Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identify... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 17, 2022 Category: Neurology Authors: Emily Connell, Gwenaelle Le Gall, Matthew G. Pontifex, Saber Sami, John F. Cryan, Gerard Clarke, Michael M üller and David Vauzour Tags: Review Source Type: research
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer ’s disease (AD), but the mechanisms for this association are not clear. The acti... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 15, 2022 Category: Neurology Authors: Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Patrick M. Sullivan and Hussein N. Yassine Tags: Research article Source Type: research
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Genetic mutations underlying familial Alzheimer ’s disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 11, 2022 Category: Neurology Authors: Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau & hellip; Tags: Research article Source Type: research
Imaging tau pathology in Alzheimer ’s disease with positron emission tomography: lessons learned from imaging-neuropathology validation studies
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 3, 2022 Category: Neurology Authors: Alexis Moscoso, Melissa C. Wren, Tammaryn Lashley, Erik Arstad, Melissa E. Murray, Nick C. Fox, Kerstin Sander and Michael Sch öll Tags: Perspective Source Type: research
TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery. Recent studies have ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - June 3, 2022 Category: Neurology Authors: Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu and Yi Tang Tags: Review Source Type: research
Prompting endogenous repair of brain injury: science fiction or reality?
Drug-refractory forms of neurological diseases could find their next breakthrough therapy in non-pharmacological approaches to brain repair. Lentini et al. present the potential of in situ brain regeneration to a... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 31, 2022 Category: Neurology Authors: Aurelie de Rus Jacquet and Francesca Cicchetti Tags: Research highlight Source Type: research
Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer ’s disease
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 13, 2022 Category: Neurology Authors: Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lle ó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne F Tags: Correction Source Type: research
Microglial lactate metabolism as a potential therapeutic target for Alzheimer ’s disease
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 12, 2022 Category: Neurology Authors: Yingjun Zhao and Huaxi Xu Tags: Research highlight Source Type: research
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer ’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regula... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 7, 2022 Category: Neurology Authors: Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran & Tags: Research article Source Type: research
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis. Despite the extensive use ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 7, 2022 Category: Neurology Authors: Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew V. Caprariello and Jason R. Plemel Tags: Review Source Type: research
Circadian clocks, cognition, and Alzheimer ’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics
Modulation of basic biochemical and physiological processes by the circadian timing system is now recognized as a fundamental feature of all mammalian organ systems. Within the central nervous system, these cl... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 7, 2022 Category: Neurology Authors: Kari R. Hoyt and Karl Obrietan Tags: Review Source Type: research
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer ’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 3, 2022 Category: Neurology Authors: A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam and Stephen M. Strittmatter Tags: Research article Source Type: research
The role of ATP-binding cassette subfamily A in the etiology of Alzheimer ’s disease
Alzheimer ’s disease (AD) is the leading cause of dementia, clinically characterized by memory deficits and progressive cognitive decline. Despite decades of research effective therapies are lacking, and a larg... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 27, 2022 Category: Neurology Authors: Liene Bossaerts, Rita Cacace and Christine Van Broeckhoven Tags: Review Source Type: research
VCP suppresses proteopathic seeding in neurons
Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly under... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 12, 2022 Category: Neurology Authors: Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Dia Tags: Research article Source Type: research
Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration
Synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD). Consequently, a surrogate marker of synapse loss could be used to monitor early pathologic changes in patients w... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 8, 2022 Category: Neurology Authors: Alba Cervantes Gonz ález, David J. Irwin, Daniel Alcolea, Corey T. McMillan, Alice Chen-Plotkin, David Wolk, Sònia Sirisi, Oriol Dols-Icardo, Marta Querol-Vilaseca, Ignacio Illán-Gala, Miguel Angel Santos-Santos, Juan Fortea, Edward B. Lee, John Q. Tro Tags: Research article Source Type: research
