Bioactive Sterol Derivatives Isolated from the Pleurotus djamor var. Roseus Induced Apoptosis in Cancer Cell Lines.
Authors: Jagadeesh R, Babu G, Lakshmanan H, Oh OM, Jang JK, Kong KW, Raaman N Abstract OBJECTIVE: The aim of the present study is to isolate and characterize the bioactive compounds responsible for cytotoxic activity against human breast cancer (MDA-MD-231) and mouse T cell lymphoma (EL4) cell lines. MATERIALS AND METHODS: Sequential fractionization and column chromatography methods were involved in the compound isolation. The structures of the isolated compound were determined by NMR, GC/MS and X-ray crystallography studies. RESULTS: The isolated compounds 1- 4 [D-mannitol (C1), Ergosta-5,7,22-trien-3&beta...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - July 15, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Pharmacological Uses of the Plants Belonging to the Genus Commiphora.
Authors: Latha S, Selvamani P, Prabha T Abstract Natural products have a unique place in the healthcare industry. The genus Commiphora emerged as a potential medicinal with huge benefits as evidenced through its use in various traditional and modern systems of medicine. Therefore, we aimed to prepare a concise review on the pharmacological activities and the indigenous uses of various plant species belonging to the genus Commiphora along with the structural information of various active botanical ingredients present in these plants based on the published literatures and scientific reports. To collect the various pu...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - July 4, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Preparation And Evaluation Of '3 Cap'pulsatile Drug Delivery System Of Ramipril.
CONCLUSION: The design results revealed that an optimum exposure of 1:2 of isopropanol: formaldehyde vapours for sixty minutes resulted in desired release of second pulse of dose after a predetermined lag time of 5 hours as desired. '3Cap' system was successful in achieving floating and pulsed release of hypertensive drug opening a 'new lease of life' to the existing drug molecule. PMID: 32484113 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - June 4, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Radioprotective effect of pioglitazone against genotoxicity induced by ionizing radiation in human healthy lymphocytes.
CONCLUSION: The anti-inflammatory property is suggested the mechanism action of PG for protection human lymphocytes against genotoxicity induced by ionizing radiation. PMID: 32448107 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 26, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Managing Cardiovascular Risk Factors without Medications: What is the Evidence?
Authors: Saha SP, Banks MA, Whayne TF Abstract In this era of potent medications and interventional cardiovascular (CV) procedures, the importance of beginning with and including therapeutic lifestyle change (TLC) is frequently forgotten. A major goal of this review article is to show and emphasize that modification of CV risk with nonmedication approaches makes an essential contribution to CV risk reduction. Available information on TLC and modifiable CV risk factors was reviewed and assessed. Modifiable major CV risk factors include diabetes mellitus, hypertension, hyperlipidemia, tobacco abuse, obesity, stress, ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 19, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Potential Antimicrobial Peptides Elucidation From The Marine Bacteria.
Authors: Barik A, Rajesh P, Malathi M, Balasubramanian V Abstract In recent years, over use of antibiotics has been raising its head to a serious problem all around the world as pathogens become drug resistant and create challenges to the medical field. This failure of most potent antibiotics that kill pathogens increases the thirst for research to look further way of killing pathogens. It has been led to the findings of antimicrobial peptide which is the most potent peptide to destroy pathogens. This review gives special emphasis to the usage of marine bacteria and other microorganisms for antimicrobial peptide (A...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 13, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

An In Silico Approach Towards Investigation of Possible Effects of Essential Oils Constituents on Receptors Involved in Cardiovascular Diseases (CVD) and Associated Risk Factors (Diabetes Mellitus and Hyperlipidemia).
CONCLUSION: Some ingredients of essential oils might be active on cardiovascular related receptors. PMID: 32386501 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 12, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Cardiovascular and Hematological Medicine in 2020 - Advances and Insights.
Authors: Mukherjee D PMID: 32375607 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 9, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

"Natural Products Chemistry and Drug Design - 2020".
