18F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging
Prostate-specific membrane antigen (PSMA)-targeted PET imaging for prostate cancer with 68Ga-labeled compounds has rapidly become adopted as part of routine clinical care in many parts of the world. However, recent years have witnessed the start of a shift from 68Ga- to 18F-labeled PSMA-targeted compounds. The latter imaging agents have several key advantages, which may lay the groundwork for an even more widespread adoption into the clinic. First, facilitated delivery from distant suppliers expands the availability of PET radiopharmaceuticals in smaller hospitals operating a PET center but lacking the patient volume to ju...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Rudolf A. Werner, Thorsten Derlin, Constantin Lapa, Sara Sheikbahaei, Takahiro Higuchi, Frederik L. Giesel, Spencer Behr, Alexander Drzezga, Hiroyuki Kimura, Andreas K. Buck, Frank M. Bengel, Martin G. Pomper, Michael A. Gorin, Steven P. Rowe Tags: Review Source Type: research

Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3 β / β -catenin pathway
Conclusion: Our findings revealed a previously unrecognized function of MSR1 in macrophages during fracture repair. Targeting MSR1 might, therefore, be a new therapeutic strategy for fracture repair. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Shu-Jie Zhao, Fan-Qi Kong, Jian Jie, Qing Li, Hao Liu, An-Di Xu, Ya-Qing Yang, Bin Jiang, Dong-Dong Wang, Zhong-Qiu Zhou, Peng-Yu Tang, Jian Chen, Qian Wang, Zheng Zhou, Qi Chen, Guo-Yong Yin, Han-Wen Zhang, Jin Fan Tags: Research Paper Source Type: research

Liver-targeted delivery of TSG-6 by calcium phosphate nanoparticles for the management of liver fibrosis
Conclusions: TSG-6 was a major antifibrotic cytokine of MSCs, TSG-6 loaded CaP@BSA NPs showed specific liver accumulation and improved therapeutic effects, which indicated translational potentials of CaP@BSA as a promising drug carrier for the liver disease management. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Min Wang, Miao Zhang, Lianhua Fu, Jing Lin, Xinmin Zhou, Pinghong Zhou, Peng Huang, Hao Hu, Ying Han Tags: Research Paper Source Type: research

Theranostic application of miR-429 in HER2+ breast cancer
Conclusions: In HER2+ BC oncogenic miR-429 is able to regulate HIF1α pathway by directly targeting VHL mRNA, a molecule important for the degradation of HIF1α. The overexpression of miR-429, observed in HER2+ BC, causes increased proliferation and migration of the BC cells. More important, silencing miR-429 succeeds in delaying tumor growth, thus miR-429 could be proposed as a therapeutic probe in HER2+ BC tumors. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Claudia Cava, Chiara Novello, Cristina Martelli, Alessia Lo Dico, Luisa Ottobrini, Francesca Piccotti, Marta Truffi, Fabio Corsi, Gloria Bertoli, Isabella Castiglioni Tags: Research Paper Source Type: research

Ultra-small Pyropheophorbide-a Nanodots for Near-infrared Fluorescence/Photoacoustic Imaging-guided Photodynamic Therapy
Conclusion: We demonstrated the excellent properties of Pa-PEG nanodots that can be an in vivo imaging-guided PDT agent with renal clearable behavior for potential future clinical translation. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Kittipan Siwawannapong, Rui Zhang, Huali Lei, Qiutong Jin, Wantao Tang, Ziliang Dong, Rung-Yi Lai, Zhuang Liu, Anyanee Kamkaew, Liang Cheng Tags: Research Paper Source Type: research

Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion
Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement C3-C3aR pathway after chronic cerebral hypoperfusion.Methods: Adult male Sprague-Dawley rats (n = 80) underwent bilateral common carotid artery occlusion for 7, 14, and 28 days. Cerebral vessel density and blood flow were examined by synchrotron radiation angiography and three-dimensional arterial spin labeling. Neurobehavioral assessments, CLARITY imaging, and immunohistochemistry were performed to eva...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Lin-Yuan Zhang, Jiaji Pan, Muyassar Mamtilahun, Yuan Zhu, Liping Wang, Ashwin Venkatesh, Rubing Shi, Xuanqiang Tu, Kunlin Jin, Yongting Wang, Zhijun Zhang, Guo-Yuan Yang Tags: Research Paper Source Type: research

Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model
Conclusion: The triggered size reduction of the pNGs by enzymatic degradation can facilitate the infiltration of the nanocarrier into dense tissue, and thereby promote the delivery of its cargo. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Gregor Nagel, Ana Sousa-Herves, Stefanie Wedepohl, Marcelo Calder ó n Tags: Research Paper Source Type: research

On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer
Background: Localized delivery of antimicrobial agents such as antimicrobial peptides (AMPs) by a biomaterial should be on-demand. Namely, AMPs should be latent and biocompatible in the absence of bacterial infection, but released in an amount enough to kill bacteria immediately in response to bacterial infection.Methods: To achieve the unmet goal of such on-demand delivery, here we turned a titanium implant with titania nanotubes (Ti-NTs) into a Pandora's box. The box was loaded with AMPs (HHC36 peptides, with a sequence of KRWWKWWRR) inside the nanotubes and “closed” (surface-modified) with a pH-responsive mo...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Junjian Chen, Xuetao Shi, Ye Zhu, Yunhua Chen, Meng Gao, Huichang Gao, Lei Liu, Lin Wang, Chuanbin Mao, Yingjun Wang Tags: Research Paper Source Type: research

A Microfluidic Platform for Single Cell Fluorometric Granzyme B Profiling
Conclusion: As proof of concept, we have shown the capability of a microfluidic platform to measure GrB production through a single cell enzymatic activity assay. Our platform might be a promising tool for evaluating the sensitivity of immunotherapies and identifying specific T cell subset responsible for the anti-tumor response. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jonathan C. Briones, Wilfred V. Espulgar, Shohei Koyama, Hiroyuki Yoshikawa, JeongHoon Park, Yujiro Naito, Atsushi Kumanogoh, Eiichi Tamiya, Hyota Takamatsu, Masato Saito Tags: Research Paper Source Type: research

Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death
Conclusions: Our findings suggested that PRMT6 might serve as a new therapeutic target to prevent hearing loss caused by aminoglycoside- and cisplatin-induced ototoxicity by preventing ROS formation and modulating the mitochondria-related damage and apoptosis. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yingzi He, Wen Li, Zhiwei Zheng, Liping Zhao, Wenyan Li, Yunfeng Wang, Huawei Li Tags: Research Paper Source Type: research

ImmunoPET Predicts Response to Met-targeted Radioligand Therapy in Models of Pancreatic Cancer Resistant to Met Kinase Inhibitors
Conclusions: Our findings demonstrate that while over-expression of Met is not predictive of Met-directed TKI response, immunoPET can detect Met over-expression in vivo and predicts for therapeutic response to Met-selective RLT. This phenomenon can be exploited for other Met-overexpressing tumor types specifically, and to any differentially overexpressed surface molecule more broadly. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Freddy E. Escorcia, Jacob L. Houghton, Dalya Abdel-Atti, Patricia R. Pereira, Andrew Cho, Nicholas T. Gutsche, Kwamena E. Baidoo, Jason S. Lewis Tags: Research Paper Source Type: research

pH-responsive perylenediimide nanoparticles for cancer trimodality imaging and photothermal therapy
Conclusion: In summary, we developed pH-responsive perylenediimide nanoparticles as multifunctional phototheranostic agent with high stability and simple synthesis procedures. This study offers a promising organic chromophore for developing phototheranostics in cancer therapy. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jianhao Li, Chang Liu, Yiseng Hu, Chendong Ji, Shuolin Li, Meizhen Yin Tags: Research Paper Source Type: research

