Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer ’s disease
Recent genetic studies on Alzheimer ’s disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes expressed in microglia. Several of these genes have been rec... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 29, 2023 Category: Neurology Authors: Gizem Terzioglu and Tracy L. Young-Pearse Tags: Review Source Type: research
Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 28, 2023 Category: Neurology Authors: Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone and Mary Helen Black Tags: Letter to the Editor Source Type: research
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson ’s disease in rodent brains
Alpha-synuclein ( α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson’s disease (PD) and related synucleinopathies. However, ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 27, 2023 Category: Neurology Authors: Morgan B érard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El-Agnaf and Abid Oueslati Tags: Research article Source Type: research
Donald Lowell Price, M.D. In memoriam
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 20, 2023 Category: Neurology Authors: Sangram Sisodia and Philip C. Wong Tags: Obituary Source Type: research
Alzheimer ’s genes in microglia: a risk worth investigating
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer ’s disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be either harmful or protective. Herei... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 20, 2023 Category: Neurology Authors: Ari Sudwarts and Gopal Thinakaran Tags: Review Source Type: research
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis. Over 70 mutations discovered in the GRN gene ... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 16, 2023 Category: Neurology Authors: Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward and Ling Hao Tags: Research article Source Type: research
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). Humans have a perip... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 16, 2023 Category: Neurology Authors: Tetiana Poliakova and Cheryl L. Wellington Tags: Review Source Type: research
Altered plasma protein profiles in genetic FTD – a GENFI study
Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of dise... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 15, 2023 Category: Neurology Authors: Abbe Ullgren, Linn Öijerstedt, Jennie Olofsson, Sofia Bergström, Julia Remnestål, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Matthis Synofzik, Daniela Galimberti, James B. Tags: Research article Source Type: research
α-Synuclein serine129 phosphorylation – the physiology of pathology
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 13, 2023 Category: Neurology Authors: Nagendran Ramalingam and Ulf Dettmer Tags: Editorial Source Type: research
Mitochondrial dysfunction in Parkinson ’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson ’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants,... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 11, 2023 Category: Neurology Authors: Martin T. Henrich, Wolfgang H. Oertel, D. James Surmeier and Fanni F. Geibl Tags: Review Source Type: research
Simple model systems reveal conserved mechanisms of Alzheimer ’s disease and related tauopathies
The lack of effective therapies that slow the progression of Alzheimer ’s disease (AD) and related tauopathies highlights the need for a more comprehensive understanding of the fundamental cellular mechanisms u... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 10, 2023 Category: Neurology Authors: Yuwei Jiang and Lesley T. MacNeil Tags: Review Source Type: research
Peptide-based approaches to directly target alpha-synuclein in Parkinson ’s disease
Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-protein interactions too large for inhibition by small molecules, and inaccessible to larg... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 9, 2023 Category: Neurology Authors: Scott G. Allen, Richard M. Meade, Lucy L. White Stenner and Jody M. Mason Tags: Review Source Type: research
Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
(Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 9, 2023 Category: Neurology Authors: John J. Alam and Ralph A. Nixon Tags: Correction Source Type: research
Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - November 8, 2023 Category: Neurology Authors: Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin and Li Gan Tags: Review Source Type: research
Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis
Patients with amyotrophic lateral sclerosis (ALS) demonstrate great heterogeneity in the age at onset (AAO), which is closely related to the course of disease. However, most genetic studies focused on the risk... (Source: Molecular Neurodegeneration)
Source: Molecular Neurodegeneration - October 23, 2023 Category: Neurology Authors: Chunyu Li, Qianqian Wei, Yanbing Hou, Junyu Lin, Ruwei Ou, Lingyu Zhang, Qirui Jiang, Yi Xiao, Kuncheng Liu, Xueping Chen, TianMi Yang, Wei Song, Bi Zhao, Ying Wu and Huifang Shang Tags: Research article Source Type: research
