BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
Abnormal accumulation of amyloid beta peptide (A β) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1, which is required for Aβ generation, is therefore be... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 4, 2023 Category: Neurology Authors: John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu and Riqiang Yan Tags: Research article Source Type: research
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been sho... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - May 2, 2023 Category: Neurology Authors: Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Katherine Bowles, Charles S. Craik, Matthew P. Jacobson and Aimee W. Kao Tags: Research article Source Type: research
Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 28, 2023 Category: Neurology Authors: Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Kurti Aishe, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Tags: Correction Source Type: research
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer ’s disease
Failed proteostasis is a well-documented feature of Alzheimer ’s disease, particularly, reduced protein degradation and clearance. However, the contribution of failed proteostasis to neuronal circuit dysfunctio... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 21, 2023 Category: Neurology Authors: Christopher Daniel Morrone, Radha Raghuraman, S. Abid Hussaini and Wai Haung Yu Tags: Review Source Type: research
Carriers of the p.P522R variant in PLC γ2 have a slightly more responsive immune system
The rs72824905 single-nucleotide polymorphism in the PLCG2 gene, encoding the p.P522R residue change in Phospholipase C gamma 2 (PLC γ2), associates with protection against several dementia subtypes and with incre... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 20, 2023 Category: Neurology Authors: Annieck M. Diks, Cristina Teodosio, Bas de Mooij, Rick J. Groenland, Brigitta A. E. Naber, Inge F. de Laat, Sandra A. Vloemans, Susan Rohde, Marien I. de Jonge, Linda Lorenz, Debbie Horsten, Jacques J. M. van Dongen, Magdalena A. Berkowska and Henne Holst Tags: Research article Source Type: research
Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer ’s disease: an updated overview of nonpharmacological therapies
Understanding and treating Alzheimer ’s disease (AD) has been a remarkable challenge for both scientists and physicians. Although the amyloid-beta and tau protein hypothesis have largely explained the key patho... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 20, 2023 Category: Neurology Authors: Douglas A. Formolo, Jiasui Yu, Kangguang Lin, Hector W. H. Tsang, Haining Ou, Georg S. Kranz and Suk-Yu Yau Tags: Review Source Type: research
NF- κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss
Inflammaging represents an accepted concept where the immune system shifts to a low-grade chronic pro-inflammatory state without overt infection upon aging. In the CNS, inflammaging is mainly driven by glia ce... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 17, 2023 Category: Neurology Authors: Judith Stefanie Schlett, Melanie Mettang, Aladdin Skaf, Pavel Schweizer, Alina Errerd, Ephraim Alemayehu Mulugeta, Tabea Melissa Hein, Konstantinos Tsesmelis, Miltiadis Tsesmelis, Ulrike F. G. B üttner, Heinrich Wendt, Alireza Abaei, Volker Rasche, Vivie Tags: Research article Source Type: research
Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation
Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer ’s disease (AD). However, the sensitivity of cholinergic neurons to AD-like tau accumulat... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 14, 2023 Category: Neurology Authors: Dongqin Wu, Nana Yu, Yang Gao, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv & hellip; Tags: Research article Source Type: research
Insights from new in vivo models of TREM2 variants
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 5, 2023 Category: Neurology Authors: Nimansha Jain and David M. Holtzman Tags: Commentary Source Type: research
Using mass spectrometry to validate mouse models of tauopathy
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 5, 2023 Category: Neurology Authors: Yan Yan and Casey N. Cook Tags: Research highlight Source Type: research
Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson’s disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays (SAAs) using cerebrospinal fluid (CSF) represent th... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - April 1, 2023 Category: Neurology Authors: Giovanni Bellomo, Silvia Paciotti, Luis Concha-Marambio, Domenico Rizzo, Anna Lidia Wojda ƚa, Davide Chiasserini, Leonardo Gatticchi, Linda Cerofolini, Stefano Giuntini, Chiara Maria Giulia De Luca, Yihua Ma, Carly M. Farris, Giuseppe Pieraccini, Sara Bo Tags: Research article Source Type: research
hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer ’s disease and potential therapeutics
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 25, 2023 Category: Neurology Authors: Julia TCW and Amaia M. Arranz Tags: Perspective Source Type: research
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid- β (Aβ) accumulation in the brain, although Aβ deposits mostly in the brain parenchyma in AD and in the cerebrovasc... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 16, 2023 Category: Neurology Authors: Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E. Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R. Gonzales, Michal Kipnis and David M. Holtzman Tags: Research article Source Type: research
Plasma phospho-tau in Alzheimer ’s disease: towards diagnostic and therapeutic trial applications
As the leading cause of dementia, Alzheimer's disease (AD) is a major burden on affected individuals, their families and caregivers, and healthcare systems. Although AD can be identified and diagnosed by cereb... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 16, 2023 Category: Neurology Authors: Fernando Gonzalez-Ortiz, Przemys ław R. Kac, Wagner S. Brum, Henrik Zetterberg, Kaj Blennow and Thomas K. Karikari Tags: Review Source Type: research
The era of cryptic exons: implications for ALS-FTD
TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 proteinopathy spans a spectrum of ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - March 15, 2023 Category: Neurology Authors: Puja R. Mehta, Anna-Leigh Brown, Michael E. Ward and Pietro Fratta Tags: Review Source Type: research