Coniferaldehyde attenuates Alzheimer's pathology via activation of Nrf2 and its targets
Conclusion: The experimental evidence overall indicated that Nrf2 activation may contribute to the potent anti-AD effects of CFA. With an excellent safety profile, further clinical investigation of coniferaldehyde might bring hope for AD prevention/therapy. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yaqiong Dong, Tessandra Stewart, Lidan Bai, Xue Li, Ting Xu, Jeffrey Iliff, Min Shi, Danfeng Zheng, Lan Yuan, Taotao Wei, Xiaoda Yang, Jing Zhang Tags: Research Paper Source Type: research

Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2
Conclusion: Our findings highlight novel molecular functions of MSI1 during stress-induced carcinomatous recurrence, and suggest a new therapeutic strategy for refractory malignancies by targeting MSI1 translocation and its interaction with AGOs. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Hsiao-Yun Chen, Mong-Lien Wang, Benoit Laurent, Chih-Hung Hsu, Ming-Teh Chen, Liang-Ting Lin, Jia Shen, Wei-Chao Chang, Jennifer Hsu, Mien-Chie Hung, Yi-Wei Chen, Pin-I Huang, Yi-Ping Yang, Chung-Pin Li, Hsin-I Ma, Chung-Hsuan Chen, Wen-Chang Lin, Shih-Hw Tags: Research Paper Source Type: research

Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium
Conclusions: Prior blocking of endocytosis of exosomes by macrophages with exosomeblocking successfully and efficiently improves the distribution of following exosometherapeutic in targeted organs, like the heart. The established two-step exosome delivery strategy (blocking the uptake of exosomes first followed by delivery of therapeutic exosomes) would be a promising method for gene therapy. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Zhuo Wan, Lianbi Zhao, Fan Lu, Xiaotong Gao, Yan Dong, Yingxin Zhao, Mengying Wei, Guodong Yang, Changyang Xing, Li Liu Tags: Research Paper Source Type: research

Soluble CD146, a cerebrospinal fluid marker for neuroinflammation, promotes blood-brain barrier dysfunction
Conclusion: Our study provides convincing evidence that CSF sCD146 is a sensitive marker of BBB damage and neuroinflammation. Furthermore, sCD146 is actively involved in BBB dysfunction. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Daji Wang, Hongxia Duan, Jing Feng, Jianquan Xiang, Liqun Feng, Dan Liu, Xuehui Chen, Lin Jing, Zheng Liu, Dexi Zhang, Hongjun Hao, Xiyun Yan Tags: Research Paper Source Type: research

ASIC1a induces synovial inflammation via the Ca2+/NFATc3/ RANTES pathway
Conclusion: ASIC1a induces synovial inflammation, which leads to the progression of RA. Our study reveals a novel RA inflammation regulatory mechanism and indicates that ASIC1a might be a potential therapeutic target for RA. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yihao Zhang, Xuewen Qian, Xiaojuan Yang, Ruowen Niu, Sujing Song, Fei Zhu, Chuanjun Zhu, Xiaoqing Peng, Feihu Chen Tags: Research Paper Source Type: research

Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer
Conclusion: Our study illustrates how cancer cells hijack the PiHL-p53 axis to promote CRC progression and chemoresistance. PiHL plays an oncogenic role in CRC carcinogenesis and is an independent prognostic factor as well as a potential therapeutic target for CRC patients. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Xuan Deng, Sihan Li, Fanyang Kong, Haoyu Ruan, Xiao Xu, Xinju Zhang, Zhiyuan Wu, Lin Zhang, Ying Xu, Hong Yuan, Haixia Peng, Da Yang, Ming Guan Tags: Research Paper Source Type: research

RNA Nanotechnology-Mediated Cancer Immunotherapy
RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and tested in cancer patients, as a form of treatment. Meanwhile, various nanomaterials have been developed to enhance RNA delivery to the tumor and immune cells. In this review article, we summarize recent advances in the development of RNA-based therapeutics and their applications in cancer immunotherapy. We als...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yao-Xin Lin, Yi Wang, Sara Blake, Mian Yu, Lin Mei, Hao Wang, Jinjun Shi Tags: Review Source Type: research

Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy
Conclusions: In this study, we present a novel 3D metastasis-on-a-chip model mimicking the progression of kidney cancer cells metastasized to the liver for predicting treatment efficacy. Taken together, our study proved that the tumor progression model based on metastasis-on-a-chip with organ-specific ECM would provide a valuable tool for rapidly assessing treatment regimens and developing new chemotherapeutic agents. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yimin Wang, Di Wu, Guohua Wu, Jianguo Wu, Siming Lu, James Lo, Yong He, Chao Zhao, Xin Zhao, Hongbo Zhang, ShuQi Wang Tags: Research Paper Source Type: research

Spatial light-modulated stimulated Raman scattering (SLM-SRS) microscopy for rapid multiplexed vibrational imaging
Conclusion: We develop novel SLM-SRS microscopy and affirm its broad applicability for rapid monitoring of dynamic biological processes at the subcellular and molecular level. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Kideog Bae, Wei Zheng, Zhiwei Huang Tags: Research Paper Source Type: research

Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression
Conclusions: F. nucleatum is enriched in CRC tissues from patients with metastasis. F. nucleatum orchestrates CARD3 and autophagy to control CRC metastasis. Measuring and targeting F. nucleatum and its associated pathways will yield approaches for the prevention and treatment of CRC metastasis. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yongyu Chen, Yan Chen, Jixiang Zhang, Pan Cao, Wenhao Su, Yunchao Deng, Na Zhan, Xiangsheng Fu, Yun Huang, Weiguo Dong Tags: Research Paper Source Type: research

Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin Hyperpigmentation
Conclusion: We propose the targeting of SCF/KIT-inducible MITF-M expression as a strategy in the therapeutics for acquired pigmentary disorders. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Cheong-Yong Yun, Eunmiri Roh, Song-Hee Kim, Jinhe Han, Jiyeon Lee, Da-Eun Jung, Ga Hyeon Kim, Sang-Hun Jung, Won-Jea Cho, Sang-Bae Han, Youngsoo Kim Tags: Research Paper Source Type: research

Genome-wide interaction target profiling reveals a novel Peblr20-eRNA activation pathway to control stem cell pluripotency
Conclusions: Our data reveal a novel epigenetic mechanism by which a lncRNA controls the fate of stem cells by trans-regulating the Pou5F1 enhancer RNA pathway. We demonstrate the potential for leveraging lncRNA biology to enhance the generation of stem cells for regenerative medicine. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Cong Wang, Lin Jia, Yichen Wang, Zhonghua Du, Lei Zhou, Xue Wen, Hui Li, Shilin Zhang, Huiling Chen, Naifei Chen, Jingcheng Chen, Yanbo Zhu, Yuanyuan Nie, Ilkay Celic, Sujun Gao, Songling Zhang, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui Tags: Research Paper Source Type: research

A cancer-specific activatable theranostic nanodrug for enhanced therapeutic efficacy via amplification of oxidative stress
Conclusion: Our study provides a new paradigm for the design of ROS-mediated therapeutics and offers a promising perspective for precise cancer treatment. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Xie-an Yu, Mi Lu, Yingping Luo, Yiting Hu, Ying Zhang, Zhiming Xu, Shuaishuai Gong, Yunhao Wu, Xiao-Nan Ma, Bo-Yang Yu, Jiangwei Tian Tags: Research Paper Source Type: research

Bax inhibitor 1 preserves mitochondrial homeostasis in acute kidney injury through promoting mitochondrial retention of PHB2
Conclusion: Our data have unveiled an essential role of BI1 as a master regulator of renal tubule function through sustaining mitochondrial localization of PHB2, revealing novel therapeutic promises against AKI. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jin Wang, Pingjun Zhu, Ruibing Li, Jun Ren, Yingmei Zhang, Hao Zhou Tags: Research Paper Source Type: research

