Clinical Implementation of Precision Medicine in Gastric Cancer.
Authors: Jeon J, Cheong JH Abstract Gastric cancer (GC) is one of the deadliest malignancies in the world. Currently, clinical treatment decisions are mostly made based on the extent of the tumor and its anatomy, such as tumor-node-metastasis staging. Recent advances in genome-wide molecular technology have enabled delineation of the molecular characteristics of GC. Based on this, efforts have been made to classify GC into molecular subtypes with distinct prognosis and therapeutic response. Simplified algorithms based on protein and RNA expressions have been proposed to reproduce the GC classification in the clinic...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Biomarkers for Evaluating the Inflammation Status in Patients with Cancer.
Authors: Guner A, Kim HI Abstract Inflammation can be a causative factor for carcinogenesis or can result from a consequence of cancer progression. Moreover, cancer therapeutic interventions can also induce an inflammatory response. Various inflammatory parameters are used to assess the inflammatory status during cancer treatment. It is important to select the most optimal biomarker among these parameters. Additionally, suitable biomarkers must be examined if there are no known parameters. We briefly reviewed the published literature for the use of inflammatory parameters in the treatment of patients with cancer. M...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Bioelectrical Impedance Analysis for Prediction of Early Complications after Gastrectomy in Elderly Patients with Gastric Cancer: the Phase Angle Measured Using Bioelectrical Impedance Analysis.
Conclusions: Our findings show that preoperative low phase angle predicts the risk of overall and severe complications. Our findings suggest that BIA should be performed to assess the risk of postoperative complications in elderly patients with gastric cancer. PMID: 31598371 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

A Novel Technique of Hand-Sewn Purse-String Suturing by Double Ligation Method (DLM) for Intracorporeal Circular Esophagojejunostomy.
Conclusions: Our procedure for hand-sewn purse-string suturing with the double ligation method is simple and safe. PMID: 31598372 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Exosomal miR-181b-5p Downregulation in Ascites Serves as a Potential Diagnostic Biomarker for Gastric Cancer-associated Malignant Ascites.
Conclusions: We identified exosomal miRNAs capable of distinguishing between non-malignant and GC-ascites, showing that the combined use of miR-181b-5p and CEA could improve diagnosis. PMID: 31598373 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Combined Detection of Serum MiR-221-3p and MiR-122-5p Expression in Diagnosis and Prognosis of Gastric Cancer.
Conclusions: The miR-221-3p and miR-122-5p are involved in the development of gastric cancer, and they have important clinical values in gastric cancer diagnosis and prognosis. PMID: 31598374 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Proposal of a New TNM Classification for Gastric Cancer: Focusing on pN3b and Cytology-Positive (CY1) Disease.
Authors: Kim SH, Lee HJ, Park JH, Choi JH, Park SH, Choe HN, Oh SY, Suh YS, Kong SH, Park DJ, Yang HK Abstract Purpose: Gastric cancer with lymph node metastasis (LNM) more than 15 (N3b) was defined as stage IV until the 6th AJCC system. However, it has been reclassified as a localized disease (stage IIb or III) since the 7th system. The aim of this study is to demonstrate that the survival of N3b is comparable to cytology-only positive (CY1-only) stage IV and to propose a new TNM system interpreting N3b as an eligibility criterion for receiving more intensive chemotherapy regimens. Materials and Methods: 1,430...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Esophagojejunal Anastomosis after Laparoscopic Total Gastrectomy for Gastric Cancer: Circular versus Linear Stapling.
Conclusions: The overlap method was superior to the HDST with respect to anastomotic complications, especially anastomosis stricture. PMID: 31598376 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Modified Book Binding Technique (MBBT) for Intracorporeal Gastroduodenostomy in Totally Laparoscopic Distal Gastrectomy: Initial Experience.
This study evaluated the safety and feasibility of MBBT in patients undergoing TLDG. Thirty-three patients who underwent TLDG with MBBT were retrospectively evaluated. The mean operation time was 277.6±37.1 minutes, including 51.9±15.7 minutes for reconstruction. Two patients had anastomosis-related complications, one patient with stricture after leakage and 1 patient with stenosis. The former patient was treated with endoscopic balloon dilatation, and the latter was managed conservatively; neither required re-operation. MBBT is a safe and feasible technique, with acceptable surgical outcomes. It may be a goo...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Long-limb Roux-en-Y Reconstruction after Subtotal Gastrectomy to Treat Severe Diabetic Gastroparesis.
