Oncologic outcome with versus without target volume compartmentalization in postoperative radiotherapy for oral cavity squamous cell carcinoma
CONCLUSIONS: De-intensified PORT limiting the treatment volume to the at-risk compartment or avoiding PORT altogether for low-risk patients with OCSCC does not seem to compromise disease control in this retrospective comparison. Based on these hypothesis-generating findings, a prospective study is being planned.PMID:38590644 | PMC:PMC10999524 | DOI:10.3389/fonc.2024.1362025 (Source: Cancer Control)
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Elena Riggenbach Manuel Waser Simon A Mueller Daniel M Aebersold Roland Giger Olgun Elicin Source Type: research
Oral bacteria accelerate pancreatic cancer development in mice
Conclusion
Taken together, our findings demonstrate a causal role for P. gingivalis in pancreatic cancer development in mice. (Source: Gut)
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Saba, E., Farhat, M., Daoud, A., Khashan, A., Forkush, E., Menahem, N. H., Makkawi, H., Pandi, K., Angabo, S., Kawasaki, H., Plaschkes, I., Parnas, O., Zamir, G., Atlan, K., Elkin, M., Katz, L., Nussbaum, G. Tags: Gut Pancreas Source Type: research
Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients
CONCLUSIONS: Significant differences in the microbial and genetic composition of saliva and dental plaque samples were observed in OC patients. Furthermore, pathogenic bacteria associated with oral diseases were predominantly enriched in saliva. The identification of inter-group differential biomarkers and pathways provide insights into the relationship between oral microbiota and the occurrence and development of OC.PMID:38575895 | DOI:10.1186/s12903-024-04181-1 (Source: Herpes)
Source: Herpes - April 4, 2024 Category: Infectious Diseases Authors: Man Zhang Yiming Zhao Abdulrahim Umar Hailin Zhang Lirong Yang Jing Huang Ying Long Zheng Yu Source Type: research
Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients
The oral cavity is home to various ecological niches, each with its own unique microbial composition. Understanding the microbial communities and gene composition in different ecological niches within the oral... (Source: BMC Oral Health)
Source: BMC Oral Health - April 4, 2024 Category: Dentistry Authors: Man Zhang, Yiming Zhao, Abdulrahim Umar, Hailin Zhang, Lirong Yang, Jing Huang, Ying Long and Zheng Yu Tags: Research Source Type: research
214 Rowell Syndrome as a Paraneoplastic Manifestation of Metastatic Mesothelioma
A 60-year-old male presented in 2021 with pulmonary metastatic epitheloid mesothelioma. Notable history included psoriasis and T4aN2bM0 sarcomatoid squamous-cell-carcinoma of the oral-cavity treated with palliative radiotherapy. Due to an extraordinary response to radiotherapy, Head and Neck Multidisciplinary-Team-Meeting re-review felt a lymphomatoid process more likely. For mesothelioma, he completed 4 cycles of palliative pemetrexed/ carboplatin chemotherapy with partial-response but then stopped due to bone-marrow toxicity. (Source: Lung Cancer)
Source: Lung Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Helen-Cara Younan, Eunice Xing, Hend Owaidat, Polyanna Leite, Danielle Power, Waleed Mohammed, Joanne Evans Tags: Case Reports Source Type: research
PD-L1 expression in head and neck squamous cell carcinoma and its clinical significance: A prospective observational study from a tertiary care centre
CONCLUSIONS: 72% of HNSCC patients in our cohort showed PD-L1 positivity and it was not associated with any patient demographic characteristics or aggressive pathological features. Positive PD-L1 expression may have a beneficial effect on overall survival in HNSCC.PMID:38554297 | DOI:10.4103/jcrt.jcrt_1239_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Sindhu Kilaru Soumya Surath Panda Lalatendu Moharana Debahuti Mohapatra Satya Sundar G Mohapatra Adyakinkar Panda Spoorthy Kolluri Suma Devaraj Ananya Kabi Bharat Das Ghanashyam Biswas Source Type: research
Lymphoepithelial carcinoma of tongue - Devil in garbs of Hodgkin lymphoma: A case report and review of literature
J Cancer Res Ther. 2024 Jan 1;20(1):445-449. doi: 10.4103/jcrt.jcrt_1559_22. Epub 2023 Apr 8.ABSTRACTLymphoepithelial carcinoma (LEC) of head and neck region predominantly arises in salivary gland, oral cavity, oropharynx, nasal cavity, paranasal sinuses, and larynx; those arising from tongue are rare. Morphologically, it is a poorly differentiated squamous cell carcinoma, with early regional and distant metastasis. Diagnosis of LEC can sometimes be challenging especially in small biopsy and more so when seen at unusual location. Combination of morphology and immunohistochemistry (IHC) helps the diagnosis. Herein, we repor...
