Knock-in models related to Alzheimer ’s disease: synaptic transmission, plaques and the role of microglia
Microglia are active modulators of Alzheimer ’s disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. We add novel findings concerning these relations... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 15, 2021 Category: Neurology Authors: Diana P. Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M. Hall, Carlijn Peerboom, Natalie Wong, Katie M. Stringer, Karina S. Vitanova, Victoria C. Smith, Dhaval Joshi, Takashi Saito, Takaomi C. Saido, John Hardy, J örg Hanrieder, Bart De Strooper & h Tags: Research article Source Type: research
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer ’s disease
Human tauopathies including Alzheimer ’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neur... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 2, 2021 Category: Neurology Authors: Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Sch öndorf, Borja Gomez Ramos, Vera Schwärzler, Marie Neu, Annabelle Schlüter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S. Ried, Per Haberkant, Laura Gasparini and Dagmar E. Ehrnhoefe Tags: Research article Source Type: research
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamyc... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 2, 2021 Category: Neurology Authors: Henry Querfurth and Han-Kyu Lee Tags: Review Source Type: research
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer ’s disease brains
Neuritic plaques in Alzheimer ’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes. Most recently, we showed that DNs form ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - July 2, 2021 Category: Neurology Authors: Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C. Saido and Riqiang Yan Tags: Research article Source Type: research
AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma
The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a prominent feature of chronic neurodegenerative disease... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 29, 2021 Category: Neurology Authors: Nicolas Belforte, Jessica Agostinone, Luis Alarcon-Martinez, Deborah Villafranca-Baughman, Florence Dotigny, Jorge L. Cueva Vargas and Adriana Di Polo Tags: Research article Source Type: research
Correction to: A pharmacological chaperone improves memory by reducing A β and tau neuropathology in a mouse model with plaques and tangles
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 28, 2021 Category: Neurology Authors: Jian-Guo Li, Jin Chiu, Mercy Ramanjulu, Benjamin E. Blass and Domenico Pratic ò Tags: Correction Source Type: research
Pharmacological rescue of cognitive function in a mouse model of chemobrain
After chemotherapy, many cancer survivors suffer from long-lasting cognitive impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive changes and the underlying mechanisms remain ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 26, 2021 Category: Neurology Authors: Lien D. Nguyen, Tom T. Fischer and Barbara E. Ehrlich Tags: Research article Source Type: research
Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
For decades, dementia has been characterized by accumulation of waste in the brain and low-grade inflammation. Over the years, emerging studies highlighted the involvement of the immune system in neurodegenera... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 25, 2021 Category: Neurology Authors: Hila Ben-Yehuda, Michal Arad, Javier Mar ía Peralta Ramos, Efrat Sharon, Giulia Castellani, Shir Ferrera, Liora Cahalon, Sarah Phoebeluc Colaiuta, Tomer-Meir Salame and Michal Schwartz Tags: Research article Source Type: research
A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy
There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying mole... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 25, 2021 Category: Neurology Authors: Laura Gutierrez-Quiceno, Eric B. Dammer, Ashlyn Grace Johnson, James A. Webster, Rhythm Shah, Duc Duong, Luming Yin, Nicholas T. Seyfried, Victor E. Alvarez, Thor D. Stein, Ann C. McKee and Chadwick M. Hales Tags: Research article Source Type: research
Identification of sixteen novel candidate genes for late onset Parkinson ’s disease
Parkinson ’s disease (PD) is a neurodegenerative movement disorder affecting 1–5% of the general population for which neither effective cure nor early diagnostic tools are available that could tackle the pathol... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 21, 2021 Category: Neurology Authors: Alessandro Gialluisi, Mafalda Giovanna Reccia, Nicola Modugno, Teresa Nutile, Alessia Lombardi, Luca Giovanni Di Giovannantonio, Sara Pietracupa, Daniela Ruggiero, Simona Scala, Stefano Gambardella, Licia Iacoviello, Fernando Gianfrancesco, Dario Acampora Tags: Research article Source Type: research
Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer ’s disease: a systematic review of symptom-general and –specific lesion patterns
Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer ’s disease (AD) and are associated with accelerated cognitive impairment and earlier deaths. This review aims to explore the neural pathoge... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 7, 2021 Category: Neurology Authors: Yaojing Chen, Mingxi Dang and Zhanjun Zhang Tags: Review Source Type: research
Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma
Early challenges to axonal physiology, active transport, and ultrastructure are endemic to age-related neurodegenerative disorders, including those affecting the optic nerve. Chief among these, glaucoma causes... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 5, 2021 Category: Neurology Authors: Michael L. Risner, Silvia Pasini, Nolan R. McGrady, Karis B. D ’Alessandro, Vincent Yao, Melissa L. Cooper and David J. Calkins Tags: Research article Source Type: research
“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
Phosphorylation is one of the most prevalent post-translational modifications found in aggregated tau isolated from Alzheimer ’s disease (AD) patient brains. In tauopathies like AD, increased phosphorylation or... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 5, 2021 Category: Neurology Authors: Yuxing Xia, Stefan Prokop and Benoit I. Giasson Tags: Review Source Type: research
Parkinson mice show functional and molecular changes in the gut long before motoric disease onset
There is increasing evidence that Parkinson ’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of do... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 2, 2021 Category: Neurology Authors: Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph R öth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isab Tags: Research article Source Type: research
Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
Mutations in LRRK2 are the most common cause of familial Parkinson ’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue. (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 24, 2021 Category: Neurology Authors: Souvarish Sarkar, Farah Bardai, Abby L. Olsen, Kelly M. Lohr, Ying-Yi Zhang and Mel B. Feany Tags: Research article Source Type: research
