Recent Advances in Intra-peritoneal Chemotherapy for Gastric Cancer.
Authors: Chia DKA, So JBY Abstract Peritoneal metastasis (PM) frequently occurs in patients with gastric cancer (GC) and confers a dismal prognosis despite advances in systemic chemotherapy. While systemic chemotherapy has poor peritoneal penetration, intraperitoneal (IP) chemotherapy remains sequestered, resulting in high peritoneal drug concentrations with less systemic side-effects. The first application of IP treatment was hyperthermic intraperitoneal chemotherapy (HIPEC) with cytoreductive surgery (CRS) for gastric cancer peritoneal metastasis (GCPM); but was associated with an increased morbidity and mortalit...
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Association between the MUC1 rs4072037 Polymorphism and Risk of Gastric Cancer and Clinical Outcomes.
This study aimed to investigate the association between the MUC1 rs4072037 polymorphism and GC in terms of the Lauren classification and long-term clinical outcomes. Materials and Methods: A total of 803 patients with GC and 816 unrelated healthy controls were enrolled in the study. The association between the MUC1 rs4072037 variant and GC histological types and clinical outcomes, including tumor recurrence and prognosis was investigated. Results: The major A allele of rs4072037 was associated with increased GC risk (P
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Conclusions: LETM1 acts as an oncogenic gene to promote GC cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Therefore, LETM1 may be a potential target for GC diagnosis and treatment. PMID: 32595998 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Long-term Efficacy of S-1 Monotherapy or Capecitabine Plus Oxaliplatin as Adjuvant Chemotherapy for Patients with Stage II or III Gastric Cancer after Curative Gastrectomy: a Propensity Score-Matched Multicenter Cohort Study.
Authors: Lee CM, Yoo MW, Son YG, Oh SJ, Kim JH, Kim HI, Park JM, Hur H, Jee YS, Hwang SH, Jin SH, Lee SE, Park JH, Seo KW, Park S, Kim CH, Jeong IH, Lee HH, Choi SI, Lee SI, Kim CY, Kim IH, Son MW, Pak KH, Kim S, Lee MS, Min JS Abstract Purpose: To compare long-term disease-free survival (DFS) between patients receiving tegafur/gimeracil/oteracil (S-1) or capecitabine plus oxaliplatin (CAPOX) adjuvant chemotherapy (AC) for gastric cancer (GC). Materials and Methods: This retrospective multicenter observational study enrolled 983 patients who underwent curative gastrectomy with consecutive AC with S-1 or CAPOX f...
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Evaluation of Submucosal or Lymphovascular Invasion Detection Rates in Early Gastric Cancer Based on Pathology Section Interval.
Authors: Kim YI, Kook MC, Choi JE, Lee JY, Kim CG, Eom BW, Yoon HM, Ryu KW, Kim YW, Choi IJ Abstract Purpose: The guidelines for pathological evaluation of early gastric cancer (EGC) recommend wider section intervals for surgical specimens (5-7 mm) than those for endoscopically resected specimens (2-3 mm). Studies in surgically resected EGC specimens showed not negligible lymph node metastasis risks in EGCs meeting the expanded criteria for endoscopic submucosal dissection (ESD). Materials and Methods: This retrospective study included 401 EGC lesions with an endoscopic size of ≤ 30 mm detected in 386 patien...
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Advantages of Distal Subtotal Gastrectomy over Total Gastrectomy in the Quality of Life of Long-Term Gastric Cancer Survivors.
Conclusions: During the 5-year period after surgery, the TG group suffered from inferior HRQoL compared to the DSG group. However, a large proportion of the DSG group also suffered HRQoL deterioration. In general, the TG group experienced more HRQoL decline, with diarrhea and body image being the major concerns for both groups. To improve HRQoL after gastrectomy, patients must be better informed about post-gastrectomy symptoms. These symptoms must be vigorously investigated, and medical interventions should be available parallel to nutritional support. Favorable evidence of function-preserving gastrectomy should be establi...
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Contrasting Prognostic Effects of Tumor-Infiltrating Lymphocyte Density in Cardia and Non-cardia Gastric Adenocarcinomas.