PET/MRI enables simultaneous in vivo quantification of β -cell mass and function
Conclusion: Simultaneous PET/MR imaging of the pancreas enabled the comprehensive in vivo quantification of β-cell function and mass using Mn and radiolabeled Ex4. Most important, our data revealed that only late time-point measurements reflect the Mn uptake in the islet β-cells, while early time points detect non-specific accumulation of Mn in the exocrine pancreas. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Filippo C. Michelotti, Gregory Bowden, Astrid K ü ppers, Lieke Joosten, Jonas Maczewsky, Volker Nischwitz, Gisela Drews, Andreas Maurer, Martin Gotthardt, Andreas M. Schmid, Bernd J. Pichler Tags: Research Paper Source Type: research

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma
Conclusion: Our data support the function of miR-101 as a tumor suppressor in osteosarcoma via downregulation of BCL6. AD-MSC derived miR-101-enriched EVs represent a potential innovative therapy for metastatic osteosarcoma. EV-miR-101 also represents a promising circulating biomarker of osteosarcoma metastasis. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Kailiang Zhang, Chuan Dong, Ming Chen, Tongtao Yang, Xin Wang, Yongheng Gao, Lijuan Wang, Yanhua Wen, Guanyin Chen, Xinli Wang, Xiuchun Yu, Yinglong Zhang, Pingshan Wang, Mingfu Shang, Kang Han, Yong Zhou Tags: Research Paper Source Type: research

Type H blood vessels in bone modeling and remodeling
In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked during bone growth and regeneration in bone modeling and during bone homeostasis in bone remodeling. Recent studies have expanded our knowledge about the molecular and cellular mechanisms responsible for coupling angiogenesis and bone formation. Type H vessels, termed such because of high expression of Endomucin (Emcn) and CD31, have recently been identified and have the ability to induce bone formation. Factors including platelet-derived growth factor type BB (PDGF-BB), slit guidance ligand 3 (SLIT3), hypoxia-inducible factor 1-alpha (HI...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yi Peng, Song Wu, Yusheng Li, Janet L. Crane Tags: Review Source Type: research

Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics
In the light of theranostics/radiotheranostics and prospective of personalized medicine in diabetes and oncology, this review presents prior and current advances in the development of radiolabeled imaging and radiotherapeutic exendin-based agents targeting glucagon-like peptide-1 receptor. The review covers chemistry, preclinical, and clinical evaluation. Such critical aspects as structure-activity-relationship, stability, physiological potency, kidney uptake, and dosimetry are discussed. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Irina Velikyan, Olof Eriksson Tags: Review Source Type: research

Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications
Drug delivery for tumor theranostics involves the extensive use of the enhanced permeability and retention (EPR) effect. Previously, various types of nanomedicines have been demonstrated to accumulate in solid tumors via the EPR effect. However, EPR is a highly variable phenomenon because of tumor heterogeneity, resulting in low drug delivery efficacy in clinical trials. Because ultrasonication using micro/nanobubbles as contrast agents can disrupt blood vessels and enhance the specific delivery of drugs, it is an effective approach to improve the EPR effect for the passive targeting of tumors. In this review, the basic th...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Lei Duan, Li Yang, Juan Jin, Fang Yang, Dong Liu, Ke Hu, Qinxin Wang, Yuanbin Yue, Ning Gu Tags: Review Source Type: research

A tumor suppressor enhancing module orchestrated by GATA4 denotes a therapeutic opportunity for GATA4 deficient HCC patients
Conclusions: Our study unveiled a previously unnoticed tumor suppressor enhancing module assembled by ectopically expressed GATA4 in HCC cells and denoted a therapeutic opportunity for GATA4 deficient HCC patients. Our study also presented an interesting case that an oncogenic transcription factor conditionally functioned as a tumor suppressor when recruited by a TSG transcription factor. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Feng Lu, Qian Zhou, Lu Liu, Guandi Zeng, Weimin Ci, Wanting Liu, Gong Zhang, Zhiyi Zhang, Peng Wang, Aiqun Zhang, Yunfei Gao, Lei Yu, Qingyu He, Liang Chen Tags: Research Paper Source Type: research

Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells
Conclusions: This study evaluated effects of targeting STING in TAMs in anti-gastric-cancer therapies. Moreover, we unveil a novel function of STING to activate the IL6R-JAK-IL24 pathway in macrophages. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Lei Miao, Jingjing Qi, Qi Zhao, Qi-Nian Wu, Da-Liang Wei, Xiao-Li Wei, Jia Liu, Jun Chen, Zhao-Lei Zeng, Huai-Qiang Ju, Hui-yan Luo, Rui-Hua Xu Tags: Research Paper Source Type: research

ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells
Conclusion: ANKRD22 induced by TME promotes the metabolic reprogramming of CRC cells. Our study has identified ANKRD22/E-Syt1 as a potential target for eradicating CCICs. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Tianhui Pan, Jingwen Liu, Song Xu, Qiao Yu, Hongping Wang, Hongxiang Sun, Jia Wu, Yue Zhu, Jianwei Zhou, Yongliang Zhu Tags: Research Paper Source Type: research

WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer
Conclusions: Our results highlight the role of WNT/PCP signaling in ovarian cancerogenesis, indicate a possible therapeutic potential of CK1 inhibitors for HGSC, and strongly suggest that the detection of WNT pathway inducing activity ascites (or WNT5A levels in ascites as a surrogate marker) could be a novel prognostic tool for HGSC patients. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Anna Kotrbov á , Petra Ovesn á , Tom á š Gybel', Tomasz Radaszkiewicz, Mark é ta Bedna ř í kov á , Jitka Hausnerov á , Eva Jand á kov á , Lubo š Min á ř , Igor Crha, V í t Weinberger, Lud ě k Z á vesk ý , V í t ě zslav Bryja, Vendula Tags: Research Paper Source Type: research

NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression
Conclusions: Our data revealed a novel signaling pathway, involving NFATc3, miR-153-3p, and Mfn1, which could be a therapeutic target for the prevention and treatment of cardiac hypertrophy. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Tao Wang, Mei Zhai, Sheng Xu, Murugavel Ponnusamy, Yan Huang, Cui-Yun Liu, Man Wang, Chan Shan, Pei-Pei Shan, Xiang-Qian Gao, Kai Wang, Xin-Zhe Chen, Jing Liu, Jing-Yi Xie, De-Yu Zhang, Lu-yu Zhou, Kun Wang Tags: Research Paper Source Type: research

Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect
Expression levels of biomarkers are generally unknown at initial diagnosis. The development of theranostic probes that do not rely on biomarker availability would expand therapy options for cancer patients, improve patient selection for nanomedicine and facilitate treatment of inoperable patients or patients with acquired therapy resistance. Herein, we report the development of star polymers, also known as nanostars, that allow for molecular imaging and/or endoradiotherapy based on passive targeting via the enhanced permeability and retention (EPR) effect.Methods: We synthesised a star copolymer, consisting of 7-8 centre-c...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jeroen A.C.M. Goos, Andrew Cho, Lukas M. Carter, Thomas R. Dilling, Maria Davydova, Komal Mandleywala, Simon Puttick, Abhishek Gupta, William S. Price, John F. Quinn, Michael R. Whittaker, Jason S. Lewis, Thomas P. Davis Tags: Research Paper Source Type: research

In vivo liposomal delivery of PPAR α / γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
Conclusions: These findings reveal for the first time that tesaglitazar has anti-inflammatory effects on adipose tissue macrophage populations in vivo. These data also suggest that while nanoparticle delivery reduced off-target effects, yet the lack of tesaglitazar actions in non-targeted cells such (as hepatocytes and adipocytes) and the uptake of drug-loaded liposomes in many other cell types, albeit to a lesser extent, may have impacted overall therapeutic efficacy. This fulsome analysis of cellular uptake of tesaglitazar-loaded liposomes provides important lessons for future studies of liposome drug delivery. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Victoria Osinski, Dustin K. Bauknight, Siva Sai Krishna Dasa, Matthew J. Harms, Tobias Kroon, Melissa A. Marshall, James C. Garmey, Anh T. Nguyen, Julia Hartman, Aditi Upadhye, Prasad Srikakulapu, Andrea Zhou, Gavin O'Mahony, Alexander L. Klibanov, Kimber Tags: Research Paper Source Type: research

