Medication Adherence And Associated Factors Among Chronic Heart Failure Clients On Follow Up Oromia Region, West Ethiopia.
CONCLUSION AND RECOMMENDATION: Even if more than half of study respondents have, good medication and self-care adherence still it need great attention in health education over on their visit. We recommend health institution strongly to give health education for clients and researcher to use advanced study design for measuring medication adherence and self-care behaviors. PMID: 31629399 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 21, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Underutilization of Cardiac Therapies in Patients with Acute Ischemic Stroke and Elevated Troponin.
This study aims to determine this rate of utilization. MATERIALS/METHODS: A single-center review of 83 patients with AIS and measured troponin was conducted. Patients were stratified based on elevated and non-elevated troponin. Between groups, we measured the utilization of evidence-based cardiac therapies and used a univariate logistic regression to compare outcomes of mortality, re-hospitalization, recurrent acute ischemic stroke, recurrent acute myocardial infarction, and a composite of these outcomes. RESULTS: Of 83 patients, 25 had elevated troponin and 58 had non-elevated troponin. There was no statistical di...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 21, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Role of whole plant extract of Nelumbo nucifera Gaertn in treatment of Thrombolysis.
CONCLUSION: Based on these findings, flavonoids present in hydroalcoholic extract may be developed into drug for clinical application for the treatment of thrombosis in patients. PMID: 31622211 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 18, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Antihypertensive and vasorelaxant effects of Matricaria pubescens in rats.
CONCLUSION: The study illustrates the beneficial action of M. pubescens as an antihypertensive agent. PMID: 31589128 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 8, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Cardiovascular and Hematological Medicine in 2019 - Advances and Insights.
Authors: Mukherjee D Abstract PMID: 31556359 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 28, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

The Superior Mesenteric Artery: from Syndrome in the Young to Vascular Atherosclerosis in the Old.
Authors: Beita AKV, Whayne TF Abstract This review is directed at increasing awareness of two diverse rare upper gastrointestinal problems that occur at opposite ends of the age spectrum and are difficult to diagnose and treat. The superior mesenteric artery syndrome (SMAS) likely involves a young patient, especially female, and is especially associated with rapid weight loss, resulting in relative strangulation of the duodenum by a narrowing of the angle between the superior mesenteric artery (SMA) and the aorta. On the other hand, atherosclerosis of the SMA is associated most likely with postprandial upper intest...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 21, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Preparing India to Leverage the Power of Mobile Technology: Development of a Bilingual Mobile Health Tool for Heart Patients.
CONCLUSION: This mobile application is developed as a research tool to further conduct a clinical study in coronary artery disease patients. Current evaluation was a pilot testing wherein this application showed promising results. PMID: 31512999 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 14, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Epidemiology and Adverse Consequences of Hookah/Waterpipe Use: A Systematic Review.
The objectives of the review are to assess the factor associated with increasing use of hookah, its health effects, options for hookah smoking cessation and public health policy initiatives to mitigate waterpipe use. PMID: 31483237 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 6, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Artificial blood.A futuristic dimension of modern day transfusion sciences.
Authors: Haldar R, Chitranshi S, Singh MK, Sachan S, Gupta D Abstract Artificial blood is a innovative concept of transfusion medicine where specifically designed compounds perform the task of transport and delivery of oxygen in the body to replace this function of allogenic human blood transfusion. Several molecules have been developed in the past few decades to achieve this objective and continous refinements are being continuously made in the quest of the ideal blood substitute. Currently available technology manufactures artificial blood from haemoglobin obtained from outdated human/bovine blood (Haemoglobin Ba...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - June 19, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Leaf aqueous extract of Argania spiniosa exhibits antihyperglycemic effect in diabetic rats.
