Preclinical modeling of chronic inhibition of the Parkinson ’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo
The most common mutation in the Leucine-rich repeat kinase 2 gene (LRRK2), G2019S, causes familial Parkinson ’s Disease (PD) and renders the encoded protein kinase hyperactive. While targeting LRRK2 activity is... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 19, 2021 Category: Neurology Authors: Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark R. Cookson and Adamantios Mamais Tags: Research article Source Type: research
High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3
Oxidative stress is a common cause of neurodegeneration and plays a central role in retinal degenerative diseases. Heme oxygenase-1 (HMOX1) is a redox-regulated enzyme that is induced in neurodegenerative dise... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 10, 2021 Category: Neurology Authors: Huirong Li, Bo Liu, Lili Lian, Jiajia Zhou, Shengjin Xiang, Yifan Zhai, Yu Chen, Xiaoyin Ma, Wencan Wu and Ling Hou Tags: Research article Source Type: research
Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer ’s disease
Emerging evidence indicates that impaired mitophagy-mediated clearance of defective mitochondria is a critical event in Alzheimer ’s disease (AD) pathogenesis. Amyloid-beta (Aβ) metabolism and the microtubule-a... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 8, 2021 Category: Neurology Authors: Vicente Roca-Agujetas, Elisabet Barbero-Camps, Cristina de Dios, Petar Podlesniy, Xenia Abadin, Albert Morales, Montserrat Mar í, Ramon Trullàs and Anna Colell Tags: Research article Source Type: research
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction
Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harb... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 4, 2021 Category: Neurology Authors: Emma M. Perkins, Karen Burr, Poulomi Banerjee, Arpan R. Mehta, Owen Dando, Bhuvaneish T. Selvaraj, Daumante Suminaite, Jyoti Nanda, Christopher M. Henstridge, Thomas H. Gillingwater, Giles E. Hardingham, David J. A. Wyllie, Siddharthan Chandran and Matthe Tags: Research article Source Type: research
Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models
Before the deposition of amyloid-beta plaques and the onset of learning memory deficits, patients with Alzheimer ’s disease (AD) experience olfactory dysfunction, typified by a reduced ability to detect, discri... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 4, 2021 Category: Neurology Authors: Ming Chen, Yunan Chen, Qingwei Huo, Lei Wang, Shuyi Tan, Afzal Misrani, Jinxiang Jiang, Jian Chen, Shiyuan Chen, Jiawei Zhang, Sidra Tabassum, Jichen Wang, Xi Chen, Cheng Long and Li Yang Tags: Research article Source Type: research