We report a case of a 37-year-old man with a history of recurrent episodes of vomiting and long-standing type 2 diabetes mellitus. Esophagogastroduodenoscopy did not reveal any findings of reflux esophagitis or obstructive lesions. A gastric emptying time scan showed prolonged gastric emptying half-time (344 minutes) indicating delayed gastric emptying. Laboratory tests revealed elevated fasting serum glucose and glycosylated hemoglobin (HbA1c, 12.9%) and normal fasting C-peptide and insulin levels. We performed Roux-en-Y reconstruction after subtotal gastrectomy to treat gastroparesis and improve glycemic control, and the...
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Erratum: Korean Practice Guideline for Gastric Cancer 2018: an Evidence-based, Multi-disciplinary Approach.
Authors: Guideline Committee of the Korean Gastric Cancer Association (KGCA), Development Working Group & Review Panel Abstract [This corrects the article on p. 1 in vol. 19, PMID: 30944757.]. PMID: 31598379 [PubMed - in process] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 12, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

History of Esophagogastric Junction Cancer Treatment and Current Surgical Management in Western Countries.
This article reviews the history of surgical EGJ cancer treatment and current surgical strategies from a Western perspective. PMID: 31245158 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Multimodal Treatment Strategies in Esophagogastric Junction Cancer: a Western Perspective.
Authors: Goetze TO, Al-Batran SE, Berlth F, Hoelscher AH Abstract Esophagogastric junction (EGJ) cancer is a solid tumor entity with rapidly increasing incidence in the Western countries. Given the high proportion of advanced cancers in the West, treatment strategies routinely employed include surgery and chemotherapy perioperatively, and chemoradiation in neoadjuvant settings. Neoadjuvant chemoradiation and perioperative chemotherapy are mostly performed in esophageal cancer that extends to the EGJ and gastric as well as EGJ cancers, respectively. Recent trials have tried to combine both strategies in a perioperat...
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Prospective Multicenter Feasibility Study of Laparoscopic Sentinel Basin Dissection after Endoscopic Submucosal Dissection for Early Gastric Cancer: SENORITA 2 Trial Protocol.
Conclusions: This study is expected to clarify the feasibility of laparoscopic sentinel basin dissection after noncurative ESD. If the feasibility is demonstrated, a multicenter phase III trial will be initiated to compare laparoscopic sentinel node navigation surgery versus laparoscopic standard gastrectomy in early gastric cancer after endoscopic resection. Trial Registration: ClinicalTrials.gov Identifier: NCT03123042. PMID: 31245160 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Similar Operative Outcomes between the da Vinci Xi ® and da Vinci Si® Systems in Robotic Gastrectomy for Gastric Cancer.
Conclusions: We found no difference in surgical outcomes after robotic gastrectomy for gastric cancer between the da Vinci Xi® and da Vinci Si® procedures. PMID: 31245161 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Rapid Staining Using the Shorr Method for Intraoperative Peritoneal Washing Cytology in Advanced Gastric Cancer: a Pilot Study from a Single Institution.
Conclusions: Shorr staining could be a rapid and reliable method for intraoperative PWC in advanced gastric cancer. PMID: 31245162 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy.
Conclusions: Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC. PMID: 31245163 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Intracorporeal Esophagojejunostomy Using a Circular or a Linear Stapler in Totally Laparoscopic Total Gastrectomy: a Propensity-Matched Analysis.
Conclusions: Both circular and linear stapling techniques are feasible and safe in performing intracorporeal EJ anastomosis during LTG. The linear group had shorter operative time, but there was no difference in anastomosis complications. PMID: 31245164 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Extremely High Mortality Rate after a Successful Gastrectomy for Cancer in Older Adults.
Conclusions: Age is an important prognostic factor of middle-term survival after gastrectomy for cancer. Geriatric assessment and better patient selection for major surgery for cancer are required to improve the outcome of gastrectomy for cancer in patients aged over 75 years. PMID: 31245165 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Prognostic Impact of Extended Lymph Node Dissection versus Limited Lymph Node Dissection on pN0 Proximal Advanced Gastric Cancer: a Propensity Score Matching Analysis.
This study aimed to investigate whether splenic hilar LND or D2 LND is essential for proximal AGC of pT2-4aN0M0 stage. Materials and Methods: Data of curative total gastrectomies (n=370) performed from 2000 to 2010 for proximal AGC of pT2-4aN0 stage were retrospectively reviewed. Clinicopathological characteristics and long-term outcomes were compared using propensity score matching between patients who underwent splenectomy (n=43) and those who did not (n=327) and between patients who underwent D2 LND (n=122) and those who underwent D1+ LND (n=248). Results: Tumors of larger size and a more advanced T stage and si...
