APOE effects on regional tau in preclinical Alzheimer ’s disease
APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are reported in animal and human cell models. The degree to which these effects are... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 4, 2023 Category: Neurology Authors: Christina B. Young, Emily Johns, Gabriel Kennedy, Michael E. Belloy, Philip S. Insel, Michael D. Greicius, Reisa A. Sperling, Keith A. Johnson, Kathleen L. Poston and Elizabeth C. Mormino Tags: Research article Source Type: research
Global neuropathologic severity of Alzheimer ’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels
Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer ’s disease (AD) biomarker changes. Examination of postmortem brains of partic... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 27, 2022 Category: Neurology Authors: Melissa E. Murray, Christina M. Moloney, Naomi Kouri, Jeremy A. Syrjanen, Billie J. Matchett, Darren M. Rothberg, Jessica F. Tranovich, Tiffany N. Hicks Sirmans, Heather J. Wiste, Baayla D. C. Boon, Aivi T. Nguyen, R. Ross Reichard, Dennis W. Dickson, Val Tags: Research article Source Type: research
TREM2 dependent and independent functions of microglia in Alzheimer ’s disease
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer ’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries th... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 23, 2022 Category: Neurology Authors: Jinchao Hou, Yun Chen, Gary Grajales-Reyes and Marco Colonna Tags: Review Source Type: research
Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
Amongst risk alleles associated with late-onset Alzheimer ’s disease (AD), those that converged on the regulation of microglia activity have emerged as central to disease progression. Yet, how canonical amyloid... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 17, 2022 Category: Neurology Authors: Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley J. Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P. Ling, Juan C. Troncoso, Philip C. Wong, Seth Blackshaw, Ronald L. Schnaar and Tong Li Tags: Research article Source Type: research
Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 13, 2022 Category: Neurology Authors: Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Tags: Research article Source Type: research
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer ’s disease continuum
Alzheimer ’s disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Ther... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 12, 2022 Category: Neurology Authors: Johan Gobom, Andr éa L. Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Henrik Zet Tags: Research article Source Type: research
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) disease spectrum, causing both nuclea... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 8, 2022 Category: Neurology Authors: Bilal Khalil, Deepak Chhangani, Melissa C. Wren, Courtney L. Smith, Jannifer H. Lee, Xingli Li, Christian Puttinger, Chih-Wei Tsai, Gael Fortin, Dmytro Morderer, Junli Gao, Feilin Liu, Chun Kim Lim, Jingjiao Chen, Ching-Chieh Chou, Cara L. Croft & hellip; Tags: Research article Source Type: research
Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad
The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic, pathological feature specific to Multiple system atrophy (MSA). Since the characterization of the disease in 1969, decades of r... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 26, 2022 Category: Neurology Authors: Kreesan Reddy and Birger Victor Dieriks Tags: Review Source Type: research
Glial interference: impact of type I interferon in neurodegenerative diseases
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 26, 2022 Category: Neurology Authors: Ethan Roy and Wei Cao Tags: Perspective Source Type: research
LRP1: a novel receptor for the transmission of pathological α-Synuclein
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 26, 2022 Category: Neurology Authors: Crystal Pan and Chao Peng Tags: Research highlight Source Type: research
Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer ’s disease in Tg2576 mice
Recent clinical and experimental studies have highlighted the involvement of Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of Alzheimer ’s Disease (AD). We have previously descri... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 25, 2022 Category: Neurology Authors: Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Ilaria Paoletti, Mauro Federici, Luana Saba, Cecilia Giacomet, Ramona Marino, Paraskevi Krashia, Marcello Melone, Flavio Keller, Nicola Biagio Mercuri, Maria Teresa Viscomi, Fiorenzo Conti and Marcello D ’ Tags: Research article Source Type: research
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
Abnormal lipid accumulation has been recognized as a key element of immune dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases. Microglia play essential roles in the clearanc... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 23, 2022 Category: Neurology Authors: Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C. Ikezu, Francis Shue, Sydney V. Doss, Alla Alnobani, Yuka A. Martens, Melissa Wren, Yan W. Asmann, Bin Zhang, Guojun Bu and Chia-Chen Liu Tags: Research article Source Type: research
Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer ’s disease
The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin, SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved, they have been recognized for th... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 18, 2022 Category: Neurology Authors: Alena Salasova, Giulia Monti, Olav M. Andersen and Anders Nykjaer Tags: Review Source Type: research
TREM2 and microglia exosomes: a potential highway for pathological tau
Tau pathology appears to spread along neuronal networks via the template misfolding of tau by pathological tau conformations. The mechanisms underlying neuron-to-neuron transmission of tau are unclear and rece... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 17, 2022 Category: Neurology Authors: Nimansha Jain and Jason D. Ulrich Tags: Commentary Source Type: research
ApoE in Alzheimer ’s disease: pathophysiology and therapeutic strategies
Alzheimer ’s disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. Among the increasing number of genetic risk factors identified, the ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 8, 2022 Category: Neurology Authors: Ana-Caroline Raulin, Sydney V. Doss, Zachary A. Trottier, Tadafumi C. Ikezu, Guojun Bu and Chia-Chen Liu Tags: Review Source Type: research
