Cancers, Vol. 16, Pages 349: Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors
Conclusion: The findings of this study may be valuable in RT treatment planning for patients with tumors of the head and neck region to reduce the need for opioid use and hospitalization during treatment. (Source: Cancers)
Source: Cancers - January 13, 2024 Category: Cancer & Oncology Authors: Robert L. Foote W. Scott Harmsen Adam C. Amundson Alan B. Carr Mauricio E. Gamez Yolanda I. Garces Scott C. Lester Daniel J. Ma Lisa A. McGee Eric J. Moore Michelle A. Neben Wittich Samir H. Patel David M. Routman Jean-Claude M. Rwigema Kathryn M. Van A Tags: Article Source Type: research
Integrated Single-cell and Bulk RNA Sequencing Analysis Cross Talk between Ferroptosis-related Genes and Prognosis in Oral Cavity Squamous Cell Carcinoma
CONCLUSION: We successfully constructed a novel 6 FRGs model and identified a prognostic immune cell, which can serve to predict clinical prognoses for OCSCC. Ferroptosis may be a new direction for immunotherapy of OCSCC.PMID:38214321 | DOI:10.2174/1574892818666230602112042 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - January 12, 2024 Category: Cancer & Oncology Authors: Tianjun Lan Siqi Ren Huijun Hu Ruixin Wang Qian Chen Fan Wu Qiuping Xu Yanyan Li Libin Shao Liansheng Wang Xin Liu Haotian Cao Jinsong Li Source Type: research
Genetically predicted circulating levels of cytokines and the risk of oral cavity and pharyngeal cancer: a bidirectional mendelian-randomization study
Conclusion: Our study systematically assessed the association between inflammatory cytokines and the risk of OCPC. We identified two upstream regulatory factors (IL-7 and CCL3) and one downstream effector factor (IL-4) that were associated with OCPC, offering potential avenues for the development of novel treatments. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - January 11, 2024 Category: Genetics & Stem Cells Source Type: research
Predicting therapeutic responses in head and neck squamous cell carcinoma from < em > TP53 < /em > mutation detected by cell-free DNA
CONCLUSIONS: TP53 mutation could be used as a specific predictor of treatment response in patients with HNSCC. Using cfDNA to detect the TP53 mutations in patients with HSNCC is a feasible method. The results suggested that the therapeutic response in patients could be predicted by detecting TP53 mutations in cfDNA, and large-scale and prospective studies are needed to validate this hypothesis.PMID:38197078 | PMC:PMC10774070 | DOI:10.21037/tcr-23-878 (Source: Cell Research)
Source: Cell Research - January 10, 2024 Category: Cytology Authors: Mei Wei Jingtai Zhi Li Li Wei Wang Source Type: research
Clinical and pathological correlation of P < sup > 53 < /sup > expression in oral cancers
Pathol Res Pract. 2023 Dec 29;253:155071. doi: 10.1016/j.prp.2023.155071. Online ahead of print.ABSTRACTIn our study, we aimed to evaluate the overexpression of P53 in 155 oral squamous cell carcinomas and to correlate with various clinicopathological features like depth of invasion, lymph nodal involvement, and margin status, which affect the local recurrence and prognosis. This cross-sectional study included 155 oral squamous cell carcinoma patients who underwent surgical resection of primary and nodal disease. The histopathological and clinical features were noted. Immunohistochemical expression was reported, and other ...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Bellala Ravishankar Bellala Venkata Madhavi Akash Kalagara Srija Bodepudi Sriharsha Harnadh P Josephine Bindu Venkateswar Rao Pydi Bellala Prithvi Raj Gopireddy Nitya Bellala Rishik Source Type: research
Clinical and pathological correlation of P < sup > 53 < /sup > expression in oral cancers
Pathol Res Pract. 2023 Dec 29;253:155071. doi: 10.1016/j.prp.2023.155071. Online ahead of print.ABSTRACTIn our study, we aimed to evaluate the overexpression of P53 in 155 oral squamous cell carcinomas and to correlate with various clinicopathological features like depth of invasion, lymph nodal involvement, and margin status, which affect the local recurrence and prognosis. This cross-sectional study included 155 oral squamous cell carcinoma patients who underwent surgical resection of primary and nodal disease. The histopathological and clinical features were noted. Immunohistochemical expression was reported, and other ...
