APO Ε4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer ’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest...

Source: Molecular Neurodegeneration - September 6, 2021 Category: Neurology Authors: Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. G Tags: Research article Source Type: research