"Natural Products Chemistry and Drug Design - 2020". Cardiovasc Hematol Agents Med Chem. 2020;18(1):3-4 Authors: Pandiyan R, Muthusami MS, Ganapathy S, Lakshmanan H PMID: 32375608 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 9, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Sacubitril-Valsartan Improves Anemia Of Cardiorenal Syndrome.
CONCLUSIONS: Sacubitril-valsartan improves anemia in CRS patients. An improvement of serum cystatin levels was observed. Few untoward effects were detected. These findings should be confirmed in wider clinical trials. PMID: 32370725 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 8, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Antidyslipidemic and Antioxidant Activities of Matricaria pubescens (Desf.) Shultz.in Streptozotocin-Induced Diabetic Rats.
CONCLUSION: In summary, this study proved that Matricaria pubescens (Desf.) Shultz. has a favorable effect on diabetic dyslipidemia. PMID: 32370726 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 8, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Bio-active Compounds in Diabetic Cardiomyopathy: Current Approaches, Potential Diagnostic and Therapeutic Targets.
Authors: Kotturu SK, Uddandrao VVS, Gosh S, Parim B Abstract Diabetic cardiomyopathy (DCM) as an imperative menace to health takes place without or with coexistence of vascular diseases. Even though numerous pathological mechanisms are accountable for DCM have been estimated, oxidative stress is extensively well thought-out as a foremost key cause for the pathogenesis of the DCM. In this review we focused on role of bioactive compounds using different sources like plant and marine products in cardiomyopathy. Natural products and their related constituents have traditionally been implausible as a resource of curativ...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - April 24, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Preclinical study of the antidiabetic effect of Traganum nudatum in diabetic rats.
CONCLUSION: In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects of T. nudatum in rats supporting then its traditional use for the management of diabetes. PMID: 32108004 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 29, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

In Vitro Demonstration of Drug-Reagent Interactions Among Commonly Used Parenteral Drugs in Cardiology.
CONCLUSION: Parenteral drugs used in cardiology can significantly interfere with troponin I, CK-MB mass, Nt-proBNP, and D-dimer tests in the analytical phase because of drug-reagent interactions. Minimal deviations in the CK, AST, and LDH tests were observed using spectrophotometric methods. Thus, changes in test results may be due to drug interference rather than the treatment itself. Clinicians should consider the possibility of drug interference in cases of doubtful cardiac test results that do not comply with the diagnosis. PMID: 32101135 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 28, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Isolation and characterization of Bioactive Metabolite from Bacillus safensis VRKK2 for controlling Bacterial blight disease in Cowpea.
CONCLUSION: This study specifies that the isolated PGPR Bacillus safensis VRKK2 found to be better biocontrol agent against bacterial blight disease in cowpea. PMID: 32072906 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 21, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

A Review on Pharmacological Activities and Active Phytoconstituents of Roadside Trees of Tamil Nadu.
Authors: Subramaniam A, Alagaraj P, Arumugam B Abstract Roadsides are habitats with very specific environmental conditions, often substantially differing from their natural surroundings. Roadside trees provide home for many floral and faunal species and have many environmental benefits including removing air pollutants, supporting wildlife etc. Many medicinal plants including road side trees have been discovered and traditionally they are being used for treating many kinds of diseases. Phytochemicals are chemical compounds that are usually secreted by the plants for performing functions like defense against insects...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 21, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

A Review on Impact of Medicinal Plants on Treatment of Oral and Dental Diseases.
Authors: Arumugam B, Subramaniam A, Alagaraj P Abstract Plants play a vital role in the general wellbeing of an individual. Globally plants are habitually used by the people for the treatment and prevention of various ailments. There is an increased attempt made from ancient days to prevent the disease occurrence rather than to treat it. Through the development of modern scientific procedures, it is now identified that the usage of plants in different forms promotes the health of the patient. Oral and dental hygiene is the primary factor of a human being to lead a healthy life. Poor diet, nutrition and improper hyg...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 21, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

A Review on Phytochemistry, Pharmacological action, Ethanobotanical uses and Nutritional potential of Kedrostis foetidissima (Jacq.) Cogn.
