Anti-angiogenic Potential of Trans-chalcone in an In Vivo Chick Chorioallantoic Membrane Model: An ATP Antagonist to VEGFR with Predicted Blood-brain Barrier Permeability
CONCLUSION: The present study showed TC to possess anti-angiogenic potential via the inhibition of VEGFR-2. In addition, the study predicted TC to cross BBB as well as a safe alternative for GBM therapy, which needs further investigation.PMID:37936455 | DOI:10.2174/0118715257250417231019102501 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 8, 2023 Category: Cardiology Authors: Anna Senrung Tanya Tripathi Nikita Aggarwal Divya Janjua Arun Chhokar Joni Yadav Apoorva Chaudhary Kulbhushan Thakur Tejveer Singh Alok Chandra Bharti Source Type: research

Combined Administration of Metformin and Vitamin D: A Futuristic Approach for Management of Hyperglycemia
Cardiovasc Hematol Agents Med Chem. 2023 Oct 27. doi: 10.2174/0118715257261643231018102928. Online ahead of print.ABSTRACTDiabetes is a series of metabolic disorders that can be categorized into three types depending on different aspects associated with age at onset, intensity of insulin resistance, and beta- cell dysfunction: Type 1 and 2 Diabetes, and Gestational Diabetes Mellitus. Type 2 Diabetes Mellitus (T2DM) has recently been found to account for more than 85% of diabetic cases. The current review intends to raise awareness among clinicians/researchers that combining vitamin D3 with metformin may pave the way for be...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 6, 2023 Category: Cardiology Authors: Sakshi Tyagi Shalini Mani Source Type: research