A systematic review of the carcinogenicity of rats and mice by sex due to exposure to phenyl compounds
ConclusionDifferences in the epigenetics of each sex begin at the moment of fertilization due to differences in sex chromosome gene expression and metabolic profiles between XX and XY embryos. These fundamental sex differences in nutrient utilization and mitochondrial activity may contribute to sex differences in the metabolic reprogramming of cancer cells, which is important during cancer development, cancer progression, and response to anticancer treatment.Purpose of reviewIn this study, I compared and considered the degree of toxicity and genome expression in each male and female gender and organ due to exposure to phen...
Source: Molecular and Cellular Toxicology - March 5, 2024 Category: Cytology Source Type: research
Impact of Adjuvant Radiotherapy Setting on Quality-of-Life in Head and Neck Squamous Cell Carcinoma
CONCLUSION: This study revealed that HNSCC patients treated with radiation at AMCs reported significantly greater phys-QoL in their first-year post-treatment compared to those treated at CMCs, but soc-QoL did not differ significantly. Further observational studies are needed to explore potential factors, including treatment planning and cancer resource engagement, behind disparities between AMCs and CMCs.LEVEL OF EVIDENCE: Step 3 Laryngoscope, 2024.PMID:38436503 | DOI:10.1002/lary.31382 (Source: Health Physics)
Source: Health Physics - March 4, 2024 Category: Physics Authors: Rahul Alapati Sarah F Wagoner Amelia Lawrence Antonio Bon Nieves Atharva Desai Yelizaveta Shnayder Chelsea Hamill Kiran Kakarala Prakash Neupane Gregory Gan Kevin J Sykes Andr és M Bur Source Type: research
GSE256413 DNA methylation profiles of lymph node tissue of head and neck cancer of unknown primary
Conclusions. On DNA methylation level, hnCUP is comparable to primary tumor tissue cancer types that commonly metastasize to cervical lymph nodes. Our SVM-based classifier can accurately predict these cancers’ tissues of origin and could significantly re duce the invasiveness of hnCUP diagnostics and enable a more precise therapy after clinical validation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 4, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
Cancer-related pain in head and neck cancer survivors: longitudinal findings from the Head and Neck 5000 clinical cohort
ConclusionsThere is high prevalence of general pain in people living with HNC. We identified subgroups more often reporting general and HN-specific pain towards whom interventions could be targeted.Implications for cancer survivorsGreater emphasis should be placed on identifying and treating pain in HNC. Systematic pain screening could help identify those who could benefit from an early pain management plan. (Source: Journal of Cancer Survivorship)
Source: Journal of Cancer Survivorship - February 29, 2024 Category: Cancer & Oncology Source Type: research
Using formalin fixed paraffin embedded tissue to characterize the microbiota in p16-positive and p16-negative tongue squamous cell carcinoma: a pilot study
CONCLUSIONS: Bacterial profiles showed a significant difference between p16-positive TSCC and p16-negative TSCC. These findings may provide insights into the relationship between p16 status and the microbial taxa in TSCC, and these bacteria may provide new clues for developing therapeutic targets for TSCC.PMID:38419008 | DOI:10.1186/s12903-024-04051-w (Source: Cancer Control)
Source: Cancer Control - February 28, 2024 Category: Cancer & Oncology Authors: Zhan Yuanbo Liu Tianyi Song Xuejing Liu Xinpeng Wang Jianqun Xu Wenxia Geng Jingshu Source Type: research
Anti-cancer management of head and neck cancers and oral microbiome —what can we clinically obtain?
Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity and primarily concerns the oral cavity and oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include human papilloma virus (HPV) (notably type 16), Epstein–Barr virus, tobacco, alcohol, and poor oral hygiene with approximately 4.5% of global cancers linked to HPV. Notably, differences in the microbiome between healthy individuals and patients with head and neck cancers (HNCs) have been identified. Recent studies highlight the significance of certain oral microbes in risk ...
Source: Frontiers in cellular and infection microbiology - February 28, 2024 Category: Microbiology Source Type: research
Clinical, Radiological, and Pathological Correlation of Mandibular Invasion in Carcinoma Bucco-alveolar Complex
AbstractA prospective cross-sectional study was conducted to correlate clinically, radiologically, and pathologically the mandibular invasion in carcinoma bucco-alveolar complex. All biopsy-proven oral cavity cancer cases (64 patients) were assessed clinically and radiologically for involvement of the mandible. Preoperative clinicoradiological findings were compared with postoperative histopathological findings. In our study, oral cancer was 4 times more prevalent in males as compared to females and clinical evaluation was found to be highly sensitive in predicting mandibular invasion. Orthopantomogram showed sensitivity o...
Source: Indian Journal of Surgical Oncology - February 28, 2024 Category: Cancer & Oncology Source Type: research
An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management
Curr Cancer Drug Targets. 2024 Feb 21. doi: 10.2174/0115680096282503240124104029. Online ahead of print.ABSTRACTIt is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, H. pylori is a deadly carcinogen. Also, causative pathogens for the development of pancreatic and colorectal cancer are found in the oral cavity, such as Fusobacterium nucleatum and Porphyr...
Source: Current Cancer Drug Targets - February 27, 2024 Category: Cancer & Oncology Authors: Pooja Jain Sradhanjali Mohapatra Uzma Farooq Nazia Hassan Mohd Aamir Mirza Zeenat Iqbal Source Type: research
An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management
Curr Cancer Drug Targets. 2024 Feb 21. doi: 10.2174/0115680096282503240124104029. Online ahead of print.ABSTRACTIt is a well-known fact that cancer is considered the second leading cause of mortality across the globe. Although the human oral cavity and intestine are the natural habitat of thousands of microbes, dysbiosis results in malignancies, such as oral squamous cell carcinoma and colorectal cancer. Amongst the intestinal microbes, H. pylori is a deadly carcinogen. Also, causative pathogens for the development of pancreatic and colorectal cancer are found in the oral cavity, such as Fusobacterium nucleatum and Porphyr...
Source: Current Cancer Drug Targets - February 27, 2024 Category: Cancer & Oncology Authors: Pooja Jain Sradhanjali Mohapatra Uzma Farooq Nazia Hassan Mohd Aamir Mirza Zeenat Iqbal Source Type: research