Authors: Hebi M, Eddouks M Abstract INTRODUCTION: Argania spinosa L. (Sapotaceae) is an endemic species from south-western Morocco. This plant has many traditional uses including treatment of diabetes. AIM OF THE STUDY: The anti-diabetic effect of Argania spinosa leaf aqueous extract (A.S.L.A.E) was evaluated in both normal and streptozotocin(STZ)-induced diabetic rats treated at a dose of 20 mg/kg body weight for 15 days. The histopathological changes in liver have been evaluated. In addition, the antioxidant activity of this extract was studied. RESULTS: Single oral administration of A.S.L.A.E showed no s...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - June 13, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Radioprotective Effect of Giclazide as an Anti-hyperglycaemic Agent Against Genotoxicity Induced by Ionizing Radiation on Human Lymphocytes.
CONCLUSION: This data provides that GL is a powerful radioprotective agent that could protect healthy cells against the chromosome damage induced by ionizing radiation through antioxidant activity. The radioprotective effect is new indication of GL for patients' protection against side effect induced by ionizing radiation. PMID: 31124426 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 29, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Emblica Officinalis (Amla) ameliorates high fat diet induced alteration of cardiovascular pathophysiology.
CONCLUSION: Ethanolic extract of Emblica Officinalis (EEO) indicates its cardio protective efficacy against rats fed with high fat diet. PMID: 30963985 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - April 10, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: A systematic review and meta-analysis.
CONCLUSION: The findings of this meta-analysis confirm the positive association between fluoroquinolones and the development of aortic aneurysm or dissection. The data tend to show that this association may be majorly driven by aortic aneurysm. Additionally, some risk factors appear to prevail including prolonged fluoroquinolone treatment and older age. PMID: 30947680 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - April 7, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Hypolipidemic and Antioxidant Activities of Corrigiola Telephiifolia in Diabetic Rats.
Authors: Hebi M, Eddouks M Abstract OBJECTIVE: the evaluation of the hypolipidemic and antioxidant activities of the aerial parts aqueous extract of Corrigiola telephiifolia (APAE of C. telephiifolia) in normal and streptozotocin(STZ)-induced diabetic rats. METHODS: The effects of oral administration of APAE of C. telephiifolia (5 mg/kg) on the lipid profile as well as the in vitro antioxidant activity of this aqueous extract have been determined. RESULTS: APAE of C. telephiifolia (5 mg/kg) reduced significantly (p
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - March 6, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Statins Can Lead to Acute Hemolysis.
Authors: Moghadasi M, Maghsoomi Z Abstract PMID: 30741131 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 12, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Flavonoid-enriched extract from desert plant Warionia saharae improves glucose and cholesterol levels in diabetic rats.
CONCLUSION: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats. PMID: 30666919 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 24, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

The cardiovascular protective effects of chrysin: A narrative review on experimental researches.
Authors: Farkhondeh T, Samarghandian S, Bafandeh F Abstract Chrysin is one of the flavonoids fruits, vegetables, and plant especially found in honey, it has been indicated that its cardiovascular protective effect is due to its antioxidative effects and anti-inflammatory activities. Chrysin exerts an antioxidant effect by enhancing the antioxidant system, suppressing pro-oxidant enzymes, scavenging free radicals and chelating redox active transition-metal ions. Chrysin decreases lipid synthesis and also increases its metabolism, thereby ameliorating blood lipid profile. Chrysin modulates vascular function by increa...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 18, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

The beneficial therapy with colchicine for atherosclerosis via anti-inflammation and decrease in hypertriglyceridemia.
CONCLUSION: Colchicine reduces the levels of inflammatory markers, stabilizes the coronary plaque, leads to more favorable cardiac healing after damage, and reduces the acute coronary syndromes event recurrence. Colchicine reduces the myocardial infarct size, myocardial fibrosis, and improves the hemodynamic parameters. Several studies report the potential attenuating role of colchicine on triglyceride levels. Current evidence though regarding the pathophysiological mechanism of colchicine's triglyceride-lowering effect remains scarce. PMID: 30526472 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hemat...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 13, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Effect of flavonoid-rich extract of Tamarix articulata Vahl. on glucose and lipid metabolism in normal and diabetic rats.
