Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson ’s disease (PD). Aggregated α-synuclein pathologically defines PD. Recent studies identified elevated LRRK2 expression i...

Source: Molecular Neurodegeneration - January 10, 2022 Category: Neurology Authors: Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, Tags: Research article Source Type: research