Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A β accumulation and plaque-related pathology in a mouse model of amyloidosis
One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid- β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for la... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 2, 2022 Category: Neurology Authors: Thomas E. Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D. Ulrich and David M. Holtzman Tags: Research article Source Type: research
Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer ’s disease
The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer ’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive. The inciden... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 29, 2022 Category: Neurology Authors: Guoxin Zhang, Lanxia Meng, Zhihao Wang, Qinyu Peng, Guiqin Chen, Jing Xiong and Zhentao Zhang Tags: Research article Source Type: research
Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in which many processes are detected including (neuro)inflammation. Many drugs have been tested for ALS in clinical trials but mos... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 24, 2022 Category: Neurology Authors: Kim A. Staats, David R. Borchelt, Mal ú Gámez Tansey and James Wymer Tags: Review Source Type: research
Dynamic changes of CSF sPDGFR β during ageing and AD progression and associations with CSF ATN biomarkers
Loss of brain capillary pericyte is involved in the pathologies and cognitive deficits in Alzheimer ’s disease (AD). The role of pericyte in early stage of AD pathogenesis remains unclear. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 15, 2022 Category: Neurology Authors: Jun Wang, Dong-Yu Fan, Hui-Yun Li, Chen-Yang He, Ying-Ying Shen, Gui-Hua Zeng, Dong-Wan Chen, Xu Yi, Ya-Hui Ma, Jin-Tai Yu and Yan-Jiang Wang Tags: Research article Source Type: research
Murine roseolovirus does not accelerate amyloid- β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains
The role of viral infection in Alzheimer Disease (AD) pathogenesis is an area of great interest in recent years. Several studies have suggested an association between the human roseoloviruses, HHV-6 and HHV-7,... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 15, 2022 Category: Neurology Authors: Tarin M. Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J. Patel, Carlos Cruchaga, Wayne M. Yokoyama and David M. Holtzman Tags: Research article Source Type: research
A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling
Viral tracers are important tools for mapping brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 10, 2022 Category: Neurology Authors: Hong Yang, Feng Xiong, Hai-Bin Qin, Qun-Tao Yu, Jin-Yan Sun, Hai-Wen Zhao, Dong Li, Youtong Zhou, Fu-Kun Zhang, Xiao-Wen Zhu, Tong Wu, Man Jiang, Xiangmin Xu, Youming Lu, Hong-Jie Shen, Wen-Bo Zeng & hellip; Tags: Research article Source Type: research
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson ’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression i... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 10, 2022 Category: Neurology Authors: Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, Tags: Research article Source Type: research
Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells
Spinal cord motor neurons (MNs) from human iPS cells (iPSCs) have wide applications in disease modeling and therapeutic development for amyotrophic lateral sclerosis (ALS) and other MN-associated neurodegenera... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 10, 2022 Category: Neurology Authors: Qian Li, Yi Feng, Yingchao Xue, Xiping Zhan, Yi Fu, Gege Gui, Weiqiang Zhou, Jean-Philippe Richard, Arens Taga, Pan Li, Xiaobo Mao, Nicholas J. Maragakis and Mingyao Ying Tags: Research article Source Type: research
TDP-43 Pathology in Alzheimer ’s Disease
Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and thus, the regulation of gene exp... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 20, 2021 Category: Neurology Authors: Axel Meneses, Shunsuke Koga, Justin O ’Leary, Dennis W. Dickson, Guojun Bu and Na Zhao Tags: Review Source Type: research
Neuropathology and molecular diagnosis of Synucleinopathies
Synucleinopathies are clinically and pathologically heterogeneous disorders characterized by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies, Lewy neurites, neuronal cytopl... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 18, 2021 Category: Neurology Authors: Shunsuke Koga, Hiroaki Sekiya, Naveen Kondru, Owen A. Ross and Dennis W. Dickson Tags: Review Source Type: research
Discrimination of MSA-P and MSA-C by RT-QuIC analysis of olfactory mucosa: the first assessment of assay reproducibility between two specialized laboratories
Detection of the pathological and disease-associated alpha-synuclein ( αSynD) in the brain is required to formulate the definitive diagnosis of multiple system atrophy (MSA) and Parkinson’s disease (PD). We recent... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 11, 2021 Category: Neurology Authors: Connor Bargar, Chiara Maria Giulia De Luca, Grazia Devigili, Antonio Emanuele Elia, Roberto Cilia, Sara Maria Portaleone, Wen Wang, Irene Tramacere, Edoardo Bistaffa, Federico Angelo Cazzaniga, Giovanni Felisati, Giuseppe Legname, Alessio Di Fonzo, Rong X Tags: Research article Source Type: research
Basal lamina changes in neurodegenerative disorders
Neurodegenerative disorders are a group of age-associated diseases characterized by progressive degeneration of the structure and function of the CNS. Two key pathological features of these disorders are blood... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 7, 2021 Category: Neurology Authors: Benjamin Nguyen, Gregory Bix and Yao Yao Tags: Review Source Type: research
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study
A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 27, 2021 Category: Neurology Authors: Sofia Bergstr öm, Linn Öijerstedt, Julia Remnestål, Jennie Olofsson, Abbe Ullgren, Harro Seelaar, John C. van Swieten, Matthis Synofzik, Raquel Sanchez-Valle, Fermin Moreno, Elizabeth Finger, Mario Masellis, Carmela Tartaglia, Rik Vandenberghe, Robert Tags: Research article Source Type: research
MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration
MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 27, 2021 Category: Neurology Authors: Thomas Wallach, Zo é J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik & hellip; Tags: Research article Source Type: research
CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice
Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer ’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphor... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 22, 2021 Category: Neurology Authors: Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan and Georgette D. Kanmogne Tags: Research article Source Type: research
