Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A β accumulation and plaque-related pathology in a mouse model of amyloidosis

One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid- β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for la...

Source: Molecular Neurodegeneration - February 2, 2022 Category: Neurology Authors: Thomas E. Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D. Ulrich and David M. Holtzman Tags: Research article Source Type: research