Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance
Cancer Biol Ther. 2024 Dec 31;25(1):2306676. doi: 10.1080/15384047.2024.2306676. Epub 2024 Jan 30.ABSTRACTFusobacterium nucleatum, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in cancer progression and prognosis. While extensive research has revealed mechanistic links between Fusobacterium nucleatum and colorectal cancer, a comprehensive review spanning its presence and metastatic implications in cancers beyond colorectal origin is conspicuously absent. This paper broadens our perspective from colorectal cancer to various malignancies a...
Source: Cancer Biology and Therapy - January 30, 2024 Category: Cancer & Oncology Authors: Chun Ye Xiao Liu Zilun Liu Chuxuan Pan Xiaowei Zhang Zhanyi Zhao Haitao Sun Source Type: research
Salivary Biomarkers for Oral Cancer Detection: Insights from Human DNA and RNA Analysis
This article presents a comprehensive review of the current research on salivary biomarkers for oral cancer detection, focusing on insights gained from human DNA and RNA analysis.PMID:38275030 | DOI:10.2174/0118715257269271231201094946 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 26, 2024 Category: Cardiology Authors: Archana Navale Atharva Deshpande Source Type: research
Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survival
Oncol Lett. 2024 Jan 8;27(3):89. doi: 10.3892/ol.2024.14223. eCollection 2024 Mar.ABSTRACTDifferentially methylated regions (DMRs) can be used as head and neck squamous cell carcinoma (HNSCC) diagnostic, prognostic and therapeutic targets in precision medicine workflows. DNA from 21 HNSCC and 10 healthy oral tissue samples was hybridized to a genome-wide tiling array to identify DMRs in a discovery cohort. Downstream analyses identified differences in promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions associated with tumor differentiation, nodal involvement and survival. Genome-wide D...
Source: Oncology Letters - January 25, 2024 Category: Cancer & Oncology Authors: Bianca Rivera-Pe ña Oluwasina Folawiyo Nitesh Turaga Rosa J Rodr íguez-Benítez Marcos E Felici Jaime A Aponte-Ortiz Francesca Pirini Sebasti án Rodríguez-Torres Roger V ázquez Ricardo L ópez David Sidransky Rafael Guerrero-Preston Adriana B áez Source Type: research
Differences in the association of time to treatment initiation and survival according to various head and neck cancer sites in a nationwide cohort
CONCLUSION: The relationship between longer TTI and decreased survival was confirmed, but slight variations in the pattern of the hazard of dying by TTI by tumour site were observed. These findings could support decisions on prioritizing treatment. However, other aspects such as extent of treatment and quality of life should be investigated further so this can also be included.PMID:38262531 | DOI:10.1016/j.radonc.2024.110107 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 23, 2024 Category: Radiology Authors: Micha ël H Frank Boukje A C van Dijk Rosanne C Schoonbeek Jaap Zindler Lot A Devriese Robert J J van Es Matthias A W Merkx Remco de Bree Source Type: research
Screening and surveillance of esophageal cancer by magnifying endoscopy with narrow band imaging improves the survival of hypopharyngeal cancer patients
This study investigated the impacts of esophageal cancer screening using magnifying endoscopy with narrow-band imaging (ME-NBI) on the outcomes of hypopharyngeal cancer patients.MethodsPatients with hypopharyngeal cancer diagnosed from 2008 to 2021 in a tertiary hospital were reviewed retrospectively. Screening and surveillance using ME-NBI examination of the esophagus were divided into three patterns: (1) ME-NBI never performed or more than 6 months after diagnosis of index primary hypopharyngeal cancer, (2) ME-NBI within 6 months only, and (3) ME-NBI within 6 months and regular surveillance.ResultsA total of 261 were rev...
Source: Frontiers in Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research
Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma
Curr Oncol. 2023 Dec 28;31(1):168-182. doi: 10.3390/curroncol31010011.ABSTRACTMicroorganisms in the oral cavity are abundant in the human body. At present, more than 700 species of oral microorganisms have been identified. Recently, a lot of literature has indicated that the oral microbiota plays an important role in the occurrence, development, and prognosis of oral squamous cell carcinoma (OSCC) through various mechanisms. And researchers are now trying to utilize oral microbiota in cancer diagnosis and treatment. However, few articles systematically summarize the effects of oral microbes in the diagnosis, treatment, and...
