Mechanistic insights and emerging therapeutic stratagems for Alzheimer's disease
Ageing Res Rev. 2024 Apr 12:102309. doi: 10.1016/j.arr.2024.102309. Online ahead of print.ABSTRACTAlzheimer's disease (AD), a multi-factorial neurodegenerative disorder has affected over 30 million individuals globally and these numbers are expected to increase in the coming decades. Current therapeutic interventions are largely ineffective as they focus on a single target. Development of an effective drug therapy requires a deep understanding of the various factors influencing the onset and progression of the disease. Aging and genetic factors exert a major influence on the development of AD. Other factors like post-viral...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Kayalvizhi Rajendran Uma Maheswari Krishnan Source Type: research
Carnitine palmitoyltransferase II (CPT II) deficiency responsible for refractory cardiac arrhythmias, acute multiorgan failure and early fatal outcome
ConclusionsCPTII deficiency may be suspected in newborns showing cardiac arrhythmias, associated or not with hypertrophic cardiomyopathy, polycystic kidneys, brain malformations, hepatomegaly. Its diagnosis should be even more suspected and investigated in cases of increased plasmatic levels of creatine phosphokinase and acylcarnitines in addition to kidney, heart and liver dysfunctions, as occurred in the present patient. Accurate family history, extended metabolic screening, and multidisciplinary approach are necessary for diagnosis and adequate management of affected subjects. Next generation sequencing (NGS) techniques...
Source: Italian Journal of Pediatrics - April 14, 2024 Category: Pediatrics Source Type: research
Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer ’s disease, in Down syndrome, and in mouse models of these conditions. We ha... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 14, 2024 Category: Neurology Authors: Pasquale D ’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio and Efrat Levy Tags: Research article Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases
Ageing Res Rev. 2024 Apr 11:102307. doi: 10.1016/j.arr.2024.102307. Online ahead of print.ABSTRACTSleep is a highly intricate biological phenomenon, and its disorders play a pivotal role in numerous diseases. However, the specific regulatory mechanisms remain elusive. In recent years, the role of mitochondria in sleep disorders has gained considerable attention. Sleep deprivation not only impairs mitochondrial morphology but also decreases the number of mitochondria and triggers mitochondrial dysfunction. Furthermore, mitochondrial dysfunction has been implicated in the onset and progression of various sleep disorder-relat...
Source: Ageing Research Reviews - April 13, 2024 Category: Genetics & Stem Cells Authors: Wentao Zhang Dan Liu Mei Yuan Ling-Qiang Zhu Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease
CONCLUSION: These findings suggested that LY96 might be a novel potential biomarker for PD, and offer insights into its immunoregulatory role.PMID:38614225 | DOI:10.1016/j.exger.2024.112415 (Source: Experimental Gerontology)
Source: Experimental Gerontology - April 13, 2024 Category: Geriatrics Authors: Haoran Peng Longyu Wu Siyuan Chen Shaopu Wu Xiaoxue Shi Jianjun Ma Hongqi Yang Xue Li Source Type: research
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases
Ageing Res Rev. 2024 Apr 11:102307. doi: 10.1016/j.arr.2024.102307. Online ahead of print.ABSTRACTSleep is a highly intricate biological phenomenon, and its disorders play a pivotal role in numerous diseases. However, the specific regulatory mechanisms remain elusive. In recent years, the role of mitochondria in sleep disorders has gained considerable attention. Sleep deprivation not only impairs mitochondrial morphology but also decreases the number of mitochondria and triggers mitochondrial dysfunction. Furthermore, mitochondrial dysfunction has been implicated in the onset and progression of various sleep disorder-relat...
Source: Ageing Research Reviews - April 13, 2024 Category: Genetics & Stem Cells Authors: Wentao Zhang Dan Liu Mei Yuan Ling-Qiang Zhu Source Type: research
Preface: Special issue: 14th International Conference on Brain Energy Metabolism: Energy substrates and microbiome govern brain bioenergetics and cognitive function with aging
This special issue, entitled “Energetics and cognition in aging brain: Impact of substrates and microbiome”, contains manuscripts from attendees at the 14th International Conference on Brain Energy Metabolism (ICBEM) held in Santa Fe, New Mexico, USA, October 24–27, 2022. Major topics include neuronal and mitochondrial en ergetics, higher brain functions involving astrocyte-neuron interactions, unique roles for glycogen, glycolytic upregulation during activation, determination of metabolite levels with genetically-encoded biosensors, dietary intervention in aging, gut-brain signaling, spreading depolarization and fun...
Source: Journal of Neurochemistry - April 13, 2024 Category: Neuroscience Authors: Mary C. McKenna,
In ‐Young Choi,
Arne Schousboe Tags: REVIEW Source Type: research
Succinic Acid Ameliorates Concanavalin A-Induced Hepatitis by Altering the Inflammatory Microenvironment and Expression of BCL-2 Family Proteins
This study provides novel insights into the biological functions and therapeutic potential of succinic acid in the treatment of autoimmune liver injury. (Source: Inflammation)
Source: Inflammation - April 13, 2024 Category: Allergy & Immunology Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson's
In this study, we have holistically determined the differential expression of all the nuclear receptors (NRs) in the presence of classical ER stress inducers. Activation of Nr1h4 and Thrb by their cognate ligands (GW4064 and T3) ameliorates the tunicamycin (TM)-induced expression of ER stress genes. A combination of both ligands is effective in mitigating cell death induced by TM. Further exploration of their protective effects in the Parkinson's disease (PD) model shows that they reduce MPP+-induced dissipation of mitochondrial membrane potential and ROS generation in an in vitro PD model in neuronal cells. Furthermore, t...
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Nancy Ahuja Shalini Gupta Rashmi Arora Ella Bhagyaraj Drishti Tiwari Sumit Kumar Pawan Gupta Source Type: research
Microbiome Profile of South Korean Vector Mosquitoes
This study sheds light on the complex interactions between mosquitoes and their microbiome, revealing potential implications for vector competence, disease transmission, and vector control strategies.PMID:38608996 | DOI:10.1016/j.actatropica.2024.107213 (Source: Acta Tropica)
Source: Acta Tropica - April 12, 2024 Category: Infectious Diseases Authors: Ashraf Akintayo Akintola Ui Wook Hwang Source Type: research
Design, synthesis, and evaluation of formylpiperazine analogs of Ferrostatin-1 as novel improved ferroptosis inhibitors
In this study, a series of new formylpiperazine-derived ferroptosis inhibitors were designed and synthesized based on the structure of a known ferroptosis inhibitor, ferrostatin-1 (Fer-1). The anti-ferroptosis activity of these synthetic compounds in human umbilical vein endothelial cells (HUVECs) induced by Erastin was evaluated. It was found that some of the new compounds, especially compound 26, showed potent anti-ferroptosis activity, as evidenced by its ability to restore cell viability, reduce iron accumulation, scavenge reactive oxygen species, maintain mitochondrial membrane potential, increase GSH levels, decrease...
Source: Bioorganic and Medicinal Chemistry - April 12, 2024 Category: Chemistry Authors: Hua-Long Ji Yi-Fan Zhang Nai-Yu Zhang Kai-Ming Wang Ning Meng Juan Zhang Cheng-Shi Jiang Source Type: research
