In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity
PLoS Pathog. 2024 Apr 26;20(4):e1012146. doi: 10.1371/journal.ppat.1012146. eCollection 2024 Apr.ABSTRACTApoptosis is a critical host antiviral defense mechanism. But many viruses have evolved multiple strategies to manipulate apoptosis and escape host antiviral immune responses. Herpesvirus infection regulated apoptosis; however, the underlying molecular mechanisms have not yet been fully elucidated. Hence, the present study aimed to study the relationship between herpesvirus infection and apoptosis in vitro and in vivo using the pseudorabies virus (PRV) as the model virus. We found that mitochondria-dependent apoptosis w...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Qiongqiong Zhou Deshi Shi Yan-Dong Tang Longfeng Zhang Boli Hu Chunfu Zheng Li Huang Changjiang Weng Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Curr Issues Mol Biol. 2024 Mar 30;46(4):3022-3038. doi: 10.3390/cimb46040189.ABSTRACTA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized. This might pose a threat, especially to critically ill patients, as they often receive high cumulative doses for daily analgosedation and often already have impaired liver function due to an underlying disease or complications during treatment. A well-established biosensor based on HepG2/C3A cells was used for the determination of the hepatotoxicity of commonly used sedatives an...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Katharina Haller Sandra Do ß Martin Sauer Source Type: research
GSE264648 Characterization of premature cell senescence in Alzheimer ’s disease using single nuclear transcriptomics
Contributors : Nurun Fancy ; Amy M Smith ; Alessia Caramello ; Stergios Tsartsalis ; Karen Davey ; Robert C Muirhead ; Aisling McGarry ; Marion Jenkins ; Eleonore Schneegans ; Vicky Chau ; Michael Thomas ; Sam Boulger ; To K Cheung ; Emily Adair ; Marianna Papageorgopoulou ; Nanet Willumsen ; Combiz Khozoie ; Diego Gomez-Nicola ; Johanna Jackson ; Paul M MatthewsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAging is associated with cell senescence and is the major risk factor for AD. We characterized premature cell senescence in post mortem brains from non-diseased c...
Source: GEO: Gene Expression Omnibus - April 26, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Molecules, Vol. 29, Pages 2005: Potential Targets of Natural Products for Improving Cardiac Ischemic Injury: The Role of Nrf2 Signaling Transduction
Zhang
Myocardial ischemia is the leading cause of health loss from cardiovascular disease worldwide. Myocardial ischemia and hypoxia during exercise trigger the risk of sudden exercise death which, in severe cases, will further lead to myocardial infarction. The Nrf2 transcription factor is an important antioxidant regulator that is extensively engaged in biological processes such as oxidative stress, inflammatory response, apoptosis, and mitochondrial malfunction. It has a significant role in the prevention and treatment of several cardiovascular illnesses, since it can control not only the expression of several an...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Wang Han Dmitrii Zhang Tags: Review Source Type: research
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction
The progression of diabetic cardiomyopathy (DCM) is noticeably influenced by mitochondrial dysfunction. Variants of caveolin 3 (CAV3) play important roles in cardiovascular diseases. However, the potential rol... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 26, 2024 Category: Research Authors: Ping Guo, Shuiqing Hu, Xiaohui Liu, Miaomiao He, Jie Li, Tingqiong Ma, Man Huang, Qin Fang and Yan Wang Tags: Research Source Type: research
SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
CONCLUSIONS: Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.PMID:38660786 | DOI:10.1161/CIRCULATIONAHA.123.066879 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Anna Kovilakath Adolfo G Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J Windle Mark A Subler Davi Source Type: research
SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
CONCLUSIONS: Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.PMID:38660786 | DOI:10.1161/CIRCULATIONAHA.123.066879 (Source: Circulation)