Authors: Hebi M, Hajji L, Eddouks M Abstract OBJECTIVE: The present study was carried out in order to evaluate the antidiabetic and antihyperlipidemic potential of flavonoid-rich extract of Tamarix articulata (FRETA) in both normal and streptozotocin (STZ)-induced diabetic rats. MATERIAL AND METHODS: Normal and diabetic rats were treated with the FRETA for 7 days. At the end of treatment, a range of parameters were tested including blood lipid profile, histopathological changes in both liver and pancreas and oral glucose tolerance test (OGTT). RESULTS: The blood glucose levels were lowered in both normal an...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 13, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Idiopathic "Cyclic" Edema: a Frustrating and Poorly Understood Clinical Problem.
Idiopathic "Cyclic" Edema: a Frustrating and Poorly Understood Clinical Problem. Cardiovasc Hematol Agents Med Chem. 2018 Dec 11;: Authors: Whayne TF, Fisher MB Abstract Idiopathic edema (IE), is a syndrome involving real or perceived weight gain secondary to the pathological retention of fluid. This syndrome of generalized edema is almost solely reported in women. The diagnosis of IE is one of exclusion and requires a careful history, physical exam, and clinical suspicion. The aim of this article is to provide a comprehensive review of the available literature in order to attempt to define I...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 13, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Reduction in Vasa Vasorum Angiogenesis by Lp-PLA2 Selective Inhibitor Through The HIF-1 ╬▒ and VEGF Expression Under Dyslipidemic Conditions in Atherosclerosis Pathogenesis.
In conclusion, darapladib injection as an Lp-PLA2 selective inhibitor correlates with the decreasing vasa vasorum angiogenesis through alteration in HIF-1α and VEGF expressions in the aorta of high fat diet rats. We recommend further experiments to determine the effectiveness of darapladib with earlier time series in the atherosclerosis process. PMID: 30394217 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 6, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Cardiovascular and Hematological Medicine in 2018 - Advances and Insights.
Authors: Mukherjee D PMID: 30215326 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 16, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Pegylated Naloxone in the Treatment of Persistent Opioid-Induced Constipation in Patients with Hematological Malignancies.
Authors: Brunetti GA, Palumbo G, Annechini G, Santopietro M, Tendas A, Niscola P, Cartoni C PMID: 30215327 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 16, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Comparison and Impact of Short-Term Use of Some Non-Aspirin NSAIDs on Bleeding Time of Mice.
The objective of the study is to determine the comparison and impact of short-term use of some non-aspirin NSAIDs on bleeding time parameter. METHOD: Each groups contained 4 animals were given the test drugs (normal group without any treatment, ketoprofen 0,26 mg/ 20 g BW of mice twice daily, ketorolac 0,078 mg/ 20 g BW of mice twice daily, diclofenac sodium 0,13 mg/ 20 g BW of mice twice daily, piroxicam 0,052 mg/ 20 g BW of mice once daily, mefenamic acid 1,3 mg/ 20 g BW of mice thrice daily, meloxicam 0,039 mg/ 20 g BW of mice once daily, celecoxib 0,52 mg/ 20 g BW of mice once daily, ibuprofen 1,04 mg/ 20 g BW of m...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 14, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Thromboxane A Synthase: a New Target for the Treatment of Cardiovascular Diseases.
Authors: Mesitskaya DF, Syrkin AL, Aksenova MG, Zhang Y, Zamyatnin AA, Kopylov PY Abstract Atherothrombosis-related diseases are one of the world's leading causes of mortality, and thus the search for new therapeutic approaches in this area remains a very urgent task. Modern pharmacogenomic technologies make it possible to obtain valuable data on disease pathogenesis and optimal therapeutic approaches. One promising research direction is the study of the thromboxane A2 - thromboxane A synthase - thromboxane A2 receptor axis. This review summarizes the recent evidence, and suggests that systematic works in this area...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - July 26, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Perception of patients regarding burdens and benefits of vitamin K antagonists among patients with nonvalvular atrial fibrillation.