Conclusions: The densities and prognostic effects of TILs differed in relation to the location of tumors within the stomach. The contrasting prognostic effects of Foxp3/CD4 ratio in cardia and non-cardia gastric cancer patients suggests that clinicians ought to consider tumor location when determining treatment strategies. PMID: 32596002 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

High Preoperative Fibrinogen and Systemic Inflammation Response Index (F-SIRI) Predict Unfavorable Survival of Resectable Gastric Cancer Patients.
This study was to investigate the prognostic significance of the preoperative fibrinogen and systemic inflammation response index (F-SIRI) in a Chinese cohort of resectable gastric cancer. Materials and Methods: Baseline characteristics, preoperative fibrinogen levels and peripheral neutrophil, monocyte, and lymphocyte counts were retrospectively reviewed in 240 patients who underwent radical gastrectomy. The optimal cut-off values for fibrinogen and SIRI were defined as 4.0 g/L and 1.2. Then patients with hyperfibrinogenemia (≥4.0 g/L) and high SIRI (≥1.2) were assigned with an F-SIRI of 2 (both of these hematol...
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Advantages of Restoring miR-205-3p Expression for Better Prognosis of Gastric Cancer via Prevention of Epithelial-mesenchymal Transition.
Authors: Zhang Z, He X, Xu J, Zhang G, Yang Y, Ma J, Sun Y, Ni H, Wang F Abstract Purpose: miR-205 is a tumor suppressor and plays an important role in tumor invasiveness. However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim of this study was to investigate the molecular mechanism of miR-205 in the regulation of EMT in GC invasion. Materials and Methods: Quantitative polymerase chain reaction (qPCR) was used to detect the expression of miR-205 in GC. Further, the correlation between the pathological parameters and prognosis of GC was statisti...
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Isoperistaltic Jejunal Loop Interposition after Total Gastrectomy for Gastric Cancer in Patients with Familial Adenomatous Polyposis.
Authors: Zuin M, Celotto F, Pucciarelli S, Urso EDL Abstract Gastric cancer is a rare condition affecting patients with familial adenomatous polyposis (FAP). The mainstay of treatment is total gastrectomy. Since duodenal cancer is the most common cause of death after total colectomy in FAP, endoscopic surveillance for duodenal cancer is mandatory. Here, we describe the use of an isoperistaltic jejunal loop interposition technique to reconstruct the digestive tract after total gastrectomy in 2 patients with FAP. There were no early or late complications. Both patients are still alive and in good clinical condition. ...
Source: Journal of Gastric Cancer - July 2, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Disadvantages of Complete No. 10 Lymph Node Dissection in Gastric Cancer and the Possibility of Spleen-Preserving Dissection: Review.
Authors: Toriumi T, Terashima M Abstract Splenic hilar lymph node dissection has been the standard treatment for advanced proximal gastric cancer. Splenectomy is typically performed as part of this procedure. However, splenectomy has some disadvantages, such as increased risk of postoperative complications, especially pancreatic fistula. Moreover, patients who underwent splenectomy are vulnerable to potentially fatal infection caused by encapsulated bacteria. Furthermore, several studies have shown an association of splenectomy with cancer development and increased risk of thromboembolic events. Therefore, splenect...
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Advantages of Splenic Hilar Lymph Node Dissection in Proximal Gastric Cancer Surgery.
Authors: Guner A, Hyung WJ Abstract Gastrectomy with lymph node dissection remains the gold standard for curative treatment of gastric cancer. Dissection of splenic hilar lymph nodes has been included as a part of D2 lymph node dissection for proximal gastric cancer. Previously, pancreatico-splenectomy has been performed for dissecting splenic hilar lymph nodes, followed by pancreas-preserving splenectomy and spleen-preserving lymphadenectomy. However, the necessity of routine splenectomy or splenic hilar lymph node dissection has been under debate due to the increased morbidity caused by splenectomy and the poor p...
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors.
Conclusions: Our study confirmed the advantage of using targeted NGS with a cancer gene panel to efficiently identify mutations associated with GISTs. These findings may provide a molecular genetic basis for developing new drugs targeting these gene mutations for GIST therapy. PMID: 32269842 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Association between Lymphovascular Invasion and Recurrence in Patients with pT1N+ or pT2-3N0 Gastric Cancer: a Multi-institutional Dataset Analysis.