Source: Cell Research - January 5, 2024 Category: Cytology Authors: Bellala Ravishankar Bellala Venkata Madhavi Akash Kalagara Srija Bodepudi Sriharsha Harnadh P Josephine Bindu Venkateswar Rao Pydi Bellala Prithvi Raj Gopireddy Nitya Bellala Rishik Source Type: research
Clinical and pathological correlation of P < sup > 53 < /sup > expression in oral cancers
Pathol Res Pract. 2023 Dec 29;253:155071. doi: 10.1016/j.prp.2023.155071. Online ahead of print.ABSTRACTIn our study, we aimed to evaluate the overexpression of P53 in 155 oral squamous cell carcinomas and to correlate with various clinicopathological features like depth of invasion, lymph nodal involvement, and margin status, which affect the local recurrence and prognosis. This cross-sectional study included 155 oral squamous cell carcinoma patients who underwent surgical resection of primary and nodal disease. The histopathological and clinical features were noted. Immunohistochemical expression was reported, and other ...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Bellala Ravishankar Bellala Venkata Madhavi Akash Kalagara Srija Bodepudi Sriharsha Harnadh P Josephine Bindu Venkateswar Rao Pydi Bellala Prithvi Raj Gopireddy Nitya Bellala Rishik Source Type: research
Development and validation of a nomogram to predict cervical lymph node metastasis in head and neck squamous cell carcinoma
ConclusionsWe established a good prediction model for cervical lymph node metastasis in head and neck squamous cell carcinoma patients which can provide reference value and auxiliary diagnosis for clinicians in making neck management decisions of HNSCC patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research
In reply to the Letter to the Editor regarding “Management of the neck in T1 and T2 buccal squamous cell carcinoma”
We thank the authors of the Letter to the Editor for their interest in our recently published study on neck management in early stage (T1 –2) buccal squamous cell carcinoma1. We agree with the authors’ emphasis on the importance of regional control in this high-risk group of patients. Based on the current literature, the National Comprehensive Cancer Network (NCCN) guidelines on cancer of the oral cavity have not been able to issu e a definitive recommendation on the role of adjuvant therapy in pN1 disease2. (Source: International Journal of Oral and Maxillofacial Surgery)
Source: International Journal of Oral and Maxillofacial Surgery - January 4, 2024 Category: ENT & OMF Authors: O.A. Nicholson, C.G.F. Van Lanschot, L. McDowell, T. Iseli, S. Koljenovic, R.J. Baatenburg de Jong, S. Keereweer, D. Wiesenfeld Tags: Letter to the Editor Source Type: research
In Reply
We thank the authors of the Letter to the Editor for their interest in our recently published study on neck management in early stage (T1 –2) buccal squamous cell carcinoma1. We agree with the authors’ emphasis on the importance of regional control in this high-risk group of patients. Based on the current literature, the National Comprehensive Cancer Network (NCCN) guidelines on cancer of the oral cavity have not been able to issu e a definitive recommendation on the role of adjuvant therapy in pN1 disease2. (Source: International Journal of Oral and Maxillofacial Surgery)
Source: International Journal of Oral and Maxillofacial Surgery - January 4, 2024 Category: ENT & OMF Authors: O.A. Nicholson, C.G.F. Van Lanschot, L. McDowell, T. Iseli, S. Koljenovic, R.J. Baatenburg de Jong, S. Keereweer, D. Wiesenfeld Tags: Letter to the Editor Source Type: research
Is elective neck dissection justified in cT2N0M0 oral cavity cancer defined according to the AJCC eighth edition staging system?
ConclusionsBy implementing risk stratification within the NO group, we found that 26% (251/979) of low-risk patients achieved outcomes similar to those in the END group. Therefore, when making decisions regarding the implementation of END in patients with cT2N0M0 OCSCC, factors such as DOI and tumor differentiation should be taken into account. (Source: Cancer Medicine)
Source: Cancer Medicine - January 3, 2024 Category: Cancer & Oncology Authors: Tsung ‐Ming Chen,
Shyuang‐Der Terng,
Li‐Yu Lee,
Shu‐Ru Lee,
Shu‐Hang Ng,
Chung‐Jan Kang,
Jin‐Ching Lin,
Chih‐Yen Chien,
Chun‐Hung Hua,
Cheng Ping Wang,
Wen‐Cheng Chen,
Yao‐Te Tsai,
Chi‐Ying Tsai,
Chien‐Yu Lin,
Kang Tags: RESEARCH ARTICLE Source Type: research
