Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer ’s disease-like neuroinflammation and cognitive impairment

Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (A β) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests...

Source: Molecular Neurodegeneration - September 15, 2021 Category: Neurology Authors: Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree and Xianlin Han Tags: Research article Source Type: research