Mitochondria dysfunction in the pathogenesis of Alzheimer ’s disease: recent advances
Alzheimer ’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by impaired cognitive function due to progressive loss of neurons in the brain. Under the microscope, neuronal ac... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 29, 2020 Category: Neurology Authors: Wenzhang Wang, Fanpeng Zhao, Xiaopin Ma, George Perry and Xiongwei Zhu Tags: Review Source Type: research

Interleukin-6 deficiency exacerbates Huntington ’s disease model phenotypes
Huntington ’s disease (HD) is an incurable neurodegenerative disorder caused by CAG trinucleotide expansions in the huntingtin gene. Markers of both systemic and CNS immune activation and inflammation have been wi... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 24, 2020 Category: Neurology Authors: Mary H. Wertz, S. Sebastian Pineda, Hyeseung Lee, Ruth Kulicke, Manolis Kellis and Myriam Heiman Tags: Short report Source Type: research

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer ’s disease
Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by lo... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 7, 2020 Category: Neurology Authors: Sruti Rayaprolu, Tianwen Gao, Hailian Xiao, Supriya Ramesha, Laura D. Weinstock, Jheel Shah, Duc M. Duong, Eric B. Dammer, James A. Webster Jr, James J. Lah, Levi B. Wood, Ranjita Betarbet, Allan I. Levey, Nicholas T. Seyfried and Srikant Rangaraju Tags: Research article Source Type: research

α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment
Studies link c-Abl activation with the accumulation of pathogenic α-synuclein (αS) and neurodegeneration in Parkinson’s disease (PD). Currently, c-Abl, a tyrosine kinase activated by cellular stress, is though... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 16, 2020 Category: Neurology Authors: Md. Razaul Karim, Elly E. Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C. Troncoso and Michael K. Lee Tags: Research article Source Type: research

NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma
Acute glaucoma, characterized by a sudden elevation in intraocular pressure (IOP) and retinal ganglion cells (RGCs) death, is a major cause of irreversible blindness worldwide that lacks approved effective the... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 15, 2020 Category: Neurology Authors: Hui Chen, Yang Deng, Xiaoliang Gan, Yonghao Li, Wenyong Huang, Lin Lu, Lai Wei, Lishi Su, Jiawen Luo, Bin Zou, Yanhua Hong, Yihai Cao, Yizhi Liu and Wei Chi Tags: Research article Source Type: research

Dynamic changes of CSF sTREM2 in preclinical Alzheimer ’s disease: the CABLE study
Loss of function of triggering receptor expressed on myeloid cell 2 (TREM2), a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer ’s disease (AD). Whether ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 10, 2020 Category: Neurology Authors: Ling-Zhi Ma, Lan Tan, Yan-Lin Bi, Xue-Ning Shen, Wei Xu, Ya-Hui Ma, Hong-Qi Li, Qiang Dong and Jin-Tai Yu Tags: Research article Source Type: research

A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson’s disease
α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson’s disease (PD). α-Syn has been shown to associate with membranes and bind acidic phospholipids. However, the physiological importanc... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 30, 2020 Category: Neurology Authors: Meir Schechter, Jessica Grigoletto, Suaad Abd-Elhadi, Hava Glickstein, Alexander Friedman, Geidy E. Serrano, Thomas G. Beach and Ronit Sharon Tags: Research article Source Type: research

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E
Several lines of evidence suggest that high-density lipoprotein (HDL) reduces Alzheimer ’s disease (AD) risk by decreasing vascular beta-amyloid (Aβ) deposition and inflammation, however, the mechanisms by whic... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 25, 2020 Category: Neurology Authors: Jerome Robert, Emily B. Button, Emma M. Martin, Luke McAlary, Zoe Gidden, Megan Gilmour, Guilaine Boyce, Tara M. Caffrey, Andrew Agbay, Amanda Clark, Judith M. Silverman, Neil R. Cashman and Cheryl L. Wellington Tags: Research article Source Type: research