Source: Circulation - April 25, 2024 Category: Cardiology Authors: Anna Kovilakath Adolfo G Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J Windle Mark A Subler Davi Source Type: research
Proteomics, Human Environmental Exposure, and Cardiometabolic Risk
Conclusions: Environmental exposures are related to an inflammatory-metabolic proteome, which identifies individuals with CMD and respiratory phenotypes and outcomes. Future work examining the dynamic impact of the environment on human cardiometabolic health is warranted.PMID:38662804 | DOI:10.1161/CIRCRESAHA.124.324559 (Source: Circulation Research)
Source: Circulation Research - April 25, 2024 Category: Cardiology Authors: Andrew S Perry Kai Zhang Venkatesh L Murthy Bina Choi Shilin Zhao Priya Gajjar Laura A Colangelo Lifang Hou Mary Rice John Jeffrey Carr April P Carson Anne E Nigra Ramachandran S Vasan Robert E Gerszten Sadiya S Khan Ravi Kalhan Matthew Nayor Ravi V Shah Source Type: research
Acetyl-CoA-dependent ac < sup > 4 < /sup > C acetylation promotes the osteogenic differentiation of LPS-stimulated BMSCs
Int Immunopharmacol. 2024 Apr 24;133:112124. doi: 10.1016/j.intimp.2024.112124. Online ahead of print.ABSTRACTThe impaired osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) caused by persistent inflammation is the main pathogenesis of inflammatory bone diseases. Recent studies show that metabolism is disturbed in osteogenically differentiated BMSCs in response to Lipopolysaccharide (LPS) treatment, while the mechanism involved remains incompletely revealed. Herein, we demonstrated that BMSCs adapted their metabolism to regulate acetyl-coenzyme A (acetyl-CoA) availability and RNA acetylation level, ultimat...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yujia Bai Wenjie Zhang Lili Hao Yiqing Zhao I-Chen Tsai Yipin Qi Qiong Xu Source Type: research
Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor
Brain Behav Immun. 2024 Apr 23:S0889-1591(24)00384-2. doi: 10.1016/j.bbi.2024.04.035. Online ahead of print.ABSTRACTElucidating mechanisms by which early-life adversity (ELA) contributes to increased disease risk is important for mitigating adverse health outcomes. Prior work has found differences in immune cell gene expression related to inflammation and mitochondrial activity. Using a within-person between-group experimental design, we investigated differences in gene expression clusters across acute psychosocial stress and no-stress conditions. Participants were young adults (N = 29, aged 18 - 25 years, 62 % female, 47 ...
Source: Brain, Behavior, and Immunity - April 25, 2024 Category: Neurology Authors: Laura Etzel Abner T Apsley Waylon J Hastings Qiaofeng Ye Idan Shalev Source Type: research
Acetyl-CoA-dependent ac < sup > 4 < /sup > C acetylation promotes the osteogenic differentiation of LPS-stimulated BMSCs
Int Immunopharmacol. 2024 Apr 24;133:112124. doi: 10.1016/j.intimp.2024.112124. Online ahead of print.ABSTRACTThe impaired osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) caused by persistent inflammation is the main pathogenesis of inflammatory bone diseases. Recent studies show that metabolism is disturbed in osteogenically differentiated BMSCs in response to Lipopolysaccharide (LPS) treatment, while the mechanism involved remains incompletely revealed. Herein, we demonstrated that BMSCs adapted their metabolism to regulate acetyl-coenzyme A (acetyl-CoA) availability and RNA acetylation level, ultimat...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yujia Bai Wenjie Zhang Lili Hao Yiqing Zhao I-Chen Tsai Yipin Qi Qiong Xu Source Type: research
Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor
Brain Behav Immun. 2024 Apr 23:S0889-1591(24)00384-2. doi: 10.1016/j.bbi.2024.04.035. Online ahead of print.ABSTRACTElucidating mechanisms by which early-life adversity (ELA) contributes to increased disease risk is important for mitigating adverse health outcomes. Prior work has found differences in immune cell gene expression related to inflammation and mitochondrial activity. Using a within-person between-group experimental design, we investigated differences in gene expression clusters across acute psychosocial stress and no-stress conditions. Participants were young adults (N = 29, aged 18 - 25 years, 62 % female, 47 ...
Source: Brain, Behavior, and Immunity - April 25, 2024 Category: Neurology Authors: Laura Etzel Abner T Apsley Waylon J Hastings Qiaofeng Ye Idan Shalev Source Type: research
