Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease spectrum that are characterized by the cytoplasmic mislocalization and aberrant phase tr... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 22, 2024 Category: Neurology Authors: Bilal Khalil, Miriam Linsenmeier, Courtney L. Smith, James Shorter and Wilfried Rossoll Tags: Review Source Type: research
Unravelling cell type-specific responses to Parkinson ’s Disease at single cell resolution
Parkinson ’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence of aggregated α-synuclein, primarily in the subst... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 20, 2024 Category: Neurology Authors: Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, Tags: Research article Source Type: research
Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease
Reactive oxidative stress is a critical player in the amyloid beta (A β) toxicity that contributes to neurodegeneration in Alzheimer’s disease (AD). Damaged mitochondria are one of the main sources of reactive ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 18, 2024 Category: Neurology Authors: Maria Calvo-Rodriguez, Elizabeth K. Kharitonova, Austin C. Snyder, Steven S. Hou, Maria Virtudes Sanchez-Mico, Sudeshna Das, Zhanyun Fan, Hamid Shirani, K. Peter R. Nilsson, Alberto Serrano-Pozo and Brian J. Bacskai Tags: Research article Source Type: research
Brain clearance of protein aggregates: a close-up on astrocytes
Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in the formation of toxic intra- and extracellular aggregates. Intracellular aggregates c... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 16, 2024 Category: Neurology Authors: Veronica Giusti, Gurkirat Kaur, Elena Giusto and Laura Civiero Tags: Review Source Type: research
Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models
Tauopathies, a group of neurodegenerative diseases that includes Alzheimer ’s disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-h... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 10, 2024 Category: Neurology Authors: Gowoon Son, Thomas C. Neylan and Lea T. Grinberg Tags: Review Source Type: research
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer ’s disease pathology
Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry ena... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 7, 2024 Category: Neurology Authors: Joseph Therriault, Marcel S. Woo, Gemma Salvad ó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jen Tags: Research article Source Type: research
Blood platelet factor 4: the elixir of brain rejuvenation
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 7, 2024 Category: Neurology Authors: Jos é M. Izquierdo Tags: Commentary Source Type: research
Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer ’s disease
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a critical role in microglial activation, survival, and apoptosis, as well as in Alzheimer ’s disease (AD) pathogenesis. We previously reported the MS... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - January 3, 2024 Category: Neurology Authors: Lihua Wang, Niko-Petteri Nyk änen, Daniel Western, Priyanka Gorijala, Jigyasha Timsina, Fuhai Li, Zhaohua Wang, Muhammad Ali, Chengran Yang, Menghan Liu, William Brock, Marta Marquié, Mercè Boada, Ignacio Alvarez, Miquel Aguilar, Pau Pastor & hellip; Tags: Research article Source Type: research
Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson ’s disease
Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across inte... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 19, 2023 Category: Neurology Authors: Kimberly C. Paul, Keren Zhang, Douglas I. Walker, Janet Sinsheimer, Yu Yu, Cynthia Kusters, Irish Del Rosario, Aline Duarte Folle, Adrienne M. Keener, Jeff Bronstein, Dean P. Jones and Beate Ritz Tags: Research article Source Type: research
Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease
“Brain-predicted age” estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 19, 2023 Category: Neurology Authors: Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricard Tags: Research article Source Type: research
Microglial APOE4: more is less and less is more
Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer ’s disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear. Fortunately, two ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 19, 2023 Category: Neurology Authors: Ghazaleh Eskandari-Sedighi and Mathew Blurton-Jones Tags: Editorial Source Type: research
Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 18, 2023 Category: Neurology Authors: Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward and Ling Hao Tags: Correction Source Type: research
Amyloid- β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice
Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of defined antigen specificity limits their therapeutic potential. This is n... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 18, 2023 Category: Neurology Authors: Pravin Yeapuri, Jatin Machhi, Yaman Lu, Mai Mohamed Abdelmoaty, Rana Kadry, Milankumar Patel, Shaurav Bhattarai, Eugene Lu, Krista L. Namminga, Katherine E. Olson, Emma G. Foster, R. Lee Mosley and Howard E. Gendelman Tags: Research article Source Type: research
Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome
Microglia, the brain-resident macrophages perform immune surveillance and engage with pathological processes resulting in phenotype changes necessary for maintaining homeostasis. In preceding studies, we showe... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 16, 2023 Category: Neurology Authors: Shabana M. Shaik, Yajun Cao, Joseph V. Gogola, Hemraj B. Dodiya, Xulun Zhang, Hejer Boutej, Weinong Han, Jasna Kriz and Sangram S. Sisodia Tags: Research article Source Type: research
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer ’s disease model
Alzheimer ’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep. Slow-wave activity (SWA) is a major restorative f... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - December 1, 2023 Category: Neurology Authors: Qiuchen Zhao, Megi Maci, Morgan R. Miller, Heng Zhou, Fang Zhang, Moustafa Algamal, Yee Fun Lee, Steven S. Hou, Stephen J. Perle, Hoang Le, Alyssa N. Russ, Eng H. Lo, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai and Ksenia V. Kastanenka Tags: Research article Source Type: research
