Differential regulation of progranulin derived granulin peptides

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual granulin peptides in the lyso...

Source: Molecular Neurodegeneration - February 4, 2022 Category: Neurology Authors: Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel and Fenghua Hu Tags: Research article Source Type: research