The CD33 short isoform is a gain-of-function variant that enhances A β1–42 phagocytosis in microglia

CD33 is genetically linked to Alzheimer ’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an A...

Source: Molecular Neurodegeneration - March 25, 2021 Category: Neurology Authors: Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel and Matthew S. Macauley Tags: Research article Source Type: research