Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci
Progressive supranuclear palsy (PSP) is a parkinsonian neurodegenerative tauopathy affecting brain regions involved in motor function, including the basal ganglia, diencephalon and brainstem. While PSP is larg... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 9, 2018 Category: Neurology Authors: Monica Y. Sanchez-Contreras, Naomi Kouri, Casey N. Cook, Daniel J. Serie, Michael G. Heckman, NiCole A. Finch, Richard J. Caselli, Ryan J. Uitti, Zbigniew K. Wszolek, Neill Graff-Radford, Leonard Petrucelli, Li-San Wang, Gerard D. Schellenberg, Dennis W. Tags: Research article Source Type: research

Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China
Hereditary spastic paraplegias (HSP) is a heterogeneous group of rare neurodegenerative disorders affecting the corticospinal tracts. To date, more than 78 HSP loci have been mapped to cause HSP. However, both... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 6, 2018 Category: Neurology Authors: En-Lin Dong, Chong Wang, Shuang Wu, Ying-Qian Lu, Xiao-Hong Lin, Hui-Zhen Su, Miao Zhao, Jin He, Li-Xiang Ma, Ning Wang, Wan-Jin Chen and Xiang Lin Tags: Research article Source Type: research

TMEM106B haplotypes have distinct gene expression patterns in aged brain
Single nucleotide polymorphisms (SNPs) inherited as one of two common haplotypes at the transmembrane protein 106B (TMEM106B) locus are associated with the risk of multiple neurodegenerative diseases, including f... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 3, 2018 Category: Neurology Authors: Yingxue Ren, Marka van Blitterswijk, Mariet Allen, Minerva M. Carrasquillo, Joseph S. Reddy, Xue Wang, Thomas G. Beach, Dennis W. Dickson, Nil üfer Ertekin-Taner, Yan W. Asmann and Rosa Rademakers Tags: Research article Source Type: research

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer ’s disease-related proteins
Microglia are innate immune cells of the brain that perform phagocytic and inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated microglia have provided novel insights into t... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 28, 2018 Category: Neurology Authors: Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Ranjita Betarbet, Duc M. Duong, James A. Webster, Chadwick M. Hales, James J. Lah, Allan I. Levey and Nicholas T. Seyfried Tags: Research article Source Type: research

iPSC-derived familial Alzheimer ’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling
Type 2 diabetes (T2D) is a recognized risk factor for the development of cognitive impairment (CI) and/or dementia, although the exact nature of the molecular pathology of T2D-associated CI remains obscure. On... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 26, 2018 Category: Neurology Authors: Cesar L. Moreno, Lucio Della Guardia, Valeria Shnyder, Maitane Ortiz-Virumbrales, Ilya Kruglikov, Bin Zhang, Eric E. Schadt, Rudolph E. Tanzi, Scott Noggle, Christoph Buettner and Sam Gandy Tags: Research article Source Type: research

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency
Loss of function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD). Progranulin is a secreted glycoprotein that localizes to lysosomes and is critical for proper lysosomal function... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 22, 2018 Category: Neurology Authors: Andrew E. Arrant, Alexandra M. Nicholson, Xiaolai Zhou, Rosa Rademakers and Erik D. Roberson Tags: Research article Source Type: research

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model
Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in tra... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 22, 2018 Category: Neurology Authors: Lodewijk J. A. Toonen, Maurice Overzier, Melvin M. Evers, Leticia G. Leon, Sander A. J. van der Zeeuw, Hailiang Mei, Szymon M. Kielbasa, Jelle J. Goeman, Kristina M. Hettne, Olafur Th. Magnusson, Marion Poirel, Alexandre Seyer, Peter A. C. ‘t Hoen and W Tags: Research article Source Type: research

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer ’s disease
The R47H variant of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) confers greatly increased risk for Alzheimer ’s disease (AD), reflective of a central role for myeloid cells in neurodegeneration. Un... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 1, 2018 Category: Neurology Authors: Paul J. Cheng-Hathaway, Erin G. Reed-Geaghan, Taylor R. Jay, Brad T. Casali, Shane M. Bemiller, Shweta S. Puntambekar, Victoria E. von Saucken, Roxanne Y. Williams, J. Colleen Karlo, Miguel Moutinho, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb and Ga Tags: Research article Source Type: research

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis
Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but u... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 1, 2018 Category: Neurology Authors: Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath and Vladimir L. Buchman Tags: Research article Source Type: research

Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration
Several molecular pathways are currently being targeted in attempts to develop disease-modifying therapies to slow down neurodegeneration in Parkinson ’s disease. Failure of cellular energy metabolism has long ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 24, 2018 Category: Neurology Authors: Emmanuel Quansah, Wouter Peelaerts, J. William Langston, David K. Simon, Jerry Colca and Patrik Brundin Tags: Review Source Type: research