Mdig promotes oncogenic gene expression through antagonizing repressive histone methylation markers
Conclusion: Taken together, our study provides the first insight into the molecular effects of mdig as an antagonist for repressive histone methylation markers and suggests that targeting mdig may represent a new area to explore in cancer therapy. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Qian Zhang, Chitra Thakur, Yao Fu, Zhuoyue Bi, Priya Wadgaonkar, Liping Xu, Zhipeng Liu, Wanqing Liu, Jian Wang, Benjamin L. Kidder, Fei Chen Tags: Research Paper Source Type: research

Supramolecular nanomaterials based on hollow mesoporous drug carriers and macrocycle-capped CuS nanogates for synergistic chemo-photothermal therapy
Conclusion: This novel supramolecular nanoplatform possesses great potential in controlled drug delivery and tumor cellular internalization for synergistic chemo-photothermal therapy, providing a promising approach for multimodal synergistic cancer treatment. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jie Yang, Dihua Dai, Xinyue Lou, Lianjun Ma, Bailiang Wang, Ying-Wei Yang Tags: Research Paper Source Type: research

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues
Conclusions: These data, taken together, support the use of 177LuBSNRs as theranostic probes as a rapid assessment tool for PK LA ARV measurements. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Bhavesh D. Kevadiya, Brendan Ottemann, Insiya Z. Mukadam, Laura Castellanos, Kristen Sikora, James R. Hilaire, Jatin Machhi, Jonathan Herskovitz, Dhruvkumar Soni, Mahmudul Hasan, Wenting Zhang, Sarella Anandakumar, Jered Garrison, JoEllyn McMillan, Benson Tags: Research Paper Source Type: research

A supramolecular protein chaperone for vaccine delivery
Conclusion: Our study demonstrated the great potential of the supramolecular protein chaperone in protein storage and delivery, vaccine production and tumor immunotherapy. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Zhongyan Wang, Yuna Shang, Zhaoqi Tan, Xiaoyan Li, Guoliang Li, Chunhua Ren, Fuqiang Wang, Zhimou Yang, Jianfeng Liu Tags: Research Paper Source Type: research

Carbon Dots as Potent Antimicrobial Agents
Carbon dots (CDots) have emerged to represent a highly promising new platform for visible/natural light-activated microbicidal agents. In this article, the syntheses, structures, and properties of CDots are highlighted, representative studies on their activities against bacteria, fungi, and viruses reviewed, and the related mechanistic insights discussed. Also highlighted and discussed are the excellent opportunities for potentially extremely broad applications of this new platform, including theranostics uses. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Xiuli Dong, Weixiong Liang, Mohammed J. Meziani, Ya-Ping Sun, Liju Yang Tags: Review Source Type: research

Ferritins as natural and artificial nanozymes for theranostics
Nanozymes are a class of nanomaterials with intrinsic enzyme-like characteristics which overcome the limitations of natural enzymes such as high cost, low stability and difficulty to large scale preparation. Nanozymes combine the advantages of chemical catalysts and natural enzymes together, and have exhibited great potential in biomedical applications. However, the size controllable synthesis and targeting modifications of nanozymes are still challenging. Here, we introduce ferritin nanozymes to solve these problems. Ferritins are natural nanozymes which exhibit intrinsic enzyme-like activities (e.g. ferroxidase, peroxida...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Bing Jiang, Long Fang, Kongming Wu, Xiyun Yan, Kelong Fan Tags: Review Source Type: research