Conclusions: LVI is an indicator of poor prognosis in patients with pT1N+ or pT2-3N0 gastric cancer. PMID: 32269843 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Multicenter Retrospective Analysis of Intraperitoneal Paclitaxel and Systemic Chemotherapy for Advanced Gastric Cancer with Peritoneal Metastasis.
Conclusions: The feasibility of IP paclitaxel and systemic chemotherapy administration was demonstrated in this experience-based retrospective analysis suggesting that the procedure is beneficial in patients with PM of AGC. PMID: 32269844 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Establishment of a [18F]-FDG-PET/MRI Imaging Protocol for Gastric Cancer PDX as a Preclinical Research Tool.
Conclusions: This preclinical gastric cancer PDX based [18F]-FDG-PET/MRI protocol reveals tumor specific FDG uptake and shows correlation to glucose metabolic proteins. Our findings provide a PET/MRI PDX model that can be applicable for translational gastric cancer research. PMID: 32269845 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Spade-Shaped Anastomosis Following a Proximal Gastrectomy Using a Double Suture to Fix the Posterior Esophageal Wall to the Anterior Gastric Wall (SPADE Operation): Case-Control Study of Early Outcomes.
Conclusions: A novel modified EG, the SPADE operation, has the potential to decrease gastroesophageal reflux following a PG. PMID: 32269846 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Risk Factors for Duodenal Stump Leakage after Laparoscopic Gastrectomy for Gastric Cancer.
Conclusions: The risk factors of DSL were BMI ≥24 kg/m2, elevated preoperative CRP level, and unreinforced duodenal stump. Nonsurgical treatments for DSL are preferred. PMID: 32269847 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy.
Conclusions: Our present study reveals that Bcl-3 knockdown inhibits cell migration and chemoresistance of gastric cancer cells through restoring HYP-induced autophagy. PMID: 32269848 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Bilateral Breast Metastases from Epstein-Barr Virus-Associated Gastric Cancer during Pregnancy: Is There a Method to Its Madness?
Authors: Quaquarini E, Vanoli A, Frascaroli M, Viglio A, Lucioni M, Presti D, Lobascio G, Pietrabissa A, Bernardo A, Paulli M Abstract Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%-2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (
Source: Journal of Gastric Cancer - April 10, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer.
Authors: Cavaliere A, Merz V, Casalino S, Zecchetto C, Simionato F, Salt HL, Contarelli S, Santoro R, Melisi D Abstract Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and esophagogastric junction cancer in Western countries. However, in a large number of cases, the tumor is extremely resistant to these treatments and the patients are exposed to unnecessary toxicity and delayed surgical therapy. The current clinical trials evaluating the combination of preoperative systemic therapies with modern targeted and immunotherap...
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Postoperative Radiotherapy Improves Survival in Gastric Signet-Ring Cell Carcinoma: a SEER Database Analysis.
Authors: Wei F, Lyu H, Wang S, Chu Y, Chen F Abstract Purpose: To identify the potential therapeutic role of postoperative radiotherapy (RT) in patients with locally advanced (stage II and stage III) gastric signet ring cell carcinoma (SRC). Materials and methods: Patients with locally advanced gastric SRC from the Surveillance, Epidemiology, and End Results program database between 2004 and 2012 were included in our study. Univariate and multivariate Cox proportional models were performed, and survival curves were generated to evaluate the prognostic effect of postoperative RT and surgery alone on SRC patients...
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Choice of Capecitabine or S1 in Combination with Oxaliplatin based on Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Status in Patients with Advanced Gastric Cancer.
Conclusions: No significant difference in clinical efficacy was found between CAPOX and SOX. TP-positive patients might respond better to CAPOX while DPD-positive patients may respond better to SOX. Our findings might serve as a guide for personalized chemotherapy for gastric cancer. PMID: 31897343 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Risk Factors for Gallbladder Stone Formation after Gastric Cancer Surgery.
Conclusions: This study presented risk factors for GB stone formation after gastric cancer surgery, and special attention should be afforded to patients with such risk factors. PMID: 31897344 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Clinical Implications of Microsatellite Instability in Early Gastric Cancer.
