Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
Alzheimer ’s disease (AD) is a neurodegenerative disorder that manifests sequential Aβ and tau brain pathology with age-dependent onset. Variants in the microglial immune receptor TREM2 are associated with enha... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 2, 2022 Category: Neurology Authors: Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Pi ña-Crespo, Huaxi Xu and Timothy Y. Huang Tags: Research article Source Type: research
CD8+ T cells in neurodegeneration: friend or foe?
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 2, 2022 Category: Neurology Authors: Dan Hu, Weiming Xia and Howard L. Weiner Tags: Perspective Source Type: research
Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 30, 2022 Category: Neurology Authors: A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam and Stephen M. Strittmatter Tags: Correction Source Type: research
Microglial TYROBP/DAP12 in Alzheimer ’s disease: Transduction of physiological and pathological signals across TREM2
TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is expressed in numerous cell types,... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 24, 2022 Category: Neurology Authors: Jean-Vianney Haure-Mirande, Mickael Audrain, Michelle E. Ehrlich and Sam Gandy Tags: Review Source Type: research
Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. A β disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and a... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 20, 2022 Category: Neurology Authors: Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury Jr, Joseph R. Mazzulli and Robert Vassar Tags: Research article Source Type: research
When the infectious environment meets the AD brain
The Amyloid theory of Alzheimer ’s disease (AD) suggests that the deposition of Amyloid β (Aβ) in the brain triggers a chain of events, involving the deposition of phosphorylated Tau and other misfolded protein... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 19, 2022 Category: Neurology Authors: Tal Ganz, Nina Fainstein and Tamir Ben-Hur Tags: Review Source Type: research
Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson ’s disease
Genetic mutations in beta-glucocerebrosidase (GBA) represent the major genetic risk factor for Parkinson ’s disease (PD). GBA participates in both the endo-lysosomal pathway and the immune response, two important ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 17, 2022 Category: Neurology Authors: Giulietta Maria Riboldi, Ricardo A. Vialle, Elisa Navarro, Evan Udine, Katia de Paiva Lopes, Jack Humphrey, Amanda Allan, Madison Parks, Brooklyn Henderson, Kelly Astudillo, Charalambos Argyrou, Maojuan Zhuang, Tamjeed Sikder, J. Oriol Narcis, Shilpa Dili Tags: Research article Source Type: research
APOE targeting strategy in Alzheimer ’s disease: lessons learned from protective variants
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 3, 2022 Category: Neurology Authors: Guojun Bu Tags: Perspective Source Type: research
Combination therapy using GDNF and cell transplant in Parkinson ’s disease
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 16, 2022 Category: Neurology Authors: Bin Xiao, Su-Chun Zhang and Eng-King Tan Tags: Research highlight Source Type: research
Crosstalk of organelles in Parkinson ’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes
Living organisms constantly need to adapt to their surrounding environment and have evolved sophisticated mechanisms to deal with stress. Mitochondria and lysosomes are central organelles in the response to en... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 16, 2022 Category: Neurology Authors: Martin Lang, Peter P. Pramstaller and Irene Pichler Tags: Review Source Type: research
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson ’s disease are associated with LRRC37A/2 expression in astrocytes
Parkinson ’s disease (PD) is genetically associated with the H1 haplotype of the MAPT 17q.21.31 locus, although the causal gene and variants underlying this association have not been identified. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 15, 2022 Category: Neurology Authors: Kathryn R. Bowles, Derian A. Pugh, Yiyuan Liu, Tulsi Patel, Alan E. Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D. Cherry, Celeste M. Karch, Steven J. Frucht, Brian H. Kopell, Inga Peter, Y. J. Park & hell Tags: Research article Source Type: research
CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer ’s disease
Despite its identification as a key checkpoint regulator of microglial activation in Alzheimer ’s disease, the overarching role of CX3CR1 signaling in modulating mechanisms of Aβ driven neurodegeneration, inclu... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 28, 2022 Category: Neurology Authors: Shweta S. Puntambekar, Miguel Moutinho, Peter Bor-Chian Lin, Vaishnavi Jadhav, Danika Tumbleson-Brink, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian Oblak, Cristian A. Lasagna-Reeves, Gary E. Landreth and Bruce T. Lamb Tags: Research article Source Type: research
The role of NURR1 in metabolic abnormalities of Parkinson ’s disease
A constant metabolism and energy supply are crucial to all organs, particularly the brain. Age-dependent neurodegenerative diseases, such as Parkinson ’s disease (PD), are associated with alterations in cellula... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 27, 2022 Category: Neurology Authors: Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng and Weidong Le Tags: Review Source Type: research
LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
Microglia plays crucial roles in Alzheimer ’s disease (AD) development. Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function. Here w... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 18, 2022 Category: Neurology Authors: Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang & hellip; Tags: Research article Source Type: research
Unraveling protein dynamics to understand the brain – the next molecular frontier
The technological revolution to measure global gene expression at the single-cell level is currently transforming our knowledge of the brain and neurological diseases, leading from a basic understanding of gen... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 18, 2022 Category: Neurology Authors: Kyle D. Brewer, Sophia M. Shi and Tony Wyss-Coray Tags: Review Source Type: research
