, Chenli Yang, Yuying Fu, Min Mu, Shasha Zhao, Zeng Wang, Yi Kuang, Huan Hou, Yuelong Wang, Wenhao Guo, Jianguo Xu, Hui Yang, Liangxue Zhou, Aiping Tong, Gang Gu Tags: Research Paper Source Type: research

Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy
Conclusion: This study offered an inspiring strategy of “broaden sources and reduce expenditure” to specifically boost tumor oxidative stress for reinforced oxidation therapy. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Xiaoyu Xu, Binyao Huang, Zishan Zeng, Jie Chen, Zeqian Huang, Zilin Guan, Meixu Chen, Yanjuan Huang, Chunshun Zhao Tags: Research Paper Source Type: research

Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers
Conclusions: Our findings advance the understanding of tumor heterogeneity regulation in APA and yield new insights into therapeutic target identification in TNBC. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Lei Wang, Guan-Tian Lang, Meng-Zhu Xue, Liu Yang, Li Chen, Ling Yao, Xiao-Guang Li, Peng Wang, Xin Hu, Zhi-Ming Shao Tags: Research Paper Source Type: research

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications
Conclusion: This study establishes that the bacterial nitroreductase NfsA_Ec can be utilized as an imaging capable reporter gene, with the ability to metabolize and trap 2-nitroimidazole PET imaging agents for non-invasive imaging of gene expression. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Alexandra Marie Mowday, Janine Naomi Copp, Sophie Philippa Syddall, Ludwig Jerome Dubois, Jingli Wang, Natasja Gabi Lieuwes, Rianne Biemans, Amir Ashoorzadeh, Maria Rosaria Abbattista, Elsie May Williams, Christopher Paul Guise, Philippe Lambin, David Fra Tags: Research Paper Source Type: research

Association of sex and APOE ε 4 with brain tau deposition and atrophy in older adults with Alzheimer's disease
Conclusions: Among elderly individuals with AD, sex modified the effects of the APOE ε4 allele on region-specific tau deposition and gray matter volume. FACs had elevated brain region-specific tau PET SUVR and decreased gray matter volume in comparison to NFACs. The study provides a basis for the use of precision medicine in the diagnosis of AD and evaluation of therapeutics using 18F-AV-1451 PET and structural MRI. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Jian Li, Tammie L.S. Benzinger, Jie Lu, Yun Zhou Tags: Research Paper Source Type: research

Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis
Conclusions: Cadherin-11 plays an important role in the pathogenesis of PVNS and forms a positive feedback loop with inflammatory factors, which further activates the NF-κB and MAPK pathways to trigger an inflammatory cascade. Cadherin-11-mediated inflammation results in PVNS with high recurrence, invasiveness, and strong cartilage destruction ability, and eventually promotes the transformation of PVNS from the initial inflammatory disease to neoplastic disease. Thus, inhibition of cadherin-11 together with its related inflammatory reaction, represents a new therapeutic strategy for PVNS. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Chenxi Cao, Fei Wu, Xingyue Niu, Xiaoqing Hu, Jin Cheng, Yan Zhang, Chuanyun Li, Xiaoning Duan, Xin Fu, Jiying Zhang, Xin Zhang, Yingfang Ao Tags: Research Paper Source Type: research

EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy
Conclusions: These results identify the EREG-EGFR-C-Myc pathway as a crucial axis that drives HNSCC oncogenesis and show that EREG expression could be a predictive functional marker of sensitivity to erlotinib therapy in HNSCC. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Shuli Liu, Yang Wang, Yong Han, Weiya Xia, Ling Zhang, Shengming Xu, Houyu Ju, Xiangkai Zhang, Guoxin Ren, Liu Liu, Weimin Ye, Zhiyuan Zhang, Jingzhou Hu Tags: Research Paper Source Type: research

Identification of second primary tumors from lung metastases in patients with esophageal squamous cell carcinoma using whole-exome sequencing
Conclusions: Our data demonstrate the limitations and insufficiency of clinicopathological criteria and that WES could be useful in understanding the clonal relationships of multiple SCCs. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Liyan Xue, Weihua Li, Xinyi Fan, Zitong Zhao, Wei Zhou, Zhimin Feng, Linxiu Liu, Hua Lin, Lin Li, Xuemin Xue, Xuanlin Huang, Peide Huang, Jia Guo, Peina Du, Ning Lu, Lin Li, Qimin Zhan, Yongmei Song Tags: Research Paper Source Type: research

CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner
Conclusion: These findings suggest that combined treatment with CDK4/6i and anti-PD-1 antibody could improve the efficacy of anti-PD-1 therapy and hold great promise for the treatment of poorly immune-infiltrated ovarian cancer. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qian-Feng Zhang, Jia Li, Kuo Jiang, Rui Wang, Jun-li Ge, Hong Yang, Shu-Juan Liu, Lin-Tao Jia, Lei Wang, Bi-Liang Chen Tags: Research Paper Source Type: research

