Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likel... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 6, 2021 Category: Neurology Authors: Inmaculada Sanjuan-Ruiz, No é Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz a Tags: Research article Source Type: research
APO Ε4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer ’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 6, 2021 Category: Neurology Authors: Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. G Tags: Research article Source Type: research
Functional microRNA targetome undergoes degeneration-induced shift in the retina
MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through thei... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 31, 2021 Category: Neurology Authors: Joshua A. Chu-Tan, Adrian V. Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis and Riccardo Natoli Tags: Research article Source Type: research
Extracellular protein components of amyloid plaques and their roles in Alzheimer ’s disease pathology
Alzheimer ’s disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ) peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary tangles. Extensive rese... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 28, 2021 Category: Neurology Authors: M. Mahafuzur Rahman and Christofer Lendel Tags: Review Source Type: research
Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer ’s disease brains
In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer ’s disease (LOAD) and translate the associations to causation. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 24, 2021 Category: Neurology Authors: Julio Barrera, Lingyun Song, Julia E. Gamache, Melanie E. Garrett, Alexias Safi, Young Yun, Ivana Premasinghe, Daniel Sprague, Danielle Chipman, Jeffrey Li, H élène Fradin, Karen Soldano, Raluca Gordân, Allison E. Ashley-Koch, Gregory E. Crawford and O Tags: Research article Source Type: research
Cellular and pathological heterogeneity of primary tauopathies
Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies. Multiple studies have suggeste... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 23, 2021 Category: Neurology Authors: Dah-eun Chloe Chung, Shanu Roemer, Leonard Petrucelli and Dennis W. Dickson Tags: Review Source Type: research
Vesicle trafficking and pathways to neurodegeneration
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 21, 2021 Category: Neurology Authors: Craig Blackstone, Fiona Elwood, Helene Plun-Favreau and Patrick A. Lewis Tags: Meeting report Source Type: research
Proteomic landscape of Alzheimer ’s Disease: novel insights into pathogenesis and biomarker discovery
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein posttranslational modifications (PTMs) in Alzheimer ’s disease (AD). Here we review the advances and limitations in historic an... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 12, 2021 Category: Neurology Authors: Bing Bai, David Vanderwall, Yuxin Li, Xusheng Wang, Suresh Poudel, Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Ka Yang and Junmin Peng Tags: Review Source Type: research
Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures
Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 11, 2021 Category: Neurology Authors: Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. H äsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Phi Tags: Research article Source Type: research
Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem motor neuron disease for which currently there is no effective treatment. There is an urgent need to identify biomarkers to tackle the disea... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 10, 2021 Category: Neurology Authors: Laura Pasetto, Stefano Callegaro, Alessandro Corbelli, Fabio Fiordaliso, Deborah Ferrara, Laura Brunelli, Giovanna Sestito, Roberta Pastorelli, Elisa Bianchi, Marina Cretich, Marcella Chiari, Cristina Potrich, Cristina Moglia, Massimo Corbo, Gianni Sorar Tags: Research article Source Type: research
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identific... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 10, 2021 Category: Neurology Authors: Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Tags: Research article Source Type: research
Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration
Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is prot... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - August 3, 2021 Category: Neurology Authors: Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson Tags: Research article Source Type: research
Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer ’s disease
Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer ’s disease (AD). Activation of DAMs is dependent on triggering rec... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 23, 2021 Category: Neurology Authors: Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan and Mathew Blurton-Jones Tags: Short report Source Type: research
The informed road map to prevention of Alzheimer Disease: A call to arms
Alzheimer disease (AD) prevention trials hold the promise to delay or prevent cognitive decline and dementia onset by intervening before significant neuronal damage occurs. In recent years, the first AD preven... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 21, 2021 Category: Neurology Authors: Eric McDade, Jorge J. Llibre-Guerra, David M. Holtzman, John C. Morris and Randall J. Bateman Tags: Review Source Type: research
Post-infection cognitive impairments in a cohort of elderly patients with COVID-19
This study aims to assess the curre... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 19, 2021 Category: Neurology Authors: Yu-Hui Liu, Ye-Ran Wang, Qing-Hua Wang, Yang Chen, Xian Chen, Ying Li, Yuan Cen, Cheng Xu, Tian Hu, Xu-Dong Liu, Ling-Li Yang, Si-Jing Li, Xue-Fei Liu, Chun-Mei Liu, Jie Zhu, Wei Li & hellip; Tags: Research article Source Type: research
