Chemistry, Biological Properties, and Bio-Analysis of Tafamidis, a New Transthyretin Stabilizer: A Systematic Review
CONCLUSION: Minimal analytical techniques are observed for quantifying the Tafamidis and transthyretin kinetic stabiliser. Therapeutic, pharmacological, and analytical considerations for the novel drug Tafamidis are discussed in this review. Particular attention is paid to the many different analytical and bioanalytical methods currently available for estimating Tafamidis, and the need is highlighted to develop a straightforward, validated technique that meets green chemistry standards.PMID:38031770 | DOI:10.2174/0118715257250153231011062855 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 30, 2023 Category: Cardiology Authors: Nikhil Agarwal Jasira Sultan Sanjay Sharma Source Type: research

An Insight into Emerging Phytocompounds for Glioblastoma Multiforme Therapy
Cardiovasc Hematol Agents Med Chem. 2023 Nov 10. doi: 10.2174/0118715257262003231031171910. Online ahead of print.ABSTRACTDespite intense research in the field of glioblastoma multiforme (GBM) therapeutics, the resistance against approved therapy remains an issue of concern. The resistance against the therapy is widely reported due to factors like clonal selection, involvement of multiple developmental pathways, and majorly defective mismatch repair (MMR) mediated by O6- methylguanine DNA methyltransferase (MGMT). Phytotherapy is one of the most effective alternatives to overcome resistance. It involves plant-based compoun...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 14, 2023 Category: Cardiology Authors: Vijeta Prakash Reema Gabrani Source Type: research