Cancers, Vol. 16, Pages 1217: Longitudinal Assessment of Quality of Life in Nasopharyngeal Cancer Patients Treated with Intensity-Modulated Proton Therapy and Volumetric Modulated Arc Therapy at Different Time Points
Conclusions: Compared to VMAT, dose reduction attributed to IMPT could translate into better functional QoL and HN35 symptoms, but the effect is time dependent and exclusively observed during the RT phase. (Source: Cancers)
Source: Cancers - March 20, 2024 Category: Cancer & Oncology Authors: Kuan-Cho Liao Yu-Jie Huang Wen-Ling Tsai Chien-Hung Lee Fu-Min Fang Tags: Article Source Type: research
Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis
CONCLUSION: The results of the meta-analysis indicated that the SMD of vitamin B12 serum and Hb levels in the case group was 52%. Our result have also showed that the odds ratio of vitamin B12, ferritin deficiencies, and decreased Hb level in case group was 2.93, 2.50, and 2.14 times more than healthy group.PMID:38493289 | DOI:10.1186/s12903-024-04072-5 (Source: Cancer Control)
Source: Cancer Control - March 17, 2024 Category: Cancer & Oncology Authors: Tahoora Mousavi Hossein Jalali Mahmood Moosazadeh Source Type: research
Characteristics of the oral and gastric microbiome in patients with early-stage intramucosal esophageal squamous cell carcinoma
CONCLUSION: Our study potentially indicates that the dysbacteriosis of both the oral and gastric microbiome was associated with EIESC. Larger scale studies and experimental animal models are urgently needed to confirm the possible role of microbial dysbacteriosis in the pathogenesis of EIESC. (Chinese Clinical Trial Registry Center, ChiCTR2200063464, Registered 07 September 2022, https://www.chictr.org.cn/showproj.html?proj=178563).PMID:38491387 | DOI:10.1186/s12866-024-03233-4 (Source: Cancer Control)
Source: Cancer Control - March 16, 2024 Category: Cancer & Oncology Authors: Han Chen Xingzhou Jiang Fengyi Zhu Ruoyun Yang Xin Yu Xiaoying Zhou Nana Tang Source Type: research
Notch signaling genes and CD8+ T ‐cell dynamics: Their contribution to immune‐checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective study
This study may enable better selection of ICI therapy with CD8+ T-cell infiltration via PD-L1 expression for oral squamous cell carcinoma patients with mutations in Notch signaling pathway. (Source: Cancer Medicine)
Source: Cancer Medicine - March 16, 2024 Category: Cancer & Oncology Authors: Kazuhiro Ogi,
Takahiro Iwamoto,
Takashi Sasaya,
Koyo Nishiyama,
Takaaki Tokura,
Takanori Sasaki,
Hironari Dehari,
Yohei Arihara,
Kazuyuki Murase,
Masato Saito,
Masanori Someya,
Kohichi Takada,
Akihiro Miyazaki Tags: BRIEF COMMUNICATION Source Type: research
Two-Year Intention-to-Treat Analysis for Tumor Outcome in Patients Treated with Avasopasem for Oral Cavity and Oral Pharynx Primaries
IMRT plus cisplatin (CRT) is established treatment for LAHNC, but ∼70% of patients develop severe oral mucositis (SOM), often requiring feeding tube nutrition. Avasopasem (AVA) is an investigational small molecule selective dismutase mimetic converting superoxide to hydrogen peroxide, which may protect normal cells from, and potentially sensitize cancer cells to , RT (Anderson 2019, Sishc 2021). In a randomized, double-blind phase 3 trial, AVA substantially reduced duration and incidence of SOM versus placebo (PBO) without an adverse effect on safety or 1-yr survival (Anderson 2022). (Source: International Journal of Rad...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: N.E. Dunlap, C.M. Lee, J.R. Kelley, G.V. Walker, V. Bar-Ad, D.A. Miller, V.J. King Sr, A.V. Peddada, D. Ciuba, F. Vincent, B.C. Muzyka, A.L. Gillespie-Twardy, S.T. Sonis, J. Holmlund, D. Saunders, R. Beardsley, C.M. Anderson Tags: 11 Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
Stratification of Fusobacterium nucleatum by local health status in the oral cavity defines its subspecies disease association
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00053-2. doi: 10.1016/j.chom.2024.02.010. Online ahead of print.ABSTRACTThe ubiquitous inflammophilic oral pathobiont Fusobacterium nucleatum (Fn) is widely recognized for its strong association with inflammatory dysbiotic diseases and cancer. Fn is subdivided into four subspecies, which are historically considered functionally interchangeable in the oral cavity. To test this assumption, we analyzed patient-matched dental plaque and odontogenic abscess clinical specimens and examined whether an inflammatory environment selects for/against particular Fn subspecies. Dental plaque h...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: Madeline Krieger Yasser M AbdelRahman Dongseok Choi Elizabeth A Palmer Anna Yoo Sean McGuire Jens Kreth Justin Merritt Source Type: research
Stratification of Fusobacterium nucleatum by local health status in the oral cavity defines its subspecies disease association
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00053-2. doi: 10.1016/j.chom.2024.02.010. Online ahead of print.ABSTRACTThe ubiquitous inflammophilic oral pathobiont Fusobacterium nucleatum (Fn) is widely recognized for its strong association with inflammatory dysbiotic diseases and cancer. Fn is subdivided into four subspecies, which are historically considered functionally interchangeable in the oral cavity. To test this assumption, we analyzed patient-matched dental plaque and odontogenic abscess clinical specimens and examined whether an inflammatory environment selects for/against particular Fn subspecies. Dental plaque h...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: Madeline Krieger Yasser M AbdelRahman Dongseok Choi Elizabeth A Palmer Anna Yoo Sean McGuire Jens Kreth Justin Merritt Source Type: research
Neurolymphomatosis as primary presentation of extra-nodal NK/T-cell lymphoma, nasal type
We describe a case of a 64-year-old female patient with NL associated with extra-nodal NK/T-cell lymphoma (ENKTL), nasal type, presenting as a painful progressive mononeuropathy multiplex with an oral cavity lesion. ENKTL is usually associated with Epstein-Barr virus (EBV) infection and rarely affects the central and peripheral nervous system. Lumbar puncture, magnetic resonance imaging (MRI), nerve biopsy, and18F-fluorodeoxyglucose positron emission tomography (FDG-PET) help to establish the diagnosis. Thereby, NL should be considered in the differential diagnosis of painful progressive multiple neuropathies, even in pati...
Source: Neurological Sciences - March 12, 2024 Category: Neurology Source Type: research
A Genome Wide CRISPR Profiling Approach Identifies Mechanisms of Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma
Conclusions Collectively, our study validates a genome-wide CRISPR/Cas9 approach for the discovery of resistance mechanisms in HNSCC, adds to the growing evidence that NOTCH1 status should be evaluated as a biomarker of cisplatin response and provides a framework for future work aimed at overcoming cisplatin resistance.PMID:38464196 | PMC:PMC10925415 | DOI:10.21203/rs.3.rs-3922565/v1 (Source: Cell Research)
Source: Cell Research - March 11, 2024 Category: Cytology Authors: Megan Ludwig Andrew Birkeland Joshua Smith Elizabeth Gensterblum-Miller JIngyi Zhai Aditi Kulkarni Hui Jiang Chad Brenner Source Type: research
