Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Res Bull. 2024 Apr 25:110955. doi: 10.1016/j.brainresbull.2024.110955. Online ahead of print.ABSTRACTIn clinical trials for Alzheimer's disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as monotherapy. Interference of cholinesterase inhibition with HMTM was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of HMTM at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate rel...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Karima Schwab Dilyara Lauer Mandy Magbagbeolu Franz Theuring Anna Gasiorowska Maciej Zadrozny Charles R Harrington Claude M Wischik Gra żyna Niewiadomska Gernot Riedel Source Type: research
Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices
Toxicol Appl Pharmacol. 2024 Apr 25:116941. doi: 10.1016/j.taap.2024.116941. Online ahead of print.ABSTRACTNitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung injury which can progress to chronic disease. Due to the complex nature of NM injury, it has been difficult to analyze early responses of resident lung cells that initiate inflammation and disease progression. To investigate this, we developed a model of acute NM toxicity using murine precision cut lung slices (PCLS), which contain all resident lung cell populations. PCLS were exposed to NM (1-100 μM) for 0.5-3 h and analyzed 1 a...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Alyssa Bellomo Julia Herbert Melissa J Kudlak Jeffrey D Laskin Andrew J Gow Debra L Laskin Source Type: research
Multi-omics analysis identifies sex-specific hepatic protein-metabolite networks in yellow catfish (Pelteobagrus fulvidraco) exposed to chronic hypoxia
Int J Biol Macromol. 2024 Apr 25:131892. doi: 10.1016/j.ijbiomac.2024.131892. Online ahead of print.ABSTRACTHypoxia disrupts the endocrine system of teleosts. The liver plays important roles in the endocrine system, energy storage, and metabolic processes. The aim of this study was to investigate the sex-specific hepatic response of yellow catfish under chronic hypoxia at the multi-omics level. Common hepatic responses in both sexes included the HIF-1 signaling pathway, glycolysis/gluconeogenesis, and steroid biosynthesis. Hypoxia dysregulated primary bile acid biosynthesis, lipid metabolism, and vitellogenin levels in fem...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Cheng Zhao Yufeng Song Guosong Zhang Kai Zhang Shaowu Yin Jie Ji Source Type: research
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer's Disease
Curr Top Med Chem. 2024 Apr 25. doi: 10.2174/0115680266296001240327090111. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most prevalent form of neurodegenerative disorder (ND), affecting more than 44 million individuals globally as of 2023. It is characterized by cognitive dysfunction and an inability to perform daily activities. The progression of AD is associated with the accumulation of amyloid beta (Aβ), the formation of neurofibrillary tangles (NFT), increased oxidative stress, neuroinflammation, mitochondrial dysfunction, and endoplasmic reticulum stress. Presently, various phytomedicines and their b...
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Sukriti Vishwas Bushra Bashir Devendra Birla Nikhil Khandale Motamarri Venkata Naga Lalitha Chaitanya Dinesh Kumar Chellappan Gaurav Gupta Poonam Negi Kamal Dua Sachin Kumar Singh Source Type: research
Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function
Food Chem Toxicol. 2024 Apr 25:114681. doi: 10.1016/j.fct.2024.114681. Online ahead of print.ABSTRACTThe methylimidazolium ionic liquid M8OI (1-octyl-3-methylimidazolium chloride, also known as [C8mim]Cl) has been detected in the environment and may represent a hazard trigger for the autoimmune liver disease primary biliary cholangitis, based in part on studies using a rat liver progenitor cell. The effect of M8OI on an equivalent human liver progenitor (undifferentiated HepaRG cells; u-HepaRG) was therefore examined. u-HepaRG cells were less sensitive (>20-fold) to the toxic effects of M8OI. The relative insensitivity ...
