Matrix ‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma
AbstractOral squamous cell carcinoma (OSCC) is a head and neck cancer (HNC) with a high mortality rate. OSCC is developed in the oral cavity and it is triggered by many etiologic factors and can metastasize both regionally and distantly. Recent research advances in OSCC improved our understanding on the molecular mechanisms involved in and the initiation of OSCC metastasis. The key roles of the extracellular matrix (ECM) in OSCC are an emerging area of intensive research as the ECM macromolecular network is actively involved in events that regulate cellular morphological and functional properties, transcription and cell si...
Source: IUBMB Life - January 3, 2024 Category: Research Authors: Nicholas S. Mastronikolis,
Efthymios Kyrodimos,
Zoi Piperigkou,
Despoina Spyropoulou,
Alexander Delides,
Evangelos Giotakis,
Miranda Alexopoulou,
Nick A. Bakalis,
Nikos K. Karamanos Tags: CRITICAL REVIEW Source Type: research
Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis
ConclusionThe evidence points to an apparent burden in HPV-related OPSCC, mostly in North America, Northern Europe, and Oceania, especially due to the HPV16 infection suggesting different trends across continents.Clinical relevanceThis updated systematic review and meta-analysis provide sufficient evidence about the global HPV prevalence in OSCC and OPSCC and the most frequent HPV subtype worldwide. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - December 30, 2023 Category: Dentistry Source Type: research
Public Awareness on Oral Cancer: A Population- Based Study in Asturias
CONCLUSION: This survey showed a worrying lack of awareness and knowledge about oral cancer among the population of Asturias, especially among those under 50 years old. The interest shown in increasing their knowledge, give us hope in the success of future awareness campaigns.PMID:38156847 | DOI:10.31557/APJCP.2023.24.12.4127 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 29, 2023 Category: Cancer & Oncology Authors: Carlota Su árez-Fernández Carlos Barrientos Mar ía García-Pola Source Type: research
Oral Cavity Cancer Surgical and Nodal Management
This review describes the evidence surrounding commonly encountered clinical scenarios in the management of the neck in patients with oral cancer. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - December 28, 2023 Category: ENT & OMF Source Type: research
CT predictors of sub-centimeter occult lymph node metastases in oral cavity squamous cell carcinoma: A case-control study
CONCLUSIONS: In cN0 OCSCC patients undergoing END, round/oval shape, asymmetric number, and disrupted fatty hilum of lymph nodes on pre-operative CT imaging are novel and highly predictive of occult nodal disease.PMID:38148295 | DOI:10.1177/19714009231224447 (Source: Cancer Control)
Source: Cancer Control - December 26, 2023 Category: Cancer & Oncology Authors: Megan V Morisada Arnaud F Bewley Kenneth Broadhead Reza Assadsangabi Alireza Paydar Andrew C Birkeland Marianne Abouyared Lihong Qi Vladimir Ivanovic Source Type: research
Risk of Parkinson's disease-related death in cancer survivors: A population-based study in Japan
CONCLUSIONS: Patients with cancer are at a high risk of PD-related death; particularly, mouth-to-stomach cancers and potentially obstructing medication for PD are attributable to a high mortality risk. Careful management, including adequate PD treatment, would benefit cancer survivors with PD and reduce the risk of PD-related death.PMID:38147694 | DOI:10.1016/j.parkreldis.2023.105966 (Source: Cancer Control)
Source: Cancer Control - December 26, 2023 Category: Cancer & Oncology Authors: Eri Hayano Yasufumi Gon Yasuyoshi Kimura Ling Zha Toshitaka Morishima Yuko Ohno Hideki Mochizuki Tomotaka Sobue Isao Miyashiro Source Type: research
Association Between Pre-operative 25-Hydroxy Vitamin D Deficiency and Surgical Site Infection After Oral Cavity Oncology Surgery: a Cross-Sectional Study in a Tertiary Cancer Center in Northwestern India
This study highlights the significant association between pre-operative 25-hydroxy vitamin D deficiency and an increased risk of surgical site infections in patients. Vitamin D plays a crucial role in modulating the immune response, promoting antimicrobial peptides, and enhancing wound he aling. These findings support the importance of assessing and addressing vitamin D deficiency in patients scheduled for oral cavity oncology surgery to potentially reduce the incidence of SSIs. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - December 22, 2023 Category: Cancer & Oncology Source Type: research
Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients' histopathological records. Of the 120,010 oral and maxillofacial biops...
Source: Cell Research - December 21, 2023 Category: Cytology Authors: Brendo Vinicius Rodrigues Louredo Maria Paula Curado Paulo Victor Mendes Penafort Jos é Alcides Almeida DE Arruda Lucas Guimar ães Abreu Ricardo Alves Mesquita D écio Dos Santos Pinto-Júnior Aline Corr êa Abrahão Bruno Augusto Benevenuto de Andrade Source Type: research
Evaluating the Hounsfield unit assignment and dose differences between CT-based standard and deep learning-based synthetic CT images for MRI-only radiation therapy of the head and neck
CONCLUSIONS: In this cohort, HU differences of CT and sCT were observed but did not translate into a reduction in gamma pass rates or differences in average PTV/OAR dose metrics greater than 3%. For sites such as the H&N where there are many tissue interfaces we did not observe large scale dose deviations but further studies using larger retrospective cohorts are merited to establish the variation in sCT dosimetric accuracy which could help to inform QA limits on clinical sCT usage.PMID:38128040 | DOI:10.1002/acm2.14239 (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - December 21, 2023 Category: Physics Authors: Kamal Singhrao Catherine Lu Dugan Christina Calvin Luis Pelayo Sue Sun Yom Jason Wing-Hong Chan Jessica Elizabeth Scholey Lisa Singer Source Type: research
Alveolar bone loss and tooth loss contribute to increase in cancer mortality among older patients
CONCLUSION: Our results indicate that older patients suffering from tooth loss or alveolar bone loss are at increased risks of cancer mortality, especially for total cancer and LOP cancer.PMID:38114973 | DOI:10.1186/s12903-023-03543-5 (Source: Cancer Control)
Source: Cancer Control - December 20, 2023 Category: Cancer & Oncology Authors: Yifeng Qian Binxin Cai Fangfang Chi Chunxia Yao Lei Zhang Lei Qi Yonggen Jiang Xudong Wang Source Type: research
