Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer ’s disease with multi-modal PET and plasma GFAP
Plasma assays for the detection of Alzheimer ’s disease neuropathological changes are receiving ever increasing interest. The concentration of plasma glial fibrillary acidic protein (GFAP) has been suggested as... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 12, 2023 Category: Neurology Authors: Konstantinos Chiotis, Charlotte Johansson, Elena Rodriguez-Vieitez, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Caroline Graff and Agneta Nordberg Tags: Research article Source Type: research
Amyloid- β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
Amyloid-related imaging abnormalities (ARIA) have been identified as the most common and serious adverse events resulting from pathological changes in the cerebral vasculature during several recent anti-amyloi... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 30, 2023 Category: Neurology Authors: Xavier Taylor, Isaiah M. Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald B. DeMattos, Yaming Wang and Feng Pan Tags: Research article Source Type: research
Translation dysregulation in neurodegenerative diseases: a focus on ALS
RNA translation is tightly controlled in eukaryotic cells to regulate gene expression and maintain proteome homeostasis. RNA binding proteins, translation factors, and cell signaling pathways all modulate the ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 25, 2023 Category: Neurology Authors: Shaopeng Wang and Shuying Sun Tags: Review Source Type: research
TDP-43-regulated cryptic RNAs accumulate in Alzheimer ’s disease brains
Inclusions of TAR DNA-binding protein 43 kDa (TDP-43) has been designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without co-occurrence of Alzheimer ’s disease (AD). Approximately,... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 21, 2023 Category: Neurology Authors: Virginia Estades Ayuso, Sarah Pickles, Tiffany Todd, Mei Yue, Karen Jansen-West, Yuping Song, Jes ús González Bejarano, Bailey Rawlinson, Michael DeTure, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, Tags: Research article Source Type: research
Oleoylethanolamide facilitates PPAR α and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease
Age is the strongest risk factor for the development of Alzheimer ’s disease (AD). Besides the pathological hallmarks of β-amyloid (Aβ) plaques and neurofibrillary tangles, emerging evidence demonstrates a crit... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 15, 2023 Category: Neurology Authors: Michele M. Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng C. Wang, Jin Wang and Hui Zheng Tags: Research article Source Type: research
Current views on meningeal lymphatics and immunity in aging and Alzheimer ’s disease
Alzheimer ’s disease (AD) is an aging-related form of dementia associated with the accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the brain. These phenomena are accompani... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 14, 2023 Category: Neurology Authors: Shanon Rego, Guadalupe Sanchez and Sandro Da Mesquita Tags: Review Source Type: research
TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
Mutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 10, 2023 Category: Neurology Authors: Hai-Shan Jiao, Peng Yuan and Jin-Tai Yu Tags: Review Source Type: research
Specific detection of tau seeding activity in Alzheimer ’s disease using rationally designed biosensor cells
The prion-like propagation of tau in neurodegenerative disorders implies that misfolded pathological tau can recruit the normal protein and template its aggregation. Here, we report the methods for the develop... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 8, 2023 Category: Neurology Authors: Aurelien Lathuiliere, Youhwa Jo, Romain Perbet, Cameron Donahue, Caitlin Commins, No é Quittot, Zhanyun Fan, Rachel E. Bennett and Bradley T. Hyman Tags: Methodology Source Type: research
Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases
The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ homeostasis, especially in cells of the nervous system. As part of a large network, VCP collaborates with many cofactors to ensure ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 7, 2023 Category: Neurology Authors: Siwei Chu, Xinyi Xie, Carla Payan and Ursula Stochaj Tags: Review Source Type: research
VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease
Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-onset, autosomal dominant Parkinson ’s disease (PD), with a single missense mutation (Asp620Asn, D620N) known to segregate with disease... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 4, 2023 Category: Neurology Authors: Xi Chen, Elpida Tsika, Nathan Levine and Darren J. Moore Tags: Research article Source Type: research
Optimizing detection of Alzheimer ’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO
Disease-modifying drug use necessitates better Alzheimer disease (AD) detection. Mild cognitive impairment (MCI) leverages cognitive decline to identify the risk group; similarly, mild behavioral impairment (M... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 29, 2023 Category: Neurology Authors: Zahinoor Ismail, Rebeca Leon, Byron Creese, Clive Ballard, Philippe Robert and Eric E. Smith Tags: Research article Source Type: research
Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Human studies consistently identify bioenergetic maladaptations in brains upon aging and neurodegenerative disorders of aging (NDAs), such as Alzheimer ’s disease, Parkinson’s disease, Huntington’s disease, and... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 20, 2023 Category: Neurology Authors: Sen Yang, Jung Hyun Park and Hui-Chen Lu Tags: Review Source Type: research
Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer ’s disease
Despite being twice as likely to get Alzheimer ’s disease (AD), African Americans have been grossly underrepresented in AD research. While emerging evidence indicates that African Americans with AD have lower c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 19, 2023 Category: Neurology Authors: Erica S. Modeste, Lingyan Ping, Caroline M. Watson, Duc M. Duong, Eric B. Dammer, Erik C. B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey and Nicholas T. Seyfried Tags: Research article Source Type: research
ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer ’s disease
Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer ’s disease (AD). Nuclear acetyl-CoA pools are generate... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 12, 2023 Category: Neurology Authors: Yingbin Lin, Anlan Lin, Lili Cai, Weibin Huang, Shanzhi Yan, Yuanxiang Wei, Xinglin Ruan, Wenting Fang, Xiaoman Dai, Jinbo Cheng, Jie Zhang, Wanjin Chen, Qinyong Ye, Xiaochun Chen and Jing Zhang Tags: Research article Source Type: research
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer ’s disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline. Severe VCID includes post-str... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 11, 2023 Category: Neurology Authors: Yasuteru Inoue, Francis Shue, Guojun Bu and Takahisa Kanekiyo Tags: Review Source Type: research
