Preclinical modeling of chronic inhibition of the Parkinson ’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

The most common mutation in the Leucine-rich repeat kinase 2 gene (LRRK2), G2019S, causes familial Parkinson ’s Disease (PD) and renders the encoded protein kinase hyperactive. While targeting LRRK2 activity is...

Source: Molecular Neurodegeneration - March 19, 2021 Category: Neurology Authors: Jillian H. Kluss, Melissa Conti Mazza, Yan Li, Claudia Manzoni, Patrick A. Lewis, Mark R. Cookson and Adamantios Mamais Tags: Research article Source Type: research