Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer ’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function...

Source: Molecular Neurodegeneration - May 3, 2022 Category: Neurology Authors: A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam and Stephen M. Strittmatter Tags: Research article Source Type: research