Methylation-mediated LINC00261 suppresses pancreatic cancer progression by epigenetically inhibiting c-Myc transcription
Conclusions: Our findings indicate that methylation-mediated LINC00261 suppresses PC progression by epigenetically repressing c-Myc expression. These findings expand the therapeutic potential of LINC00261, possibly providing evidence to support the development of epigenetic drugs or therapeutic strategies. This research adds further insights into the etiology of PC and indicates that LINC00261 may be a prognostic and therapeutic target in PC. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Songsong Liu, Yao Zheng, Yujun Zhang, Junfeng Zhang, Fuming Xie, Shixiang Guo, Jianyou Gu, Jiali Yang, Ping Zheng, Jiejuan Lai, Liangyu Yin, Huaizhi Wang Tags: Research Paper Source Type: research

3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer
Conclusions: The multifunctional intelligent scaffold represents an excellent treatment modality for breast cancer following resection, and provides great potential for efficient cancer therapy. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Xuelei Shi, Yanxiang Cheng, Jian Wang, Haoxiang Chen, Xiaocheng Wang, Xinghuan Li, Weihong Tan, Zhikai Tan Tags: Research Paper Source Type: research

Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis
Conclusion: We showed that rhein could modulate gut microbiota, which indirectly changed purine metabolism in the intestine and subsequently alleviated colitis. Our study has identified a new approach to the clinical treatment of colitis. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Jiawei Wu, Zhonghong Wei, Peng Cheng, Cheng Qian, Fangming Xu, Yu Yang, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu Tags: Research Paper Source Type: research

circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion
Conclusions: Our findings reveal a crucial role for the circ-PRKCB/miR-339-5p/p66Shc signaling pathway in regulating oxidative stress in the I/R intestine. This pathway may be a potential therapeutic target for intestinal I/R injury. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Dongcheng Feng, Zhecheng Wang, Yan Zhao, Yang Li, Deshun Liu, Zhao Chen, Shili Ning, Yan Hu, Jihong Yao, Xiaofeng Tian Tags: Research Paper Source Type: research

Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens
Conclusion: Our findings revealed that melatonin serves as a promising colistin adjuvant against MCR-positive Gram-negative pathogens. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yuan Liu, Yuqian Jia, Kangni Yang, Ziwen Tong, Jingru Shi, Ruichao Li, Xia Xiao, Wenkai Ren, R ü diger Hardeland, Russel J. Reiter, Zhiqiang Wang Tags: Research Paper Source Type: research

M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation
Conclusions: The findings of this study emphasize the prominent role of M2Es during VSMC dedifferentiation and vascular tissue repair via activation of the c-Jun/AP-1 signaling pathway, which has a profound impact on the therapeutic strategies of coronary stenting techniques. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen, Guixue Wang Tags: Research Paper Source Type: research

The ER α -miR-575-p27 feedback loop regulates tamoxifen sensitivity in ER-positive Breast Cancer
Conclusions: Our data reveal the ERα-miR-575-CDKN1B feedback loop in ER+ breast cancer, suggesting that miR-575 can be used as a prognostic biomarker in patients with ER+ breast cancer, as well as a predictor or a promising target for tamoxifen sensitivity. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Shu-Shu Liu, Yun Li, Hui Zhang, Di Zhang, Xiao-Bei Zhang, Xin Wang, Yue Yu Tags: Research Paper Source Type: research

Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
The origin and functions of mast cells (MCs) have been debated since their description by Paul Ehrlich in 1879. MCs have long been considered 'reactive bystanders' and 'amplifiers' in inflammatory processes, allergic reactions, and host responses to infectious diseases. However, knowledge about the origin, phenotypes and functions of MCs has increased substantially over the past 50 years. MCs are now known to be derived from multipotent hematopoietic progenitors, which, through a process of differentiation and maturation, form a unique hematopoietic lineage residing in multiple organs. In particular, MCs are distinguishabl...
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Peter Valent, Cem Akin, Karin Hartmann, Gunnar Nilsson, Andreas Reiter, Olivier Hermine, Karl Sotlar, Wolfgang R. Sperr, Luis Escribano, Tracy I. George, Hanneke C. Kluin-Nelemans, Celalettin Ustun, Massimo Triggiani, Knut Brockow, Jason Gotlib, Alberto O Tags: Review Source Type: research

A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis
Conclusion: Our study uncovers a GEF-independent role of ECT2 in promoting survival of breast cancer cells, provides a molecular insight for the reciprocal regulation of ECT2 and USP7, and supports the pursuit of ECT2/USP7 as potential targets for breast cancer intervention. (Source: Theranostics)
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qi Zhang, Cheng Cao, Wenchen Gong, Kaiwen Bao, Qian Wang, Yuejiao Wang, Liyuan Bi, Shuai Ma, Jiao Zhao, Ling Liu, Shanshan Tian, Kai Zhang, Jie Yang, Zhi Yao, Nan Song, Lei Shi Tags: Research Paper Source Type: research