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Diksha Karki Meenakshi Kamboj Sunil Pasricha Ghanashyam Mandal Vishal Yadav Vikas Arora Source Type: research
Accelerated hypofractionated chemoradiation for locally advanced head and neck cancer during COVID 19 pandemic: A tertiary care experience
CONCLUSION: During a pandemic crisis with limited manpower & technical resources accelerated hypofractionated radiotherapy with concurrent chemotherapy can be considered a feasible therapeutic option for HNSCC which can significantly reduce the overall Treatment Time (OTT) with comparable local control and manageable toxicities.PMID:38554353 | DOI:10.4103/jcrt.jcrt_1747_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Sumit Agarwal Isha Jaiswal Uday P Shahi Abhijit Mandal Lalit M Aggarwal Ankita Singh Anil Jaiswal Nandlal Yadawa Source Type: research
Accelerated hypofractionated chemoradiation for locally advanced head and neck cancer during COVID 19 pandemic: A tertiary care experience
CONCLUSION: During a pandemic crisis with limited manpower & technical resources accelerated hypofractionated radiotherapy with concurrent chemotherapy can be considered a feasible therapeutic option for HNSCC which can significantly reduce the overall Treatment Time (OTT) with comparable local control and manageable toxicities.PMID:38554353 | DOI:10.4103/jcrt.jcrt_1747_22 (Source: Cancer Control)
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Sumit Agarwal Isha Jaiswal Uday P Shahi Abhijit Mandal Lalit M Aggarwal Ankita Singh Anil Jaiswal Nandlal Yadawa Source Type: research
Anatomical variations in the superficial venous system of the neck: an image-based study using contrast-enhanced computed tomography
ConclusionThese findings indicate that the AJV has a rightward preference during its course. The course of the FV is diverse and affects the diameter of connected veins. (Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - March 27, 2024 Category: Anatomy Source Type: research
Ginsenoside Rb1 Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress, and Antimetastasis in Oral Squamous Carcinoma Cells
Appl Biochem Biotechnol. 2024 Mar 26. doi: 10.1007/s12010-024-04880-z. Online ahead of print.ABSTRACTThere are numerous therapeutic applications for ginsenoside Rb1 (GRb1), the primary saponin derived from ginseng root. According to earlier research, ginsenoside Rb1 causes apoptosis and reduces the cell cycle. Its adverse effects, especially those on the development of the embryo, still need to be thoroughly studied. A host's lifestyle choices, including smoking, drinking too much alcohol, using tobacco products, and having an HPV infection, can increase the risk of oral squamous cell carcinoma (OSCC), one of the most prev...
Source: Applied Biochemistry and Biotechnology - March 26, 2024 Category: Biochemistry Authors: Le An Yang Yu Long He Xu Xiao Pengcheng Li Source Type: research
Ginsenoside Rb1 Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress, and Antimetastasis in Oral Squamous Carcinoma Cells
Appl Biochem Biotechnol. 2024 Mar 26. doi: 10.1007/s12010-024-04880-z. Online ahead of print.ABSTRACTThere are numerous therapeutic applications for ginsenoside Rb1 (GRb1), the primary saponin derived from ginseng root. According to earlier research, ginsenoside Rb1 causes apoptosis and reduces the cell cycle. Its adverse effects, especially those on the development of the embryo, still need to be thoroughly studied. A host's lifestyle choices, including smoking, drinking too much alcohol, using tobacco products, and having an HPV infection, can increase the risk of oral squamous cell carcinoma (OSCC), one of the most prev...
Source: Applied Biochemistry and Biotechnology - March 26, 2024 Category: Biochemistry Authors: Le An Yang Yu Long He Xu Xiao Pengcheng Li Source Type: research
Persistent poverty disparities in incidence and outcomes among oral and pharynx cancer patients
CONCLUSION: This study found an association between oral cavity and pharyngeal cancer outcomes among patients in persistent poverty indicating a multidimensional strategy to improve survival.PMID:38520565 | DOI:10.1007/s10552-024-01867-3 (Source: Cancer Control)
Source: Cancer Control - March 23, 2024 Category: Cancer & Oncology Authors: Shama Karanth Shilpi Mistry Meghann Wheeler Tomi Akinyemiju Joel Divaker Jae Jeong Yang Hyung-Suk Yoon Dejana Braithwaite Source Type: research
Persistent poverty disparities in incidence and outcomes among oral and pharynx cancer patients
ConclusionThis study found an association between oral cavity and pharyngeal cancer outcomes among patients in persistent poverty indicating a multidimensional strategy to improve survival. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - March 23, 2024 Category: Cancer & Oncology Source Type: research
Unusual Presentation of Squamous Cell Carcinoma in a Young Male: Clinicopathological Insights and Considerations
We present a case of a 21-year-old male student who presented with a painless, gradually increasing, occasionally bleeding, nodulo-ulcerated lower lip lesion. The lesion was removed 3 months back with a carbon dioxide laser, and this was a recurrent lesion. We did lesion biopsy which confirmed squamous cell carcinoma. The patient started treatment at the T2N0M0 stage. Patient has responded well to the radiotherapy treatment. Our case had no known predisposing risk factors for c arcinoma. For etiopathogenesis in this case, role of prior lesion removal with carbon dioxide laser is debatable. As laser treatment does not spa...
Source: Indian Journal of Surgical Oncology - March 23, 2024 Category: Cancer & Oncology Source Type: research
