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Anti-angiogenic Potential of Trans-chalcone in an In Vivo Chick Chorioallantoic Membrane Model: An ATP Antagonist to VEGFR with Predicted Blood-brain Barrier Permeability
CONCLUSION: The present study showed TC to possess anti-angiogenic potential via the inhibition of VEGFR-2. In addition, the study predicted TC to cross BBB as well as a safe alternative for GBM therapy, which needs further investigation.PMID:37936455 | DOI:10.2174/0118715257250417231019102501 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 8, 2023 Category: Cardiology Authors: Anna Senrung Tanya Tripathi Nikita Aggarwal Divya Janjua Arun Chhokar Joni Yadav Apoorva Chaudhary Kulbhushan Thakur Tejveer Singh Alok Chandra Bharti Source Type: research

Combined Administration of Metformin and Vitamin D: A Futuristic Approach for Management of Hyperglycemia
Cardiovasc Hematol Agents Med Chem. 2023 Oct 27. doi: 10.2174/0118715257261643231018102928. Online ahead of print.ABSTRACTDiabetes is a series of metabolic disorders that can be categorized into three types depending on different aspects associated with age at onset, intensity of insulin resistance, and beta- cell dysfunction: Type 1 and 2 Diabetes, and Gestational Diabetes Mellitus. Type 2 Diabetes Mellitus (T2DM) has recently been found to account for more than 85% of diabetic cases. The current review intends to raise awareness among clinicians/researchers that combining vitamin D3 with metformin may pave the way for be...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 6, 2023 Category: Cardiology Authors: Sakshi Tyagi Shalini Mani Source Type: research

Endothelial Dysfunction Under the Scope of Arterial Hypertension, Coronary Heart Disease, and Diabetes Mellitus Using the Angioscan
CONCLUSION: In conclusion, the study of endothelial function using non-invasive angioscan reflects the influence of risk factors on the vascular wall. The most severe endothelial dysfunction is expressed in patients with diabetes. The results of endothelium-dependent vasodilation and the vascular wall stiffness index (SI) correspond to the scale of evaluation of the 10-year CVD mortality risk (SCORE). These results indicate a deterioration in the vascular ability to vasodilate in patients in response to mechanical deformation of the endothelium and the effect of NO on smooth muscle vascular cells.PMID:37921186 | DOI:10.217...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 3, 2023 Category: Cardiology Authors: Basheer Abdullah Marzoog Source Type: research

Evaluation of Enhanced Cytotoxicity Effect of Repurposed Drug Simvastatin/ Thymoquinone Combination against Breast Cancer Cell Line
CONCLUSION: It was concluded that the combined effect of simvastatin and thymoquinone stimulates apoptosis in breast cancer cells.PMID:37907488 | DOI:10.2174/0118715257259037231012182741 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 1, 2023 Category: Cardiology Authors: Pallavi Kumari Shweta Dang Source Type: research

Cardioprotective Role of Tinospora cordifolia against Trimethylamine-NOxide and Glucose Induced Stress in Rat Cardiomyocytes
CONCLUSION: Conclusively, our study has reported that the Indian medicinal plant Tinospora cordifolia has the ability to treat diabetic cardiomyopathy. Our study can open up a new herbal therapeutic strategy against diabetic cardiomyopathy.PMID:37907489 | DOI:10.2174/0118715257270512231013064533 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 1, 2023 Category: Cardiology Authors: Shivani Singhal Vibha Rani Source Type: research

Comparison between the ECG Outcomes of Metoprolol and Bisoprolol
CONCLUSION: In this retrospective cross-sectional study, we have compared the effects of metoprolol and bisoprolol beta blockers on ECG changes. The findings have indicated no difference between metoprolol and bisoprolol groups in terms of all ECG readings, particularly PR/ms, QTC-ms, and ventricular rate. Further studies are required to confirm these findings.PMID:37909439 | DOI:10.2174/0118715257252349231018151957 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 1, 2023 Category: Cardiology Authors: Ahmad Abdulrahman Almeman Yousef Obaid Alharbi Abdulaziz Sulaiman Alwahhabi Abdulaziz Abdullah Almutairi Moayad Yousef Alnasr Abdulrahaman Almesnid Source Type: research