Host Transcriptional Regulatory Genes and Microbiome Networks Crosstalk through Immune Receptors Establishing Normal and Tumor Multiomics Metafirm of the Oral-Gut-Lung Axis
Int J Mol Sci. 2023 Nov 23;24(23):16638. doi: 10.3390/ijms242316638.ABSTRACTThe microbiome has shown a correlation with the diet and lifestyle of each population in health and disease, the ability to communicate at the cellular level with the host through innate and adaptative immune receptors, and therefore an important role in modulating inflammatory process related to the establishment and progression of cancer. The oral cavity is one of the most important interaction windows between the human body and the environment, allowing the entry of an important number of microorganisms and their passage across the gastrointesti...
Source: Cancer Control - December 9, 2023 Category: Cancer & Oncology Authors: Beatriz Andrea Ot álora-Otálora Juan Javier L ópez-Rivera Claudia Aristiz ábal-Guzmán Mario Arturo Isaza-Ruget Carlos Arturo Álvarez-Moreno Source Type: research
Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study
Observational epidemiological studies revealed that multiple serum biomarkers can be associated with the risk of oral and oropharyngeal cancer (OC/OPC). However, the causal relationship between them remains la... (Source: BMC Oral Health)
Source: BMC Oral Health - December 9, 2023 Category: Dentistry Authors: Weixing Liu, Yue Liu, Pei Li, Zhiyuan Wang, Jia Chen, Hui Liu and Jin Ye Tags: Research Source Type: research
Cancers, Vol. 15, Pages 5735: Clinical Use of a Commercial Artificial Intelligence-Based Software for Autocontouring in Radiation Therapy: Geometric Performance and Dosimetric Impact
Conclusions: When an autocontouring system is used in combination with human review, the time of the RT workflow is significantly reduced without affecting dose distribution and plan quality. (Source: Cancers)
Source: Cancers - December 7, 2023 Category: Cancer & Oncology Authors: S M Hasibul Hoque Giovanni Pirrone Fabio Matrone Alessandra Donofrio Giuseppe Fanetti Angela Caroli Rahnuma Shahrin Rista Roberto Bortolus Michele Avanzo Annalisa Drigo Paola Chiovati Tags: Article Source Type: research
A novel APC mutation associated with Gardner syndrome in a Chinese family
Gene. 2023 Dec 1:148051. doi: 10.1016/j.gene.2023.148051. Online ahead of print.ABSTRACTGardner syndrome (GS) is a specific form of familial adenomatous polyposis (FAP), which manifests as colorectal polyps, multiple osteomas and soft tissue tumors, and in the oral cavity as osteomas of the jaws, odontomas, and abnormal tooth counts. The underlying cause of GS is attributed to mutations in the APC gene. Mutations in this gene disrupt the normal functioning of the protein and lead to the development of GS. To further investigate GS, a family affected by the syndrome was selected from Dongguan, Guangdong Province. The family...
Source: Gene - December 3, 2023 Category: Genetics & Stem Cells Authors: Ming Zeng Xinchen Yao Yuhua Pan Hongxiang Gu Fu Xiong Xuemin Yin Buling Wu Ting Chen Source Type: research
Oral micro-electronic platform for temperature and humidity monitoring
Sci Rep. 2023 Dec 2;13(1):21277. doi: 10.1038/s41598-023-48379-9.ABSTRACTIntraoral theranostics, the integration of diagnostics and therapeutics within the oral cavity, is gaining significant traction. This pioneering approach primarily addresses issues like xerostomia (dry mouth), commonly resulting from cancer treatment, with a specific focus on monitoring temperature and humidity. This paper introduces the innovative Intra-Oral Portable Micro-Electronic (IOPM) fluidic theranostic device platform. It leverages conventional dental spoons by incorporating advanced sensors for precise measurements of oral temperature and hu...
Source: Cancer Control - December 2, 2023 Category: Cancer & Oncology Authors: Željko V Popović Aung Thiha Fatimah Ibrahim Bojan B Petrovi ć Nuraina Anisa Dahlan Lazar Mili ć Sanja Koji ć Goran M Stojanovi ć Source Type: research
Cancers, Vol. 15, Pages 5680: Shifting Epidemiology Trends in Tongue Cancer: A Retrospective Cohort Study
In this study, we aimed to determine current trends in tongue cancer regarding age and gender. Data from 197 tongue cancer patients were extracted from The Oncology Center, Mansoura University (OCMU) database from 2006 to 2021. The patients were divided into two time periods: (2006–2013) and (2014–2021). We computed counts and proportions of tongue cancer for demographic and tumor characteristics. The data were analyzed using SPSS. Gender showed no statistically significant difference in both groups, while the percentages of diagnosed females were 52.7% and 52%, respectively. The percentages of ...