Authors: Kim DG, An JY, Kim H, Shin SJ, Choi S, Seo WJ, Roh CK, Cho M, Son T, Kim HI, Cheong JH, Hyung WJ, Noh SH, Choi YY Abstract Purpose: We aimed to evaluate the clinical characteristics of microsatellite instability in early gastric cancer. Materials and Methods: The microsatellite instability status of resected early gastric tumors was evaluated using two mononucleotide repeat markers (BAT25 and BAT26) and three dinucleotide repeat markers (D5S346, D2S123, and D17S250). Tumors with instability in two or more markers were defined as microsatellite instability-high (MSI-H) and others were classified as micr...
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Feasibility of Linear-Shaped Gastroduodenostomy during the Performance of Totally Robotic Distal Gastrectomy.
This study compared the feasibility of LSGD in patients undergoing TRDG and TLDG. Materials and Methods All c: onsecutive patients who underwent LSGD after distal gastrectomy for gastric cancer between January 2009 and December 2017 were analyzed retrospectively. Propensity score matching (PSM) analysis was performed to reduce the selection bias between TRDG and TLDG. Short-term outcomes, functional outcomes, learning curve, and risk factors for postoperative complications were analyzed. Results: This analysis included 414 patients, of whom 275 underwent laparoscopy and 139 underwent robotic surgery. PSM analysis s...
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Feasibility of No Prophylactic Antibiotics Use in Patients Undergoing Total Laparoscopic Distal Gastrectomy for Gastric Carcinoma: a Propensity Score-Matched Case-Control Study.
Conclusions: Postoperative morbidity, including SSI rates, did not significantly increase in patients undergoing TLDG without prophylactic antibiotic use. A large prospective randomized trial is warranted to reappraise the efficacy of prophylactic antibiotic use in patients undergoing TLDG. PMID: 31897347 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

LINC00703 Acts as a Tumor Suppressor via Regulating miR-181a/KLF6 Axis in Gastric Cancer.
Conclusions: LINC00703 may have an anti-cancer function via modulation of the miR-181a/KLF6 axis. This study also provides a new potential diagnostic marker and therapeutic target for GC treatment. PMID: 31897348 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Dorsal Track Control (DTC): A Modified Surgical Technique for Atraumatic Handling of the Distal Esophagus in Esophagojejunostomy.
Authors: Lehwald-Tywuschik N, Steinfurth F, Kröpil F, Krieg A, Sarikaya H, Knoefel WT, Krüger M, Benhidjeb T, Beshay M, Schulte Am Esch J Abstract Surgical therapy for adenocarcinoma of the esophagogastric junction II requires distal esophagectomy, in which a transhiatal management of the lower esophagus is critical. The 'dorsal track control' (DTC) maneuver presented here facilitates the atraumatic handling of the distal esophagus, in preparation for a circular-stapled esophagojejunostomy. It is based on a ventral semicircular incision in the distal esophagus, with an intact dorsal wall for traction cont...
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Laparoscopic Whipple's Operation for Locally Advanced Gastric Cancer Invading the Pancreas and Duodenum: a Case Report.
Authors: Lee CM, Yoon SY, Park S, Park SH Abstract Few surgeons have adopted pancreaticoduodenectomy (PD) for the treatment of advanced gastric cancer (AGC) invading the pancreas or duodenum because it remains controversial whether its prognostic benefits outweigh the high morbidity rates in such advanced cases. However, recent technical advances have revived diverse surgical procedures in minimally invasive approaches. Inspired by this trend, laparoscopic PD procedures have been performed for AGC in our institute since 2014. We recently performed a laparoscopic Whipple's operation in a case of cT4b gastric cancer ...
Source: Journal of Gastric Cancer - January 4, 2020 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Clinical Implementation of Precision Medicine in Gastric Cancer.
Authors: Jeon J, Cheong JH Abstract Gastric cancer (GC) is one of the deadliest malignancies in the world. Currently, clinical treatment decisions are mostly made based on the extent of the tumor and its anatomy, such as tumor-node-metastasis staging. Recent advances in genome-wide molecular technology have enabled delineation of the molecular characteristics of GC. Based on this, efforts have been made to classify GC into molecular subtypes with distinct prognosis and therapeutic response. Simplified algorithms based on protein and RNA expressions have been proposed to reproduce the GC classification in the clinic...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Biomarkers for Evaluating the Inflammation Status in Patients with Cancer.
