Brucella-driven host N-glycome remodeling controls infection
Cell Host Microbe. 2024 Mar 20:S1931-3128(24)00083-0. doi: 10.1016/j.chom.2024.03.003. Online ahead of print.ABSTRACTMany powerful methods have been employed to elucidate the global transcriptomic, proteomic, or metabolic responses to pathogen-infected host cells. However, the host glycome responses to bacterial infection remain largely unexplored, and hence, our understanding of the molecular mechanisms by which bacterial pathogens manipulate the host glycome to favor infection remains incomplete. Here, we address this gap by performing a systematic analysis of the host glycome during infection by the bacterial pathogen B...
Source: Cell Host and Microbe - March 26, 2024 Category: Microbiology Authors: Ana-Lucia Cabello Kelsey Wells Wenjing Peng Hui-Qiang Feng Junyao Wang Damien F Meyer Christophe Noroy En-Shuang Zhao Hao Zhang Xueqing Li Haowu Chang Gabriel Gomez Yuxin Mao Kristin L Patrick Robert O Watson William K Russell Aiying Yu Jieqiang Zhong Fen Source Type: research

Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity
Cell Host Microbe. 2024 Mar 13:S1931-3128(24)00059-3. doi: 10.1016/j.chom.2024.02.016. Online ahead of print.ABSTRACTThe plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like (MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL)-receptor-triggered immunity. Here, we show that Arabidopsis MLKL1 (AtMLKL1) clusters into puncta at the plasma membrane upon TNL activation and that this sub-cellular reorganization is dependent on the TNL signal transducer, EDS1. We find that AtMLKLs confer TNL-triggered immunity in parallel with RPW8-type HeLo-domain-containing NLRs (RNL...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Qiaochu Shen Keiichi Hasegawa Nicole Oelerich Anna Prakken Lea Weiler Tersch Junli Wang Frowin Reichhardt Alexandra Tersch Je Cuan Choo Ton Timmers Kay Hofmann Jane E Parker Jijie Chai Takaki Maekawa Source Type: research

Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00060-X. doi: 10.1016/j.chom.2024.03.001. Online ahead of print.ABSTRACTInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived gut microbiota promotes the deterioration of colonic mucus, leading to lethal colitis. Inflammation starts with the e...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Gabriel Vasconcelos Pereira Marie Boudaud Mathis Wolter Celeste Alexander Alessandro De Sciscio Erica T Grant Bruno Caetano Trindade Nicholas A Pudlo Shaleni Singh Austin Campbell Mengrou Shan Li Zhang Qinnan Yang St éphanie Willieme Kwi Kim Trisha Denik Source Type: research

A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00075-1. doi: 10.1016/j.chom.2024.03.002. Online ahead of print.ABSTRACTImmunotherapy has revolutionized cancer treatment, but inconsistent responses persist. Our study delves into the intriguing phenomenon of enhanced immunotherapy sensitivity in older individuals with cancers. Through a meta-analysis encompassing 25 small-to-mid-sized trials of immune checkpoint blockade (ICB), we demonstrate that older individuals exhibit heightened responsiveness to ICB therapy. To understand the underlying mechanism, we reanalyze single-cell RNA sequencing (scRNA-seq) data from multiple stu...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Xiaoqiang Zhu Xiaowen Huang Muni Hu Rongrong Sun Jiantao Li Hai Wang Xuefeng Pan Yanru Ma Lijun Ning Tianying Tong Yilu Zhou Jinmei Ding Ying Zhao Baoqin Xuan Jing-Yuan Fang Jie Hong Jason Wing Hon Wong Youwei Zhang Haoyan Chen Source Type: research

Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity
Cell Host Microbe. 2024 Mar 13:S1931-3128(24)00059-3. doi: 10.1016/j.chom.2024.02.016. Online ahead of print.ABSTRACTThe plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like (MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL)-receptor-triggered immunity. Here, we show that Arabidopsis MLKL1 (AtMLKL1) clusters into puncta at the plasma membrane upon TNL activation and that this sub-cellular reorganization is dependent on the TNL signal transducer, EDS1. We find that AtMLKLs confer TNL-triggered immunity in parallel with RPW8-type HeLo-domain-containing NLRs (RNL...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Qiaochu Shen Keiichi Hasegawa Nicole Oelerich Anna Prakken Lea Weiler Tersch Junli Wang Frowin Reichhardt Alexandra Tersch Je Cuan Choo Ton Timmers Kay Hofmann Jane E Parker Jijie Chai Takaki Maekawa Source Type: research

Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00060-X. doi: 10.1016/j.chom.2024.03.001. Online ahead of print.ABSTRACTInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived gut microbiota promotes the deterioration of colonic mucus, leading to lethal colitis. Inflammation starts with the e...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Gabriel Vasconcelos Pereira Marie Boudaud Mathis Wolter Celeste Alexander Alessandro De Sciscio Erica T Grant Bruno Caetano Trindade Nicholas A Pudlo Shaleni Singh Austin Campbell Mengrou Shan Li Zhang Qinnan Yang St éphanie Willieme Kwi Kim Trisha Denik Source Type: research

A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00075-1. doi: 10.1016/j.chom.2024.03.002. Online ahead of print.ABSTRACTImmunotherapy has revolutionized cancer treatment, but inconsistent responses persist. Our study delves into the intriguing phenomenon of enhanced immunotherapy sensitivity in older individuals with cancers. Through a meta-analysis encompassing 25 small-to-mid-sized trials of immune checkpoint blockade (ICB), we demonstrate that older individuals exhibit heightened responsiveness to ICB therapy. To understand the underlying mechanism, we reanalyze single-cell RNA sequencing (scRNA-seq) data from multiple stu...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Xiaoqiang Zhu Xiaowen Huang Muni Hu Rongrong Sun Jiantao Li Hai Wang Xuefeng Pan Yanru Ma Lijun Ning Tianying Tong Yilu Zhou Jinmei Ding Ying Zhao Baoqin Xuan Jing-Yuan Fang Jie Hong Jason Wing Hon Wong Youwei Zhang Haoyan Chen Source Type: research

Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity
Cell Host Microbe. 2024 Mar 13:S1931-3128(24)00059-3. doi: 10.1016/j.chom.2024.02.016. Online ahead of print.ABSTRACTThe plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like (MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL)-receptor-triggered immunity. Here, we show that Arabidopsis MLKL1 (AtMLKL1) clusters into puncta at the plasma membrane upon TNL activation and that this sub-cellular reorganization is dependent on the TNL signal transducer, EDS1. We find that AtMLKLs confer TNL-triggered immunity in parallel with RPW8-type HeLo-domain-containing NLRs (RNL...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Qiaochu Shen Keiichi Hasegawa Nicole Oelerich Anna Prakken Lea Weiler Tersch Junli Wang Frowin Reichhardt Alexandra Tersch Je Cuan Choo Ton Timmers Kay Hofmann Jane E Parker Jijie Chai Takaki Maekawa Source Type: research

Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00060-X. doi: 10.1016/j.chom.2024.03.001. Online ahead of print.ABSTRACTInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived gut microbiota promotes the deterioration of colonic mucus, leading to lethal colitis. Inflammation starts with the e...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Gabriel Vasconcelos Pereira Marie Boudaud Mathis Wolter Celeste Alexander Alessandro De Sciscio Erica T Grant Bruno Caetano Trindade Nicholas A Pudlo Shaleni Singh Austin Campbell Mengrou Shan Li Zhang Qinnan Yang St éphanie Willieme Kwi Kim Trisha Denik Source Type: research