CONCLUSIONS: Satisfaction with treatment was high among patients with AF chronically anticoagulated with VKA, suggesting that quality of life is not impaired in this population. PMID: 29879893 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - June 9, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Free Fatty Acids: Circulating Contributors of Metabolic Syndrome.
Authors: Suiter C, Singha SK, Khalilli R, Shariat-Madar Z Abstract Metabolic syndrome induces an increased cardiovascular morbidity and mortality. Most importantly, the prevalence of metabolic syndrome in adult population is expanding. Both clinical and preclinical studies indicate that increased free fatty acids (FFAs) are involved in the pathogenesis of insulin resistance and subsequent development of metabolic syndrome. The relevance of FFAs in protecting and restoring tissue function is quite vast. The search to correlate the functional deterioration of the tissues within the cardiovascular system and increased...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 30, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Glucose lowering activity of the aqueous extract of Warionia saharae in normal and diabetic rats.
Authors: Eddouks M, Hebi M Abstract The current study was carried out to investigate the effect of a single dose and daily oral administration for 15 days of the aerial part aqueous extract (A.P.A.E) of Warionia saharae (W. saharae) at a dose of 5 mg/kg body weight on blood glucose levels and the histopathological changes in liver and pancreas both in normal and streptozotocin-induced diabetic rats (STZ). Also, the effect of this extract to improve glucose tolerance in normal rats was demonstrated. Single oral administration of W. saharae A.P.A.E reduced blood glucose levels 6 h after administration in normal rats ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 9, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Protective Effects of Diuretics Against Development of Cardiovascular Disease in Patients with Chronic Kidney Disease: Systematic Review.
Authors: Aomatsu A, Ookawara S, Ishibashi K, Morishita Y Abstract Cardiovascular disease is one of the most important risk factors for mortality and morbidity in patients with chronic kidney disease (CKD). This systematic review focuses on the protective effects of diuretics against the development of cardiovascular disease in patients with CKD. Among various kinds of diuretics, spironolactone, a mineralocorticoid receptor antagonist, has been shown to have protective effects against cardiovascular disease in patients with all stages of CKD, including pre-dialysis, hemodialysis, and peritoneal dialysis. Low-dose lo...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - April 3, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Entresto, a new Panacea for Heart Failure?
This article reviews the stages that led to the development of this drug, the failure of its preceding agents, the lessons we have learnt, and the current trials of Entresto for new indications. PMID: 29532764 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - March 14, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Fibrinolytic protease from marine Streptomyces rubiginosus VITPSSM.
Authors: Devi CS, Mohanasrinivasan V, Verma PD, Chaterjee S, Keziah SM Abstract Fibrinolytic enzymes must currently originate a significant product in the arena of medical research. Very limited studies are stated on fibrinolyticenzyme production from actinomycetes.Streptomyces sp. isolated from marine soil was chosen to optimize its fibrinolytic protease production. 16s rRNA sequencing confirmed the isolated potent strain to be Streptomyces rubiginosus VITPSSM. A fibrinolytic protease was then purified from Streptomyces rubiginosus VITPSSM, with the target of producing a cost effective feasible enzyme from a poten...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 28, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Coagonist of GLP-1 and glucagon receptor ameliorates development of non-alcoholic fatty liver disease.
Conclusion- Coagonist prevented development of HFD-induced NAFLD by ameliorating obesity, diabetes, inflammation and fibrosis. PMID: 29357809 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 25, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Aqueous extract of Argania spinosa L. fruits ameliorates diabetes in streptozotocin-induced diabetic rats.
CONCLUSION: This study demonstrates antihyperglycemic, lowering plasma cholesterol levels and antioxidant effects of A.E.P.F.A.S. in severe diabetic state. Further investigations are needed to elucidate the mechanism(s) of action of A.E.P.F.A.S. and the active constituent(s) of the extract. PMID: 29299990 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 6, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Nattokinase: an updated critical review on challenges and perspectives.