Authors: Pavithra K, Saravanan G Abstract Nature is an amazing source for food, shelter, clothing and medicine. An impressive number of modern drugs are isolated from many sources like plants, animals and microbes. The development of natural products from traditional medicines is of great importance to society. Modern concepts and methodologies with abundant clinical studies, unique diversity of chemical structures and biological activities aid the modern drug discovery process. Kedrostis foetidissima (Jacq.) Cogn., a traditional medicinal plant of the Cucurbitaceae family, found in India, Sri Lanka, Ethiopia and W...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 14, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Toddalia asiatica. L. - A rich Source of Phytoconstituents and Potential Pharmacological Actions, an Appropriate Plant for Recent Global Arena.
Authors: Alagaraj P, Muthukrishnan S Abstract Toddalia asiatica. L. is used for a long period against various chronic diseases. The main objective of the present review is to search literature for the folklore uses, phytochemicals isolated and their pharmacological properties of Toddalia asiatica.L. The individual plant parts possess many phytoconstituents with therapeutic actions. Root bark of the plant is antimalarial, antipyretic and carminative. Plant leaves and stem have bitter taste and analgesic in nature. Leaf essential oil is used in relieving rheumatic arthritis, sprains, contusions, intercostal neuralgia...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 14, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Antiobesity effect of Biochanin-A: Effect on trace element metabolism in high fat diet-induced obesity in rats.
Authors: Antony Rathinasamy JIR, Uddandrao VVS, Raveendran N, Sasikumar V Abstract BACKGROUND: Imbalanced diets have contributed to the increased prevalence of obesity and other metabolic disorders in the modern world including trace element metabolism. However, the underlying mechanisms are not fully understood. AIM AND OBJECTIVES: The present study investigated the effects of Biochanin A (BCA) on the changes in element metabolism induced by HFD-induced obese rats. METHODS: BCA was administered orally for 30 days to experimental obese rats. Changes in body weight, glucose, insulin resistance and lipid prof...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 9, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Evaluation of the antioxidant and antidiabetic potential of the Poly Herbal Formulation. Identification of bioactive factors.
CONCLUSION: In conclusion, it could be reasoned that due to the nearness of antioxidant components, the PHF has good potential in the administration of hyperglycemia, diabetes and the related state of oxidative stress. This study shows that PHF is superior to individual plant extracts, supporting the conventional PHF concept. PMID: 32031078 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 9, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Stevia as a Natural sweetener: A Review.
Authors: Arumugam B, Subramaniam A, Alaguraj P Abstract Stevia rebaudiana of Asteraceae family is a perennial shurb. It is a sweetener herb also known as Sweet Weed, Sweet Leaf, Sweet Herbs and Honey Leaf, native to Argentina, Brazil and Paraguay. The leaves of stevia are sweeter than sucrose with zero calories. Steviol, diterpenoid glycoside derivative identified from this plant is sweeter than sucrose and is safe when used as a sweetening agent. Diabetic and obese persons with hyperglycemia who are in a condition to follow strict diet can use steviosides as an alternative sweetener. In addition to its hypoglycemi...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 9, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Therapeutic potential of biochanin-A against isoproterenol -induced myocardial infarction in rats.
CONCLUSION: In conclusion, this study suggested that BCA exerts cardioprotective effects through modulating lipid peroxidation, enhancing antioxidants, and detoxifying enzyme systems. PMID: 32026788 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 8, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Patent foramen ovale, role of antiplatelet therapy alone or anticoagulant therapy alone versus device closure for cryptogenic stroke: A review of literature and current recommendations.
Authors: Nagarajarao HS, Ojha CP, Kedar A, Mukherjee D Abstract Cryptogenic stroke and its relation to the Patent foramen ovale (PFO) is a long debated topic. Recent clinical trials have unequivocally established the relationship between cryptogenic strokes and paradoxical embolism across the PFO. This slit like communication exists in everyone before birth, but most often closes shortly after birth. PFO may persist as a narrow channel of communication between right and left atria in approximately 25-27% of adults [1, 2]. In this review we examine the clinical relevance of the PFO with analysis of latest trials eva...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 6, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Design and Development of Lomustine Loaded Chitosan Nanoparticles for Efficient Brain Targeting.
