Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer ’s disease

Emerging evidence indicates that impaired mitophagy-mediated clearance of defective mitochondria is a critical event in Alzheimer ’s disease (AD) pathogenesis. Amyloid-beta (Aβ) metabolism and the microtubule-a...

Source: Molecular Neurodegeneration - March 8, 2021 Category: Neurology Authors: Vicente Roca-Agujetas, Elisabet Barbero-Camps, Cristina de Dios, Petar Podlesniy, Xenia Abadin, Albert Morales, Montserrat Mar í, Ramon Trullàs and Anna Colell Tags: Research article Source Type: research