Tauopathies: new perspectives and challenges
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 7, 2022 Category: Neurology Authors: Yi Zhang, Kai-Min Wu, Liu Yang, Qiang Dong and Jin-Tai Yu Tags: Review Source Type: research
Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications
The retina, as part of the central nervous system (CNS) with limited capacity for self-reparation and regeneration in mammals, is under cumulative environmental stress due to high-energy demands and rapid prot... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 28, 2022 Category: Neurology Authors: Todd McLaughlin, Andy Medina, Jacob Perkins, Maria Yera, Joshua J. Wang and Sarah X. Zhang Tags: Review Source Type: research
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer ’s disease
Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer ’s disease (AD) and is considered to result from neurodegeneration. T-tau levels, however, can be increased in very ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 28, 2022 Category: Neurology Authors: Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lle ó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne F Tags: Research article Source Type: research
Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro
Microglia, the resident immune cells of the brain, play a critical role in numerous diseases, but are a minority cell type and difficult to genetically manipulate in vivo with viral vectors and other approache... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 28, 2022 Category: Neurology Authors: Mika P. Cadiz, Tanner D. Jensen, Jonathon P. Sens, Kuixi Zhu, Won-Min Song, Bin Zhang, Mark Ebbert, Rui Chang and John D. Fryer Tags: Research article Source Type: research
In Memoriam of John T. Trojanowski, MD, PhD 1946-2022
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 24, 2022 Category: Neurology Authors: Hui Zheng and David M. Holtzman Tags: Commentary Source Type: research
Solving neurodegeneration: common mechanisms and strategies for new treatments
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 21, 2022 Category: Neurology Authors: Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G Tags: Review Source Type: research
The role of inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD
Neuroinflammation is an important hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). An inflammatory reaction to neuronal injury is deemed vital for neuronal health a... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 18, 2022 Category: Neurology Authors: Pegah Masrori, Jimmy Beckers, Helena Gossye and Philip Van Damme Tags: Review Source Type: research
Does proteopathic tau propagate trans-synaptically in the brain?
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 16, 2022 Category: Neurology Authors: Wen Hu, Fei Liu, Cheng-Xin Gong and Khalid Iqbal Tags: Commentary Source Type: research
The route of SARS-CoV-2 to brain infection: have we been barking up the wrong tree?
This letter draws attention to recent work supporting the notion that the SARS-CoV-2 virus may use the nervus terminalis rather than the olfactory nerve as a shortcut route from the nasal cavity to infect the ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 15, 2022 Category: Neurology Authors: Rafal Butowt and Christopher S. von Bartheld Tags: Letter to the Editor Source Type: research
Alzheimer ’s disease – the journey of a healthy brain into organ failure
As the most common dementia, Alzheimer ’s disease (AD) exacts an immense personal, societal, and economic toll. AD was first described at the neuropathological level in the early 1900s. Today, we have mechanist... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 5, 2022 Category: Neurology Authors: Todd E. Golde Tags: Review Source Type: research
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer ’s disease
The implication of gut microbiota in the control of brain functions in health and disease is a novel, currently emerging concept. Accumulating data suggest that the gut microbiota exert its action at least in ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 5, 2022 Category: Neurology Authors: Diane Bairamian, Sha Sha, Nathalie Rolhion, Harry Sokol, Guillaume Doroth ée, Cynthia A. Lemere and Slavica Krantic Tags: Review Source Type: research
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer ’s disease: review, recommendation, implementation and application
Alzheimer ’s disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic studies have revealed biomarkers, risk fact... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 2, 2022 Category: Neurology Authors: Minghui Wang, Won-min Song, Chen Ming, Qian Wang, Xianxiao Zhou, Peng Xu, Azra Krek, Yonejung Yoon, Lap Ho, Miranda E. Orr, Guo-Cheng Yuan and Bin Zhang Tags: Review Source Type: research
Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson ’s disease
Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson ’s disease (PD). We previously showed that MC1R signaling can facilitate n... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 23, 2022 Category: Neurology Authors: Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild and Xiqun Chen Tags: Research article Source Type: research
Retraction Note: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13024-021-00438-3. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 4, 2022 Category: Neurology Authors: Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang and Hussein N. Yassine Tags: Retraction Note Source Type: research
Differential regulation of progranulin derived granulin peptides
Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual granulin peptides in the lyso... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 4, 2022 Category: Neurology Authors: Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel and Fenghua Hu Tags: Research article Source Type: research