CONCLUSION: In conclusion, the results of this suggested that the optimised lomustine loaded chitosan nanoparticles are useful for brain targeting hence holds potential for further research and clinical application. PMID: 32013840 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 6, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Mitigating Perspectives of Asiatic acid in the Renal derangements of Streptozotocin-Nicotinamide induced Diabetic Rats.
CONCLUSION: Hence, this study concluded that AA can protect against renal dysfunction by attenuating carbohydrate metabolic disorder and subsequently enhances glucose utilization and renal function in STZ-NAD-induced diabetic rats. PMID: 32003703 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 2, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Effect of aglycon and glycoside flavonoid-enriched extracts obtained from Buxus sempervirens L. on glucose and lipid metabolism in diabetic rats.
Authors: Ajebli M, Eddouks M Abstract BACKGROUND: Buxus sempervirens L. is a medicinal plant with several beneficial effects on health and is widely used in the Moroccan folklore as antidiabetic plant. OBJECTIVE: The aim of this study was to evaluate the antidiabetic effect of both aglycone and glycoside flavonoid enriched extracts of this plant in the experimental diabetic state. METHODS: in the current work, the effect of an aglycone and a glycoside flavonoid-enriched extracts from the leaves of Buxus sempervirens L. (AFBS and GFBS) (10 mg/kg) on blood glucose levels has been evaluated in normal and strep...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 10, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Prognostic Utility of Troponin I and N Terminal-ProBNP among Patients with Heart Failure due to Non-Ischemic Cardiomyopathy and Important Correlations.
CONCLUSION: Troponin I and NT-ProBNP at admission are the best predictors of re-hospitalization 6 months after discharge among patients with HFrEF. Hemoglobin is the only predictor of 30 -day rehospitalization among HFrEF patients in this study. High-risk patients may require aggressive therapy to improve outcomes. PMID: 31875779 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 27, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

p-Cymene Modulate Oxidative Stress and Inflammation in Murine Macrophages: Potential Implication in atherosclerosis.
CONCLUSION: Our findings clearly demonstrate that exposure to p-CYM over time promotes oxidative stress by down regulating antioxidants genes as shown in PON-1 and also stimulates inflammation a key process during the initiation and progression of atherosclerosis. PMID: 31738151 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 20, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Syncope in a Child with Pulmonary Hypertension and Positive Gene Tests for Hereditary Hemorrhagic Telangiectasia and Long QT Syndrome.
We present a 10 year old boy with syncope who was found to have long-QT syndrome and severe pulmonary hypertension (PH) both in the absence of a secondary cause, to our knowledge this is the first report with this unusual coexistence. His genetic tests were positive for hereditary hemorrhagic telangiectasia and long QT syndrome (LQTS) without any family history of PH or LQTS. We demonstrated that digital subtraction pulmonary angiography was more useful compared to CT angiogram to demonstrate pulmonary vascular changes which correlated with a no-response to acute vasoreactivity testing during right heart catheterization. H...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 30, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Medication Adherence And Associated Factors Among Chronic Heart Failure Clients On Follow Up Oromia Region, West Ethiopia.
CONCLUSION AND RECOMMENDATION: Even if more than half of study respondents have, good medication and self-care adherence still it need great attention in health education over on their visit. We recommend health institution strongly to give health education for clients and researcher to use advanced study design for measuring medication adherence and self-care behaviors. PMID: 31629399 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 21, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Underutilization of Cardiac Therapies in Patients with Acute Ischemic Stroke and Elevated Troponin.
This study aims to determine this rate of utilization. MATERIALS/METHODS: A single-center review of 83 patients with AIS and measured troponin was conducted. Patients were stratified based on elevated and non-elevated troponin. Between groups, we measured the utilization of evidence-based cardiac therapies and used a univariate logistic regression to compare outcomes of mortality, re-hospitalization, recurrent acute ischemic stroke, recurrent acute myocardial infarction, and a composite of these outcomes. RESULTS: Of 83 patients, 25 had elevated troponin and 58 had non-elevated troponin. There was no statistical di...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 21, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Role of whole plant extract of Nelumbo nucifera Gaertn in treatment of Thrombolysis.