2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling
Neurodegenerative diseases, such as Alzheimer ’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people every year and so far, there... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 22, 2018 Category: Neurology Authors: Eduarda G Z Centeno, Helena Cimarosti and Angela Bithell Tags: Review Source Type: research

Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson ’s disease
Administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) increases regulatory T cell (Treg) number and function with control of neuroinflammation and neuronal protection in the 1-methyl-4-ph... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 21, 2018 Category: Neurology Authors: Charles R. Schutt, Howard E. Gendelman and R. Lee Mosley Tags: Research article Source Type: research

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the mutant huntingtin protein (mHtt), which is known to disrupt a multitude of... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 21, 2018 Category: Neurology Authors: Rebecca Kusko, Jennifer Dreymann, Jermaine Ross, Yoonjeong Cha, Renan Escalante-Chong, Marta Garcia-Miralles, Liang Juin Tan, Michael E. Burczynski, Ben Zeskind, Daphna Laifenfeld, Mahmoud Pouladi, Michal Geva, Iris Grossman and Michael R. Hayden Tags: Research article Source Type: research

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer ’s disease
Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in Alzheimer ’s disease (AD). An understanding of heterogenei... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 21, 2018 Category: Neurology Authors: Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Priyadharshini Rathakrishnan, Hailian Xiao, Tianwen Gao, Duc M. Duong, Michael W. Pennington, James J. Lah, Nicholas T. Seyfried and Allan I. Levey Tags: Research article Source Type: research

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
Prior studies in C. elegans demonstrated that the expression of aggregation-prone polyglutamine proteins in muscle wall cells compromised the folding of co-expressed temperature-sensitive proteins, prompting inte... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 18, 2018 Category: Neurology Authors: Michael C. Pace, Guilian Xu, Susan Fromholt, John Howard, Benoit I. Giasson, Jada Lewis and David R. Borchelt Tags: Research article Source Type: research

AMPA-ergic regulation of amyloid- β levels in an Alzheimer’s disease mouse model
Extracellular aggregation of the amyloid- β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 15, 2018 Category: Neurology Authors: Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman and John R. Cirrito Tags: Research article Source Type: research

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
Intraneuronal α-synuclein (α-Syn) aggregates known as Lewy bodies (LBs) and the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the pathological hallmarks of Parkinson’s disease (... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 11, 2018 Category: Neurology Authors: Norihito Uemura, Hisashi Yagi, Maiko T. Uemura, Yusuke Hatanaka, Hodaka Yamakado and Ryosuke Takahashi Tags: Research article Source Type: research

Vibrational spectroscopy: a promising approach to discriminate neurodegenerative disorders
Neurodegenerative diseases are a growing burden in modern society, thus crucially calling for the development of accurate diagnostic strategies. These diseases are currently incurable, a fact which has been at... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 2, 2018 Category: Neurology Authors: Maria Paraskevaidi, Pierre L. Martin-Hirsch and Francis L. Martin Tags: Commentary Source Type: research

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa
Retinitis pigmentosa (RP) is a group of hereditary retinal neurodegenerative conditions characterized by primary dysfunction and death of photoreceptor cells, resulting in visual loss and, eventually, blindnes... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 16, 2018 Category: Neurology Authors: Alonso S ánchez-Cruz, Beatriz Villarejo-Zori, Miguel Marchena, Josefa Zaldivar-Díez, Valle Palomo, Carmen Gil, Ignacio Lizasoain, Pedro de la Villa, Ana Martínez, Enrique J. de la Rosa and Catalina Hernández-Sánchez Tags: Research article Source Type: research

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein
Proteolytic processing of the prion protein (PrPC) by endogenous proteases generates bioactive membrane-bound and soluble fragments which may help to explain the pleiotropic roles of this protein in the nervous s... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 6, 2018 Category: Neurology Authors: Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, J örg Tatzelt, Paul Saftig, Markus Glatzel and Hermann C. Altmeppen Tags: Research article Source Type: research

Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury
Traumatic Brain Injury (TBI) is a major cause of disability and mortality, to which there is currently no comprehensive treatment. Blood Brain Barrier (BBB) dysfunction is well documented in human TBI patients... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 4, 2018 Category: Neurology Authors: Bevan S. Main, Sonia Villapol, Stephanie S. Sloley, David J. Barton, Maia Parsadanian, Chinyere Agbaegbu, Kathryn Stefos, Mondona S. McCann, Patricia M. Washington, Olga C. Rodriguez and Mark P. Burns Tags: Research article Source Type: research

Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration
Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related d... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 4, 2018 Category: Neurology Authors: Todd McLaughlin, Marek Falkowski, Jae Whan Park, Stephen Keegan, Michael Elliott, Joshua J. Wang and Sarah X. Zhang Tags: Research article Source Type: research

