The association between neighborhood-level income and cancer stage at diagnosis and survival in Alberta
CONCLUSIONS: Disparities were observed in cancer outcomes across neighborhood-level income groups in Alberta, which demonstrates that health inequities by SES exist in countries with single-payer health care systems. Further research is needed to better understand the underlying causes and to develop strategies to mitigate these disparities.PMID:37994148 | DOI:10.1002/cncr.35098 (Source: Cancer Control)
Source: Cancer Control - November 23, 2023 Category: Cancer & Oncology Authors: Yibing Ruan Emily Heer Matthew T Warkentin Tamer N Jarada Dylan E O'Sullivan Desiree Hao Doreen Ezeife Winson Cheung Darren R Brenner Source Type: research
Multidisciplinary management of pregnancy-associated and early post-partum head and neck cancer patients
ConclusionAll patients received state-of-the-art therapy, with encouraging long-term results, highlighting treatment safety in women with HNC during pregnancy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 22, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 15, Pages 5540: Oral Bacteria, Virus and Fungi in Saliva and Tissue Samples from Adult Subjects with Oral Squamous Cell Carcinoma: An Umbrella Review
assimo Amato
Oral squamous cell carcinoma (OSCC) is the most common oral cavity malignancy associated with multiple risk factors. In the last 14 years, oral dysbiosis has attracted the scientific community’s attention as a potential oncogenic factor, in parallel with the development of omics technologies that have revolutionized microbiological research. The present umbrella review aimed to investigate the oral microbiological content (bacilli, viruses, and fungi) of tissue and saliva samples from adult (>18 years) patients with OSCC. The secondary objective was to compare the oral microbiome o...
Source: Cancers - November 22, 2023 Category: Cancer & Oncology Authors: Federica Di Spirito Maria Pia Di Palo Veronica Folliero Davide Cannat à Gianluigi Franci Stefano Martina Massimo Amato Tags: Systematic Review Source Type: research
Anesthetic management of airway stent placement by rigid bronchoscopy with superior laryngeal nerve block while preserving spontaneous breathing: A case report
Key Clinical MessageThe combination of superior laryngeal nerve block can reduce the respiratory depression that occurs during management under total intravenous anesthesia.AbstractAnesthetic management of endobronchial stent placement by rigid bronchoscopy requires the maintenance of spontaneous breathing while suppressing upper airway reflexes. The combination of superior laryngeal nerve block (SLNB) can reduce the respiratory depression that occurs during management under total intravenous anesthesia. The patient was diagnosed as having lung cancer with invasion into the right middle bronchus and stenosis of the right m...
Source: Clinical Case Reports - November 20, 2023 Category: General Medicine Authors: Toshio Okada,
Mio Yoshida,
Tomoko Matsushita,
Yusuke Ishida,
Kinya Furukawa,
Michihiro Murozono Tags: CASE REPORT Source Type: research
Impact of Adjuvant Radiotherapy in Squamous Cell Carcinoma of the Oral Cavity with Perineural Invasion
CONCLUSION: The real benefit of PORT in OSCC patients with PNI is still unclear, although it may have a positive impact on DFS. Clinicians should consider individual patient's characteristics, tumor factors, and treatment goals when deciding whether to recommend PORT. Further studies are needed to clarify which entity of PNI really benefits from PORT.LEVEL OF EVIDENCE: N/A Laryngoscope, 2023.PMID:37975480 | DOI:10.1002/lary.31148 (Source: Cancer Control)
Source: Cancer Control - November 17, 2023 Category: Cancer & Oncology Authors: Bianca Maria Festa Andrea Costantino Gian Marco Pace Gerardo Petruzzi Flaminia Campo Raul Pellini Giuseppe Spriano Armando De Virgilio Source Type: research
Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma
CONCLUSIONS: Management of the neck in OCSCC should be tailored based on primary tumor factors and considered for early-stage tumors.PMID:37967536 | DOI:10.1159/000534491 (Source: Cancer Control)
Source: Cancer Control - November 15, 2023 Category: Cancer & Oncology Authors: Ryan M Carey Vincent J Anagnos Aman Prasad Neel R Sangal Karthik Rajasekaran Rabie M Shanti Steven B Cannady Jason G Newman Jason A Brant Robert M Brody Source Type: research
Cancers, Vol. 15, Pages 5425: A Radiomics-Based Machine Learning Perspective on the Parotid Gland as a Potential Surrogate Marker for HPV in Oropharyngeal Cancer
Conclusions: The results suggest involvement of the parotid gland in HPV infections of the oropharyngeal region. While the role of HPV in parotid lesions is under active discussion, the migration of the virus from the oral cavity to the parotid gland seems plausible. The imaging of the parotid gland offers the benefit of fewer streak artifacts due to teeth and dental implants and the potential to screen for HPV in cases of an absent or unlocatable tumor. Future investigation can be directed to validation of the results in independent datasets and to the potential of improvement of current classification models by addition ...
