Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer ’s disease brains

Neuritic plaques in Alzheimer ’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes. Most recently, we showed that DNs form ...

Source: Molecular Neurodegeneration - July 2, 2021 Category: Neurology Authors: Md Golam Sharoar, Sarah Palko, Yingying Ge, Takaomi C. Saido and Riqiang Yan Tags: Research article Source Type: research