Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 27, 2024 Category: Neurology Authors: Jun Yup Lee, Dylan J. Harney, Jonathan D. Teo, John B. Kwok, Greg T. Sutherland, Mark Larance and Anthony S. Don Tags: Correction Source Type: research
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over 50 human disorders, including Alzheimer ’s and Parkinson’s diseases. Increasing evidence implicates misfolded protein... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 20, 2024 Category: Neurology Authors: Dillon J. Rinauro, Fabrizio Chiti, Michele Vendruscolo and Ryan Limbocker Tags: Review Source Type: research
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
It has recently become well-established that there is a connection between Alzheimer ’s disease pathology and gut microbiome dysbiosis. We have previously demonstrated that antibiotic-mediated gut microbiota pe... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 17, 2024 Category: Neurology Authors: Megan E. Bosch, Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L. Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Tags: Research article Source Type: research
Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer ’s Disease
Novel phosphorylated-tau (p-tau) blood biomarkers (e.g., p-tau181, p-tau217 or p-tau231), are highly specific for Alzheimer ’s disease (AD), and can track amyloid-β (Aβ) and tau pathology. However, because thes... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 17, 2024 Category: Neurology Authors: Juan Lantero-Rodriguez, Gemma Salvad ó, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, Andrea L. Benedet, Niklas Mattsson-Carlgren, Pontus Tideman, Shorena Janelidze, Sebastian Palmqvist, Erik Stomrud, Nicholas J. Ashton, Henrik Zetterberg, Kaj Bl Tags: Research article Source Type: research
Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 16, 2024 Category: Neurology Authors: Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson and David R. Borchelt Tags: Correction Source Type: research
Unraveling the dual nature of brain CD8+ T cells in Alzheimer ’s disease
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 14, 2024 Category: Neurology Authors: Dan Hu and Howard L. Weiner Tags: Perspective Source Type: research
CSF protein ratios with enhanced potential to reflect Alzheimer ’s disease pathology and neurodegeneration
Amyloid and tau aggregates are considered to cause neurodegeneration and consequently cognitive decline in individuals with Alzheimer ’s disease (AD). Here, we explore the potential of cerebrospinal fluid (CSF)... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 13, 2024 Category: Neurology Authors: S ára Mravinacová, Vilma Alanko, Sofia Bergström, Claire Bridel, Yolande Pijnenburg, Göran Hagman, Miia Kivipelto, Charlotte Teunissen, Peter Nilsson, Anna Matton and Anna Månberg Tags: Research article Source Type: research
Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The clinical features associated with CTE pathology are unclear. In brain do... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 6, 2024 Category: Neurology Authors: Michael L. Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O ’Connor, John F. Crary, Lee E. Goldstein, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Ch Tags: Research article Source Type: research
Microglial ferroptotic stress causes non-cell autonomous neuronal death
Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also imp... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - February 5, 2024 Category: Neurology Authors: Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthon Tags: Research article Source Type: research
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 29, 2024 Category: Neurology Authors: Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar-Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju and Hui-Chen Lu Tags: Research article Source Type: research
Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target
The extracellular matrix is a richly bioactive composition of substrates that provides biophysical stability, facilitates intercellular signaling, and both reflects and governs the physiological status of the ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 25, 2024 Category: Neurology Authors: Lauren K. Wareham, Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf and David J. Calkins Tags: Review Source Type: research
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models
Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson ’s disease (PD). Functional analysis of genes linke... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 25, 2024 Category: Neurology Authors: Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen and Alexander J. Whitworth Tags: Research article Source Type: research
Fluid biomarkers for amyotrophic lateral sclerosis: a review
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are available to help slow functional de... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 24, 2024 Category: Neurology Authors: Katherine E. Irwin, Udit Sheth, Philip C. Wong and Tania F. Gendron Tags: Review Source Type: research
Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease spectrum that are characterized by the cytoplasmic mislocalization and aberrant phase tr... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 22, 2024 Category: Neurology Authors: Bilal Khalil, Miriam Linsenmeier, Courtney L. Smith, James Shorter and Wilfried Rossoll Tags: Review Source Type: research
Unravelling cell type-specific responses to Parkinson ’s Disease at single cell resolution
Parkinson ’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the subst... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 20, 2024 Category: Neurology Authors: Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, Tags: Research article Source Type: research
