Modulating innate immune activation states impacts the efficacy of specific A β immunotherapy
Passive immunotherapies targeting A β continue to be evaluated as Alzheimer’s disease (AD) therapeutics, but there remains debate over the mechanisms by which these immunotherapies work. Besides the amount of p... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 6, 2021 Category: Neurology Authors: Yona Levites, Cory Funk, Xue Wang, Paramita Chakrabarty, Karen N. McFarland, Baxter Bramblett, Veronica O ’Neal, Xufei Liu, Thomas Ladd, Max Robinson, Mariet Allen, Minerva M. Carrasquillo, Dennis Dickson, Pedro Cruz, Danny Ryu, Hong-Dong Li & hellip; Tags: Research article Source Type: research
Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson ’s disease brain
Parkinson ’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dys... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 5, 2021 Category: Neurology Authors: Lilah Toker, Gia T. Tran, Janani Sundaresan, Ole-Bj ørn Tysnes, Guido Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle and Charalampos Tzoulis Tags: Research article Source Type: research
A blood-based diagnostic test incorporating plasma A β42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis
The development of blood-based biomarker tests that are accurate and robust for Alzheimer ’s disease (AD) pathology have the potential to aid clinical diagnosis and facilitate enrollment in AD drug trials. We d... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 1, 2021 Category: Neurology Authors: Tim West, Kristopher M. Kirmess, Matthew R. Meyer, Mary S. Holubasch, Stephanie S. Knapik, Yan Hu, John H. Contois, Erin N. Jackson, Scott E. Harpstrite, Randall J. Bateman, David M. Holtzman, Philip B. Verghese, Ilana Fogelman, Joel B. Braunstein and Kev Tags: Research article Source Type: research
Protective genes and pathways in Alzheimer ’s disease: moving towards precision interventions
Alzheimer ’s disease (AD) is a progressive, neurodegenerative disorder that is characterized by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks. The etiology of Alzheim... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 29, 2021 Category: Neurology Authors: Mabel Seto, Rebecca L. Weiner, Logan Dumitrescu and Timothy J. Hohman Tags: Review Source Type: research
Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer ’s disease
Mitochondrial electron transport chain abnormalities have been reported in postmortem pathological specimens of Alzheimer ’s disease (AD). However, it remains unclear how amyloid and tau are associated with mit... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 26, 2021 Category: Neurology Authors: Tatsuhiro Terada, Joseph Therriault, Min Su Peter Kang, Melissa Savard, Tharick Ali Pascoal, Firoza Lussier, Cecile Tissot, Yi-Ting Wang, Andrea Benedet, Takashi Matsudaira, Tomoyasu Bunai, Tomokazu Obi, Hideo Tsukada, Yasuomi Ouchi and Pedro Rosa-Neto Tags: Research article Source Type: research
Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer ’s disease risk
Alzheimer ’s disease (AD) is the most common type of dementia, affecting millions of people worldwide; however, no disease-modifying treatments are currently available. Genome-wide association studies (GWASs) h... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 21, 2021 Category: Neurology Authors: Gloriia Novikova, Shea J. Andrews, Alan E. Renton and Edoardo Marcora Tags: Review Source Type: research
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer ’s disease (AD), but the mechanisms for this association are not clear. The acti... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 16, 2021 Category: Neurology Authors: Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Carol Miller, Patrick M. Sullivan, Hoau-Yan Wang and Hussein N. Yassine Tags: Research article Source Type: research
Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 14, 2021 Category: Neurology Authors: Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu and Tsuneya Ikezu Tags: Correction Source Type: research
AIF3 splicing switch triggers neurodegeneration
Apoptosis-inducing factor (AIF), as a mitochondrial flavoprotein, plays a fundamental role in mitochondrial bioenergetics that is critical for cell survival and also mediates caspase-independent cell death onc... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 14, 2021 Category: Neurology Authors: Shuiqiao Liu, Mi Zhou, Zhi Ruan, Yanan Wang, Calvin Chang, Masayuki Sasaki, Veena Rajaram, Andrew Lemoff, Kalyani Nambiar, Jennifer E. Wang, Kimmo J. Hatanpaa, Weibo Luo, Ted M. Dawson, Valina L. Dawson and Yingfei Wang Tags: Research article Source Type: research
Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer ’s disease
Recently, we and other researchers reported that brain metabolic disorders are implicated in Alzheimer ’s disease (AD), a progressive, devastating and incurable neurodegenerative disease. Hence, novel therapeut... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 13, 2021 Category: Neurology Authors: Tahir Ali, Shafiq Ur Rehman, Amjad Khan, Haroon Badshah, Noman Bin Abid, Min Woo Kim, Myeung Hoon Jo, Seung Soo Chung, Hyoung-gon Lee, Bart P. F. Rutten and Myeong Ok Kim Tags: Research article Source Type: research
TREM2/PLC γ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapid... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 6, 2021 Category: Neurology Authors: Lorenza Magno, Tom D. Bunney, Emma Mead, Fredrik Svensson and Magda N. Bictash Tags: Review Source Type: research
Correction to: New approaches to symptomatic treatments for Alzheimer ’s disease
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 1, 2021 Category: Neurology Authors: Jeffrey Cummings Tags: Correction Source Type: research
Fred W. van Leeuwen (1949 –2021)
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 31, 2021 Category: Neurology Authors: Bert M. Verheijen and Aaron Ciechanover Tags: Obituary Source Type: research
The CD33 short isoform is a gain-of-function variant that enhances A β1–42 phagocytosis in microglia
CD33 is genetically linked to Alzheimer ’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an A... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 25, 2021 Category: Neurology Authors: Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel and Matthew S. Macauley Tags: Research article Source Type: research
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer ’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurod... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 22, 2021 Category: Neurology Authors: Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu and Tsuneya Ikezu Tags: Research article Source Type: research