Source: Current Oncology - January 22, 2024 Category: Cancer & Oncology Authors: Jingyi Wang Bo Gao Source Type: research
Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1
Extracellular vesicles (EVs) have been revealed to facilitate the development of oral squamous cavity cell carcinoma (OCSCC), while its supporting role in lymph node metastases is under continuous investigatio... (Source: BMC Cancer)
Source: BMC Cancer - January 22, 2024 Category: Cancer & Oncology Authors: Tianzhu Lv, Hongjing Liu, Ling Mao, Yanrong Song, Lili Liao, Kun Zhong, Binbin Shuai, Yingkun Luo, Tingting Guo, Wentao Huang and Shenyingjie Zhang Tags: Research Source Type: research
Genes, Vol. 15, Pages 132: The Causal Relationship between PCSK9 Inhibitors and Malignant Tumors: A Mendelian Randomization Study Based on Drug Targeting
Conclusions: The study indicates a divergent causal relationship of PCSK9 inhibitors with certain cancers. While negatively associated with breast and lung cancers, a positive causal association was observed with gastric, hepatic, oral cavity, and pharyngeal cancers and cervical carcinoma in situ. No causal links were found with bladder, thyroid, pancreatic, colorectal, certain kidney, brain, and esophageal cancers. (Source: Genes)
Source: Genes - January 21, 2024 Category: Genetics & Stem Cells Authors: Wenxin Wang Wei Li Dan Zhang Yongrun Mi Jingyu Zhang Guoyang He Tags: Article Source Type: research
Squamous cell carcinoma of the oral cavity, oropharynx and upper oesophagus
Squamous cell carcinomas of the oral cavity, oropharynx and oesophagus are relatively common and are classically associated with heavy alcohol and tobacco use. The dramatic increase in incidence of oropharyngeal cancers over the past three decades has been attributed to human papillomavirus (HPV) infection. These cancers often remain clinically silent until they are locally advanced, although many can still be treated radically with multimodality treatment. The prognosis depends upon the stage of the disease, and the age and fitness of the patient, their smoking history and whether or not the tumour is HPV driven. (Source: Medicine)
Source: Medicine - January 20, 2024 Category: Internal Medicine Authors: Elinor R. Gatfield, William H.J. Ince, Sarah J. Jefferies Tags: Mouth and oesophagus Source Type: research
Differences in the association of time to treatment initiation and survival according to various head and neck cancer sites in a nationwide cohort
The incidence of cancer and related mortality are increasing rapidly worldwide. The incidence was estimated at 14.1 million cases in 2012 and increased to over 19.3 million new cases in 2020, while cancer-related deaths increased from 8.2 million in 2012 to almost 10 million in 2018 [1]. Approximately 900,000 new head and neck cancers (HNC) are reported annually [1,2]. HNC is an umbrella term that encompasses mainly epithelial malignancies that arise in the oral cavity, pharynx and larynx. Almost all of these epithelial malignancies are squamous cell carcinomas (SCCs), for which the most important risk factors are tobacco ...
Source: Radiotherapy and Oncology - January 20, 2024 Category: Radiology Authors: Micha ël.H. Frank, Boukje A.C. van Dijk, Rosanne.C. Schoonbeek, Jaap Zindler, Lot A. Devriese, Robert J.J. van Es, Matthias A.W. Merkx, Remco de Bree Tags: Original Article Source Type: research
Detection of oral mucosal lesions by the fluorescence spectroscopy and classification of cancerous stages by support vector machine
AbstractDetection of oral mucosal lesions has been performed by an in-house developed fluorescence-based portable device in the present study. A laser diode of 405 nm wavelength and a UV-visible spectrometer are utilized in the portable device as excitation and detection sources. At the 405 nm excitation wavelength, the flavin adenine dinucleotide (FAD) band at 500 nm and three porphyrin bands at 634, 676, and 703 nm are observed in the fluorescence spectrum of the oral cavity tissue. We have conducted this clinical study on a total of 189 tissue sites of 36 oral squamous cell carcinoma (OSCC) patients, 18 dysplastic (prec...
Source: Lasers in Medical Science - January 19, 2024 Category: Laser Surgery Source Type: research
In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations
Oral cancer is a severe health problem that accounts for an alarmingly high number of fatalities worldwide. Withania somnifera (L.) Dunal has been extensively studied against various tumor cell lines from different body organs, rarely from the oral cavity. We thus investigated the cytotoxicity of W. somnifera fruits (W-F) and roots (W-R) hydromethanolic extracts and their chromatographic fractions against oral squamous cell carcinoma (OSCC) cell lines [Ca9-22 (derived from gingiva), HSC-2, HSC-3, and HSC-4 (derived from tongue)] and three normal oral mesenchymal cells [human gingival fibroblast (HGF), human periodontal lig...
Source: Frontiers in Pharmacology - January 18, 2024 Category: Drugs & Pharmacology Source Type: research
Cancers, Vol. 16, Pages 414: Predictive Factors for Critical Weight Loss in Saudi Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy
In conclusion, weight loss is highly prevalent among HNC patients during treatment. Accordingly, pretreatment BMI, cancer in the oral cavity, and being male can be considered predictive factors for CWL. (Source: Cancers)
Source: Cancers - January 18, 2024 Category: Cancer & Oncology Authors: Alaa S. Redwan Fayrooz A. Kattan Maha A. Alidrisi Gayur A. Ali Mazen M. Ghaith Ahmad F. Arbaeen Hussain A. Almasmoum Najlaa H. Almohmadi Sarah O. Alkholy Walaa E. Alhassani Wafaa F. Abusudah Abrar M. Babateen Mai A. Ghabashi Ahmad A. Obeidat Azzam N. Al Y Tags: Article Source Type: research
Unveiling the Gastrointestinal Microbiome Symphony: Insights Into Post-Gastric Cancer Treatment Microbial Patterns and Potential Therapeutic Avenues
In conclusion, understanding the intricate interplay between the gastrointestinal microbiome and gastric cancer treatment offers prospects for predicting responses and enhancing postoperative recovery. Probiotics, with their positive impact on inflammation and immunity, have emerged as potential adjuncts in patient care. Continued research is imperative to fully harness the potential of microbiome-based interventions in the management of gastric cancer.PMID:38225768 | PMC:PMC10774752 | DOI:10.5230/jgc.2024.24.e4 (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 16, 2024 Category: Gastroenterology Authors: Chan Hyuk Park Source Type: research