Authors: Selvarajan E Abstract Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT is a well studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy. Nattokinase is witnessed to be a useful enzyme for the com-plete removal of the vitreous and associated proliferative tissues in proliferative vitreo retinal disorders. This review ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 10, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Preface.
Authors: Mukherjee D PMID: 29185917 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 2, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Andrographolide reorganise hyperglycaemia and distorted antioxidant profile in streptozotocin-induced diabetic rats.
In conclusion, the results revealed that andrographolide shown beneficial potentiality against neuropathy in STZ induced diabetic rats. PMID: 29076435 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 28, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Phytocompounds as Potential Agents to Treat Obesity-Cardiovascular Ailments.
This study strengthens our understanding on obesity-CVDs and paves the way to develop novel and cost-effective plant based drugs/formulations with minimum side effects to treat these lifestyle based diseases. PMID: 28875833 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 7, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Argemone mexicana: A Boon to Medicinal and Pharmacological Approaches in Current Scenario.
Authors: Nancy A, Praveena A Abstract Nature is God's gift to human beings. Natural products are a source of new chemical diversity and are the choice of today's world. Nature itself gives remedy to all our health problems. The sources of natural product are plants, animals and microorganisms. Among them plant and its products are more reliable for its renewability and therefore, considered as fortunate thing for human welfare. Our traditional system of medicine which has been followed by our ancestors has its own impact on human life. Due to the inadequate knowledge many plant derived products (drugs) has not yet ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 7, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

The Biological Potentialsof Indian Traditional Medicine, Curcumin for Treating Human Diseases.
Authors: Sumathi CS Abstract Curcumin is an active compound extracted from the rhizomes of Curcuma longa L. (Turmeric). It possesses a di phenolic structure and there are three important fractions of curcumin namely curcumin, mono-desmethoxycurcumin and bis-desmethoxycurcumin. Curcumin is having high medicinal value. It is widely in Ayurveda, Siddha and Unani medicine formulations to treat various diseases. It is effective against microbial pathogens like bacteria, virus and fungi. It is highly potent and kills cancerous cells. Curcumin exhibits antioxidant activity and reduces lipoperoxidation. Cardioprotective na...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 7, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Association Between Apo B Levels in Mothers and in their Pre-school Age Offspring.
CONCLUSIONS: This study suggests that maternal apo B levels were strongly associated with apo B concentration in their pre-school age children. PMID: 28799493 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - August 12, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Effects of some indigenous plants of north Karnataka (India) on cardiovascular and glucose regulatory systems in diabetic rats.
CONCLUSION: The results indicate possible cardiovascular protective influences of all the three indigenous plants of North Karnataka (India) especially of Lactuca scariola Linn with strong antidiabetic efficacy too. Further studies on these medicinal plants are required. PMID: 28707593 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - July 16, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.
Authors: Asadov C, Aliyeva G, Mustafayeva K Abstract Thiopurine S-methyltransferase (TPMT) enzyme metabolizes thiopurine drugs which are widely used in various disciplines as well as in leukemias. Individual enzyme activity varies depending on the genetic polymorphisms of TPMT gene located at chromosome 6. Up to 14% of population is known to have a decreased enzyme activity, and if treated with standard doses of thiopurines, these individuals are at the high risk of severe adverse drug reactions (ADR) as myelosuppression, gastrointestinal intolerance, pancreatitis and hypersensitivity. However, TPMT-deficient patie...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 30, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Polypharmacy in Cardiovascular Medicine: Problems and Promises!
Authors: Abolbashari M, Macaulay TE, Whayne TF, Mukherjee D, Saha S Abstract Polypharmacy is now a frequent aspect and reality of current medicine practice, driven by managing multiple comorbidities, especially in older adults. However and unfortunately, polypharmacy can expose patients to adverse drug reactions, and drug-drug or drug-disease interactions. On the other hand, clinicians are often hesitant to add new drugs to complex regimens even when recommended by evidence-based medicine and guidelines. In addition, there is frequently a failure to assess which medications might not be beneficial and may therefore...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 30, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Discovery of Chromen-7-yl Furan-2-Carboxylate as a Potent and Selective Factor XIa Inhibitor.