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer ’s disease (AD) and other neurodegenerative diseases. Whi... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 27, 2018 Category: Neurology Authors: Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu and Xiao-Fen Chen Tags: Research article Source Type: research

Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells
Metabolically-obese, normal-weight (MONW) individuals are not obese in terms of weight and height but have a number of obesity-related features (e.g. greater visceral adiposity, insulin resistance, and increas... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 22, 2018 Category: Neurology Authors: Margalida Cifre, Andreu Palou and Paula Oliver Tags: Research article Source Type: research

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
We have evaluated the efficacy of targeting the toxic, oligomeric form of tau protein by passive immunotherapy in a mouse model of synucleinopathy. Parkinson ’s disease and Lewy body dementia are two of the mos... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 15, 2018 Category: Neurology Authors: Julia E. Gerson, Kathleen M. Farmer, Natalie Henson, Diana L. Castillo-Carranza, Mariana Carretero Murillo, Urmi Sengupta, Alan Barrett and Rakez Kayed Tags: Research article Source Type: research

Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia
Degeneration of cone photoreceptors leads to loss of vision in patients suffering from age-related macular degeneration (AMD) and other cone dystrophies. Evidence, such as choroidal ischemia and decreased chor... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 7, 2018 Category: Neurology Authors: Maya Barben, Christian Schori, Marijana Samardzija and Christian Grimm Tags: Research article Source Type: research

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer ’s disease
Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheim... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 1, 2018 Category: Neurology Authors: Justyna Sosna, Stephan Philipp, Ricardo Albay III, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M. LaFerla and Charles G. Glabe Tags: Research article Source Type: research

Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice
Dynactin p150Glued, the largest subunit of the dynactin macromolecular complex, binds to both microtubules and tubulin dimers through the N-terminal cytoskeleton-associated protein and glycine-rich (CAP-Gly) and ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 1, 2018 Category: Neurology Authors: Jia Yu, Chen Lai, Hoon Shim, Chengsong Xie, Lixin Sun, Cai-Xia Long, Jinhui Ding, Yan Li and Huaibin Cai Tags: Research article Source Type: research

Extracellular α-synuclein levels are regulated by neuronal activity
α-Synuclein is a presynaptic protein abundant in the cytoplasmic compartment of neurons, whereas its presence in the extracellular space has also been observed under physiological conditions. Extracellular α-s... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 22, 2018 Category: Neurology Authors: Kaoru Yamada and Takeshi Iwatsubo Tags: Short report Source Type: research

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson ’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that m... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 13, 2018 Category: Neurology Authors: Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, Ho Chul Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Valina L. Dawson, Ted M. Dawson, Eun-Mi Hur and Byoung Dae Lee Tags: Research article Source Type: research

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration
Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein dep... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 6, 2018 Category: Neurology Authors: Laura M. Taylor, Pamela J. McMillan, Nicole F. Liachko, Timothy J. Strovas, Bernardino Ghetti, Thomas D. Bird, C. Dirk Keene and Brian C. Kraemer Tags: Research article Source Type: research

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice
β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patie... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 2, 2018 Category: Neurology Authors: WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon and Giuseppina Tesco Tags: Research article Source Type: research

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex
Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD).... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 1, 2018 Category: Neurology Authors: Sirui Jiang, Priya Nandy, Wenzhang Wang, Xiaopin Ma, Jeffrey Hsia, Chunyu Wang, Zhenlian Wang, Mengyue Niu, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Ying Xu, Hyoung-gon Lee, George Perry, Jun Liu and Xiongwei Zhu Tags: Research article Source Type: research

Piperine ameliorates SCA17 neuropathology by reducing ER stress
Spinocerebellar ataxia 17 (SCA17) belongs to the family of neurodegenerative diseases caused by polyglutamine (polyQ) expansion. In SCA17, polyQ expansion occurs in the TATA box binding protein (TBP) and leads... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 30, 2018 Category: Neurology Authors: Jifeng Guo, Yiting Cui, Qiong Liu, Yang Yang, Yujing Li, Ling Weng, Beisha Tang, Peng Jin, Xiao-Jiang Li, Su Yang and Shihua Li Tags: Research article Source Type: research

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
Mutations in LRRK2 are a common genetic cause of Parkinson ’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centr... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 23, 2018 Category: Neurology Authors: Jes ús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Mun Tags: Research article Source Type: research

Molecular and functional signatures in a novel Alzheimer ’s disease mouse model assessed by quantitative proteomics
Alzheimer ’s disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathologic... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 16, 2018 Category: Neurology Authors: Dong Kyu Kim, Joonho Park, Dohyun Han, Jinhee Yang, Ahbin Kim, Jongmin Woo, Youngsoo Kim and Inhee Mook-Jung Tags: Research article Source Type: research

