Mitochondrial administration alleviates lead- and cadmium-induced toxicity in rat renal cells
Cell Biol Int. 2024 Apr 29. doi: 10.1002/cbin.12165. Online ahead of print.ABSTRACTThe role of heavy metals such as lead (Pb) and cadmium (Cd) in the etiology of many diseases has been proven. Also, these heavy metals can affect the normal mitochondrial function. Mitochondrial administration therapy is one of the methods used by researchers to help improve mitochondrial defects and diseases. The use of isolated mitochondria as a therapeutic approach has been investigated in in vivo and in vitro studies. Accordingly, in this study, the effects of mitochondrial administration on the improvement of toxicity caused by Pb and C...
Source: Cell Biology International - April 29, 2024 Category: Cytology Authors: Enayatollah Seydi Alireza Kanani Nambani Ali Khorasani Farzaneh Kamranfar Abdollah Arjmand Jalal Pourahmad Source Type: research
Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes
CONCLUSION: In our study, we demonstrated that each senescence inducer activates a unique combination of senescence markers in PMH. Doxorubicin demonstrated the highest efficacy in inducing senescence, followed by cisplatin and H2O2, with no impact on apoptosis. Each inducer prompted DNA damage response and mitochondrial dysfunction, independent of MAPK/AKT.PMID:38684535 | DOI:10.1007/s00018-024-05230-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 29, 2024 Category: Cytology Authors: Pavitra Kumar Mohsin Hassan Frank Tacke Cornelius Engelmann Source Type: research
DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/ β-catenin pathway-dependent manner
CONCLUSION: Upregulation of DKK3 caused by m6A modification activated the Wnt/β-catenin pathway to increase MFF transcriptional expression, leading to mitochondrial dysfunction and oxidative stress, thereby promoting RF progression.PMID:38682264 | DOI:10.1080/0886022X.2024.2343817 (Source: Renal Failure)
Source: Renal Failure - April 29, 2024 Category: Urology & Nephrology Authors: Jianling Song Yanxia Chen Yan Chen Minzi Qiu Wenliu Xiang Ben Ke Xiangdong Fang Source Type: research
L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury
This study investigates if L-DOPA, used in Parkinson's disease treatment, alleviates GCI/R-induced cell death by enhancing mitochondrial quality. Metabolomics and transcriptomic results showed that GCI/R damage affected the Tricarboxylic acid (TCA) cycle in the hippocampus. The results of this study show that L-DOPA stabilized mitochondrial membrane potential and ultrastructure in hippocampus of GCI/R rats, increased dopamine level in hippocampus, decreased succinic acid level, and stabilized Ca2+ level in CA1 subregion of hippocampus. As a precursor of dopamine, L-DOPA is presumed to improves mitochondrial function in hip...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Wenzhu Wang Jingyu Zhao Zihan Li Xiaoyu Kang Ting Li Nickolay K Isaev Elena A Smirnova Hui Shen Lixu Liu Yan Yu Source Type: research
A simple mitochondria-immobilized fluorescent probe for the detection of hydrogen peroxide
Talanta. 2024 Apr 10;275:126091. doi: 10.1016/j.talanta.2024.126091. Online ahead of print.ABSTRACTHydrogen peroxide (H2O2), as one of reactive oxygen species (ROS) widely present in the human body, is involved in a variety of physiological activities. Many human diseases are associated with abnormal levels of H2O2 in the body. Mitochondria are the main organelles producing H2O2 in the human body, and monitoring the level of H2O2 in mitochondria can help to deepen the understanding of the detailed functions of H2O2 in physiological activities. However, due to the highly dynamic nature of the cells, real-time quantitative m...