Amplification-driven BCL6-suppressed cytostasis is mediated by transrepression of FOXO3 and post-translational modifications of FOXO3 in urinary bladder urothelial carcinoma
Conclusion: Overexpression of BCL6 served a poor prognostic factor in UBUC patients. In vivo and in vitro studies suggested that BCL6 functions as an oncogene through direct transrepression of the FOXO3 gene, downregulation and phosphorylation of the FOXO3 protein. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Wen-Ren Wu, Jen-Tai Lin, Cheng-Tang Pan, Ti-Chun Chan, Chen-Liang Liu, Wen-Jeng Wu, Jim Jinn-Chyuan Sheu, Bi-Wen Yeh, Steven K. Huang, Jheng-Yan Jhung, Meng-Shin Hsiao, Chien-Feng Li, Yow-Ling Shiue Tags: Research Paper Source Type: research

Mesenchymal stem cell-loaded thermosensitive hydroxypropyl chitin hydrogel combined with a three-dimensional-printed poly( ε -caprolactone) /nano-hydroxyapatite scaffold to repair bone defects via osteogenesis, angiogenesis and immunomodulation
Conclusions: PCL/nHA + HPCH hybrid scaffolds effectively promoted vascularization and osteoinduction via osteogenesis promotion and immunomodulation, which suggests promising applications for bone regeneration. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Xiongfa Ji, Xi Yuan, Limin Ma, Bo Bi, Hao Zhu, Zehua Lei, Wenbin Liu, HongXu Pu, Jiawei Jiang, Xulin Jiang, Yu Zhang, Jun Xiao Tags: Research Paper Source Type: research

A sericin/ graphene oxide composite scaffold as a biomimetic extracellular matrix for structural and functional repair of calvarial bone
Conclusion: Aiming to meet clinical demands and overcome current limitations of existing artificial bones, we have developed a new type of sericin/ graphene oxide composite scaffold and provided histological, functional, and molecular evidence demonstrating that it is capable of effectively repairing defective bones by inducing autologous BMSCs directional migration and osteogenic differentiation. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Chao Qi, Yan Deng, Luming Xu, Cheng Yang, Yuanyuan Zhu, Guobin Wang, Zheng Wang, Lin Wang Tags: Research Paper Source Type: research

Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives
The marked augment of drug-resistance to traditional antibiotics underlines the crying need for novel replaceable antibacterials. Research advances have revealed the considerable sterilization potential of two-dimension graphene-based nanomaterials. Subsequently, two-dimensional nanomaterials beyond graphene (2D NBG) as novel antibacterials have also demonstrated their power for disinfection due to their unique physicochemical properties and good biocompatibility. Therefore, the exploration of antibacterial mechanisms of 2D NBG is vital to manipulate antibacterials for future applications. Herein, we summarize the recent r...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Linqiang Mei, Shuang Zhu, Wenyan Yin, Chunying Chen, Guangjun Nie, Zhanjun Gu, Yuliang Zhao Tags: Review Source Type: research

Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy
Conclusion: We developed and showed the therapeutic functions of a novel nanosystem with the combination of multiple theranostic nanoplatforms that can be triggered and activated by 808 nm NIR laser and US. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Wen-Tse Huang, Ming-Hsien Chan, Xueyuan Chen, Michael Hsiao, Ru-Shi Liu Tags: Research Paper Source Type: research

Allosteric regulation of protein 14-3-3 ζ scaffold by small-molecule editing modulates histone H3 post-translational modifications
Conclusion: Our findings demonstrate the feasibility of editing histone PTM patterns by targeting transcription regulation factor 14-3-3ζ, and provide a distinctive PTM editing strategy which differs from current histone modification approaches. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Yan-Jun Wan, Li-Xi Liao, Yang Liu, Heng Yang, Xiao-Min Song, Li-Chao Wang, Xiao-Wen Zhang, Yi Qian, Dan Liu, Xiao-Meng Shi, Li-Wen Han, Qing Xia, Ke-Chun Liu, Zhi-Yong Du, Yong Jiang, Ming-Bo Zhao, Ke-Wu Zeng, Peng-Fei Tu Tags: Research Paper Source Type: research