Authors: Guner A, Kim HI Abstract Inflammation can be a causative factor for carcinogenesis or can result from a consequence of cancer progression. Moreover, cancer therapeutic interventions can also induce an inflammatory response. Various inflammatory parameters are used to assess the inflammatory status during cancer treatment. It is important to select the most optimal biomarker among these parameters. Additionally, suitable biomarkers must be examined if there are no known parameters. We briefly reviewed the published literature for the use of inflammatory parameters in the treatment of patients with cancer. M...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Bioelectrical Impedance Analysis for Prediction of Early Complications after Gastrectomy in Elderly Patients with Gastric Cancer: the Phase Angle Measured Using Bioelectrical Impedance Analysis.
Conclusions: Our findings show that preoperative low phase angle predicts the risk of overall and severe complications. Our findings suggest that BIA should be performed to assess the risk of postoperative complications in elderly patients with gastric cancer. PMID: 31598371 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

A Novel Technique of Hand-Sewn Purse-String Suturing by Double Ligation Method (DLM) for Intracorporeal Circular Esophagojejunostomy.
Conclusions: Our procedure for hand-sewn purse-string suturing with the double ligation method is simple and safe. PMID: 31598372 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Exosomal miR-181b-5p Downregulation in Ascites Serves as a Potential Diagnostic Biomarker for Gastric Cancer-associated Malignant Ascites.
Conclusions: We identified exosomal miRNAs capable of distinguishing between non-malignant and GC-ascites, showing that the combined use of miR-181b-5p and CEA could improve diagnosis. PMID: 31598373 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Combined Detection of Serum MiR-221-3p and MiR-122-5p Expression in Diagnosis and Prognosis of Gastric Cancer.
Conclusions: The miR-221-3p and miR-122-5p are involved in the development of gastric cancer, and they have important clinical values in gastric cancer diagnosis and prognosis. PMID: 31598374 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Proposal of a New TNM Classification for Gastric Cancer: Focusing on pN3b and Cytology-Positive (CY1) Disease.
Authors: Kim SH, Lee HJ, Park JH, Choi JH, Park SH, Choe HN, Oh SY, Suh YS, Kong SH, Park DJ, Yang HK Abstract Purpose: Gastric cancer with lymph node metastasis (LNM) more than 15 (N3b) was defined as stage IV until the 6th AJCC system. However, it has been reclassified as a localized disease (stage IIb or III) since the 7th system. The aim of this study is to demonstrate that the survival of N3b is comparable to cytology-only positive (CY1-only) stage IV and to propose a new TNM system interpreting N3b as an eligibility criterion for receiving more intensive chemotherapy regimens. Materials and Methods: 1,430...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Esophagojejunal Anastomosis after Laparoscopic Total Gastrectomy for Gastric Cancer: Circular versus Linear Stapling.
Conclusions: The overlap method was superior to the HDST with respect to anastomotic complications, especially anastomosis stricture. PMID: 31598376 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Modified Book Binding Technique (MBBT) for Intracorporeal Gastroduodenostomy in Totally Laparoscopic Distal Gastrectomy: Initial Experience.
This study evaluated the safety and feasibility of MBBT in patients undergoing TLDG. Thirty-three patients who underwent TLDG with MBBT were retrospectively evaluated. The mean operation time was 277.6±37.1 minutes, including 51.9±15.7 minutes for reconstruction. Two patients had anastomosis-related complications, one patient with stricture after leakage and 1 patient with stenosis. The former patient was treated with endoscopic balloon dilatation, and the latter was managed conservatively; neither required re-operation. MBBT is a safe and feasible technique, with acceptable surgical outcomes. It may be a goo...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Long-limb Roux-en-Y Reconstruction after Subtotal Gastrectomy to Treat Severe Diabetic Gastroparesis.
We report a case of a 37-year-old man with a history of recurrent episodes of vomiting and long-standing type 2 diabetes mellitus. Esophagogastroduodenoscopy did not reveal any findings of reflux esophagitis or obstructive lesions. A gastric emptying time scan showed prolonged gastric emptying half-time (344 minutes) indicating delayed gastric emptying. Laboratory tests revealed elevated fasting serum glucose and glycosylated hemoglobin (HbA1c, 12.9%) and normal fasting C-peptide and insulin levels. We performed Roux-en-Y reconstruction after subtotal gastrectomy to treat gastroparesis and improve glycemic control, and the...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Erratum: Korean Practice Guideline for Gastric Cancer 2018: an Evidence-based, Multi-disciplinary Approach.