Source: Talanta - April 28, 2024 Category: Chemistry Authors: Caiyun Liu Xinke Li Hanchuang Zhu Kun Wang Xiaodi Rong Lixue Ma Xiaohui Zhang Mengyuan Liu Wenzhai Li Wenlong Sheng Baocun Zhu Source Type: research
L-DOPA ameliorates hippocampus-based mitochondria respiratory dysfunction caused by GCI/R injury
This study investigates if L-DOPA, used in Parkinson's disease treatment, alleviates GCI/R-induced cell death by enhancing mitochondrial quality. Metabolomics and transcriptomic results showed that GCI/R damage affected the Tricarboxylic acid (TCA) cycle in the hippocampus. The results of this study show that L-DOPA stabilized mitochondrial membrane potential and ultrastructure in hippocampus of GCI/R rats, increased dopamine level in hippocampus, decreased succinic acid level, and stabilized Ca2+ level in CA1 subregion of hippocampus. As a precursor of dopamine, L-DOPA is presumed to improves mitochondrial function in hip...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Wenzhu Wang Jingyu Zhao Zihan Li Xiaoyu Kang Ting Li Nickolay K Isaev Elena A Smirnova Hui Shen Lixu Liu Yan Yu Source Type: research
Higher peripheral blood mitochondrial DNA copy number and relative telomere length in under 48 years Indonesian breast cancer patients
Breast cancer is the leading cause of cancer incidence and mortality among Indonesian women. A comprehensive investigation is required to enhance the early detection of this disease. Mitochondrial DNA copy num... (Source: BMC Research Notes)
Source: BMC Research Notes - April 28, 2024 Category: Research Authors: Prisca C. Limardi, Sonar Soni Panigoro, Nurjati Chairani Siregar, Noorwati Sutandyo, Fiastuti Witjaksono, Lidwina Priliani, Sukma Oktavianthi and Safarina G. Malik Tags: Research Note Source Type: research
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Res Bull. 2024 Apr 25:110955. doi: 10.1016/j.brainresbull.2024.110955. Online ahead of print.ABSTRACTIn clinical trials for Alzheimer's disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as monotherapy. Interference of cholinesterase inhibition with HMTM was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of HMTM at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate rel...
Source: Brain Research Bulletin - April 27, 2024 Category: Neurology Authors: Karima Schwab Dilyara Lauer Mandy Magbagbeolu Franz Theuring Anna Gasiorowska Maciej Zadrozny Charles R Harrington Claude M Wischik Gra żyna Niewiadomska Gernot Riedel Source Type: research
Role of intracranial bone marrow mesenchymal stem cells in stroke recovery: A focus on post-stroke inflammation and mitochondrial transfer
Brain Res. 2024 Apr 25:148964. doi: 10.1016/j.brainres.2024.148964. Online ahead of print.ABSTRACTStem cell therapy has become a hot research topic in the medical field in recent years, with enormous potential for treating a variety of diseases. In particular, bone marrow mesenchymal stem cells (BMSCs) have wide-ranging applications in the treatment of ischemic stroke, autoimmune diseases, tissue repair, and difficult-to-treat diseases. BMSCs can differentiate into multiple cell types and exhibit strong immunomodulatory properties. Although BMSCs can regulate the inflammatory response activated after stroke, the mechanism ...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Jiang Ming Yidong Liao Wenxue Song Zili Wang Junshuan Cui Longcai He Guangtang Chen Kaya Xu Source Type: research
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Res Bull. 2024 Apr 25:110955. doi: 10.1016/j.brainresbull.2024.110955. Online ahead of print.ABSTRACTIn clinical trials for Alzheimer's disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as monotherapy. Interference of cholinesterase inhibition with HMTM was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of HMTM at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate rel...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Karima Schwab Dilyara Lauer Mandy Magbagbeolu Franz Theuring Anna Gasiorowska Maciej Zadrozny Charles R Harrington Claude M Wischik Gra żyna Niewiadomska Gernot Riedel Source Type: research
Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices
Toxicol Appl Pharmacol. 2024 Apr 25:116941. doi: 10.1016/j.taap.2024.116941. Online ahead of print.ABSTRACTNitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung injury which can progress to chronic disease. Due to the complex nature of NM injury, it has been difficult to analyze early responses of resident lung cells that initiate inflammation and disease progression. To investigate this, we developed a model of acute NM toxicity using murine precision cut lung slices (PCLS), which contain all resident lung cell populations. PCLS were exposed to NM (1-100 μM) for 0.5-3 h and analyzed 1 a...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Alyssa Bellomo Julia Herbert Melissa J Kudlak Jeffrey D Laskin Andrew J Gow Debra L Laskin Source Type: research
Multi-omics analysis identifies sex-specific hepatic protein-metabolite networks in yellow catfish (Pelteobagrus fulvidraco) exposed to chronic hypoxia
Int J Biol Macromol. 2024 Apr 25:131892. doi: 10.1016/j.ijbiomac.2024.131892. Online ahead of print.ABSTRACTHypoxia disrupts the endocrine system of teleosts. The liver plays important roles in the endocrine system, energy storage, and metabolic processes. The aim of this study was to investigate the sex-specific hepatic response of yellow catfish under chronic hypoxia at the multi-omics level. Common hepatic responses in both sexes included the HIF-1 signaling pathway, glycolysis/gluconeogenesis, and steroid biosynthesis. Hypoxia dysregulated primary bile acid biosynthesis, lipid metabolism, and vitellogenin levels in fem...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Cheng Zhao Yufeng Song Guosong Zhang Kai Zhang Shaowu Yin Jie Ji Source Type: research
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer's Disease
Curr Top Med Chem. 2024 Apr 25. doi: 10.2174/0115680266296001240327090111. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most prevalent form of neurodegenerative disorder (ND), affecting more than 44 million individuals globally as of 2023. It is characterized by cognitive dysfunction and an inability to perform daily activities. The progression of AD is associated with the accumulation of amyloid beta (Aβ), the formation of neurofibrillary tangles (NFT), increased oxidative stress, neuroinflammation, mitochondrial dysfunction, and endoplasmic reticulum stress. Presently, various phytomedicines and their b...
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Sukriti Vishwas Bushra Bashir Devendra Birla Nikhil Khandale Motamarri Venkata Naga Lalitha Chaitanya Dinesh Kumar Chellappan Gaurav Gupta Poonam Negi Kamal Dua Sachin Kumar Singh Source Type: research
Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function
Food Chem Toxicol. 2024 Apr 25:114681. doi: 10.1016/j.fct.2024.114681. Online ahead of print.ABSTRACTThe methylimidazolium ionic liquid M8OI (1-octyl-3-methylimidazolium chloride, also known as [C8mim]Cl) has been detected in the environment and may represent a hazard trigger for the autoimmune liver disease primary biliary cholangitis, based in part on studies using a rat liver progenitor cell. The effect of M8OI on an equivalent human liver progenitor (undifferentiated HepaRG cells; u-HepaRG) was therefore examined. u-HepaRG cells were less sensitive (>20-fold) to the toxic effects of M8OI. The relative insensitivity ...
Source: Food and Chemical Toxicology - April 27, 2024 Category: Food Science Authors: Tarek M Abdelghany Shireen A Hedya Alex Charlton Fahad A Aljehani Khalid Alanazi Alaa A Budastour Larissa Marin Matthew C Wright Source Type: research
Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
Protein Cell. 2024 Apr 27:pwae020. doi: 10.1093/procel/pwae020. Online ahead of print.ABSTRACTCaspase-2, a highly conserved member of the caspase family, is considered an initiator caspase that triggers apoptosis in response to some cellular stresses. Previous studies suggest that an intracellular multi-protein complex PIDDosome, induced by genotoxic stress, serves as a platform for caspase-2 activation. However, due to caspase-2's inability to process effector caspases, the mechanism underlying caspase-2-mediated cell death upon PIDDosome activation remains unclear. Here we conducted an unbiased genome-wide genetic screen...
Source: Protein and Cell - April 27, 2024 Category: Cytology Authors: Mengxue Zeng Kun Wang Qingcui Wu Jingjin Ding Dan Xie Xiangbing Qi Feng Shao Source Type: research