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson ’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 8, 2018 Category: Neurology Authors: Seung Pil Yun, Donghoon Kim, Sangjune Kim, SangMin Kim, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Saebom Lee, Tae-In Kam, Suhyun Lee, Sangwoo Ham, Jae Hong Park, Valina L. Dawson, Ted M. Dawson, Yunjong Lee and Han Seok Ko Tags: Research article Source Type: research

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders that share genetic risk factors and pathological hallmarks. Intriguingly, these shared factors result in a ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 28, 2017 Category: Neurology Authors: Zhiqiang Deng, Patricia Sheehan, Shi Chen and Zhenyu Yue Tags: Review Source Type: research

Practical considerations for choosing a mouse model of Alzheimer ’s disease
Alzheimer ’s disease (AD) is behaviorally identified by progressive memory impairment and pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and neurodegeneration. Genetic ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 22, 2017 Category: Neurology Authors: Joanna L. Jankowsky and Hui Zheng Tags: Review Source Type: research

Anti-aggregant tau mutant promotes neurogenesis
The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggrega... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 4, 2017 Category: Neurology Authors: Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow and Eva-Maria Mandelkow Tags: Research article Source Type: research

A validated antibody panel for the characterization of tau post-translational modifications
Tau is a microtubule-binding protein, which is subject to various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncati... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 21, 2017 Category: Neurology Authors: Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle and Dagmar E. Ehrnhoefer Tags: Research article Source Type: research

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer ’s disease
Alzheimer ’s disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 14, 2017 Category: Neurology Authors: Yang Bai, Miao Li, Yanmei Zhou, Lei Ma, Qian Qiao, Wanling Hu, Wei Li, Zachary Patrick Wills and Wen-Biao Gan Tags: Research article Source Type: research

NADPH oxidases in Parkinson ’s disease: a systematic review
Parkinson ’s disease (PD) is a progressive movement neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. Oxidative stress, a condition that occurs due t... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 13, 2017 Category: Neurology Authors: Karim Belarbi, Elodie Cuvelier, Alain Dest ée, Bernard Gressier and Marie-Christine Chartier-Harlin Tags: Review Source Type: research

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition where loss of motor neurons within the brain and spinal cord leads to muscle atrophy, weakness, paralysis and ultimately... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 13, 2017 Category: Neurology Authors: Yuri Ciervo, Ke Ning, Xu Jun, Pamela J. Shaw and Richard J. Mead Tags: Review Source Type: research

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebros... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 10, 2017 Category: Neurology Authors: Franc Llorens, Katrin Th üne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andr Tags: Research article Source Type: research

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer ’s disease
Oligodendrocytes (OLs) and myelin are critical for normal brain function and have been implicated in neurodegeneration. Several lines of evidence including neuroimaging and neuropathological data suggest that ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 6, 2017 Category: Neurology Authors: Andrew T. McKenzie, Sarah Moyon, Minghui Wang, Igor Katsyv, Won-Min Song, Xianxiao Zhou, Eric B. Dammer, Duc M. Duong, Joshua Aaker, Yongzhong Zhao, Noam Beckmann, Pei Wang, Jun Zhu, James J. Lah, Nicholas T. Seyfried, Allan I. Levey & hellip; Tags: Research article Source Type: research

Correction to: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice
ᅟ (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 3, 2017 Category: Neurology Authors: Anna K. Engstrom, Jessica M. Snyder, Nobuyo Maeda and Zhengui Xia Tags: Correction Source Type: research

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity
Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson ’s disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefo... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 3, 2017 Category: Neurology Authors: Wojciech Bobela, Sameer Nazeeruddin, Graham Knott, Patrick Aebischer and Bernard L. Schneider Tags: Research article Source Type: research

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders
Genome wide association studies have identified microtubule associated protein tau (MAPT) H1 haplotype single nucleotide polymorphisms (SNPs) as leading common risk variants for Parkinson ’s disease, progressive s... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 30, 2017 Category: Neurology Authors: Mang Ching Lai, Anne-Laure Bechy, Franziska Denk, Emma Collins, Maria Gavriliouk, Judith B. Zaugg, Brent J. Ryan, Richard Wade-Martins and Tara M. Caffrey Tags: Research article Source Type: research

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases
Neuronal degeneration is a common mechanism of many neurological diseases including Parkinson ’s disease (PD), Alzheimer’s disease (AD), and Multiple Sclerosis (MS). While AD and PD are classical neurodegenerat... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 27, 2017 Category: Neurology Authors: Annika Sommer, Beate Winner and Iryna Prots Tags: Review Source Type: research