CONCLUSION: Based on these findings, flavonoids present in hydroalcoholic extract may be developed into drug for clinical application for the treatment of thrombosis in patients. PMID: 31622211 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 18, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Antihypertensive and vasorelaxant effects of Matricaria pubescens in rats.
CONCLUSION: The study illustrates the beneficial action of M. pubescens as an antihypertensive agent. PMID: 31589128 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 8, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Cardiovascular and Hematological Medicine in 2019 - Advances and Insights.
Authors: Mukherjee D Abstract PMID: 31556359 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 28, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

The Superior Mesenteric Artery: from Syndrome in the Young to Vascular Atherosclerosis in the Old.
Authors: Beita AKV, Whayne TF Abstract This review is directed at increasing awareness of two diverse rare upper gastrointestinal problems that occur at opposite ends of the age spectrum and are difficult to diagnose and treat. The superior mesenteric artery syndrome (SMAS) likely involves a young patient, especially female, and is especially associated with rapid weight loss, resulting in relative strangulation of the duodenum by a narrowing of the angle between the superior mesenteric artery (SMA) and the aorta. On the other hand, atherosclerosis of the SMA is associated most likely with postprandial upper intest...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 21, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Preparing India to Leverage the Power of Mobile Technology: Development of a Bilingual Mobile Health Tool for Heart Patients.
CONCLUSION: This mobile application is developed as a research tool to further conduct a clinical study in coronary artery disease patients. Current evaluation was a pilot testing wherein this application showed promising results. PMID: 31512999 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 14, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Epidemiology and Adverse Consequences of Hookah/Waterpipe Use: A Systematic Review.
The objectives of the review are to assess the factor associated with increasing use of hookah, its health effects, options for hookah smoking cessation and public health policy initiatives to mitigate waterpipe use. PMID: 31483237 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - September 6, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Artificial blood.A futuristic dimension of modern day transfusion sciences.
Authors: Haldar R, Chitranshi S, Singh MK, Sachan S, Gupta D Abstract Artificial blood is a innovative concept of transfusion medicine where specifically designed compounds perform the task of transport and delivery of oxygen in the body to replace this function of allogenic human blood transfusion. Several molecules have been developed in the past few decades to achieve this objective and continous refinements are being continuously made in the quest of the ideal blood substitute. Currently available technology manufactures artificial blood from haemoglobin obtained from outdated human/bovine blood (Haemoglobin Ba...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - June 19, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Leaf aqueous extract of Argania spiniosa exhibits antihyperglycemic effect in diabetic rats.
Authors: Hebi M, Eddouks M Abstract INTRODUCTION: Argania spinosa L. (Sapotaceae) is an endemic species from south-western Morocco. This plant has many traditional uses including treatment of diabetes. AIM OF THE STUDY: The anti-diabetic effect of Argania spinosa leaf aqueous extract (A.S.L.A.E) was evaluated in both normal and streptozotocin(STZ)-induced diabetic rats treated at a dose of 20 mg/kg body weight for 15 days. The histopathological changes in liver have been evaluated. In addition, the antioxidant activity of this extract was studied. RESULTS: Single oral administration of A.S.L.A.E showed no s...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - June 13, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Radioprotective Effect of Giclazide as an Anti-hyperglycaemic Agent Against Genotoxicity Induced by Ionizing Radiation on Human Lymphocytes.
CONCLUSION: This data provides that GL is a powerful radioprotective agent that could protect healthy cells against the chromosome damage induced by ionizing radiation through antioxidant activity. The radioprotective effect is new indication of GL for patients' protection against side effect induced by ionizing radiation. PMID: 31124426 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - May 29, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Emblica Officinalis (Amla) ameliorates high fat diet induced alteration of cardiovascular pathophysiology.
CONCLUSION: Ethanolic extract of Emblica Officinalis (EEO) indicates its cardio protective efficacy against rats fed with high fat diet. PMID: 30963985 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - April 10, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: A systematic review and meta-analysis.