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Influence of Helicobacter pylori Infection on Endoscopic Findings of Gastric Adenocarcinoma of the Fundic Gland Type.
Conclusions: The change in background mucosa due to HP infection influenced the thickness of the covering layer over the tumor ducts and M-NBI finding of GA-FG-CCP. PMID: 31245167 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - June 29, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Korean Practice Guideline for Gastric Cancer 2018: an Evidence-based, Multi-disciplinary Approach.
Authors: Guideline Committee of the Korean Gastric Cancer Association (KGCA), Development Working Group & Review Panel PMID: 30944757 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Intraoperative Neurophysiologic Testing of the Perigastric Vagus Nerve Branches to Evaluate Viability and Signals along Nerve Pathways during Gastrectomy.
Conclusions: Intraoperative neurophysiologic testing seems to be a feasible methodology for monitoring the perigastric vagus nerves. Innervation of the duodenum via the celiac branch and postoperative preservation of the function of the vagus nerves were confirmed in most patients. Trial Registration: Clinical Research Information Service Identifier: KCT0000823. PMID: 30944758 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Long-term Outcomes of Laparoscopic Versus Open Transhiatal Approach for the Treatment of Esophagogastric Junction Cancer.
Conclusions: The LA is feasible and safe with short- and long-term oncologic outcomes similar to those of the OA. PMID: 30944759 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Implementation of Enhanced Recovery after Surgery (ERAS) Program in Perioperative Management of Gastric Cancer Surgery: a Nationwide Survey in Korea.
Conclusions: Perioperative management of gastric cancer surgery is largely heterogeneous among gastric surgeons in South Korea. Standard perioperative care based on scientific evidence needs to be established to improve the quality of surgical care and patient outcomes. PMID: 30944760 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Oncologic Outcomes after Laparoscopic and Open Distal Gastrectomy for Advanced Gastric Cancer: Propensity Score Matching Analysis.
Conclusions: LDG is safe and feasible for AGC, with earlier recovery after surgery and long-term oncologic outcomes comparable to those of ODG. PMID: 30944761 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Trends and Outcomes of Non-compliance with Treatment for Gastric Cancer in Korea over the 16 years from 1999 to 2015.
Conclusions: The proportion of NCT gastric cancer patients has decreased during the last 16 years. However, considerable numbers of elderly patients are still NCT. There must be a strategy to decrease NCT and improve the nationwide survival rate of patients with gastric cancer. PMID: 30944762 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Long-term Survival Outcomes of Laparoscopic Gastrectomy for Advanced Gastric Cancer: Five-year Results of a Phase II Prospective Clinical Trial.
Conclusions: In addition to being technically feasible for treatment of AGC in terms of morbidity, LG with D2 LND for locally advanced gastric cancer showed acceptable 3-year DFS outcomes. Trial Registration: ClinicalTrials.gov Identifier: NCT01441336. PMID: 30944763 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Short-Term Outcomes of Intracorporeal Delta-Shaped Gastroduodenostomy Versus Extracorporeal Gastroduodenostomy after Laparoscopic Distal Gastrectomy for Gastric Cancer.
Conclusion: The surgical safety of ICBI was similar to that of ECBI. Although the chosen anastomotic technique was not a risk factor for surgical complications, ECBI was more vulnerable to surgical complications than ICBI in patients with a high BMI (≥30). PMID: 30944764 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Prognostic Threshold of Neuroendocrine Differentiation in Gastric Carcinoma: a Clinicopathological Study of 945 Cases.
This study aimed to determine the prognostic threshold of meaningful NED in GC and clarify its unclear features in existing classifications. Materials and Methods: Immunohistochemical staining for synaptophysin, chromogranin A, and neural cell adhesion molecule was performed for 945 GC specimens. Survival analysis was performed using the log-rank test and univariate/multivariate models with percentages of NED (PNED) and demographic and clinicopathological parameters. Results: In total, 275 (29.1%) cases were immunoreactive to at least 1 neuroendocrine (NE) marker. GC-NED was more common in the upper third of the st...
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Incarcerated Hiatal Hernia with Perforation after Laparoscopic Total Gastrectomy with Roux-en-Y Reconstruction: a Case Report.
We report the case of a 76-year-old man who presented with dyspnea, vomiting, and fever around 8 days after total gastrectomy with Roux-en-Y reconstruction. Abdominal computed tomography revealed a hiatal hernia containing part of the small intestine in the left thoracic cavity. Emergent reduction and repair of the hiatal hernia were performed later. Operative findings revealed that the Roux limb was incarcerated in the left pleural cavity. Esophagojejunostomy leakage, perforation of the small intestine with transient ischemic change, and pyothorax were also found. Thus, feeding jejunostomy, thoracoscopic decortication, an...
