BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer ’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regula...

Source: Molecular Neurodegeneration - May 7, 2022 Category: Neurology Authors: Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran & Tags: Research article Source Type: research