Source: Cancers - November 15, 2023 Category: Cancer & Oncology Authors: Gordian Prasse Agnes Glaas Hans-Jonas Meyer Veit Zebralla Andreas Dietz Kathrin Hering Thomas Kuhnt Timm Denecke Tags: Article Source Type: research
B cell immune profiles in dysbiotic vermiform appendixes of pancreatic cancer patients
In this study, we analyzed healthy vermiform appendix (VA) from 20 patients with PDAC and 32 patients with colon diseases by gene expression immune profiling, flow cytometry analysis, and microbiome sequencing. We show that the VA GALT of PDAC patients exhibits markers of increased inflammation and cytotoxic cell activity. In contrast, B cell function is decreased in PDAC VA GALT based on gene expression profiling; B cells express significantly fewer MHC class II surface receptors, whereas plasma cells express the immune checkpoint molecule HLA-G. Additionally, the vermiform appendix microbiome of PDAC patients is enriched...
Source: Frontiers in Immunology - November 10, 2023 Category: Allergy & Immunology Source Type: research
Season of radiotherapy and outcomes of head & neck cancer patients in the MACH-NC & MARCH meta-analyses
Head and neck squamous cell cancer (HNSCC) accounts for approximately 800,000 cases and 400,000 deaths annually worldwide [1]. The standard of care for locally-advanced disease for oral cavity, oropharynx, hypopharynx, and larynx subsites is a multimodality treatment with permutations of radiation therapy (RT), chemotherapy (CT), and surgery, in function of tumor localization. Treatment sequelae in these highly functional zones may significantly affect quality of life; and despite optimal treatment, mortality remains high. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - November 10, 2023 Category: Radiology Authors: Elaine LIMKIN, Pierre BLANCHARD, Benjamin LACAS, Jean BOURHIS, Mahesh PARMAR, Lisa LICITRA, Quynh-Thu LE, Sue YOM, Catherine FORTPIED, Johannes LANGENDIJK, Jan B VERMORKEN, Jacques BERNIER, Jens OVERGAARD, Jonathan HARRIS, Jean-Pierre PIGNON, Anne AUPERIN Tags: Original Article Source Type: research
The oral-gut-circulatory axis: from homeostasis to colon cancer
The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the ho...
Source: Frontiers in cellular and infection microbiology - November 8, 2023 Category: Microbiology Source Type: research
A polyhexamethylene biguanide-assembly assisted strategy of dentin bonding greatly promotes bonding effects and caries treatment
J Mater Chem B. 2023 Nov 7. doi: 10.1039/d3tb02083e. Online ahead of print.ABSTRACTStructural degeneration of a hybrid layer composed of a demineralized dentin matrix (DDM) and adhesive causes unsatisfactory functional outcomes in terms of bonding repair and caries treatment and is accompanied by high prevalence of secondary caries. Clinically, defects in the hybrid layer from insufficient adhesive infiltration, bacterial load from retained infected-dentin, and bacterial attack from the oral cavity are the main threats to degeneration. Currently, there is no strategy to simultaneously address adhesive penetration and bacte...
Source: Cancer Control - November 7, 2023 Category: Cancer & Oncology Authors: Chang Shu Yadong Chen Zhenzhen Zhang Yuqing Lei Jiajia Xu Weiwei Lao Qingping Xi Qiang Sun Xiaojun Li Hongbing Liao Qiaojie Luo Xiaodong Li Source Type: research
Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis
CONCLUSION: The results of this study suggest that LVI is a significant predictor of the presence of cervical lymph node metastasis at presentation independent of other known prognostic factors. LVI, however, was not found to be a significant independent predictor of locoregional or distant recurrence.Level of Evidence: Level III.PMID:37927046 | DOI:10.1177/00034894231211116 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - November 6, 2023 Category: ENT & OMF Authors: Abigail E Moore Sameer A Alvi Osama Tarabichi Vivian L Zhu Marisa R Buchakjian Source Type: research
Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis
CONCLUSION: The results of this study suggest that LVI is a significant predictor of the presence of cervical lymph node metastasis at presentation independent of other known prognostic factors. LVI, however, was not found to be a significant independent predictor of locoregional or distant recurrence.Level of Evidence: Level III.PMID:37927046 | DOI:10.1177/00034894231211116 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - November 6, 2023 Category: ENT & OMF Authors: Abigail E Moore Sameer A Alvi Osama Tarabichi Vivian L Zhu Marisa R Buchakjian Source Type: research
Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis
CONCLUSION: The results of this study suggest that LVI is a significant predictor of the presence of cervical lymph node metastasis at presentation independent of other known prognostic factors. LVI, however, was not found to be a significant independent predictor of locoregional or distant recurrence.Level of Evidence: Level III.PMID:37927046 | DOI:10.1177/00034894231211116 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - November 6, 2023 Category: ENT & OMF Authors: Abigail E Moore Sameer A Alvi Osama Tarabichi Vivian L Zhu Marisa R Buchakjian Source Type: research
Role of Lymphovascular Invasion in Oral Cavity Squamous Cell Carcinoma Regional Metastasis and Prognosis
CONCLUSION: The results of this study suggest that LVI is a significant predictor of the presence of cervical lymph node metastasis at presentation independent of other known prognostic factors. LVI, however, was not found to be a significant independent predictor of locoregional or distant recurrence.Level of Evidence: Level III.PMID:37927046 | DOI:10.1177/00034894231211116 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - November 6, 2023 Category: ENT & OMF Authors: Abigail E Moore Sameer A Alvi Osama Tarabichi Vivian L Zhu Marisa R Buchakjian Source Type: research