Source: Food and Chemical Toxicology - April 27, 2024 Category: Food Science Authors: Tarek M Abdelghany Shireen A Hedya Alex Charlton Fahad A Aljehani Khalid Alanazi Alaa A Budastour Larissa Marin Matthew C Wright Source Type: research
Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
Protein Cell. 2024 Apr 27:pwae020. doi: 10.1093/procel/pwae020. Online ahead of print.ABSTRACTCaspase-2, a highly conserved member of the caspase family, is considered an initiator caspase that triggers apoptosis in response to some cellular stresses. Previous studies suggest that an intracellular multi-protein complex PIDDosome, induced by genotoxic stress, serves as a platform for caspase-2 activation. However, due to caspase-2's inability to process effector caspases, the mechanism underlying caspase-2-mediated cell death upon PIDDosome activation remains unclear. Here we conducted an unbiased genome-wide genetic screen...
Source: Protein and Cell - April 27, 2024 Category: Cytology Authors: Mengxue Zeng Kun Wang Qingcui Wu Jingjin Ding Dan Xie Xiangbing Qi Feng Shao Source Type: research
Role of intracranial bone marrow mesenchymal stem cells in stroke recovery: A focus on post-stroke inflammation and mitochondrial transfer
Brain Res. 2024 Apr 25;1837:148964. doi: 10.1016/j.brainres.2024.148964. Online ahead of print.ABSTRACTStem cell therapy has become a hot research topic in the medical field in recent years, with enormous potential for treating a variety of diseases. In particular, bone marrow mesenchymal stem cells (BMSCs) have wide-ranging applications in the treatment of ischemic stroke, autoimmune diseases, tissue repair, and difficult-to-treat diseases. BMSCs can differentiate into multiple cell types and exhibit strong immunomodulatory properties. Although BMSCs can regulate the inflammatory response activated after stroke, the mecha...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Jiang Ming Yidong Liao Wenxue Song Zili Wang Junshuan Cui Longcai He Guangtang Chen Kaya Xu Source Type: research
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Res Bull. 2024 Apr 25:110955. doi: 10.1016/j.brainresbull.2024.110955. Online ahead of print.ABSTRACTIn clinical trials for Alzheimer's disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as monotherapy. Interference of cholinesterase inhibition with HMTM was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of HMTM at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate rel...
Source: Brain Research - April 27, 2024 Category: Neurology Authors: Karima Schwab Dilyara Lauer Mandy Magbagbeolu Franz Theuring Anna Gasiorowska Maciej Zadrozny Charles R Harrington Claude M Wischik Gra żyna Niewiadomska Gernot Riedel Source Type: research
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Brain Res Bull. 2024 Apr 25:110955. doi: 10.1016/j.brainresbull.2024.110955. Online ahead of print.ABSTRACTIn clinical trials for Alzheimer's disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as monotherapy. Interference of cholinesterase inhibition with HMTM was observed also in a tau transgenic mouse model, where rivastigmine reduced the pharmacological activity of HMTM at multiple brain levels including hippocampal acetylcholine release, synaptosomal glutamate rel...
