Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer ’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurod...

Source: Molecular Neurodegeneration - March 22, 2021 Category: Neurology Authors: Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu and Tsuneya Ikezu Tags: Research article Source Type: research