A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00075-1. doi: 10.1016/j.chom.2024.03.002. Online ahead of print.ABSTRACTImmunotherapy has revolutionized cancer treatment, but inconsistent responses persist. Our study delves into the intriguing phenomenon of enhanced immunotherapy sensitivity in older individuals with cancers. Through a meta-analysis encompassing 25 small-to-mid-sized trials of immune checkpoint blockade (ICB), we demonstrate that older individuals exhibit heightened responsiveness to ICB therapy. To understand the underlying mechanism, we reanalyze single-cell RNA sequencing (scRNA-seq) data from multiple stu...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Xiaoqiang Zhu Xiaowen Huang Muni Hu Rongrong Sun Jiantao Li Hai Wang Xuefeng Pan Yanru Ma Lijun Ning Tianying Tong Yilu Zhou Jinmei Ding Ying Zhao Baoqin Xuan Jing-Yuan Fang Jie Hong Jason Wing Hon Wong Youwei Zhang Haoyan Chen Source Type: research

Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity
Cell Host Microbe. 2024 Mar 13:S1931-3128(24)00059-3. doi: 10.1016/j.chom.2024.02.016. Online ahead of print.ABSTRACTThe plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like (MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL)-receptor-triggered immunity. Here, we show that Arabidopsis MLKL1 (AtMLKL1) clusters into puncta at the plasma membrane upon TNL activation and that this sub-cellular reorganization is dependent on the TNL signal transducer, EDS1. We find that AtMLKLs confer TNL-triggered immunity in parallel with RPW8-type HeLo-domain-containing NLRs (RNL...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Qiaochu Shen Keiichi Hasegawa Nicole Oelerich Anna Prakken Lea Weiler Tersch Junli Wang Frowin Reichhardt Alexandra Tersch Je Cuan Choo Ton Timmers Kay Hofmann Jane E Parker Jijie Chai Takaki Maekawa Source Type: research

Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00060-X. doi: 10.1016/j.chom.2024.03.001. Online ahead of print.ABSTRACTInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with host genetics, diet and gut bacteria are thought to contribute prominently to IBDs, but mechanisms are still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived gut microbiota promotes the deterioration of colonic mucus, leading to lethal colitis. Inflammation starts with the e...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Gabriel Vasconcelos Pereira Marie Boudaud Mathis Wolter Celeste Alexander Alessandro De Sciscio Erica T Grant Bruno Caetano Trindade Nicholas A Pudlo Shaleni Singh Austin Campbell Mengrou Shan Li Zhang Qinnan Yang St éphanie Willieme Kwi Kim Trisha Denik Source Type: research

A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00075-1. doi: 10.1016/j.chom.2024.03.002. Online ahead of print.ABSTRACTImmunotherapy has revolutionized cancer treatment, but inconsistent responses persist. Our study delves into the intriguing phenomenon of enhanced immunotherapy sensitivity in older individuals with cancers. Through a meta-analysis encompassing 25 small-to-mid-sized trials of immune checkpoint blockade (ICB), we demonstrate that older individuals exhibit heightened responsiveness to ICB therapy. To understand the underlying mechanism, we reanalyze single-cell RNA sequencing (scRNA-seq) data from multiple stu...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Xiaoqiang Zhu Xiaowen Huang Muni Hu Rongrong Sun Jiantao Li Hai Wang Xuefeng Pan Yanru Ma Lijun Ning Tianying Tong Yilu Zhou Jinmei Ding Ying Zhao Baoqin Xuan Jing-Yuan Fang Jie Hong Jason Wing Hon Wong Youwei Zhang Haoyan Chen Source Type: research

A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research

A new piece of the microbiota pie: Mining 'omics for DNA inversion states
Cell Host Microbe. 2024 Mar 13;32(3):293-295. doi: 10.1016/j.chom.2024.02.009.ABSTRACTIn this issue of Cell Host & Microbe, Carasso et al. survey invertible DNA sites in Bacteroidales from patients with inflammatory bowel disease (IBD) and healthy control individuals. They identify complex functional interactions between Bacteroides fragilis, an invertible promoter, a capsular polysaccharide, a bacteriophage, and the human host. The establishment of 'omics approaches to characterizing genomic targets and functional roles is still required.PMID:38484706 | DOI:10.1016/j.chom.2024.02.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Danielle E Campbell Megan T Baldridge Source Type: research