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
Frontotemporal lobar degeneration (FTLD) is a devastating and progressive disorder, and a common cause of early onset dementia. Progranulin (PGRN) haploinsufficiency due to autosomal dominant mutations in the ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 16, 2020 Category: Neurology Authors: Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler D. Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Tan, James B. Jaquith, Karen R. Jansen-West, Francis C. Lynn, Fen-Biao Gao, Leonard Petrucelli, Howard H. Feldman, Ian R. Macken Tags: Research article Source Type: research

Correction to: Parkinson ’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging
The original article had mistakenly inverted co-author, Wang Zheng ’s name. This has since been corrected. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 16, 2020 Category: Neurology Authors: Xi Chen, Chengsong Xie, Wotu Tian, Lixin Sun, Wang Zheng, Sarah Hawes, Lisa Chang, Justin Kung, Jinhui Ding, Shengdi Chen, Weidong Le and Huaibin Cai Tags: Correction Source Type: research

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson ’s disease
That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson ’s disease is a widely appreciated but poorly understood phenomenon. Many vulnerable subpopulation... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 13, 2020 Category: Neurology Authors: Preston Ge, Valina L. Dawson and Ted M. Dawson Tags: Review Source Type: research

Initiation and propagation of α-synuclein aggregation in the nervous system
The two main pathological hallmarks of Parkinson ’s disease are loss of dopamine neurons in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of α-synuclein, called Lewy patho... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 6, 2020 Category: Neurology Authors: Baraa A. Hijaz and Laura A. Volpicelli-Daley Tags: Review Source Type: research

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency
Mutations in PINK1 and parkin cause autosomal recessive Parkinson ’s disease (PD). Evidence placing PINK1 and parkin in common pathways regulating multiple aspects of mitochondrial quality control is burgeoning... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 5, 2020 Category: Neurology Authors: Sheila K. Pirooznia, Changqing Yuan, Mohammed Repon Khan, Senthilkumar S. Karuppagounder, Luan Wang, Yulan Xiong, Sung Ung Kang, Yunjong Lee, Valina L. Dawson and Ted M. Dawson Tags: Research article Source Type: research

Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS
Recombinant adeno-associated virus (rAAV) is widely used in the neuroscience field to manipulate gene expression in the nervous system. However, a limitation to the use of rAAV vectors is the time and expense ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 2, 2020 Category: Neurology Authors: Marshall S. Goodwin, Cara L. Croft, Hunter S. Futch, Daniel Ryu, Carolina Ceballos-Diaz, Xuefei Liu, Giavanna Paterno, Catalina Mejia, Doris Deng, Kimberly Menezes, Laura Londono, Kefren Arjona, Mary Parianos, Van Truong, Eva Rostonics, Amanda Hernandez & Tags: Methodology Source Type: research

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD
The C9ORF72 hexanucleotide repeat expansion is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two fatal age-related neurodegenerative diseases. Th... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 24, 2020 Category: Neurology Authors: Nadja S. Andrade, Melina Ramic, Rustam Esanov, Wenjun Liu, Mathew J. Rybin, Gabriel Gaidosh, Abbas Abdallah, Samuel Del ’Olio, Tyler C. Huff, Nancy T. Chee, Sadhana Anatha, Tania F. Gendron, Claes Wahlestedt, Yanbin Zhang, Michael Benatar, Christian Mue Tags: Research article Source Type: research

Parkinson ’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging
Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with familial forms of late onset Parkinson ’s disease (PD), the most common age-related movement disorder. The dysfunction of ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 19, 2020 Category: Neurology Authors: Xi Chen, Chengsong Xie, Wotu Tian, Lixin Sun, Zheng Wang, Sarah Hawes, Lisa Chang, Justin Kung, Jinhui Ding, Shengdi Chen, Weidong Le and Huaibin Cai Tags: Research article Source Type: research

Circulating cell-free mitochondrial DNA levels in Parkinson ’s disease are influenced by treatment
Several studies have linked circulating cell-free mitochondrial DNA (ccf-mtDNA) to human disease. In particular, reduced ccf-mtDNA levels in the cerebrospinal fluid (CSF) of both Alzheimer ’s and Parkinson’s di... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 18, 2020 Category: Neurology Authors: Hannah Lowes, Angela Pyle, Mauro Santibanez-Koref and Gavin Hudson Tags: Short report Source Type: research

