Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Parkinson ’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Pa... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 12, 2021 Category: Neurology Authors: Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O ’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler & hellip; Tags: Research article Source Type: research
Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer ’s disease brain
Mitochondrial dysfunction is a feature of neurodegenerative diseases, including Alzheimer ’s disease (AD). Changes in the mitochondrial DNA copy number (mtDNAcn) and increased mitochondrial DNA mutation burden ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 6, 2021 Category: Neurology Authors: Hans-Ulrich Klein, Caroline Trumpff, Hyun-Sik Yang, Annie J. Lee, Martin Picard, David A. Bennett and Philip L. De Jager Tags: Research article Source Type: research
The promise of microRNA-based therapies in Alzheimer ’s disease: challenges and perspectives
Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as alternatives to classical monotarget therapies and microRNAs are of particular interest in that regard. MicroRNA resear... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 6, 2021 Category: Neurology Authors: Hannah Walgrave, Lujia Zhou, Bart De Strooper and Evgenia Salta Tags: Perspective Source Type: research
Talking points for physicians, patients and caregivers considering Aduhelm ® infusion and the accelerated pathway for its approval by the FDA
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 4, 2021 Category: Neurology Authors: Sam Gandy, David S. Knopman and Mary Sano Tags: Commentary Source Type: research
Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors
Aldh1a1 neurons are a subtype of gamma-aminobutyric acid (GABA) inhibitory neurons that use Aldh1a1 rather than glutamate decarboxylase (GAD) as an enzyme for synthesizing GABA transmitters. However, the behav... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 26, 2021 Category: Neurology Authors: Xinyan Li, Wenting Chen, Xian Huang, Wei Jing, Tongmei Zhang, Quntao Yu, Hongyan Yu, Hao Li, Qing Tian, Yumei Ding and Youming Lu Tags: Research article Source Type: research
Correction to: Proteomic landscape of Alzheimer ’s Disease: novel insights into pathogenesis and biomarker discovery
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 20, 2021 Category: Neurology Authors: Bing Bai, David Vanderwall, Yuxin Li, Xusheng Wang, Suresh Poudel, Hong Wang, Kaushik Kumar Dey, Ping-Chung Chen, Ka Yang and Junmin Peng Tags: Correction Source Type: research
Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophi... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 18, 2021 Category: Neurology Authors: Silvia Bono, Marco Feligioni and Massimo Corbo Tags: Review Source Type: research
The TGF β/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar
Contrasting with zebrafish, retinal regeneration from M üller cells (MCs) is largely limited in mammals, where they undergo reactive gliosis that consist of a hypertrophic response and ultimately results in vis... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 30, 2021 Category: Neurology Authors: Federica Maria Conedera, Ana Maria Quintela Pousa, Nadia Mercader, Markus Tschopp and Volker Enzmann Tags: Research article Source Type: research
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer ’s disease through aberrant cell cycle events
In this study, we explored the potential role of RNA m6 (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 30, 2021 Category: Neurology Authors: Fanpeng Zhao, Ying Xu, Shichao Gao, Lixia Qin, Quillan Austria, Sandra L. Siedlak, Kinga Pajdzik, Qing Dai, Chuan He, Wenzhang Wang, James M. O ’Donnell, Beisha Tang and Xiongwei Zhu Tags: Research article Source Type: research
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid- β plaques
Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer ’s disease comes from molecular and functional studies in rodent models. Howeve... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 25, 2021 Category: Neurology Authors: Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison M Goate, Bart De Strooper and Amaia M Arranz Tags: Methodology Source Type: research
Measuring the cognitive costs of the COVID-19 pandemic
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 23, 2021 Category: Neurology Authors: Gregory S Day Tags: Commentary Source Type: research
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing
Aberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribut... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 22, 2021 Category: Neurology Authors: Qingyang Zhang, Juan Zhang, Jin Ye, Xiaohui Li, Hongda Liu, Xiaolin Ma, Chao Wang, Keqiang He, Wei Zhang, Ji Yuan, Yingjun Zhao, Huaxi Xu and Qiang Liu Tags: Research article Source Type: research
Nuclear dynamics and stress responses in Alzheimer ’s disease
In response to extracellular and intracellular stressors, the nucleus and nuclear compartments undergo distinct molecular changes to maintain cell homeostasis. In the context of Alzheimer ’s disease, misfolded ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 17, 2021 Category: Neurology Authors: Artemis Iatrou, Eric M. Clark and Yanling Wang Tags: Review Source Type: research
Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer ’s disease-like neuroinflammation and cognitive impairment
Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (A β) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 15, 2021 Category: Neurology Authors: Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree and Xianlin Han Tags: Research article Source Type: research
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
The misfolding of host-encoded proteins into pathological prion conformations is a defining characteristic of many neurodegenerative disorders, including Alzheimer ’s disease, Parkinson’s disease, and Lewy body... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - September 9, 2021 Category: Neurology Authors: Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson and David R. Borchelt Tags: Research article Source Type: research
