Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis. Over 70 mutations discovered in the GRN gene ...

Source: Molecular Neurodegeneration - November 16, 2023 Category: Neurology Authors: Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward and Ling Hao Tags: Research article Source Type: research