Source: Journal of Gastric Cancer - April 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Evidence-Based Practice Guideline for Surgical Treatment of Gastroesophageal Reflux Disease 2018.
Authors: Seo HS, Choi M, Son SY, Kim MG, Han DS, Lee HH Abstract The prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea, and physicians, including surgeons, have been focusing on its treatment. Indeed, in Korea, medical treatment using a proton pump inhibitor is the mainstream treatment for GERD, while awareness of surgical treatment is limited. Accordingly, to promote the understanding of surgical treatment for GERD, the Korean Anti-Reflux Surgery Study Group published the Evidence-Based Practice Guideline for the Surgical Treatment of GERD. The guideline consists of 2 sections: fundamenta...
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Epidemiology of Gastroesophageal Junction Adenocarcinoma in Korea.
Authors: Kim JJ Abstract The incidence of gastroesophageal junction adenocarcinoma (GEJAC) in Western countries has increased in recent decades, in addition to a rise in the incidence of esophageal adenocarcinoma (EAC). Gastroesophageal reflux disease (GERD), obesity, smoking, alcohol consumption, and low Helicobacter pylori (HP) infection rate have been nominated as risk factors for such cancers. Among these risk factors, the increased prevalence of GERD and obesity and the decreased prevalence of HP infection are of special interest owing to the currently increasing prevalence of GEJAC in Western countries. Altho...
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Can proximal Gastrectomy Be Justified for Advanced Adenocarcinoma of the Esophagogastric Junction?
Conclusions: Radical PG may be indicated for patients with AEG with gastric invasion length of less than 40 mm. PMID: 30607297 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Adjuvant Chemotherapy with or without Concurrent Radiotherapy for Patients with Stage IB Gastric Cancer: a Subgroup Analysis of the Adjuvant Chemoradiotherapy in Stomach Tumors (ARTIST) Phase III Trial.
Conclusions: The role of adjuvant chemoradiotherapy in the treatment of stage IB GC (AJCC 2002) warrants further investigation. PMID: 30607298 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

KLK6 Promotes Growth, Migration, and Invasion of Gastric Cancer Cells.
Conclusions: Together, these results suggest an important role for KLK6 in human gastric cancer progression. PMID: 30607299 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

The Fibrinogen to Mean Platelet Volume Ratio Can Predict Overall Survival of Patients with Non-Metastatic Gastric Cancer.
Conclusions: Elevated fibrinogen, platelets, and MPV levels were in accordance with advanced stages, and fibrinogen, platelet, and MPV, in combination, can be used to predict survival of patients with non-metastatic GC. FMR was an independent prognostic factor for overall survival of patients with GC. PMID: 30607300 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Gastric Cancer Patients with Peritoneal Metastasis (PM): Results of a Single-Center Experience and Register Study.
Conclusions: Our data show that PIPAC is safe and well tolerated, and that the production of ascites can be controlled by PIPAC in GC patients. Patients, who received 2 or more PIPAC procedures, reported a stable overall quality of life. Further studies are required to document the significance of PIPAC as a palliative multimodal therapy. Trial Registration: ClinicalTrials.gov Identifier: NCT03100708. PMID: 30607301 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Risk Factors for the Development of Incisional Hernia in Mini-laparotomy Wounds Following Laparoscopic Distal Gastrectomy in Patients with Gastric Cancer.
Conclusions: A median follow-up of 58 months showed that the overall incidence of IH in mini-laparotomy wounds was 2.8%. Multivariate analysis showed that female sex, higher BMI, and presence of comorbidity were significant risk factors of IH. Thus, surgeons should monitor the closure of mini-laparotomy wounds in patients with risk factors of IH undergoing laparoscopic distal gastrectomy. PMID: 30607302 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

A Single-Center Experience of Endoscopic Resection for Early Gastric Cancer with Lymphoid Stroma.
Conclusions: In patients with early GCLS, endoscopic resection is technically feasible and has favorable clinical outcomes. Therefore, endoscopic resection might represent an alternative treatment modality in patients with early GCLS with a low likelihood of LN metastasis. PMID: 30607303 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Gastric Adenocarcinoma of Fundic Gland Type with Aggressive Transformation and Lymph Node Metastasis: a Case Report.
