Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophi...

Source: Molecular Neurodegeneration - October 18, 2021 Category: Neurology Authors: Silvia Bono, Marco Feligioni and Massimo Corbo Tags: Review Source Type: research