Source: Cancers - December 1, 2023 Category: Cancer & Oncology Authors: Yara Sakr Omar Hamdy Maher Eldeghedi Rabab Abdelaziz Echreiva Med Sidi El Moctar Mohammed Alharazin Shadi Awny Tags: Article Source Type: research
40. Multiple synchronous and metachronous oral carcinomas in an immune- compromised patient; the detrimental role of candidiasis in carcinogenesis
Candida is a prevalent commensal pathogen in the oral cavity. However, an interesting pathological association exists between these fungi, oral precancerous, and cancerous lesions. Candida has been shown to increase the degree of dysplasia, and progression to neoplasia in leukoplakia. Chronic candidiasis in immunocompromised results in colonization of the epithelium by the organism, which can invade the keratinocytes, damage the DNA, and break the tissue matrix, through several proposed mechanisms, resulting in cancer initiation and spread. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2023 Category: ENT & OMF Authors: Hussein Ali Mohammed Abdulnabi, Hussein Ali Mohammed Abdulnabi, Sabah A Issa, Dalya Q Majid, Bashar Kazaal Source Type: research
33. How fast is too fast? Post-operative & physical function milestones for patients undergoing maxillofacial surgery with free flap reconstruction
Around 75% of patients with oral cavity cancers undergo OMFS with tracheostomy and free flap reconstruction. H&N ERAS is complex and challenging, hence modest uptake. Our tertiary HNC service introduced ERAS in 2010. Aim: Describe postoperative milestones and assess iatrogenic influences by measuring physical function perioperatively (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2023 Category: ENT & OMF Authors: Rachel Wijayarathna, Rachel Wijayarathna, Matthew Fergusson, Janvi Patel, Sarah Coupe, Gareth Jones Source Type: research
58. Contralateral drainage in oral cavity cancer in a sentinel lymph node biopsy referral centre
Sentinel lymph node biopsy (SNB) determines lymph node status on a patient specific basis. This approach identifies first echelon nodes outside the typically dissected neck levels, such as well-lateralised tumors which drain to the contralateral neck. We aim to report the incidence of contralateral/bilateral drainage in well-lateralised oral cavity cancers and identify predictive factors. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2023 Category: ENT & OMF Authors: Jeevan Ubhi, Jeevan Ubhi, Axel Sahovaler, Simon Wan, Mark McGurk, Clare Schilling Source Type: research
P031 The relationship between social disadvantage and staging of oral squamous cell carcinomas presenting to an oral and maxillofacial unit in the west of Ireland
This study aimed to investigate the relationship between social disadvantage and the stage of OSCC upon presentation in the West and North West of Ireland, a region which experiences an inequality of investment when compared to other regions of Ireland in terms of healthcare, education, infrastructure and transport. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2023 Category: ENT & OMF Authors: Caoimh ín O'Higgins, Caoimhín O'Higgins, Paul Sexton, Ahmed El Minshawi, Patrick McCann, Tom Barry Source Type: research
P028 End-of-life outcomes in oral cavity cancer patients receiving palliative care —a two- year retrospective review
Incurable oral cavity cancer may cause distressing symptoms of pain, dysphagia, dyspnoea, and uncontrolled bleeding. We aimed to look at the outcomes of patients undergoing palliative treatment for oral cavity cancer. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2023 Category: ENT & OMF Authors: Adam Kara, Adam Kara, Nidhi Parmar, Omar Sheikh, Kunmi Fasanmade, Montey Garg Source Type: research
Correlation of Intra-tumoral and Peripheral PD-1/PD-L1 Immunity in Head and Neck Cancer
CONCLUSION: Our data demonstrate significant connections between systemic and intra-tumoral PD-1/PD-L1 immune patterns, both of which may serve as promising combined biomarkers for treatment decisions in patients with head and neck cancer.PMID:38030173 | DOI:10.21873/anticanres.16738 (Source: Cell Research)
Source: Cell Research - November 29, 2023 Category: Cytology Authors: Christian Idel Julika Ribbat-Idel Amelie VON Bernuth Jonas Fleckner Dirk Rades Jutta Kirfel Verena Sailer Kirstin Pl ötze-Martin Karl-Ludwig Bruchhage Ralph Pries Source Type: research
Anesthetic management of airway stent placement by rigid bronchoscopy with superior laryngeal nerve block while preserving spontaneous breathing: A case report
Clin Case Rep. 2023 Nov 19;11(11):e8232. doi: 10.1002/ccr3.8232. eCollection 2023 Nov.ABSTRACTKEY CLINICAL MESSAGE: The combination of superior laryngeal nerve block can reduce the respiratory depression that occurs during management under total intravenous anesthesia.ABSTRACT: Anesthetic management of endobronchial stent placement by rigid bronchoscopy requires the maintenance of spontaneous breathing while suppressing upper airway reflexes. The combination of superior laryngeal nerve block (SLNB) can reduce the respiratory depression that occurs during management under total intravenous anesthesia. The patient was diagno...
Source: Clinical Lung Cancer - November 29, 2023 Category: Cancer & Oncology Authors: Toshio Okada Mio Yoshida Tomoko Matsushita Yusuke Ishida Kinya Furukawa Michihiro Murozono Source Type: research
Clinical outcomes and failure patterns after postoperative radiotherapy for oral cavity squamous cell carcinoma
CONCLUSION: PORT was effective for postoperative recurrences as well as for initially diagnosed oral cavity cancer. Doses greater than 56 Gy to the primary site may be required in PORT for OSCC.PMID:37999789 | DOI:10.1007/s00066-023-02171-w (Source: Cancer Control)
Source: Cancer Control - November 24, 2023 Category: Cancer & Oncology Authors: Saori Tatsuno Hiroshi Doi Masahiro Inada Takuya Uehara Yutaro Wada Kazuki Ishikawa Kaoru Tanaka Mutsukazu Kitano Yasumasa Nishimura Source Type: research
Clinical outcomes and failure patterns after postoperative radiotherapy for oral cavity squamous cell carcinoma
ConclusionPORT was effective for postoperative recurrences as well as for initially diagnosed oral cavity cancer. Doses greater than 56 Gy to the primary site may be required in PORT for OSCC. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - November 24, 2023 Category: Cancer & Oncology Source Type: research