Authors: Okumura Y, Takamatsu M, Ohashi M, Yamamoto Y, Yamamoto N, Kawachi H, Ida S, Kumagai K, Nunobe S, Hiki N, Sano T Abstract A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenecto...
Source: Journal of Gastric Cancer - January 6, 2019 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Surgical Treatment of Gastroesophageal Junction Cancer.
This study aimed to provide an update on the surgical treatment of GEJ adenocarcinoma by reviewing previous reports and propose recommended surgical approaches. The Siewert classification is widely used for determining which surgical procedure is used, because previous studies have shown that the pattern of lymph node (LN) metastasis depends on tumor location. In terms of surgical approaches for GEJ adenocarcinoma, a consensus was reached based on two randomized controlled trials. Siewert types I and III are treated as esophageal cancer and gastric cancer, respectively. Although no consensus has been reached regarding the ...
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Preoperative Nodal 18F-FDG Avidity Rather than Primary Tumor Avidity Determines the Prognosis of Patients with Advanced Gastric Cancer.
Conclusions: 18F-FDG avidity of LNs is an independent prognostic factor for predicting RFS. Preoperative 18F-FDG PET/CT can be used to determine the risk and prognosis of patients with AGC after curative resection. PMID: 30275999 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Enhanced Recovery after Surgery for Gastric Cancer Patients Improves Clinical Outcomes at a US Cancer Center.
Authors: Desiderio J, Stewart CL, Sun V, Melstrom L, Warner S, Lee B, Schoellhammer HF, Trisal V, Paz B, Fong Y, Woo Y Abstract Purpose: Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GC-ERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERAS protocol at a National Comprehensive Cancer Center in the United States. Materials and Methods: We reviewed medical records of patients surgically treated for gastric ...
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Sarcopenia and Post-Operative Morbidity and Mortality in Patients with Gastric Cancer.
Conclusions: In patients undergoing curative resection for gastric cancer, there was a statistically significant association between sarcopenia and both decreased overall survival and serious post-operative complications. The measurement and reporting of skeletal muscle index on pre-operative computed tomography should be considered. PMID: 30276001 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Impact of Various Types of Comorbidities on the Outcomes of Laparoscopic Total Gastrectomy in Patients with Gastric Carcinoma.
Conclusions: Among the various comorbidities investigated, patients with pulmonary disease had a significantly higher risk of postoperative complications after LTG. Proper perioperative care for optimizing pulmonary function may be required for patients with pulmonary disease. PMID: 30276002 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Who Can Perform Adjuvant Chemotherapy Treatment for Gastric Cancer? A Multicenter Retrospective Overview of the Current Status in Korea.
Conclusions: S-1 monotherapy and XELOX are a main stay of AC, regardless of whether the prescribing physician is a medical or surgical oncologist. The better compliance with AC by surgical oncologists is a valid reason to advocate that surgical oncologists perform the treatment of AC for stage II or III gastric cancers. PMID: 30276003 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

The Impact of Preoperative Low Body Mass Index on Postoperative Complications and Long-term Survival Outcomes in Gastric Cancer Patients.
Authors: Kim CH, Park SM, Kim JJ Abstract Purpose: The aim of this study was to investigate the impact of preoperative low body mass index (BMI) on both the short- and long-term outcomes in patients with gastric cancer. Materials and Methods: A total of 510 patients with gastric cancer were divided into the following 3 groups: low BMI group (≤18.5 kg/m2, n=51), normal BMI group (18.6-24.9 kg/m2, n=308), and high BMI group (≥25.0 kg/m2, n=151). Results: There were significantly more stage III/IV patients in the low BMI group than in the other groups (P=0.001). Severe postoperative complications were mo...
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Safety of Laparoscopic Radical Gastrectomy in Gastric Cancer Patients with End-Stage Renal Disease.
Conclusions: In ESRD patients, LG yielded non-inferior short- and long-term surgical outcomes compared to OG. Laparoscopic procedures might be safely adopted for ESRD patients who can benefit from the advantages of minimally invasive surgery. PMID: 30276005 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy as Treatment Options for Peritoneal Metastasis of Advanced Gastric Cancer.
Conclusions: CRS with HIPEC may have a beneficial effect in patients with PM of AGC. However, the rates of complications and mortality associated with this combined therapeutic approach are high. Therefore, this treatment should be performed only in selected patients by surgeons experienced in the field of gastric cancer with PM. PMID: 30276006 [PubMed] (Source: Journal of Gastric Cancer)
Source: Journal of Gastric Cancer - October 4, 2018 Category: Gastroenterology Tags: J Gastric Cancer Source Type: research