Authors: Guideline Committee of the Korean Gastric Cancer Association (KGCA), Development Working Group & Review Panel Abstract [This corrects the article on p. 1 in vol. 19, PMID: 30944757.]. PMID: 31598379 [PubMed - in process] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

History of Esophagogastric Junction Cancer Treatment and Current Surgical Management in Western Countries.
This article reviews the history of surgical EGJ cancer treatment and current surgical strategies from a Western perspective. PMID: 31245158 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Multimodal Treatment Strategies in Esophagogastric Junction Cancer: a Western Perspective.
Authors: Goetze TO, Al-Batran SE, Berlth F, Hoelscher AH Abstract Esophagogastric junction (EGJ) cancer is a solid tumor entity with rapidly increasing incidence in the Western countries. Given the high proportion of advanced cancers in the West, treatment strategies routinely employed include surgery and chemotherapy perioperatively, and chemoradiation in neoadjuvant settings. Neoadjuvant chemoradiation and perioperative chemotherapy are mostly performed in esophageal cancer that extends to the EGJ and gastric as well as EGJ cancers, respectively. Recent trials have tried to combine both strategies in a perioperat...
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Prospective Multicenter Feasibility Study of Laparoscopic Sentinel Basin Dissection after Endoscopic Submucosal Dissection for Early Gastric Cancer: SENORITA 2 Trial Protocol.
Conclusions: This study is expected to clarify the feasibility of laparoscopic sentinel basin dissection after noncurative ESD. If the feasibility is demonstrated, a multicenter phase III trial will be initiated to compare laparoscopic sentinel node navigation surgery versus laparoscopic standard gastrectomy in early gastric cancer after endoscopic resection. Trial Registration: ClinicalTrials.gov Identifier: NCT03123042. PMID: 31245160 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Similar Operative Outcomes between the da Vinci Xi ® and da Vinci Si® Systems in Robotic Gastrectomy for Gastric Cancer.
Conclusions: We found no difference in surgical outcomes after robotic gastrectomy for gastric cancer between the da Vinci Xi® and da Vinci Si® procedures. PMID: 31245161 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Rapid Staining Using the Shorr Method for Intraoperative Peritoneal Washing Cytology in Advanced Gastric Cancer: a Pilot Study from a Single Institution.
Conclusions: Shorr staining could be a rapid and reliable method for intraoperative PWC in advanced gastric cancer. PMID: 31245162 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy.
Conclusions: Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC. PMID: 31245163 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Intracorporeal Esophagojejunostomy Using a Circular or a Linear Stapler in Totally Laparoscopic Total Gastrectomy: a Propensity-Matched Analysis.
Conclusions: Both circular and linear stapling techniques are feasible and safe in performing intracorporeal EJ anastomosis during LTG. The linear group had shorter operative time, but there was no difference in anastomosis complications. PMID: 31245164 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Extremely High Mortality Rate after a Successful Gastrectomy for Cancer in Older Adults.
Conclusions: Age is an important prognostic factor of middle-term survival after gastrectomy for cancer. Geriatric assessment and better patient selection for major surgery for cancer are required to improve the outcome of gastrectomy for cancer in patients aged over 75 years. PMID: 31245165 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Prognostic Impact of Extended Lymph Node Dissection versus Limited Lymph Node Dissection on pN0 Proximal Advanced Gastric Cancer: a Propensity Score Matching Analysis.
This study aimed to investigate whether splenic hilar LND or D2 LND is essential for proximal AGC of pT2-4aN0M0 stage. Materials and Methods: Data of curative total gastrectomies (n=370) performed from 2000 to 2010 for proximal AGC of pT2-4aN0 stage were retrospectively reviewed. Clinicopathological characteristics and long-term outcomes were compared using propensity score matching between patients who underwent splenectomy (n=43) and those who did not (n=327) and between patients who underwent D2 LND (n=122) and those who underwent D1+ LND (n=248). Results: Tumors of larger size and a more advanced T stage and si...
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research