In this report, we studied 4-methyl-2-oxo-2H-chromen-7-yl furan-2-carboxylate 1, a coumarin derivative, for direct FXIa inhibition. This small molecule was found to inhibit FXIa with an IC50 value of 0.77 μM. Coumarin 1 also displayed a moderate-to-high selectivity for FXIa inhibition over other coagulation, digestive, and fibrinolysis serine proteases. Coumarin 1 selectively doubled APTT of human plasma at a concentration of 72 μM. Insights about the structural features that contribute to the unique potential of such small molecule were deduced by profiling similar molecules in PubChem Open Chemistry Database as wel...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 30, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Pernicious anemia: Fundamental and practical aspects in diagnosis.
Authors: Tun AM, Thein KZ, Myint ZW, Oo TH Abstract Pernicious anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of pernicious anemia is still challenging for clinicians because of its complexity and diverse clinical presentations. Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. W...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 8, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Anti-angiogenic drugs, vascular toxicity and thromboembolism in solid cancer.
Authors: Riondino S, Monte GD, Fratangeli F, Guadagni F, Roselli M, Ferroni P Abstract Neo-angiogenesis, a key step in cancer progression, is a highly regulated process, in which vascular endothelial growth factor (VEGF) plays a fundamental role, thus representing the most suitable anti-angiogenic target. In the last years, a number of anti-VEGF drugs have been developed and approved for therapeutic use, especially in combination with standard chemotherapy. VEGF, however, is not only crucial for physiological and pathological angiogenesis, but also for maintenance of vascular homeostasis, at a point that its pharma...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 2, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Altered prolylcarboxypeptidase expression and function in response to different risk factors of diabetes.
CONCLUSION: Our data indicate that elevated palmitate inhibits PRCP expression in rat cardiomyocyte. From this inference PRCP level should be monitored in obese or diabetic patients because this simple measure could identify individuals at high risk of developing health problems, such as heart failure. PMID: 28034286 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 1, 2017 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Pathophysiology of Myocardial Infarction and Acute Management Strategies.
Authors: Petrovi─Ź D, Tibaut M, Mekiš D Abstract Yearly, 13,2% of all deaths are attributable to coronary artery disease (CAD), which with 7.4 million deaths makes CAD leading cause of death in the world. In this review we discuss current knowledge in pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation - myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, ischemia-reperfusion injury, left-ventricular remodeling and complications of MI. Furthermore, we add acute management strategies concent...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 22, 2016 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

In vitro vasorelaxant effect of Artemisia herba alba Asso. in spontaneously hypertensive rats.
Authors: Naoufel Z, Hebi M, Ajebli M, Michel JB, Eddouks M Abstract BACKGROUND: The present study aims to evaluate the in vitro vasorelaxant effect of Artemisia herba alba (Ah) aqueous extract. METHOD: Aortic rings were isolated from spontaneously hypertensive rats and incubated in aqueous Ah extract at the following doses: 3, 5, 10 and 20 mg/ml. Incubation of aqueous Ah extract for 30 minutes produced a significant shift of the dose response curve to Norepinephrine (NE) (10-8 to 10-5 M) (p
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 22, 2016 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Ultrasound Promoted Synthesis and Anticoagulant Activity of 2-amino-4H-chromen-4-ylphosphonates.
CONCLUSION: The findings from this study highlight that ultrasonication of the one pot three compo-nent reaction of salicylaldehyde derivatives, malononitrile and dialkyl phosphite with piperazine as a catalyst for the synthesis of 2-amino-4H-chromen-4-ylphosphonates is the best method. In vitro co-agulant assay in terms of prothrombin time (PT) revealed that 4j, 4h and 4g possess promising antico-agulant properties. Other compounds (4a-l) were also found to have significant anticoagulant effect when compared with the heparin as positive control. Thus, these compounds qualify for further clinical studies to be used as the ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 7, 2016 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research