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer ’s disease
One of the primary genetic risk factors for Alzheimer ’s disease (AD) is the presence of the Ɛ4 allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major cholesterol carrier in the br... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 31, 2020 Category: Neurology Authors: Tosha Williams, David R. Borchelt and Paramita Chakrabarty Tags: Review Source Type: research

Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers
A repeat expansion in the C9orf72-SMCR8 complex subunit (C9orf72) is the most common genetic cause of two debilitating neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 30, 2020 Category: Neurology Authors: Jazmyne L. Jackson, NiCole A. Finch, Matthew C. Baker, Jennifer M. Kachergus, Mariely DeJesus-Hernandez, Kimberly Pereira, Elizabeth Christopher, Mercedes Prudencio, Michael G. Heckman, E. Aubrey Thompson, Dennis W. Dickson, Jaimin Shah, Bj örn Oskarsson Tags: Research article Source Type: research

A pharmacological chaperone improves memory by reducing A β and tau neuropathology in a mouse model with plaques and tangles
The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 22, 2020 Category: Neurology Authors: Jian-Guo Li, Jin Chiu, Mercy Ramanjulu, Benjamin E. Blass and Domenico Pratic ò Tags: Research article Source Type: research

Correction to: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson ’s disease
The original article [1] contains an error in the y-axes of Fig. 8 ’s sub-figures whereby ‘CSF’ is mistakenly mentioned instead of ‘serum’. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 15, 2020 Category: Neurology Authors: Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett and Frances M. Platt Tags: Correction Source Type: research

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
Misfolding and aggregation of the presynaptic protein alpha-synuclein ( αsyn) is a hallmark of Parkinson’s disease (PD) and related synucleinopathies. Although predominantly localized in the cytosol, a body of ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 13, 2020 Category: Neurology Authors: Jae-Hyeon Park, Jeremy D. Burgess, Ayman H. Faroqi, Natasha N. DeMeo, Fabienne C. Fiesel, Wolfdieter Springer, Marion Delenclos and Pamela J. McLean Tags: Research article Source Type: research

VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice
Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer ’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF le... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 10, 2020 Category: Neurology Authors: Farida El Gaamouch, Mickael Audrain, Wei-Jye Lin, Noam Beckmann, Cheng Jiang, Siddharth Hariharan, Peter S. Heeger, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich and Stephen R. Salton Tags: Research article Source Type: research

Contribution of GABAergic interneurons to amyloid- β plaque pathology in an APP knock-in mouse model
The amyloid- β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). Howeve... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 8, 2020 Category: Neurology Authors: Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horr é, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit and Bart De Strooper Tags: Short report Source Type: research

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy
The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how tha... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 6, 2020 Category: Neurology Authors: Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo and Li Gan Tags: Research article Source Type: research

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study
Previous studies regarding the cholesterol-cognition relationship in midlife have generated conflicting results. We thus investigated whether dietary and blood cholesterol were associated with cognitive decline. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 30, 2019 Category: Neurology Authors: Yu An, Xiaona Zhang, Ying Wang, Yushan Wang, Wen Liu, Tao Wang, Zhongsheng Qin and Rong Xiao Tags: Research article Source Type: research

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer ’s disease
New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer ’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 26, 2019 Category: Neurology Authors: Ravi S. Pandey, Leah Graham, Asli Uyar, Christoph Preuss, Gareth R. Howell and Gregory W. Carter Tags: Research article Source Type: research

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central to the aetiology of Parkinson ’s disease, a considerable amount of work has gone into uncovering its basic cellula... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 21, 2019 Category: Neurology Authors: Daniel C. Berwick, George R. Heaton, Sonia Azeggagh and Kirsten Harvey Tags: Review Source Type: research

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
Alzheimer ’s disease (AD) is a fatal neurodegenerative disease. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 15-fold compared to the common APOE3. Importantly, female (♀) APOE4 carriers ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 20, 2019 Category: Neurology Authors: Juan Maldonado Weng, Ishita Parikh, Ankur Naqib, Jason York, Stefan J. Green, Steven Estus and Mary Jo LaDu Tags: Short report Source Type: research