CONCLUSION: The findings of this meta-analysis confirm the positive association between fluoroquinolones and the development of aortic aneurysm or dissection. The data tend to show that this association may be majorly driven by aortic aneurysm. Additionally, some risk factors appear to prevail including prolonged fluoroquinolone treatment and older age. PMID: 30947680 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - April 7, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Hypolipidemic and Antioxidant Activities of Corrigiola Telephiifolia in Diabetic Rats.
Authors: Hebi M, Eddouks M Abstract OBJECTIVE: the evaluation of the hypolipidemic and antioxidant activities of the aerial parts aqueous extract of Corrigiola telephiifolia (APAE of C. telephiifolia) in normal and streptozotocin(STZ)-induced diabetic rats. METHODS: The effects of oral administration of APAE of C. telephiifolia (5 mg/kg) on the lipid profile as well as the in vitro antioxidant activity of this aqueous extract have been determined. RESULTS: APAE of C. telephiifolia (5 mg/kg) reduced significantly (p
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - March 6, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Statins Can Lead to Acute Hemolysis.
Authors: Moghadasi M, Maghsoomi Z Abstract PMID: 30741131 [PubMed - in process] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 12, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Flavonoid-enriched extract from desert plant Warionia saharae improves glucose and cholesterol levels in diabetic rats.
CONCLUSION: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats. PMID: 30666919 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 24, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

The cardiovascular protective effects of chrysin: A narrative review on experimental researches.
Authors: Farkhondeh T, Samarghandian S, Bafandeh F Abstract Chrysin is one of the flavonoids fruits, vegetables, and plant especially found in honey, it has been indicated that its cardiovascular protective effect is due to its antioxidative effects and anti-inflammatory activities. Chrysin exerts an antioxidant effect by enhancing the antioxidant system, suppressing pro-oxidant enzymes, scavenging free radicals and chelating redox active transition-metal ions. Chrysin decreases lipid synthesis and also increases its metabolism, thereby ameliorating blood lipid profile. Chrysin modulates vascular function by increa...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - January 18, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

The beneficial therapy with colchicine for atherosclerosis via anti-inflammation and decrease in hypertriglyceridemia.
CONCLUSION: Colchicine reduces the levels of inflammatory markers, stabilizes the coronary plaque, leads to more favorable cardiac healing after damage, and reduces the acute coronary syndromes event recurrence. Colchicine reduces the myocardial infarct size, myocardial fibrosis, and improves the hemodynamic parameters. Several studies report the potential attenuating role of colchicine on triglyceride levels. Current evidence though regarding the pathophysiological mechanism of colchicine's triglyceride-lowering effect remains scarce. PMID: 30526472 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hemat...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 13, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Effect of flavonoid-rich extract of Tamarix articulata Vahl. on glucose and lipid metabolism in normal and diabetic rats.
Authors: Hebi M, Hajji L, Eddouks M Abstract OBJECTIVE: The present study was carried out in order to evaluate the antidiabetic and antihyperlipidemic potential of flavonoid-rich extract of Tamarix articulata (FRETA) in both normal and streptozotocin (STZ)-induced diabetic rats. MATERIAL AND METHODS: Normal and diabetic rats were treated with the FRETA for 7 days. At the end of treatment, a range of parameters were tested including blood lipid profile, histopathological changes in both liver and pancreas and oral glucose tolerance test (OGTT). RESULTS: The blood glucose levels were lowered in both normal an...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 13, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Idiopathic "Cyclic" Edema: a Frustrating and Poorly Understood Clinical Problem.
Idiopathic "Cyclic" Edema: a Frustrating and Poorly Understood Clinical Problem. Cardiovasc Hematol Agents Med Chem. 2018 Dec 11;: Authors: Whayne TF, Fisher MB Abstract Idiopathic edema (IE), is a syndrome involving real or perceived weight gain secondary to the pathological retention of fluid. This syndrome of generalized edema is almost solely reported in women. The diagnosis of IE is one of exclusion and requires a careful history, physical exam, and clinical suspicion. The aim of this article is to provide a comprehensive review of the available literature in order to attempt to define I...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - December 13, 2018 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research