Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo

Mutations in LRRK2 are the most common cause of familial Parkinson ’s disease and typically cause disease in the context of abnormal aggregation and deposition of α-synuclein within affected brain tissue.

Source: Molecular Neurodegeneration - May 24, 2021 Category: Neurology Authors: Souvarish Sarkar, Farah Bardai, Abby L. Olsen, Kelly M. Lohr, Ying-Yi Zhang and Mel B. Feany Tags: Research article Source Type: research