BrightFocus Alzheimer ’s Fast Track 2019
The 3 day workshop “Alzheimer’s Fast Track” is a unique opportunity for graduate students, postdoctoral fellows, or other early-career scientists, focused on Alzheimer’s disease research, to gain new knowledge... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 20, 2019 Category: Neurology Authors: Keith W. Whitaker, Frank M. LaFerla, Harry W. M. Steinbusch, Cynthia A. Lemere and Diane E. Bovenkamp Tags: Meeting report Source Type: research

Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration
Microglia play an essential role for central nervous system (CNS) development and homeostasis and have been implicated in the onset, progression, and clearance of numerous diseases affecting the CNS. Previous ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 19, 2019 Category: Neurology Authors: Anna M. Speicher, Heinz Wiendl, Sven G. Meuth and Matthias Pawlowski Tags: Review Source Type: research

Organotypic brain slice cultures to model neurodegenerative proteinopathies
Organotypic slice cultures of brain or spinal cord have been a longstanding tool in neuroscience research but their utility for understanding Alzheimer ’s disease (AD) and other neurodegenerative proteinopathie... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 2, 2019 Category: Neurology Authors: C. L. Croft, H. S. Futch, B. D. Moore and T. E. Golde Tags: Review Source Type: research

Autophagy protein NRBF2 has reduced expression in Alzheimer ’s brains and modulates memory and amyloid-beta homeostasis in mice
Dysfunctional autophagy is implicated in Alzheimer ’s Disease (AD) pathogenesis. The alterations in the expression of many autophagy related genes (ATGs) have been reported in AD brains; however, the disparity ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 27, 2019 Category: Neurology Authors: V éronik Lachance, Qian Wang, Eric Sweet, Insup Choi, Cui-Zan Cai, Xu-Xu Zhuang, Yuanxi Zhang, Jessica Li Jiang, Robert D. Blitzer, Ozlem Bozdagi-Gunal, Bin Zhang, Jia-Hong Lu and Zhenyu Yue Tags: Research article Source Type: research

Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury
Traumatic brain injury (TBI) is a major cause of CNS neurodegeneration and has no disease-altering therapies. It is commonly associated with a specific type of biomechanical disruption of the axon called traum... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 27, 2019 Category: Neurology Authors: Derek S. Welsbie, Nikolaos K. Ziogas, Leyan Xu, Byung-Jin Kim, Yusong Ge, Amit K. Patel, Jiwon Ryu, Mohamed Lehar, Athanasios S. Alexandris, Nicholas Stewart, Donald J. Zack and Vassilis E. Koliatsos Tags: Research article Source Type: research

Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis
A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins are susceptible to misfolding and abnormally... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 19, 2019 Category: Neurology Authors: Eiichi Tokuda, Yo-ichi Takei, Shinji Ohara, Noriko Fujiwara, Isao Hozumi and Yoshiaki Furukawa Tags: Research article Source Type: research

Application of CRISPR genetic screens to investigate neurological diseases
The adoption of CRISPR-Cas9 technology for functional genetic screens has been a transformative advance. Due to its modular nature, this technology can be customized to address a myriad of questions. To date, ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 14, 2019 Category: Neurology Authors: Raphaella W. L. So, Sai Wai Chung, Heather H. C. Lau, Jeremy J. Watts, Erin Gaudette, Zaid A. M. Al-Azzawi, Jossana Bishay, Lilian Tsai-Wei Lin, Julia Joung, Xinzhu Wang and Gerold Schmitt-Ulms Tags: Review Source Type: research

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson ’s disease
Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson ’s disease (PD). Recently, more than fifty o... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 8, 2019 Category: Neurology Authors: Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett and Frances M. Platt Tags: Research article Source Type: research

Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3
Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of autosomal dominantly inherited spinocerebellar ataxias (SCAs). No validated blood biomarker is available to assess either disease progression ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 4, 2019 Category: Neurology Authors: Quan-Fu Li, Yi Dong, Lu Yang, Juan-Juan Xie, Yin Ma, Yi-Chu Du, Hao-Ling Cheng, Wang Ni and Zhi-Ying Wu Tags: Research article Source Type: research

Targeting tauopathy with engineered tau-degrading intrabodies
The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic app... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 22, 2019 Category: Neurology Authors: Gilbert Gallardo, Connie H. Wong, Sara M. Ricardez, Carolyn N. Mann, Kent H. Lin, Cheryl E. G. Leyns, Hong Jiang and David M. Holtzman Tags: Research article Source Type: research

Lack of hepatic apoE does not influence early A β deposition: observations from a new APOE knock-in model
The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majorit... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 17, 2019 Category: Neurology Authors: Tien-Phat V. Huynh, Chao Wang, Ainsley C. Tran, G. Travis Tabor, Thomas E. Mahan, Caroline M. Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E. Tanzi, Jason D. Ulrich and David M. Holtzman Tags: Research article Source Type: research

Glucocerebrosidase and its relevance to Parkinson disease
Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are among the most common known genetic risk factors for the development of Parkinson disease and related synucleinopathies. A great d... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 29, 2019 Category: Neurology Authors: Jenny Do, Cindy McKinney, Pankaj Sharma and Ellen Sidransky Tags: Review Source Type: research

Impaired dopamine metabolism in Parkinson ’s disease pathogenesis
A full understanding of Parkinson ’s Disease etiopathogenesis and of the causes of the preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A multiple-hit hypothesis has... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 20, 2019 Category: Neurology Authors: Anna Masato, Nicoletta Plotegher, Daniela Boassa and Luigi Bubacco Tags: Review Source Type: research

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson’s disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 16, 2019 Category: Neurology Authors: Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin and Patrik Brundin Tags: Research article Source Type: research

A circuit view of deep brain stimulation in Alzheimer ’s disease and the possible mechanisms
Alzheimer ’s disease (AD) is characterized by chronic progressive cognitive deterioration frequently accompanied by psychopathological symptoms, including changes in personality and social isolation, which seve... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 8, 2019 Category: Neurology Authors: Danfang Yu, Huanhuan Yan, Jun Zhou, Xiaodan Yang, Youming Lu and Yunyun Han Tags: Review Source Type: research

The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 7, 2019 Category: Neurology Tags: Meeting abstracts Source Type: research

The neuropathological diagnosis of Alzheimer ’s disease
Alzheimer ’s disease is a progressive neurodegenerative disease most often associated with memory deficits and cognitive decline, although less common clinical presentations are increasingly recognized. The car... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 2, 2019 Category: Neurology Authors: Michael A. DeTure and Dennis W. Dickson Tags: Review Source Type: research

Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
The original article [1] mistakenly omitted essential information regarding Fig. 1c; thus, the authors would like to note that Fig. 1c describes transmission electron microscopy of α-Syn PFFs before sonication. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 26, 2019 Category: Neurology Authors: Norihito Uemura, Hisashi Yagi, Maiko T. Uemura, Yusuke Hatanaka, Hodaka Yamakado and Ryosuke Takahashi Tags: Correction Source Type: research

Alpha-synuclein structure and Parkinson ’s disease – lessons and emerging principles
Alpha-synuclein ( αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atro... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 22, 2019 Category: Neurology Authors: Richard M. Meade, David P. Fairlie and Jody M. Mason Tags: Review Source Type: research

Pineal gland dysfunction in Alzheimer ’s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis
Alzheimer ’s disease (AD) is a globally common neurodegenerative disease, which is accompanied by alterations to various lifestyle patterns, such as sleep disturbance. The pineal gland is the primary endocrine ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 11, 2019 Category: Neurology Authors: Juhyun Song Tags: Review Source Type: research

Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities
Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic late... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 10, 2019 Category: Neurology Authors: Val érie Bercier, Jeffrey M. Hubbard, Kevin Fidelin, Karine Duroure, Thomas O. Auer, Céline Revenu, Claire Wyart and Filippo Del Bene Tags: Research article Source Type: research