Source: Brain Research Bulletin - April 27, 2024 Category: Neurology Authors: Karima Schwab Dilyara Lauer Mandy Magbagbeolu Franz Theuring Anna Gasiorowska Maciej Zadrozny Charles R Harrington Claude M Wischik Gra żyna Niewiadomska Gernot Riedel Source Type: research
Multi-omics analysis identifies sex-specific hepatic protein-metabolite networks in yellow catfish (Pelteobagrus fulvidraco) exposed to chronic hypoxia
Int J Biol Macromol. 2024 Apr 25:131892. doi: 10.1016/j.ijbiomac.2024.131892. Online ahead of print.ABSTRACTHypoxia disrupts the endocrine system of teleosts. The liver plays important roles in the endocrine system, energy storage, and metabolic processes. The aim of this study was to investigate the sex-specific hepatic response of yellow catfish under chronic hypoxia at the multi-omics level. Common hepatic responses in both sexes included the HIF-1 signaling pathway, glycolysis/gluconeogenesis, and steroid biosynthesis. Hypoxia dysregulated primary bile acid biosynthesis, lipid metabolism, and vitellogenin levels in fem...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Cheng Zhao Yufeng Song Guosong Zhang Kai Zhang Shaowu Yin Jie Ji Source Type: research
Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices
Toxicol Appl Pharmacol. 2024 Apr 25:116941. doi: 10.1016/j.taap.2024.116941. Online ahead of print.ABSTRACTNitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung injury which can progress to chronic disease. Due to the complex nature of NM injury, it has been difficult to analyze early responses of resident lung cells that initiate inflammation and disease progression. To investigate this, we developed a model of acute NM toxicity using murine precision cut lung slices (PCLS), which contain all resident lung cell populations. PCLS were exposed to NM (1-100 μM) for 0.5-3 h and analyzed 1 a...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Alyssa Bellomo Julia Herbert Melissa J Kudlak Jeffrey D Laskin Andrew J Gow Debra L Laskin Source Type: research
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer's Disease
Curr Top Med Chem. 2024 Apr 25. doi: 10.2174/0115680266296001240327090111. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most prevalent form of neurodegenerative disorder (ND), affecting more than 44 million individuals globally as of 2023. It is characterized by cognitive dysfunction and an inability to perform daily activities. The progression of AD is associated with the accumulation of amyloid beta (Aβ), the formation of neurofibrillary tangles (NFT), increased oxidative stress, neuroinflammation, mitochondrial dysfunction, and endoplasmic reticulum stress. Presently, various phytomedicines and their b...
Source: Current Topics in Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Sukriti Vishwas Bushra Bashir Devendra Birla Nikhil Khandale Motamarri Venkata Naga Lalitha Chaitanya Dinesh Kumar Chellappan Gaurav Gupta Poonam Negi Kamal Dua Sachin Kumar Singh Source Type: research
Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
Protein Cell. 2024 Apr 27:pwae020. doi: 10.1093/procel/pwae020. Online ahead of print.ABSTRACTCaspase-2, a highly conserved member of the caspase family, is considered an initiator caspase that triggers apoptosis in response to some cellular stresses. Previous studies suggest that an intracellular multi-protein complex PIDDosome, induced by genotoxic stress, serves as a platform for caspase-2 activation. However, due to caspase-2's inability to process effector caspases, the mechanism underlying caspase-2-mediated cell death upon PIDDosome activation remains unclear. Here we conducted an unbiased genome-wide genetic screen...
Source: Protein and Cell - April 27, 2024 Category: Cytology Authors: Mengxue Zeng Kun Wang Qingcui Wu Jingjin Ding Dan Xie Xiangbing Qi Feng Shao Source Type: research
The crosstalk between mitochondrial quality control and metal-dependent cell death
Cell Death & Disease, Published online: 27 April 2024; doi:10.1038/s41419-024-06691-wThe crosstalk between mitochondrial quality control and metal-dependent cell death (Source: Cell death and disease)
Source: Cell death and disease - April 27, 2024 Category: Internal Medicine Authors: Qi-yuan Zhou Chao Ren Jing-yan Li Lu Wang Yu Duan Ren-qi Yao Ying-ping Tian Yong-ming Yao Source Type: research
Ketogenic Diets Hold Therapeutic Potential Against Periodontal Inflammation
AbstractPurpose of ReviewPeriodontitis, one of the most prevalent diseases in the world, is caused by the accumulation of dysbiotic microbial biofilm on the teeth leading to chronic inflammation of the tissues surrounding the teeth. Type 2 diabetes mellitus (T2DM), obesity, chronic stress, and smoking are some of the risk factors for the disease. A high-carbohydrate diet also increases the risk of periodontal inflammation. Modifying diet and nutrition could serve as a preventive and therapeutic tool to target multiple risk factors simultaneously.Recent FindingsEmerging evidence shows that the ketogenic diet induces hormeti...
Source: Current Oral Health Reports - April 27, 2024 Category: Dentistry Source Type: research
